CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination.

Background: Cancer-associated fibroblasts (CAFs) can facilitate tumor progression through multiple approaches. Research indicates that CAFs in various tumors exhibit robust lactate metabolism, ultimately becoming the primary source of lactate in the tumor microenvironment. Emerging evidence has established that CAFs could orchestrate gastric cancer (GC) immune evasion.

A solid-solution approach for controllable photomechanical crystalline materials.

Solid solutions are a unique and elegant crystal engineering strategy to control the properties of crystalline materials, and the tunability of physicochemical properties it provides has a wide scope of applications. In this research, we bring this strategy to the realm of smart molecular crystals and explore solid solutions of organic photomechanical crystals to create flexible structures that exhibit a gradient of predetermined emissive, mechanical, and reactive properties. Specifically, we demonstrate that fluorescence, mechanical properties, and solid-state photoreactivity in a binary mixed crystal system of 9-anthraldehyde (9AA) and 9-methylanthracene (9MA) can be simultaneously and precisely tuned simply by changing the composition.

Exosome-Functionalized Hydrogels Improve Cartilage Repair by Modulating BMSCs Migration and Differentiation.

Articular cartilage exhibits inherently poor self-repair capacity, and conventional therapeutic strategies often yield suboptimal long-term functional restoration due to inadequate tissue remodeling and mechanical instability. To address this challenge, we developed a biomimetic hydrogel scaffold integrating bone marrow mesenchymal stem cell (BMSC)-derived exosomes within a cartilage-mimetic matrix composed of gelatin methacrylate (GelMA), chondroitin sulfate methacrylate (CSMA), and hyaluronic acid methacrylate (HAMA). In vitro analyses demonstrated the composite hydrogel's robust capacity to drive chondrogenic differentiation of BMSCs, as evidenced by upregulated expression of collagen II and aggrecan.

p-Synephrine Loaded by Injectable Gelma Hydrogel Ameliorates Cartilage Degeneration in Osteoarthritis by Inhibiting the MAPK and NF-κB Signaling Pathways.

Inflammation is a key factor that contributes to cartilage degeneration in osteoarthritis (OA). p-Synephrine has anti-inflammatory effects. Nevertheless, the effects of p-synephrine on OA remain to be elucidated.

Groundwater nitrate contamination around a municipal landfill: hydrogeochemical insights, source identification, and health risk assessment.

This study intended to investigate the hydrochemical characteristics and sources of nitrate (NO-N) in groundwater, and to evaluate the potential health risks in the vicinity of the Jiangcungou landfill in Northwest China. To fulfill these purposes, a total of 41 groundwater sourced primarily from the phreatic aquifer were collected and analyzed. The study found that NO-N concentrations in the area varied between 0.

Efficient synchronization of high expression and site-specific biotinylation of the PTBP1 RRM3/4 domain.

Polypyrimidine tract-binding protein 1 (PTBP1), a key regulator of mRNA alternative splicing, has emerged as a promising therapeutic target for neurodegenerative diseases and cancer treatment. Given the critical role of its RRM4 domain's lysine residues in binding to polypyrimidine single-stranded RNA, nonspecific biotinylation could potentially alter PTBP1's activity. Here, we describe a method for the concurrent high-level expression and site-specific biotinylation of the PTBP1 RRM3/4 domain using the pQE80L vector and AVB101 host strain.

Precision surface-immobilized peptide on graphene/chitosan composite sponge for rapid hemostasis of uncontrolled bleeding.

Efficient and safe hemostasis for trauma-induced bleeding remains a critical challenge. In this study, we developed a peptide-immobilized graphene/chitosan composite sponge (GCCS-TRAP) for enhanced hemostatic performance. The thrombin receptor-activating peptide (TRAP) was precisely immobilized on the surface of a graphene/chitosan crosslinked sponge via thiol-ene photoclick chemistry.

Adversarial Range Gate Pull-Off Jamming Against Tracking Radar.

Range gate pull-off (RGPO) jamming is an effective method for track deception aimed at radar systems. Nevertheless, enhancing the effectiveness of the jamming strategy continues to pose challenges, restricting the RGPO jamming method from achieving its maximum potential. This paper focuses on addressing the problem of optimizing the strategy for white-box RGPO jamming, serving as a foundational step toward quantitative optimization research on RGPO jamming strategies.

High-sensitive detection of Li and Zn in aqueous solutions using capillary effect-enhanced laser-induced breakdown spectroscopy.

To ensure the safe operation of pressurized water reactors, the real-time and high-sensitive monitoring of Li and Zn in primary cooling water is required. Laser-induced breakdown spectroscopy (LIBS) is a real-time analytical method with great application potential for elemental monitoring in primary cooling water. However, when LIBS directly detects liquids, plasma quenching will reduce the detection sensitivity.

Compound Fault Diagnosis of Wind Turbine Gearbox via Modified Signal Quality Coefficient and Versatile Residual Shrinkage Network.

Wind turbine gearbox fault diagnosis is critical to guarantee working efficiency and operational safety. However, the current diagnostic methods face enormous restrictions in handling nonlinear noise signals and intricate compound fault patterns. Herein, a compound fault diagnosis method based on modified signal quality coefficient (MSQC) and versatile residual shrinkage network (VRSN) is proposed to resolve these issues.

Antimicrobial Silicon Rubber Crosslinked with Bornyl-Siloxane.

Silicone rubber (SiR) has a wide range of medical applications, but it lacks antimicrobial properties, leading to potential infection issues with related implants or medical devices. Most studies focus on adding anti-bacterial agents or surface modification, which usually result in composites with anti-bacterial properties, rather than synthesizing SiR with intrinsically antimicrobial performances. To tackle this issue, a double substituted bornyl-siloxane crosslinker (BC) is designed.

Directly anterior approach for total hip arthroplasty with an acetabular structural bone graft for developmental dysplasia of the hip (Crowe III and IV): a concise 5-year follow-up evaluation.

Background: This study evaluated the results of total hip arthroplasty (THA) via the direct anterior approach (DAA) in the lateral decubitus position combined with acetabular reconstruction via a bulk autograft for patients with developmental dysplasia of the hip (Crowe III and IV).

Patients And Methods: A retrospective study was conducted to analyse 16 patients (16 hips) with Crowe type III and IV developmental dysplasia of the hip (DDH) who underwent THA from June 2016 to July 2021. We recorded and analysed variables such as age, sex, height, body mass index (BMI), length of surgical incision, duration of surgery, intraoperative blood loss, Harris hip score, visual analogue scale (VAS) score, lower limb length, and pelvic radiograph analysis.

Rapid Response to Penpulimab Combined With Anlotinib and Chemotherapy in a Thoracic SMARCA4-UT Without PD-L1 Expression: A Case Report and Review of Literature.

SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) in the chest is a high-grade malignant tumor that grows rapidly and often carries a poor prognosis. Unfortunately, there are currently no effective treatment available until now. Here, we report a case of SMARCA4-UT in a patient who showed a swift response to a combination treatment of penpulimab, anlotinib, and chemotherapy.

Quadruple Stimuli-Responsive Behaviour of Acylhydrazone Crystals: Mechanical, Photomechanical, Thermomechanical, and Optical Waveguide Properties.

As society advances, the demand for high-performance crystal materials with versatile stimuli-responsive capabilities has increased. However, there remains a notable shortage of simple molecular crystals that exhibit stable and swift responses to various stimuli. In this study, we synthesized a novel acylhydrazone crystal by integrating benzene-fused heterocycles and halogens, achieving a crystal material with multiple stimuli-responsive behaviours.

The long noncoding RNA ELFN1-AS1 promotes gastric cancer growth and metastasis by interacting with TAOK1 to inhibit the Hippo signaling pathway.

Gastric cancer (GC) is a common digestive malignancy that causes numerous cancer-related deaths. Long noncoding RNAs (lncRNAs) play a crucial role in the development of various tumors, including GC. In this study, we revealed that ELFN1-AS1, a lncRNA with aberrantly high expression, contributes to the proliferation and metastasis of GC.

Tailoring Zn Flux by an Ion Acceleration Layer Modified Separator for High-Rate Long-Lasting Zn Metal Anodes.

A large concentration gradient originating from sluggish ion transport on the surface of Zn metal anodes will result in uneven Zn flux, giving rise to severe dendrite growth, especially at high current density. Herein, an ion acceleration layer is introduced by a facile separator engineering strategy to realize modulated Zn flux and dendrite-free deposition. Zinc hexacyanoferrate as the modifying agent featuring strong zincophilicity and rapid diffusion tunnel can enable fast trap for Zn near the electrode surface and immediate transport onto deposition sites, respectively.

Insight into NO emission and denitrifier communities under different aeration intensities in composting of cattle manure from perspective of multi-factor interaction analysis.

Nitrous oxide (NO) emission from composting is a significant contributor to greenhouse effect and ozone depletion, which poses a threat to environment. To address the challenge of mitigating NO emission during composting, this study investigated the response of NO emission and denitrifier communities (detected by metagenome sequencing) to aeration intensities of 6 L/min (C6), 12 L/min (C12), and 18 L/min (C18) in cattle manure composting using multi-factor interaction analysis. Results showed that NO emission occurred mainly at mesophilic phase.

Comparative Analysis of Gut Bacterial Community Composition in Two Tropical Economic Sea Cucumbers under Different Seasons of Artificial Environment.

With the continuous rise of the sea cucumber aquaculture industry in China, the tropical sea cucumber aquaculture industry is also improving. However, research on the gut microorganisms of tropical sea cucumbers in captivity is scarce. In this study, high-throughput sequencing methods were used to analyze the gut microbial composition of and in the dry season and wet season of artificial environments.

Recent Progress of Bioinspired Cell Membrane in Cancer Immunotherapy.

By modifying immune cells, immunotherapy can activate immune response to establish long-term immune memory and prevent tumor recurrence. However, their effectiveness is largely constricted by the poor immunogenicity, immune escape, and immune tolerance of the tumor. This is related to the characteristics of the tumor itself, such as genome instability and mutation.

Simplified design method for optical imaging systems based on aberration characteristics of optical-digital joint optimization.

With the continuous improvement of imaging performance requirements, the design of imaging systems has become increasingly complex, making it more difficult and expensive to manufacture and test. To overcome these problems, a simplified design framework for imaging systems based on aberration characteristics of optical-digital joint optimization was built in this paper. Specifically, an improved total variation regularization restoration algorithm was proposed, and the difficulty of correction for different monochromatic aberrations was evaluated.

Transformation and Detoxification of Typical Metallurgical Hazardous Waste into a Resource: A Review of the Development of Harmless Treatment and Utilization in China.

The production process of the metallurgical industry generates a significant quantity of hazardous waste. At present, the common disposal method for metallurgical hazardous waste is landfilling, which synchronously leads to the leaching of toxic elements and the loss of valuable metals. This paper presents a comprehensive review of the research progress in the harmless treatment and resource utilization of stainless steel dust/sludge (including stainless steel dust and stainless steel pickling sludge) and aluminum ash (including primary aluminum ash and secondary aluminum dross), which serve as representative hazardous wastes in ferrous metallurgy and nonferrous metallurgy, respectively.

Evaluation of Rice Straw, Corncob, and Soybean Straw as Substrates for the Cultivation of .

is a type of high-quality rare edible and medicinal mushroom, and its research boom is just beginning. More than 80 million tons of grain crop residues are produced each year in Heilongjiang Province. To realize the exploration and utilization of wild mushrooms and also provide a theoretical support for the high-value utilization of these resources in Heilongjiang Province, we evaluated the cultivation of mushrooms using rice straw, corncob, and soybean straw as substrates.

Spherical aberration-based compensation method for narcissus.

A narcissus-compensation method is proposed based on a mathematical model that connects the spherical aberration and the narcissus-induced temperature difference (NITD). Through non-sequential ray tracing analysis in ZEMAX, we simulate a compact, five-lens, long-wave infrared (LWIR) optical system with NITD as low as 0.7 mK.

Fast Stray Light Performance Evaluation Based on BSDF and Radiative Transfer Theory.

Evaluating the stray light cancellation performance of an optical system is an essential step in the search for superior optical systems. However, the existing evaluation methods, such as the Monte Carlo method and the ray tracing method, suffer from the problems of vast arithmetic and cumbersome processes. In this paper, a method for a rapid stray light performance evaluation model and quantitatively determining high-magnitude stray light outside the field of view are proposed by adopting the radiative transfer theory based on the scattering property of the bidirectional scattering distribution function (BSDF).

Miniaturized Low-Frequency Communication System Based on the Magnetoelectric Effect.

Recently, the realization of electromagnetic wave signal transmission and reception has been achieved through the utilization of the magnetoelectric effect, enabling the development of compact and portable low-frequency communication systems. In this paper, we present a miniaturized low-frequency communication system including a transmitter device and a receiver device, which operates at a frequency of 44.75 kHz, and the bandwidth is 1.