Long-term effects of radiofrequency ablation on symptom severity, depression, anxiety and quality of life in patients with atrial fibrillation: a longitudinal observational study.

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia, significantly affecting patients' quality of life (QoL) and increasing the risk of complications such as heart failure, stroke and dementia. In addition to the physical burden, psychological distress, including depression and anxiety, is prevalent among patients with AF and can exacerbate clinical symptoms and worsen overall well-being. While radiofrequency ablation (RFA) is widely used for rhythm control in AF, its long-term effects on both physical and psychological outcomes, including symptom severity, anxiety, depression and QoL, remain underexplored.

Self-management behaviors in patients with epilepsy: A dual-process model.

Background: Effective self-management is essential for patients with epilepsy to achieve optimal health outcomes. However, previous studies indicate that self-management performance remains suboptimal in this population. This study aimed to evaluate the relationships between patient empowerment, disease-related fear, self-regulatory fatigue, and self-management behaviors in patients with epilepsy in China, utilizing dual systems theory as a framework.

Melatonin Enhances Blast Disease Resistance via Inducing Rice Immunity and Inhibits the Growth of the Magnaporthe Oryzae.

Biopesticides are promising alternatives to chemical pesticides because of their low residual effects, high selectivity, and capacity for long-term disease control. Melatonin (N-acetyl-5-methoxytryptamine) may be an ideal candidate for biopesticide because it is widely present in the plant kingdom, involved in growth, development, and stress-induced responses in plants, and can inhibit the growth and propagation of some microbial pathogens. However, it remains largely unclear whether melatonin influences rice and the blast fungus Magnaporthe oryzae.

Split potassium application delays senescence and increases grain yield in winter wheat grown on sandy and silt loam soils.

Background: The judicious application of potassium (K) fertilizer plays a critical role in increasing potassium use efficiency, leaf photosynthesis capacity, and winter wheat yield. However, there is no unified conclusion on the yield-increasing effect of split K fertilizer application. In addition, the response mechanism of winter wheat to split K application across different soil types remains unclear.

Research progress in the role of tubal ciliary movement in female infertility-related disorders.

Tubal ciliary movement is one of the essential transport mechanisms for female fertility, playing a key role in facilitating oocyte pickup and transporting the fertilized ovum. This movement is mediated by multiciliated cells and regulated by specific proteins and hormones that modulate ciliary number, length, polarity, beat frequency, and amplitude to ensure proper function. Genetic mutations, inflammatory stimuli, and hormonal fluctuations can impair ciliary activity or induce ciliary apoptosis, leading to ciliary dysfunction.

Factors influencing self-management in patients with epilepsy: a systematic review and meta-analysis.

Background: Self-management is significant for the quality of life, physical and mental health, and prognosis of patients with epilepsy. There is evidence that various factors significantly affect the level of self-management in people with epilepsy, however, the reported factors affecting self-management vary greatly. Therefore, it is particularly important to further unify and clarify the factors affecting self-management in people with epilepsy.

Divergent response associates with the differential amplitudes of immunity against by different blast resistance genes.

Rice blast disease, caused by , poses the most devastating threat to global rice production. The products of most blast resistance () genes specifically recognize corresponding a virulence effectors from the pathogen, thereby mediating robust immune responses that are crucial for disease resistance. However, it is unclear why different genes endow with differential amplitudes of immunity against .

Study on the Differentiation of Infiltrating Breast Cancer Molecular Subtypes Based on Ultrasound Radiomics.

Objective: To establish and validate a 2-dimensional ultrasound (US) radiomics model for the noninvasive preoperative differentiation of various molecular subtypes of infiltrating breast cancer (IBC).

Methods: A retrospective analysis of 210 female patients diagnosed with IBC through surgical operation or needle biopsy pathology at our hospital between May 2019 and February 2024 was conducted. Relevant data were collected to establish predictive models for different molecular subtypes of IBC.

Donations triggered by inequality tolerance affect the evolution of cooperation in spatial public goods game.

Generosity through donation plays a crucial role in reducing inequality and influencing human behavior. However, previous research on donation has overlooked individuals' acceptance of the extent of inequality, which acts as a trigger for donation. To address this gap, this paper systematically explores the impact of donation based on inequality tolerance on the evolution of cooperation in spatial public goods game.

The ignored structure in female fertility: cilia in the fallopian tubes.

Cilia in the fallopian tubes (CFT) play an important role in female infertility, but have not been explored comprehensively. This review reveals the detection techniques for CFT function and morphology, and the related analysis of female infertility and other gynaecological disorders. CFT differentiate from progenitor cells, and develop into primary cilia and motile cilia.

Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding.

Objective: We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding.

Methods: Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed.

Early-Life Gut Microbiota: A Possible Link Between Maternal Exposure to Non-Nutritive Sweeteners and Metabolic Syndrome in Offspring.

Metabolic syndrome (MetS) is recognized as a group of metabolic abnormalities, characterized by clustered interconnected traits that elevate the risks of obesity, cardiovascular and atherosclerotic diseases, hyperlipidemia, and type 2 diabetes mellitus. Non-nutritive sweeteners (NNS) are commonly consumed by those with imbalanced calorie intake, especially in the perinatal period. In the past, accumulating evidence showed the transgenerational and mediated roles of human microbiota in the development of early-life MetS.

Human β-casein-derived peptide BCCY-1 improved the intestinal barrier integrity by regulating the TLR4/eNOS/3-Nitrotyrosine axis.

Necrotizing enterocolitis (NEC) is a lethal gastrointestinal disease affecting premature infants. Although earlier studies have highlighted protective effects of milk-derived peptides against NEC, the role of the human β-casein-derived peptide BCCY-1 in intestinal barrier protection has never been investigated. Here, we showed that BCCY-1 alleviated the phenotype of NEC, reduced intestinal expression of Toll-like receptor 4 (TLR4) and interleukin-6, and improved the intestinal barrier integrity.

Metabolic profiles in gestational diabetes mellitus can reveal novel biomarkers for prediction of adverse neonatal outcomes.

Background: Gestational diabetes mellitus (GDM) significantly affects the fetal metabolic environment, elevating risks of neonatal hypoglycemia and macrosomia. Metabolomics offers promising avenues for early prediction and diagnosis of GDM and associated adverse offspring outcomes.

Methods: This study analyzed serum samples from pregnant women diagnosed with GDM at 24 to 28 weeks of gestation using untargeted metabolomics.

The Role of Left Ventricular Pressure-strain Loop in Evaluating Myocardial Work in Patients with Type 2 Diabetes.

Objective: To quantitatively analyze the myocardial work of patients with type 2 diabetes (T2D) by use of the pressure-strain loop and to investigate the clinical factors that affect myocardial work in the left ventricle.

Methods: We analyzed data from 50 control patients and 180 case patients, with 70 cases in group A (T2D only), 40 cases in group B (T2D + high blood pressure), 33 cases in group C (T2D + coronary heart disease), and 37 cases in group D (T2D + high blood pressure + coronary heart disease). Each patient received conventional ultrasonography and 2-dimensional speckle-tracking echocardiography, and the pressure-strain loop technique was applied to measure the left ventricular myocardial work parameters to compare the control and case groups.

Interventions for Postextubation Dysphagia in Critically Ill Patients: A Systematic Review and Meta-analysis.

Objective: This review evaluates the efficacy and safety of dysphagia interventions for patients with prolonged endotracheal intubation (⩾48 h) in critical care units.

Data Sources: We systematically searched PubMed, Cochrane Library, Medline, Embase, OVID, CINAHL, Wanfang (China), CNKI (China), and ProQuest Dissertations for studies published up to December 31, 2023.

Study Selection: Inclusion criteria encompassed randomized controlled trials (RCTs), quasi-randomized trials, and cohort studies comparing dysphagia rehabilitation - such as swallowing stimulation, swallowing and respiratory muscle exercise, and neuromuscular electrical stimulation - with standard care or no treatment.

Fear of disease in patients with epilepsy - a network analysis.

Background: Disease-related fear among patients with epilepsy has significantly impacted their quality of life. The Disease-Related Fear Scale (D-RFS), comprising three dimensions, serves as a relatively well-established tool for assessing fear in these patients. However, certain problems potentially exist within the D-RFS's attribution of items, and its internal structure is still unclear.

AGIDB: a versatile database for genotype imputation and variant decoding across species.

The high cost of large-scale, high-coverage whole-genome sequencing has limited its application in genomics and genetics research. The common approach has been to impute whole-genome sequence variants obtained from a few individuals for a larger population of interest individually genotyped using SNP chip. An alternative involves low-coverage whole-genome sequencing (lcWGS) of all individuals in the larger population, followed by imputation to sequence resolution.

Validity and reliability of the Chinese version of the disease-related fear scale in patients with epilepsy.

Objective: This study aims to test the validity and reliability of the Chinese version of the Disease-Related Fear Scale (D-RFS) in order to understand the experience of fear in patients with epilepsy (PWE).

Methods: The researchers obtained translation permission and followed international guidelines to develop a Chinese version of the D-RFS. A total of 609 PWE were recruited from a general tertiary hospital in Hangzhou, China, between January 2023 and June 2023.

The relationship between nuclear factor-erythrocyte-related factor 2 and antioxidant enzymes in the placenta of patients with gestational diabetes and the metabolism of umbilical cord endothelial cells.

The paper aimed to explore the relationship between nuclear factor erythroid 2 related factor 2 (Nrf2), antioxidant enzymes and the metabolism of umbilical cord endothelial cells in the placenta of patients with gestational diabetes (GDM). A total of 200 pregnant women who underwent an obstetric examination at the Municipal Maternity and Child Health Hospital from March 2018 to December 2019 were selected, with an average age of 30.91±3.

Prediction of NH and HCN yield from biomass fast pyrolysis: Machine learning modeling and evaluation.

Rapid pyrolysis is a promising technique to convert biomass into fuel oil, where NO emission remains a substantial environmental risk. NH and HCN are top precursors for NO emission. In order to clarify their migration path and provide appropriate strategies for their controlling, six up-to-date machine learning (ML) models were established to predict the NH and HCN yield during rapid pyrolysis of 26 biomass feedstocks.

miR167d-ARFs Module Regulates Flower Opening and Stigma Size in Rice.

Flower opening and stigma exertion are two critical traits for cross-pollination during seed production of hybrid rice (Oryza sativa L.). In this study, we demonstrate that the miR167d-ARFs module regulates stigma size and flower opening that is associated with the elongation of stamen filaments and the cell arrangement of lodicules.