[Research progress on improving stem cell treatment of erectile dysfunction].

Stem cells therapy is an emerging method for the treatment of erectile dysfunction (ED) in men. Compared with traditional treatment, it has the advantage lies in the ability to treat the pathological damage of the penis in patients with ED, which provides new ideas for solving erectile dysfunction fundamentally. However, due to the special anatomical structure of the penis, the therapeutic effect of stem cells is sometimes unsatisfactory.

Effects of bisphenol A on root traits and rhizosphere bacteria: exploring the link between rhizosphere bacterial and root growth.

Background: Bisphenol A (BPA), a widespread environmental pollutant, has been extensively studied for its effects on bacteria and plant, but its impact on rhizosphere bacterial communities and plant root traits is less understood. At the same time, the role of bacteria in helping plants resist adversity is widely recognized, but the relationship between BPA-induced with rhizosphere bacterial changes and root development is still unclear. Therefore, this study investigated the effects of varying BPA concentrations (1.

Dolabellane Diterpenoids from Soft Coral with Anti-Inflammatory Activities.

A chemical investigation of the EtOAc fraction from soft coral resulted in the isolation of 12 undescribed dolabellane-type diterpenoids, namely clavirolides W-Z (-), clavularols A-H (-), and three known analogs (-). Their structures were characterized by an extensive analysis of spectroscopic data, including X-ray diffraction and ECD calculations for the assignment of absolute configurations. The structures of and - are feathered as peroxyl-substituted derivatives, while compounds - possess additional oxidative cyclization, including epoxide or furan that are rare in the dolabellane family.

A hexatopic-carboxylate-based type luminescent zirconium-organic framework for the detection of glutathione.

As one of the most studied subclasses of metal-organic frameworks (MOFs), zirconium-based MOFs (Zr-MOFs) have aroused extensive interest due to unlimited variety of organic linkers and diversity of structures, compositions and functions induced by varying Zr-oxo clusters. It has been proven that organic linker-directed precise control over the composition, underlying net and porosity of the resultant Zr-MOFs is essential to achieve desired crystalline structures, functions or enhanced performances. Herein, we designed and constructed a new Zr-MOF (HIAM-4062) possessing a topology using one hexatopic carboxylate linker.

Erratum: Diffusion MRI biomarkers predict the outcome of irreversible electroporation in a pancreatic tumor mouse model.

[This corrects the article on p. 1615 in vol. 8, PMID: 30210929.

Evaluation of the analgesic efficacy of ultrasound-guided quadratus lumborum block for laparoscopic renal surgery: a randomized controlled trial.

Purpose: To evaluate the analgesic efficacy of ultrasound-guided quadratus lumborum block (QLB) for laparoscopic renal surgery.

Methods: Sixty-eight patients who underwent unilateral laparoscopic renal surgery were enrolled. All patients were separated into two groups: group QLB (n = 34) and group C (n = 34).

Carbon Dioxide Capture by a Hydrothermally Synthesized Water-Resistant Zinc-Oxalate-Aminotriazolate Framework.

Selective capture of carbon dioxide (CO) from flue gas employing physisorbents represents an appealing approach owing to its potentially low energy penalty and cost-effectiveness. Microporous metal-organic frameworks (MOFs), characterized by their highly customizable pore structure and functionality, offer significant promise in this field. However, challenges such as thermal/moisture resistance, green/scalable synthesis, and adsorption durability remain unresolved.

Efficacy and safety of transcatheter arterial chemoembolization combined with microwave ablation for hepatic hemangiomas (> 5 cm).

Background: Hepatic hemangiomas represent the most prevalent benign liver tumors. Surgical management of large symptomatic hepatic hemangiomas remains controversial and there is an increasing interest in minimally invasive techniques, such as transcatheter arterial chemoembolization (TACE) and microwave ablation (MWA).

Aim: To evaluate the efficacy and safety of TACE combined with MWA for large hepatic hemangiomas.

Kendrick Mass Defect Analysis for Structural Characterization of Additives in Low-Viscosity Engine Oils: A Concise Review.

Ultrahigh-resolution mass spectrometry (UHRMS), whether hyphenated or not, has emerged as a powerful analytical technique for the molecular characterization of formulated lubricants. These lubricants, particularly motor vehicle/engine oils, are complex mixtures composed of base oils and various additives. However, the resulting data from UHRMS are highly complex due to the intricate nature of these samples, making it challenging to identify the molecular structures of lubricant additives.

Complete genome analysis of a novel mitovirus in the phytopathogenic fungus Penicillium digitatum.

Citrus is one of the most widely cultivated and economically important fruit crops globally. However, the postharvest pathogen Penicillium digitatum causes green mold decay in citrus fruits, leading to significant economic losses. Here, a novel mycovirus, Penicillium digitatum mitovirus 1 (PdMV1), was isolated from the phytopathogenic fungus P.

Dual interfacial H-bonding-enhanced deep-blue hybrid copper-iodide LEDs.

Solution-processed light-emitting diodes based on non-toxic copper-iodide hybrids are a compelling solution for efficient and stable deep-blue lighting, owing to their tunability, high photoluminescence efficiency and environmental sustainability. Here we present a hybrid copper-iodide that shows near-unity photoluminescence quantum yield (99.6%) with an emission wavelength of 449 nm and colour coordinates (0.

Constructing Alkali Metal-Organic Frameworks with High Porosity Utilizing a High-Connectivity Organic Linker.

Alkali metal-organic frameworks (AMOFs) hold considerable promise for a broad spectrum of applications, benefiting from their low toxicity and lightweight. However, the construction of AMOFs with permanent porosity remains a significant challenge due to the tendency of alkali metals to coordinate with polar solvents, thereby forming coordination polymers with low dimensionality. Here, we introduce a connectivity-regulated approach for the synthesis of porous AMOFs by using highly connected organic linkers.

Gradient aware adaptive quantization: Locally uniform quantization with learnable clipping thresholds for globally non-uniform weights.

Non-uniform quantization has been shown to achieve promising performance for compressing neural networks, due to its better adaptation to the distribution of weights. However, traditional non-uniform quantization methods rely solely on weight distribution density, resulting in diminished model performance post-quantization. To tackle this challenge, we propose a novel non-uniform quantization method that can not only automatically learn the clipping threshold but also adaptively adjust the quantization levels, which can effectively reduce the quantization error.

Isolation and characterization of xuetonlignans L-P, previously undescribed spirobenzofuranoid dibenzocyclooctadiene lignans from the fruits of Kadsura heteroclita.

Five previously undescribed spirobenzofuranoid dibenzocyclooctadiene lignans, xuetonlignans L-P (1-5), and three known dibenzocyclooctadiene lignans (6-8) were isolated from the fruits of Kadsura heteroclita. Their structures were elucidated by analysis of HR-ESI-MS, NMR spectroscopy, CD spectra and single-crystal X-ray structure determination. The hepatoprotective activity against HO-induced toxicity in HepG2 cells and anti-inflammatory activity against NO (nitric oxide) were performed.

A Luminescent Zirconium-Pentacarboxylate Framework with 10-Connected Zr Clusters for Dichromate Detection.

Zirconium-based metal-organic frameworks (Zr-MOFs) have received great attention due to their abundant structural diversity and controllable functionalizations. However, pentacarboxylic acid-based Zr-MOFs are less studied. Herein, we report a new pentacarboxylic acid-based organic linker, 4″,4‴″,4‴‴″-((4-(4,5-bis(4-carboxyphenyl)-1-imidazol-2-yl)phenyl)methanetriyl)tris(([1,1':4',1″-terphenyl]-4-carboxylic acid)), which has been successfully employed to construct a Zr-MOF, HIAM-4055 (HIAM = Hoffmann Institute of Advanced Materials).

Combined association of systemic inflammatory response index and prognostic nutritional index with survival among US cancer survivors.

Background: Systemic inflammation and nutritional status play critical roles in determining clinical outcomes across multiple disease entities, particularly malignancies. Significantly, these two pathophysiological factors exhibit dynamic interplay through shared pathobiological mechanisms. This study sought to investigate the independent and combined prognostic capacity of the systemic inflammatory response index (SIRI) and prognostic nutritional index (PNI) in predicting all-cause, cancer-specific, and non-cancer mortality among cancer survivors.

Xuetonlignans E-K, unusual spirobenzofuranoid dibenzocyclooctadiene lignans with hepatoprotective activity from the roots of Kadsura heteroclita.

Further phytochemical investigation on the roots of Kadsura heteroclita led to the isolation of sixteen spirobenzofuranoid dibenzocyclooctadiene lignans, including six previously undescribed ones named xuetonlignans E-J (1-6), and one being isolated for the first time from a natural source, xuetonlignan K (7). The structures and absolute configurations of 1-7 were elucidated by 1D and 2D NMR techniques, as well as calculated ECD spectra. Additionally, the absolute configurations of 1 and 5 were further confirmed by single crystal X-ray crystallographic analysis.

Polystyrene microplastics induces the injury of human corneal epithelial cells through ROS-mediated p53 pathway.

Objective: To investigate the effects of polystyrene microplastics (PS-MPs) on human corneal epithelial cells (HCEP).

Methods: The cytotoxicity of PS-MPs on HCEP cells was evaluated using a CCK-8 assay to measure cell viability, flow cytometry to analyze cell cycle and status, immunofluorescence to detect reactive oxygen species (ROS) and γ-H2AX levels, and western blotting to assess protein expression.

Results: The effects of PS-MPs on HCEP cell morphology and viability were particle size- and concentration-dependent.

Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China.

Background: Luspatercept, approved by the FDA and EMA for patients with transfusion-dependent lower-risk myelodysplastic syndrome (LR-MDS) unresponsive to erythropoiesis-stimulating agents (ESAs), lacks extensive real-world data, particularly in China.

Methods: We retrospectively analyzed 14 LR-MDS-SF3B1 patients treated with luspatercept for ≥12 weeks.

Results: Median age was 60 years (range 47-72); 42.

Building ultramicroporous zirconium metal‒organic frameworks with ligands of high coordination density through a reticular approach.

The rational design and synthesis of ultramicroporous solids featuring uniform pore dimensions remains a notable challenge, yet these materials are critical for the selective discrimination of molecules with similar physicochemical properties. Here we report a family of ten ultramicroporous zirconium-based metal-organic frameworks assembled from isophthalate-based octatopic or hexatopic carboxylate linkers with high coordination density and Zr nodes with relatively low connectivity (4, 6 and 8). The diverse inorganic node geometry, ligand connectivity, structural topology, framework stability and ultramicroporosity of the resultant metal-organic frameworks underscore the pivotal role of linker geometry and functionality in tailoring the adsorptive properties of the material.

Integration of single-cell sequencing and mendelian randomization reveals novel causal pathways between monocytes and hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) represents one of the most prevalent malignant neoplasms worldwide, characterized by poor prognosis and low 5-year survival rates. Despite extensive research, its pathogenesis remains largely unclear. Within the tumor microenvironment (TME), monocytes play a dual role: they participate in tumor cell recognition and elimination while regulating immune responses through cytokine secretion.

Domino-Annulation-Based Approach to Synthesize Bridged Bis-thiopyrano[2,3-]indoles and Unbridged Thiopyrano[2,3-]indoles.

A novel domino strategy for the construction of intricate bridged bis-thiopyrano[2,3-]indoles was disclosed, which involved one molecule of 3-formylchromones and two molecules of indoline-2-thiones, enabling the formation of four new bonds in a single operation. The transformation occurred under mild reaction conditions, facilitated by the synergistic action of the base NaHCO and the catalytic acid ZnCl. Notably, when these bridged bis-thiopyrano[2,3-]indole skeletons were treated with alkyl halides under basic conditions, they underwent deconstruction to yield alkylthio-substituted indole-decorated thiopyrano[2,3-]indoles.

Farey tree locking of terahertz quantum cascade laser frequency combs.

Frequency combs show various applications in molecular fingerprinting, imaging, communications, and so on. In the terahertz frequency range, semiconductor-based quantum cascade lasers (QCLs) are ideal platforms for realizing the frequency comb operation. Although self-started frequency comb operation can be obtained in free-running terahertz QCLs due to the four-wave mixing locking effects, resonant/off-resonant microwave injection, phase locking, and femtosecond laser based locking techniques have been widely used to broaden and stabilize terahertz QCL combs.

Pegylated Liposomal Doxorubicin Combined with Cytarabine and Granulocyte Colony-Stimulating Factor for Treating Newly Diagnosed Older and Unfit Acute Myeloid Leukemia Patients: A Prospective, Single-Center, Single-arm, Phase II Study.

BackgroundEffective treatment options are limited for elderly patients with acute myeloid leukemia (AML). A prospective phase II study was conducted to investigate the safety and efficacy of pegylated liposomal doxorubicin (PLD) combined with low-dose cytarabine (LDAC) and granulocyte colony-stimulating factor (G-CSF) in newly diagnosed older and unfit AML patients.MethodsTwenty-two patients were enrolled and deemed evaluable.