Multifunctional Superparamagnetic Copper Iron Oxide Nanoparticles for Synergistic Cancer Therapy via Magnetic Hyperthermia, Oxidative Stress and Immune Reprogramming.

Aggressive cancers, characterized by high metastatic potential and resistance to conventional therapies, present a significant challenge in oncology. Current treatments often fail to effectively target metastasis, recurrence, and the immunosuppressive tumor microenvironment, while causing significant off-target toxicity. Here, we present superparamagnetic copper iron oxide nanoparticles (SCIONs) as a multifunctional platform that integrates magnetic hyperthermia therapy, immune modulation, and targeted chemotherapeutic delivery, aiming to provide a more comprehensive cancer treatment.

Coupled extracellular and intracellular electron transfer chains in methanogens: Mechanisms, energy conservation, and application potential.

Syntrophic interaction between acetogens and methanogens is the key to address thermodynamic challenges in anaerobic digestion (AD), the strengthening of which can benefit microbial energy production and their application in environmental remediation. Metabolic activities occurring during the syntrophic interactions primarily involve extracellular to intracellular electron transfers, facilitating the optimum exchange and utilization of energy. This occurs extracellularly through mediated interspecies electron transfer (MIET) and direct interspecies electron transfer (DIET), while in methanogens, electron transport phosphorylation (ETP) as a membrane-based process and flavin-based electron bifurcation (FBEB) for intracellular electron transfer are the main pathways.

Identification of characteristic lipids of Tan lamb and their potential health benefits.

Increasing evidence highlights the beneficial effects of dietary lipids on human health, and understanding the nutritional and bioactive properties of characteristic lipids in high-quality agri-food products can further advance biomarker-driven personalized nutrition. Here we characterize the lipidomic landscape of Tan lamb using UPLC-Q-Extractive-MS/MS, identifying 1521 lipid species and revealing significant differences in glycerolipid (GL) abundance between the Longissimus Dorsi and Rectus Femoris. Further differential lipid analysis identified 50 lipid biomarkers of Tan lamb, all of which exhibited higher levels compared to those in Oula and Bahan.

A forchheimer-based fluid-solid coupling model for nonlinear flow of power-law grouts in fractured rock grouting.

Grouting in fractured rock masses is crucial in numerous engineering projects such as tunnel seepage prevention, foundation reinforcement, and energy storage. However, slurry flow within fractures involves complex nonlinear behavior and significant fluid-solid coupling effects, and its accurate modeling remains a challenge. This study aims to establish a more accurate coupled model for slurry flow in fractures and rock mass deformation.

Double-Gyroid Network Morphologies Formed by Asymmetric ABB Triblock Amphiphiles over Wide Volume Fraction Range.

Molecular dynamics simulations are used to investigate the phase behavior of asymmetric ABB-type miktoarm triblock amphiphiles, composed of a sugar-based acyclic headgroup (A) and two hydrocarbon tails (B and B). ABB amphiphiles with significantly shorter B tails ( / ≫ 1, where is the volume fraction) form lamellar (LAM) and perforated lamellae (PL) structures, whereas those with nearly equal tail lengths ( ≈ ) assemble into hexagonally packed cylinders (CYL). Amphiphiles with a B/B length ratio near 2:1 (2 ≈ ) stabilize double gyroid (DG) networks, where the headgroups form the interconnected channels and the tails constitute the matrix, displaying feature sizes from 1.

Exploring the Self-Assembly of Glycolipids into Three-Dimensional Network Phases.

Glycolipids are sugar-based amphiphiles that play crucial roles in many biological processes. Under thermotropic and lyotropic conditions, glycolipids self-assemble into a variety of mesophases, including cocontinuous network phases, such as the double gyroid. In this work, a two-stage molecular dynamics simulation workflow is developed to probe network formation for solvent-free amphiphiles at different temperatures.

AKT signaling upregulates BDNF expression in induced neural stem cells that interact with microglia.

Background: Brain-derived neurotrophic factor (BDNF) has the capacity to promote neuronal survival that is crucial to neurological recovery after closed head injury (CHI). We previously reported that intracerebral-transplanted induced neural stem cells (iNSCs) can up-regulate BDNF levels to exert neurotrophic effects in CHI-damaged brains. Here we aim to elucidate the mechanism of BDNF up-regulation in iNSCs.

Intersliceboost: Identifying tissue layers in three-dimensional ultrasound images for chronic lower back pain (cLBP) assessment.

Background: Available studies on chronic lower back pain (cLBP) typically focus on one or a few specific tissues rather than conducting a comprehensive layer-by-layer analysis. Since three-dimensional (3-D) images often contain hundreds of slices, manual annotation of these anatomical structures is both time-consuming and error-prone.

Objectives: We aim to develop and validate a novel approach called InterSliceBoost to enable the training of a segmentation model on a partially annotated dataset without compromising segmentation performance.

Responsible leadership and employee creativity: a moderated mediation model based on social cognitive and situational strength theories.

Background: In today’s uncertain organizational environment, employee creativity has become the key driver of enterprise sustainability. Although previous studies have found the influence of responsible leadership on employee creativity, there remains a lack of study on how responsible leadership promotes employee creativity via intrinsic motivation mechanisms and what situational factors may moderate this process. This paper aims to construct a moderate-mediation model to examine the impact of responsible leadership and employee creativity through social cognitive theory and situational strength theory.

Trend in testicular volume change after orchiopexy in 854 children with cryptorchidism.

The aim of this study was to investigate the trend in testicular volume changes after orchiopexy in children with cryptorchidism. The clinical data of 854 children with cryptorchidism who underwent orchiopexy between January 2013 and December 2016 in Shenzhen Children's Hospital (Shenzhen, China) were retrospectively analyzed. The mean (standard deviation) age of the patients was 2.

The chromosome-level genome and multi-omics analysis provide new insights into the iridoids biosynthetic pathway.

Introduction: (Rubiaceae) is a medicinal herb with significant therapeutic potential, primarily attributed to its bioactive iridoid compounds. However, the molecular mechanisms governing iridoid biosynthesis in this species remain poorly characterized, limiting its biotechnological and pharmaceutical applications.

Methods: We generated a telomere-to-telomere (T2T) chromosomal-scale genome assembly of (∼482.

Three-dimensional changes in hard-tissue symmetry and soft-tissue parameters after stabilization splint therapy in adult patients with temporomandibular joint disorders and mandibular deviation: A retrospective study.

Background: The authors analyzed 3-dimensional changes in hard-tissue symmetry (HTS) and associated soft-tissue contour (STC) and evaluated soft-tissue thickness (STT) after stabilization splint (SS) therapy in adult patients with temporomandibular joint disorder (TMD) and mandibular deviation (MD).

Methods: In this retrospective clinical study, 35 adults with TMD and MD were treated with SS therapy; the patients' mean (SD) age was 25.14 (6.

Cell-free DNA profiles of dermatomyositis and its potential role in discriminating phenotypes.

Background: Cell-free DNA (cfDNA) functions in the early-detection and monitoring of autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis. However, investigations into cfDNA profiles in dermatomyositis and their potential clinical implications remain scarce.

Objectives: To explore the overall landscape of cfDNA profiles in dermatomyositis and investigate potential roles in discriminating subtypes.

Comprehensive Three-Dimensional Evaluation of Temporomandibular Joint Changes Following Stabilization Splint Therapy.

Introduction And Aims: While stabilization splints (SSs) have shown promising therapeutic effects for temporomandibular disorders (TMDs), comprehensive studies evaluating temporomandibular joint (TMJ) changes following SS therapy are necessary. This study aimed to assess TMJ structural, positional, and condylar remodelling changes in TMD patients by using advanced three-dimensional assessment and shape correspondence analysis.

Methods: This retrospective study included 80 adult TMD (arthralgia) patients treated with SS.

Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli.

Background: As one of the most promising monomers of biobased polyamides, cadaverine has wide industrial application prospects. However, in microbial cadaverine fermentation with glucose as the sole carbon source, the impaired coordination between precursor (lysine) utilization and cytotoxic cadaverine accumulation has been identified as the primary bottleneck limiting high-yield biosynthesis. Here, we developed a lysine biosensor in Escherichia coli to dynamically regulate cadaverine biosynthesis.

Preoperative embolization of head and neck tumors: a systematic review and meta-analysis.

Purpose: Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis.

Methods: A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane databases to identify relevant literature on preoperative embolization for head and neck tumors up to March 2025.

Biohydrogen production from food waste using a novel rotational drum reactor integrated with milli-magnetite.

Dark fermentation, regarded as a promising path for sustainable hydrogen production from food waste, is hindered by slow hydrolysis and low hydrogen yield. This study presented a novel rotational drum reactor integrated with milli-magnetite (RD-M) to enhance hydrogen production, using potato peel as feedstock. The RD-M designed to simultaneously achieve grinding and biochemical stimulation.

Exploring the toxicity of bisphenol A and its analogue bisphenol S-MPE to Escherichia coli K12 from integrated AutoQSAR and transcriptomics analysis.

Bisphenol A (BPA) analogues are a group of emerging contaminants as substitutes for BPA. Bacteria are acknowledged as indispensable parts of the ecosystem, whereas the bacterial toxicity data for BPA analogues is still lacking. Herein the wild-type and Δacriflavine resistance B (acrB) strains of E.

Injectable PLGA-based In Situ Forming Subconjunctival Implant for Sustained Ocular Delivery of Ketotifen Fumarate: Formulation, Drug Release, and Biocompatibility Studies.

Ketotifen fumarate is very effective in treating ocular conditions like allergic conjunctivitis. However, its clinical effectiveness is limited by rapid washout, frequent dosing, and poor bioavailability. This study developed a ketotifen fumarate-loaded in situ forming subconjunctival injectable implant (ISFSI) for use in large animal species such as horses and alpacas.

The glymphatic system was impaired in spontaneously hypertensive rats.

Hypertension is a clinical syndrome characterized by elevated systemic arterial blood pressure, which can be accompanied by functional impairment of or organic damage to the heart, brain, kidney and other organs. Hypertensive emergencies occur when significant increases in blood pressure result in persistent target organ damage. Hypertensive encephalopathy is a rare hypertensive emergency.

Riddled with challenges: Are zero-waste cities transitioning to circular economies? Insights from Chinese cities.

Institutional isomorphism provides a framework for latecomers to learn from successful organizations. However, some scholars highlight the drawbacks of mimetic isomorphism, such as the inability to consider unique characteristics. This study uses the 2018 zero-waste city pilot program in China as a natural experiment, evaluating its performance in waste utilization and economic efficiency.

Unconventional Carrier Transfer Enabled Direct O Reduction by Oxygen Vacancies for Efficient Photooxidation of CH.

Photocatalytic oxidation of methane (CH) to high value-added liquid oxygenates with oxygen (O) as an oxidant has long been a promising process. In addition to the activation of CH, the selective reduction of O to hydroperoxyl (OOH) is also a crucial factor in determining the efficiency and selectivity of the overall reaction. In thermal catalysis, strong interactions between oxygen vacancies (OVs) on the catalyst surface and O are widely adopted as a means of enhancing O activation.

Design optimization for evaporation property of coal fly ash-based evaporator during solar-driven interfacial evaporation process.

Solar-driven interfacial evaporation has recently attracted many attentions due to its energy-saving and environmentally friendly advantages. Researches on structural parameters optimization for the ceramic interfacial evaporators to improve their evaporation performance are lack. In this work, ceramic evaporators with different structural parameters are prepared using coal fly ash as the main material.