Publications by authors named "Weiru Liang"
Background: Luspatercept, approved by the FDA and EMA for patients with transfusion-dependent lower-risk myelodysplastic syndrome (LR-MDS) unresponsive to erythropoiesis-stimulating agents (ESAs), lacks extensive real-world data, particularly in China.
Methods: We retrospectively analyzed 14 LR-MDS-SF3B1 patients treated with luspatercept for ≥12 weeks.
Results: Median age was 60 years (range 47-72); 42.
Background: Abdominal obesity, assessed via the body roundness index (BRI), is a critical determinant of health outcomes. This study explores the association between abdominal obesity and frailty progression across different stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome in a nationwide longitudinal cohort.
Methods: Data were derived from the China Health and Retirement Longitudinal Study, including individuals aged ≥ 45 years.
Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients.
J Health Popul Nutr
February 2025
Background: Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, albumin, lymphocytes, and platelets. It serves as a valuable tool for assessing both inflammation and nutritional status in critically ill patients. However, there hasn't been a specific study exploring the role of the HALP score in critically ill patients.
View Article and Find Full Text PDFBackground: Impaired renal function (IRF) is associated with an elevated risk of major adverse renal events (MARE). However, the relationship between age-adapted estimated glomerular filtration rate (eGFR) criteria and in-hospital MARE has not been extensively studied in critically ill patients. Furthermore, the impact of eGFR trajectory changes on in-hospital MARE in this patient population remains underexplored.
View Article and Find Full Text PDFVacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a rare disease described by Beck et al. in 2020. Here we report a case of VEXAS syndrome with progressive worsening of pancytopenia.
View Article and Find Full Text PDFArticle Synopsis
- Severe aplastic anemia (SAA) is a serious condition causing bone marrow failure, and adding the drug avatrombopag (AVA) to standard immunosuppressive therapy (IST) shows promise in improving treatment responses without liver damage.
- A study compared 42 patients receiving AVA + IST with a historical group of 84 patients on IST alone, revealing that those on AVA had significantly higher complete and overall response rates at both 3 and 6 months.
- AVA was well-tolerated with no observed liver toxicity, and better treatment outcomes were noted, especially for those starting ATG treatment within 6 months of disease onset.
Objectives: The study aimed to investigate the relationship between blood pressure (BP) levels and mortality among critically ill older adults in the intensive care unit (ICU), establish optimal BP target for this population, and assess the mediating effect of severe malnutrition on BP-related mortality.
Methods: Data were extracted from the Medical Information Mart for Intensive Care IV version 2.2 database, focusing on critically ill patients aged 80 years and older.
Article Synopsis
- Critically ill patients in the ICU often experience dysglycaemia, and this study focused on the relationship between acute kidney injury (AKI) and dysglycaemia in both diabetic and non-diabetic patients.
- Analysis of 20,008 patients revealed that those with AKI had a significantly higher risk of dysglycaemia, including both hypoglycemia and hyperglycemia, particularly among non-diabetic individuals.
- The combination of AKI and dysglycaemia also correlated with increased long-term mortality, highlighting the need for improved glycemic management strategies in patients with AKI.
Article Synopsis
- A study compared the effectiveness of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with repeated immunosuppressive therapy (IST) for patients with severe aplastic anemia (SAA) who did not respond to initial treatment, finding a 57.6% overall response rate in the IST group and high hematologic recovery in the HSCT group.
- All patients in the HSCT group achieved neutrophil engraftment with no primary graft failures, while the cumulative incidences of acute and chronic graft-versus-host disease (GVHD) indicated some degree of complications, but overall survival rates were similar between the two groups.
- The results suggested that younger patients
Article Synopsis
- This study explores the link between sarcopenia (muscle loss) and cognitive impairment in older adults, aiming to clarify their relationship and long-term health implications.
- Analyzing data from 2,890 participants in the NHANES survey, results show that those with sarcopenia are significantly more likely to experience cognitive impairment, with a higher mortality risk from heart and brain diseases.
- The findings indicate that older adults with both sarcopenia and cognitive issues, along with existing health conditions like diabetes and cardiovascular diseases, face an even greater risk of death compared to those without sarcopenia.
Some aplastic anemia(AA) patients only have partial hematological responses after immunosuppressive therapy. Failure to achieve complete normalization of blood counts, particularly hemoglobin, will reduce their quality of life. This open-label pilot study was conducted to evaluate the efficacy and safety of roxadustat in this setting.
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- Juvenile myelomonocytic leukemia (JMML) is a complex blood disorder found mainly in infants and young children, where both overproduction and abnormal development of blood cells occur.
- Current methods for predicting patient outcomes in JMML are inadequate, leading researchers to seek new prognostic indicators like red cell distribution width (RDW), which reflects the size variability of red blood cells.
- A study found that a higher RDW (over 17.35%) at diagnosis significantly correlates with worse survival rates, suggesting RDW could be an affordable and insightful biomarker for predicting outcomes in JMML patients.*
Background: Hypochloremia and red blood cell distribution width (RDW) play important roles in congestive heart failure (CHF) pathophysiology, and they were associated with the prognosis of CHF. However, the prognostic value of chloride combined with RDW in patients with CHF remains unknown.
Methods: We retrospectively analyzed critically ill patients with CHF.
In critically ill patients with acute myocardial infarction (AMI), the relationship between the early administration of β-blockers and the risks of in-hospital and long-term mortality remains controversial. Furthermore, there are conflicting evidences for the efficacy of the early administration of intravenous followed by oral β-blockers in AMI. We conducted a retrospective analysis of critically ill patients with AMI who received the early administration of β-blockers within 24 hours of admission.
View Article and Find Full Text PDFRelationship between stress hyperglycemia ratio and allcause mortality in critically ill patients: Results from the MIMIC-IV database.
Front Endocrinol (Lausanne)
April 2023
Background: Stress hyperglycemia ratio (SHR) was developed to reduce the impact of long-term chronic glycemic factors on stress hyperglycemia levels, which have been linked to clinical adverse events. However, the relationship between SHR and the short- and long-term prognoses of intensive care unit (ICU) patients remains unclear.
Methods: We retrospectively analyzed 3,887 ICU patients (cohort 1) whose initial fasting blood glucose and hemoglobin A1c data within 24 hours of admission were available and 3,636 ICU patients (cohort 2) who were followed-up for 1-year using the Medical Information Mart for Intensive Care IV v2.