Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.

Alzheimer's disease (AD), a leading cause of dementia, represents a critical unmet global medical need. While the precise mechanisms underlying AD pathogenesis remain elusive, increasing evidence underscores the pivotal role of neuroinflammation in driving cognitive impairment. N6-methyladenosine (m6A), an epigenetic modification regulating RNA metabolism, has been found to be dysregulated in AD.

Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.

The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).

Glucose restriction: double edged sword in cancer treatment.

Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural killer (NK) cell-deficient pre-metastatic niche (PMN).

S100A4 Facilitates Radiation-Induced Tumor Repopulation by Driving Polyploid Giant Cancer Cells Budding.

Radiotherapy, a pivotal treatment for colorectal cancer, is compromised by tumor repopulation, which is characterized by accelerated growth and increased treatment resistance. Although radiation-induced DNA breaks eliminate most cells, a subset of polyploid giant cancer cells (PGCCs) evade death through massive genomic amplification, subsequently undergoing depolyploidization via a viral budding-like process to generate proliferative progeny. Critically, these PGCCs drive tumor repopulation and underpin therapeutic failure.

A prospective study of physical activity in full-term pregnant women and its effect on pregnancy outcomes.

Background: The effects of physical activity (PA), especially brisk walking, on labor outcomes and pregnancy health have not been clearly established. This study aimed to investigate the relationship between PA and cervical ripeness and pregnancy outcomes in term pregnant women.

Basic Procedures: A prospective cohort study was conducted with 52 pregnant women (30.

Thorough Physiological Assessment in Non-Culprit Vessels of Patients with Acute Myocardial Infarction: Is It a Required Action?

Backgrounds: The management of non-culprit vessels (NCV) among individuals with acute myocardial infarction (AMI) remains an unsolved problem. Angiography-derived physiological assessments developed recently may help address this issue. Our study aims to measure angiography-derived fractional flow reserve (Angio-FFR) and angiography-derived index of microcirculatory resistance (Angio-IMR) in NCVs of AMI patients and explore their prognostic values and necessity.

Global research trends in endoscopic breast surgery: a bibliometric analysis from 1994 to 2024.

Endoscopic breast surgery (EBS) is designed to reduce surgical trauma and optimize cosmetic outcomes through inconspicuous incisions. However, a comprehensive understanding of the evolution of research focus in EBS is lacking. This study aimed to analyze global publication trends, academic impacts, and evolving research directions in the field of EBS.

Dual-Functional Nanoliposome with High BPA Loading for Targeted MRI-Guided BNCT of Glioblastoma.

Glioblastoma is a highly malignant brain tumor with few available therapeutic options, for which boron neutron capture therapy (BNCT) has emerged as a promising precision radiotherapy approach. However, its efficacy remains suboptimal due to inadequate tumor targeting of boron agents and lack of in vivo visualization. Herein, a gadolinium-boron integrated lipid nanocarrier (BPA-F&DOTA-Gd@LIPO-ANG) was developed for targeted boron delivery and MRI-guided BNCT.

Intracerebral Hemorrhage: An Acute Manifestation of Small Vessel Disease?

Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis.

Estrogen receptor beta in lateral habenula mediates antidepressant effects of estrogen in postpartum-hormone-withdrawal-induced depression.

Dramatic drop in reproductive hormone, especially estrogen level, from pregnancy to postpartum period is known to contribute to postpartum depression (PPD), but the underlying mechanism and the role of the estrogen receptors (ERs) in this process were unclear. Here, we used an estrogen-withdrawal-induced PPD model following hormone simulated pregnancy (HSP) in female Sprague-Dawley rats to induce depressive-like behaviors. After estrogen withdrawal, we observe an up-regulation of astrocyte-specific potassium channel (Kir4.

Long-term effects of radiofrequency ablation on symptom severity, depression, anxiety and quality of life in patients with atrial fibrillation: a longitudinal observational study.

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia, significantly affecting patients' quality of life (QoL) and increasing the risk of complications such as heart failure, stroke and dementia. In addition to the physical burden, psychological distress, including depression and anxiety, is prevalent among patients with AF and can exacerbate clinical symptoms and worsen overall well-being. While radiofrequency ablation (RFA) is widely used for rhythm control in AF, its long-term effects on both physical and psychological outcomes, including symptom severity, anxiety, depression and QoL, remain underexplored.

Leadership Roles, Care Models, and Effectiveness of Advanced Practice Nurse-Led Multidisciplinary Teams: A Scoping Review.

Aim: This review aimed to delineate the leadership roles, care models, and effectiveness of advanced practice nurse (APN)-led multidisciplinary teams in healthcare settings.

Background: Emerging international evidence suggests leadership constitutes a core characteristic of APN roles. Despite expanding involvement of advanced practice nurses in leading advanced and sustainable care within multidisciplinary teams, the current understanding of such care models is limited.

Cutting-edge technologies in neural regeneration.

Neural regeneration stands at the forefront of neuroscience, aiming to repair and restore function to damaged neural tissues, particularly within the central nervous system (CNS), where regenerative capacity is inherently limited. However, recent breakthroughs in biotechnology, especially the revolutions in genetic engineering, materials science, multi-omics, and imaging, have promoted the development of neural regeneration. This review highlights the latest cutting-edge technologies driving progress in the field, including optogenetics, chemogenetics, three-dimensional (3D) culture models, gene editing, single-cell sequencing, and 3D imaging.

A rapid and ultrasensitive CRISPR/Cas12a-based assay for the accurate identification of T-even type phages.

Phage contamination poses a significant threat to industrial fermentation, leading to substantial economic losses. Virulent T-even type phages (T2/T4/T6) represent particularly concerning biological hazards in fermentation systems. This paper developed a novel CRISPR/Cas12a-based system integrated with recombinase polymerase amplification (RPA), enabling ultrasensitive identification of T-even type phages.

Multicenter Practice of Non/Minimized Fluoroscopy Ablation for Paroxysmal AF in China: The PAF-ICE Trial.

Background: Intracardiac echocardiography (ICE)-guided non/minimized-fluoroscopy catheter ablation for atrial fibrillation (AF) has been reported, but its effectiveness and safety still lack multicenter evidence.

Objectives: The authors sought to evaluate the effectiveness and safety of ICE-guided non/minimized-fluoroscopy catheter ablation compared with the traditional fluoroscopy-guided approach in patients with paroxysmal AF.

Methods: A total of 448 patients with paroxysmal AF, from 15 centers in China, were randomly assigned in a 1:1 ratio to a non/minimized-fluoroscopy group (n = 223) and a traditional approach group (n = 225).

[Research progress on improving stem cell treatment of erectile dysfunction].

Stem cells therapy is an emerging method for the treatment of erectile dysfunction (ED) in men. Compared with traditional treatment, it has the advantage lies in the ability to treat the pathological damage of the penis in patients with ED, which provides new ideas for solving erectile dysfunction fundamentally. However, due to the special anatomical structure of the penis, the therapeutic effect of stem cells is sometimes unsatisfactory.

Review of Perioperative Care in Elderly Patients With Esophageal Hiatal Hernia and Cardiopulmonary Disease.

This article aims to explore the clinical characteristics and corresponding nursing points of elderly patients with massive hiatal hernia. A case study of an elderly patient with massive hiatal hernia and severe cardiopulmonary disease was reviewed, along with relevant literature. Nursing points are the following: multidisciplinary team to estimate surgical risks and develop individualized pre-rehabilitation management strategies; assessment and intervention for thrombosis and bleeding risks; postoperative hemodynamic monitoring and precise fluid management; dynamic observation of inflammatory indicators and infection prevention and care; and follow-up visits and health guidance after discharge.

Impact of Buccal Bone Arch Contour on Bone Remodeling and Esthetics in Guided Bone Regeneration: A Retrospective Study.

Objectives: To assess the stability of hard tissue following simultaneous guided bone regeneration (GBR) in the anterior maxilla, analyze the impact of the buccal bone arch contour on postoperative bone remodeling and restorative outcomes.

Methods: Patients who underwent anterior maxillary implantation and simultaneous GBR were included. Radiographic metrics were evaluated using preoperative, immediate postoperative, and follow-up cone beam computer tomography (CBCT) scans, and esthetic indicators were extracted from follow-up clinical records.

Vitamin Interventions in ASD and ADHD: Systematic Review and Meta-Analysis.

Background: Vitamin interventions have emerged as a cost-effective and accessible approach to managing Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD), primarily for alleviating gastrointestinal symptoms such as constipation. Recent studies suggest vitamins may also improve core symptoms, yet most existing research focuses on comparisons between patients and healthy controls, lacking clinically relevant, evidence-based insights.

Methods: A meta-analysis was conducted using studies retrieved from PubMed, Web of Science, and the Cochrane Library, focusing on vitamin interventions in ASD and ADHD populations.

Red yeast rice-induced severe rhabdomyolysis complicated by acute kidney injury and respiratory failure: a case report.

Red yeast rice (RYR), a commonly used supplement with statin-like properties, is generally considered safe but may cause severe adverse effects such as rhabdomyolysis. We report a rare case of severe RYR-induced rhabdomyolysis complicated by acute kidney injury (AKI) and respiratory failure, with diaphragmatic dysfunction as a key contributing factor. A 78-year-old woman developed progressive proximal muscle weakness, dyspnea, and tea-colored urine after taking RYR (2 g/day) for 1 month.

Preparation Methods of Hydrogel Microspheres and Recent Advances in Their Application for Treating Diabetic Wounds.

Diabetic wounds are characterized by complex pathologies, such as vascular changes, nerve damage, and immune dysfunction, which make healing difficult. Hydrogel microspheres have shown great potential in the field of wound treatment due to their excellent biocompatibility, high water content, and soft physical properties. The review summarizes the preparation methods of hydrogel microspheres in detail, including microfluidic technology, spray method, electro spraying, emulsion method, phase separation, photomask method, and 3D printing technology.