A prospective study of physical activity in full-term pregnant women and its effect on pregnancy outcomes.

Background: The effects of physical activity (PA), especially brisk walking, on labor outcomes and pregnancy health have not been clearly established. This study aimed to investigate the relationship between PA and cervical ripeness and pregnancy outcomes in term pregnant women.

Basic Procedures: A prospective cohort study was conducted with 52 pregnant women (30.

Distribution Patterns and Assembly Mechanisms of Rhizosphere Soil Microbial Communities in Across Altitudinal Gradients.

To investigate the characteristics of rhizosphere soil microbial communities associated with across different altitudinal gradients and to reveal the driving factors of microbial community dynamics, this study collected rhizosphere soil samples at four elevations: 900 m (HB1), 1100 m (HB2), 1300 m (HB3), and 1500 m (HB4). High-throughput sequencing and molecular ecological network analysis were employed to analyze the microbial community composition and species interactions. A null model was applied to elucidate community assembly mechanisms.

Building simplified cancer subtyping and prediction models with glycan gene signatures.

We identified a gene panel comprising 71 glycosyltransferases (GTs) that alter glycan patterns on cancer cells as they become more virulent. When these cancer-pattern GTs (CPGTs) were run through an algorithm trained on The Cancer Genome Atlas, they differentiated tumors from healthy tissue with 97% accuracy and clustered 27 cancers with 94% accuracy in external validation, revealing each variety's "biometric glycan ID." Using machine learning, we built four models for cancer classification, including two for detecting the molecular subtypes of breast cancer and glioma using even smaller CPGT sets.

Evidence for various interventions to reduce depressive symptoms for children and adolescents: protocol of a global evidence and gap map.

Background: Children and adolescent depression conditions are responsible for high levels of disability burden and negatively influence academic participation and life-long outcomes while their interventions and outcomes remain controversial.

Methods: We conducted a comprehensive search in multiple databases of primary studies. The EPPI-Mapper mapping tool was applied to present identified studies as framework-described results.

A new type of congenital hepatic hemangioma - rapid postnatal proliferation followed by regression.

Objective: This study aimed to analyze and summarize the prenatal and postnatal imaging findings, as well as the postnatal growth curves, of patients with hepatic hemangiomas (HHs) that were identified and continued to proliferate after birth.

Methods: A retrospective study was conducted to collect and analyze data from children with congenital hepatic hemangiomas (CHH) who were diagnosed and followed-up at our hospital between January 1, 2016 and December 30, 2023. These children exhibited rapid postnatal proliferation of lesions, followed by spontaneous regression.

Targeting steroid receptor RNA activator as a novel therapeutic strategy for myocardial hypertrophy.

Myocardial hypertrophy develops when the heart is subjected to biomechanical stress, neurohormonal or hemodynamic stimuli. Isoprenaline (ISO)-induced myocardial hypertrophy in mice was associated with abnormally elevated steroid receptor RNA activator (SRA) level in hypertrophic myocardium, suggesting SRA's potential functions in hypertrophic pathogenesis. SRA knockout or cardiac-specific knockdown attenuated cardiac remodeling without impairing baseline cardiac function.

CT-Mamba: A hybrid convolutional State Space Model for low-dose CT denoising.

Low-dose CT (LDCT) significantly reduces the radiation dose received by patients, however, dose reduction introduces additional noise and artifacts. Currently, denoising methods based on convolutional neural networks (CNNs) face limitations in long-range modeling capabilities, while Transformer-based denoising methods, although capable of powerful long-range modeling, suffer from high computational complexity. Furthermore, the denoised images predicted by deep learning-based techniques inevitably exhibit differences in noise distribution compared to normal-dose CT (NDCT) images, which can also impact the final image quality and diagnostic outcomes.

Unveiling the Differential Impacts of S-nZVI and nZVI on Microbial Dechlorination of Trichloroethene by .

Sulfidated nanoscale zerovalent iron (S-nZVI) is a promising material for the remediation of chlorinated hydrocarbons (CHCs) in groundwater, offering enhanced reactivity and selectivity over unmodified nanoscale zerovalent iron (nZVI). However, integrating S-nZVI with bioremediation using organohalide-respiring bacteria (OHRB) poses potential cytotoxicity challenges. This study investigated the differential impacts of S-nZVI and nZVI on the dechlorination activity of strain 195 ( 195), a representative OHRB.

Crystallinity-Directed In Situ Reconstruction of Cu-Al Oxides Yielding Tunable Cu Sites for Electrochemical CO-to-C Conversion.

During the electrochemical CO reduction reaction (CORR), copper catalysts continuously undergo structural evolution, which is less controllable, and its impact on the product distribution of CORR remains unclear. Here, crystallinity-tunable Cu-Al mixed metal oxide (CuAl-MMO-) precatalysts were first synthesized via layered double hydroxide calcination. These precatalysts subsequently underwent in situ electrochemical reconstruction to form active CuAl-MMO-R catalysts with tailored Cu valence states.

Automatic Magnetic Dispersive Solid-Phase Extraction Combined With LC-MS/MS for the Rapid Quantitation of Six Gelsemium elegans Alkaloids in Biological Samples.

In this study, an innovative, rapid, and automated method for quantifying six Gelsemium elegans alkaloids in biological samples using magnetic dispersive solid-phase extraction (MDSPE) and liquid chromatography tandem mass spectrometry (LC-MS/MS). Magnetic HLB extractant, NaHPO/NaHPO buffer (0.2 M, pH 7) and acetonitrile were used in automatic MDSPE.

Nanozymes enhancing field-effect transistor nanosensor for in-situ monitoring intracellular hydrogen peroxide release.

Field-effect transistor (FET) nanodevices are widely recognized as highly sensitive sensors for continuous detection of bioactive molecules like hydrogen peroxide (HO). However, accurate and real-time monitoring of HO poses challenges due to its instability and low concentration in organisms. To address these challenges, we construct an enhanced FET by one-step interfacing with nanozymes that possess natural enzyme-like catalytic properties and exceptional stability.

Serotype Distribution, Virulence, and Antibiotic Resistance Genomic Characterization of Group B Streptococcus - China, 1998-2024.

Introduction: , or group B Streptococcus (GBS), can cause severe infections in humans, yet comprehensive genomic characterization from China remains limited. This study presents an extensive genomic analysis of GBS isolates collected in China from 1998 to 2024.

Methods: GBS genomes were obtained from public databases and through de novo sequencing.

Construction of a MIL-101-DGA (MOF) Coupling Betaine Hydrochloride System for the Green and Efficient Separation of Zirconium and Hafnium.

Metal-organic framework materials (MOFs) have potential for practical applications in solid-phase separation technology. However, no studies of the separation of hafnium and zirconium using MOFs have been performed. This work synthesized MIL-101-DGA solid-phase adsorbent material, which was synthesized using amino-containing MIL-101-NH as a matrix material by introducing diglycolic acid (DGA) functional groups through a one-step ring-opening reaction.

Presence of disease resistance genes in tomato germplasm revealed by gene-based or gene-linked molecular markers.

Unlabelled: Tomato ( L.) is a worldwide economically important vegetable crop, but the production is severely threatened by diseases and pests. Clarifying the presence of disease resistant genes in tomato germplasm is helpful for the development and deployment of resistant cultivars.

Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery.

Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite nanodrug delivery system by encapsulating the chemotherapy drug DOX is establish to efficiently target breast cancer.

Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.

Brain diseases are a leading cause of disability and death worldwide. Early detection can lead to earlier intervention and better outcomes for patients. In recent years, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging have been widely used in stroke, traumatic brain injury (TBI), and brain cancer due to their advantages of , unlabeled, and high-resolution 3D microvessel imaging at the capillary resolution level.

Hepatic SIRT6 protects against cholestatic liver disease primarily inhibiting bile acid synthesis.

Cholestatic liver disease, caused by the accumulation of hazardous bile acids in the liver, may result in cirrhosis, fibrosis, or liver failure. Activation of sirtuin 6 (SIRT6) prevents cholestasis-associated pathological events, such as oxidative stress and mitochondrial biogenesis dysfunction, and inhibits bile acid synthesis to alleviate cholestatic liver injury. However, it remains uncertain which pathway mediates the therapeutic effect of SIRT6 in reducing cholestasis.

Universal synthesis of pure-phase IB-group Sn-based alloys with modulable electrocatalytic CO reduction products.

We present a universal preparation method for synthesizing a range of pure-phase IB-group Sn-based alloy catalysts (CuSn, AgSn, and AuSn) for electrochemical reduction of CO to C product. The selectivity can be widely adjusted by altering metal composition and potential, improving the understanding of the structure-activity relationship in various Sn-based alloys.

Photocatalyzed Imino-Difluoromethylation of Alkenes with Bifunctional Oxime Esters.

Herein, we report a simple and versatile difluoromethylene-imide reaction in which a series of olefins can undergo a difluoromethylenimine reaction under photocatalytic conditions through an energy transfer (EnT) process. The reaction has mild conditions and a wide range of applicability. We successfully synthesized 27 molecules containing difluoromethylene units, featuring easily accessible starting materials and operational simplicity.

Full-length RNA sequencing and single-nucleus sequencing deciphers programmed cell death and developmental trajectories in laticiferous canals of fruits.

Introduction: Programmed cell death (PCD) is a fundamental biological process crucial for plant development. Despite recent advancements in our understanding of PCD's molecular mechanisms, the intricate orchestration of this process within plant cells remains enigmatic. To address this knowledge gap, the present study focuses on , a plant species renowned for its unique fruit anatomy, including laticiferous canals that secrete latex.

Unpaired fundus image enhancement based on constrained generative adversarial networks.

Fundus photography (FP) is a crucial technique for diagnosing the progression of ocular and systemic diseases in clinical studies, with wide applications in early clinical screening and diagnosis. However, due to the nonuniform illumination and imbalanced intensity caused by various reasons, the quality of fundus images is often severely weakened, brings challenges for automated screening, analysis, and diagnosis of diseases. To resolve this problem, we developed strongly constrained generative adversarial networks (SCGAN).