A retrospective study on Mohs micrographic surgery combined with adjuvant radiotherapy in the treatment of extramammary Paget's disease: analysis of 87 patients.

Purpose: This retrospective study assessed the effectiveness of Mohs micrographic surgery (MMS) combined with adjuvant radiotherapy for the treatment of extramammary Paget's disease (EMPD).

Methods: This retrospective study included 87 patients with pathologically confirmed EMPD and complete follow-up data who were treated at the Radiation Therapy Department of Peking University First Hospital between January 2012 and December 2021. The surgical approach for the primary lesion involved MMS, followed by postoperative radiotherapy with doses ranging from 50 to 60 Gy administered over 25-30 fractions.

Electrocatalytic Polyester Waste Upcycling via Lattice Oxygen Redox Activation.

Electrocatalytic upcycling of waste polyester plastics into valuable organic acids offers a dual solution for mitigating plastic pollution and promoting sustainable carbon cycling. However, practical implementation remains limited by the scarcity of cost-effective and high-performance electrocatalysts. In this work, we investigate MCoO (where M═Mn, Fe, Co, Cu, and Ni) as model catalysts and identify lattice oxygen activity as a critical factor governing the electrochemical upgrading of waste polyethylene terephthalate (PET).

Pollution characteristics of microplastics in the wild tropical sea cucumber Holothuria atra (Echinodermata: Holothuroidea) and its habitat at different seasons.

Microplastics (MPs), as a long-term micropollutant source, are widely present in the marine environment, necessitating investigations into their temporal variations in representative organisms and surrounding ecosystems. Here, we used the tropical sea cucumber Holothuria atra as a model organism and conducted a four-season MPs sampling survey from summer 2019 to spring 2020 in the coral reef area of Yunlong Bay, China. Results showed a 100 % detection rate of MPs across all samples, with an initial decrease followed by an increase in MPs abundance in both environmental and tissue samples over the investigation period.

Oxide Heterostructure Engineering Drives Stable Lattice Oxygen Evolution for Highly Efficient and Robust Water Electrolysis.

Achieving a highly active and stable oxygen evolution reaction (OER) is critical for the implementation of water electrolysis in green hydrogen production but remains challenging. Steering the OER pathway from an adsorbate evolution mechanism (AEM), where a metal site serves as the active site, to the lattice oxygen mechanism (LOM) has been found to enhance OER activity; however, it suffers from low stability. In this work, we propose to construct CuO/CoO heterointerface, which enables the realization of a stable LOM pathway.

Genomic census of invasive nontyphoidal Salmonella infections reveals global and local human-to-human transmission.

Extraintestinal infections caused by Enterobacteriaceae represent a global concern, further exacerbated by the growing prevalence of antimicrobial resistance (AMR). Among these, invasive nontyphoidal Salmonella (iNTS) infections have become increasingly challenging to manage, and their global spread remains poorly understood. Here we compiled 1,115 patient records and generated a comprehensive genomic dataset on iNTS.

Genomic epidemiology and public health implications of zoonotic monophasic Typhimurium ST34.

Background: Monophasic Typhimurium sequence type 34 (mSTM ST34) has emerged as a significant global health threat, but our understanding of its genomic epidemiology and potential public health implications in international and regional contexts remains limited. This study aims to fill this crucial gap by assessing the genomic epidemiology of multidrug resistance (MDR) mSTM ST34, as well as its clinical characteristics and virulence.

Methods: To achieve the objectives of this study, we conducted a comprehensive genomic analysis of mSTM ST34 isolates.

A genomic and phenotypic investigation of pigeon-adaptive Salmonella.

Salmonella, a significant threat to public safety, inflicts substantial economic losses on the poultry industry. The unique "parental feeding" breeding model of pigeon farms, against the "all-in & all-out" biosecurity strategy, makes them susceptible to Salmonella infections and subsequent outbreaks of pigeon paratyphoid. This study initially studied three pigeon paratyphoid outbreak incidents in Henan, China, in which 53 strains of pigeon-origin Salmonella Typhimurium (STM) were identified.

Avian-specific transition to endemicity is accompanied by localized resistome and mobilome interaction.

Bacterial regional demonstration after global dissemination is an essential pathway for selecting distinct finesses. However, the evolution of the resistome during the transition to endemicity remains unaddressed. Using the most comprehensive whole-genome sequencing dataset of serovar Gallinarum (.

Genomic and resistome analysis of isolates from retail markets in Yichun city, China.

Nontyphoidal (NTS) causes global outbreaks of foodborne disease. The main source of for humans is animal-borne foods; however, the monitoring of in the food chain via genomic platforms was limited in China. This study evaluated the prevalence, resistome, and virulome diversity of strains identified from pork, retail environment, aquatic products, and poultry eggs of retail markets in Yichun city, Jiangxi province.

Which is more priority, substrate type or food quality? A case study on a tropical coral reef sea cucumber Stichopus chloronotus revealed by prokaryotic biomarker.

Background: Different species of sea cucumbers in various regions have diverse preferred habitats and feeding habits. However, detailed research on the correlation between food selection and habitat preference of sea cucumbers, as well as their adaptive adjustments to specific habitat types, is still lacking.

Methods: A field study was carried out to explore the relationship between food selection and habitat preference, as well as the adaptation process, of the tropical sea cucumber Stichopus chloronotus, which has specific food preferences.

Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.

Salmonella, a common zoonotic pathogen, is a significant concern for public health, particularly when it contaminates animal-borne products. The potential for Salmonella to infect duck embryos and disrupt their normal development not only causes substantial economic losses for the industry but also poses a severe threat to public health. However, there is a lack of understanding about the prevalence of Salmonella in duck embryos and their potential public health implications.

Emerging -positive in Chinese pediatric infections.

Non-typhoidal (NTS) is a common zoonotic foodborne pathogen, whose rising antimicrobial resistance has been an urgent threat to global public health. Here, we reported two carbapenem-resistant (CRSE) strains (NBFE-049 and NBFE-164) carrying the genes, which were recovered from two Chinese children, belonged to serovar Typhimurium (. Typhimurium) monophasic variant (.

A global genome dataset for Salmonella Gallinarum recovered between 1920 and 2024.

Salmonella enterica serovar Gallinarum (S. Gallinarum) is an avian-specific pathogen responsible for fowl typhoid, a severe systemic disease with high mortality in chickens. This disease poses a substantial burden to the poultry industry, particularly in developing countries like China.

The Evolution of Vaccines Development across Serovars among Animal Hosts: A Systematic Review.

is a significant zoonotic foodborne pathogen, and the global spread of multidrug-resistant (MDR) strains poses substantial challenges, necessitating alternatives to antibiotics. Among these alternatives, vaccines protect the community against infectious diseases effectively. This review aims to summarize the efficacy of developed vaccines evaluated in various animal hosts and highlight key transitions for future vaccine studies.

Nationwide trends and features of human salmonellosis outbreaks in China.

Salmonellosis is one of the most common causes of diarrhea, affecting 1/10 of the global population. Salmonellosis outbreaks (SO) pose a severe threat to the healthcare systems of developing regions. To elucidate the patterns of SO in China, we conducted a systematic review and meta-analysis encompassing 1,134 reports across 74 years, involving 89,050 patients and 270 deaths.

Comparative Analysis of Gut Bacterial Community Composition in Two Tropical Economic Sea Cucumbers under Different Seasons of Artificial Environment.

With the continuous rise of the sea cucumber aquaculture industry in China, the tropical sea cucumber aquaculture industry is also improving. However, research on the gut microorganisms of tropical sea cucumbers in captivity is scarce. In this study, high-throughput sequencing methods were used to analyze the gut microbial composition of and in the dry season and wet season of artificial environments.

Predicting antimicrobial resistance in with discriminative position fused deep learning classifier.

() has become a particular concern due to the increasing incidence of antimicrobial resistance (AMR) observed worldwide. Using machine learning (ML) to predict AMR is a more efficient method than traditional laboratory testing. However, further improvement in the predictive performance of existing models remains challenging.