Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population.

Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation.

Aims: This study investigated association of VCAM-1 and ICAM-1 with presence of CSVD and CSVD burden.

Detecting Acute Ischemic Lesions Using Mobile, Low-Field MRI in TIA and minor stroke in the Emergency Room.

Background: Using mobile low-field MRI in the emergency department to detect cerebral infarction(s) in patients with minor ischemic stroke (MIS) and transient ischemic attack (TIA) has not yet been thoroughly reported.

Aim: We aimed to evaluate the performance of mobile low-field (0.23T) MRI in detecting acute ischemic infarction in MIS or TIA patients within 72 hours of symptom onset and compare it to CT in those scanned within 24 hours.

Stroke-Aware CycleGAN: Improving Low-Field MRI Image Quality for Accurate Stroke Assessment.

Low-field portable magnetic resonance imaging (pMRI) devices address a crucial requirement in the realm of healthcare by offering the capability for on-demand and timely access to MRI, especially in the context of routine stroke emergency. Nevertheless, images acquired by these devices often exhibit poor clarity and low resolution, resulting in their reduced potential to support precise diagnostic evaluations and lesion quantification. In this paper, we propose a 3D deep learning based model, named Stroke-Aware CycleGAN (SA-CycleGAN), to enhance the quality of low-field images for further improving diagnosis of routine stroke.

Cancer Immunotherapy in Combination with Radiotherapy and/or Chemotherapy: Mechanisms and Clinical Therapy.

Since the United States Food and Drug Administration approved the first immune checkpoint inhibitor ipilimumab for metastatic melanoma in 2011, ICIs have been approved for a range of cancers and significantly improving treatment outcomes. However, the objective response rate of ICI monotherapy remains modest (10-40%), with clinical benefit observed in only 15-20% of patients. The limited efficacy of ICIs in many patients is often attributed to poorly immunogenic ("cold") tumors.

Integrated Analysis of Serum and Fecal Metabolites Reveals the Role of Bile Acid Metabolism in Drug-induced Liver Injury: Implications for Diagnostic and Prognostic Biomarkers.

Background And Aims: Drug-induced liver injury (DILI) represents a prevalent adverse event associated with medication use. However, the exact mechanisms underlying DILI remain incompletely understood, and the lack of specific diagnostic and prognostic biomarkers poses significant challenges to the clinical diagnosis and treatment of this condition. Consequently, our study aimed to endeavor to identify serum and fecal metabolic biomarkers, enabling more accurate DILI diagnosis and improved prediction of chronic progression.

Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression.

Cancer cells with stemness characteristics effectively escape the recognition and killing of immune-active cells, such as T cells, which has been considered as the root cause of cancer recurrence and metastasis. To sensitize cancer immunotherapy, we have developed salinomycin-repurposed endoplasmic reticulum (ER) stress nanoinducers (DTSS NPs) to synergistically suppress cancer cell stemness. Salinomycin, as a polyether antibiotic demonstrating robust cytotoxicity against tumor stem cell, is co-assembled with thymopentin (TP5) and ER-targeted phototherapeutic agent s-780, and tailored with DSPE-PEG-biotin to obtain DTSS NPs.

Exploring the Association Between Cerebellar Regional Volumes and Health-Related Quality of Life in Patients with Ischemic Stroke: A Prospective Cohort Study.

The roles of cerebellum after ischemic stroke remains unclear. This study aimed to assess the influence of cerebellar regional volumes on health-related quality of life (HRQoL) outcomes in patients with ischemic stroke. Using data from the China National Stroke Registry III (CNSR-III) cohort, patients having supratentorial ischemic stroke (SIS) with complete clinical and neuroimaging data were included.

A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease.

Background: T2DM and COPD are prevalent and high-burden diseases which are closely related, with poor patient outcomes. In this study, we aimed to identify common diagnostic markers for T2DM and COPD and their therapeutic potential.

Methods: Microarray data from the GEO database were analyzed to identify DEGs, whereas WGCNA, co-differential gene analyses were employed to identify co-expression modules and DEGs functions.

Metabolic Targeting of Oxidative Phosphorylation Enhances Chemosensitivity in Triple-Negative Breast Cancer via a Synergistic Nanomedicine.

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer. There are very few targeted treatment options with satisfactory therapeutic indexes for TNBC. Although chemotherapy is the principal treatment modality for TNBC, its effectiveness is significantly compromised by low chemosensitivity in the TNBC patient population.

Protamine-Facilitated Same-Day Discharge Following Distal Transradial Angiography.

Background: Despite growing adoption of distal transradial approach (dTRA), data on same-day discharge with protamine-assisted hemostasis following coronary angiography (CAG) remain limited. This pilot study investigated its safety and feasibility.

Methods: From January 2022 to September 2024, a total of 34 patients who were discharged on the same-day after elective CAG via dTRA in our center were included, as well as 34 matched patients who underwent CAG via standard transradial approach (sTRA) during the same period.

Coronary Atherosclerosis and Subclinical Cerebral Small Vessel Disease: A Robust Association Beyond Intracranial Atherosclerosis and Cardiac Systolic Function.

Background: This study investigates the associations between asymptomatic coronary atherosclerosis and subclinical cerebral small vessel disease (CSVD) in a community-based population, considering potential confounding by intracranial atherosclerosis and cardiac systolic function.

Methods: Community-dwelling residents from the PRECISE (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) study in Lishui City, China (n=3021; mean age, 61.2±6.

Effect of Stroke Severity on Efficacy and Safety of Indobufen versus Aspirin in Patients with Moderate to Severe Stroke: Results from the INSURE Randomized Clinical Trial.

Aims: Stroke severity may affect the benefits and safety of antiplatelet therapies. We aimed to investigate whether the efficacy and safety of indobufen versus aspirin were affected by stroke severity.

Methods: We compared the efficacy and safety of indobufen versus aspirin in patients with NIHSS scores of 4-6, 7-9, and 10-18.

Exploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis.

Chemotherapy serves as the primary therapeutic approach for triple-negative breast cancer (TNBC), yet its efficacy remains unsatisfactory. This study was a single-arm, open-label, single-center clinical trial (NCT05447702) involving patients with newly diagnosed stage II-III TNBC at West China Hospital. The treatment regimen consisted of camrelizumab (200 mg intravenously every 2 weeks, 12 cycles), apatinib (250 mg orally daily), and alternating chemotherapy [nab-paclitaxel (d1, 8, 15 every 4 weeks) for 4 cycles and epirubicin plus cyclophosphamide (every 2 weeks) for 4 cycles].

Transcriptome-wide decoding the roles of aberrant splicing in melanoma MAPK-targeted resistance evolution.

Drug resistance critically limits the long-term efficacy of MAPK-targeted therapy in melanoma. While resistance mechanisms at genetic, epigenetic, and transcriptional scales are well-documented, post-transcriptional splicing regulation remains poorly understood. By analyzing patient-matched pre-treatment and resistant melanoma biopsies, we uncover widespread alternative splicing alterations during therapy resistance.

Dual Antiplatelet Therapy in Patients With Metabolic Syndrome After Mild Ischemic Stroke or Transient Ischemic Attack.

Background: Metabolic syndrome (MetS) attenuates antiplatelet agent effects. This study investigated the efficacy and safety of clopidogrel-aspirin therapy for secondary stroke prevention in patients with MetS.

Methods: Data were obtained from the INSPIRES (Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis) trial.

Comprehensive Screening of Multiple Prohibited Substances in Chinese Traditional Patent Medicine by UHPLC-Q-Orbitrap HRMS.

An ultrahigh performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) system was established for the rapid screening of doping agents in Chinese traditional patent medicine (CTPM), aiming to enhance the prevention and control of doping risks associated with herbal medicines. Samples were extracted by ultrasonic extraction with acetonitrile, while oily CTPM samples were extracted with 80% acetonitrile in water and purified using a Captiva EMR General Pigmented Dry cartridge. The extraction was concentrated under nitrogen flow, and the residues were dissolved, filtered, and detected using a Thermo Scientific UHPLC-Q-Orbitrap HRMS system.

Human resource development: An empirical study on analyzing the role of human resource development in organizational efficiency.

BackgroundProfessional activity and intellectual knowledge in the field of human resource development are comparatively modern. Due to organizations' strong interest in managing human resources in the face of fierce competition and shifting business conditions, this field of management development has experienced the quickest growth over the past decades.ObjectivesThe purpose of this study is to examine the human resource development practices impacting the employee efficiency and organization effectiveness.

Detection of metabolic signatures implicated in the progression from hepatitis to cirrhosis to hepatocellular carcinoma.

Background And Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The mechanisms driving the transition from hepatitis to cirrhosis, and eventually, to HCC are unclear. This study aimed to clarify the metabolic changes that underly the progression of HCC and identify potential prognostic and therapeutic biomarkers.

Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial.

Importance: The role of intra-arterial tenecteplase for acute large vessel occlusion (LVO) stroke after successful endovascular therapy is uncertain.

Objective: To assess the efficacy and safety of intra-arterial tenecteplase in patients with successful endovascular therapy (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2b to 3) after endovascular therapy.

Design, Setting, And Participants: This was a prospective, open-label, blinded end point, randomized trial.

Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson's disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study.

Background: Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson's disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate the optimal DNH assessment method as a biomarker for PD, idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson-plus syndromes, and to explore the nigral iron deposition patterns in these diseases.

Methods: Three-dimensional gradient-echo T2*-weighted images were acquired by 7T MRI from a total of 402 patients and 100 healthy controls (HCs) in two independent cohorts (development and validation cohorts).

A UGW communication method using Barker encoding and improved PPM for rail structural health monitoring.

Given the high communication cost in the existing rail structural health monitoring (SHM) system UGW-based and no GPRS signals in the tunnel, a novel communication method in the rail based on Barker encoding and improved pulse position modulation (IPPM) is proposed in this work. Firstly, to overcome the low signal-to-noise ratio (SNR) of UGW signals resulting from dispersion and multimodal properties, Barker codes are involved in encoding excitation signals for piezoelectric ultrasonic transducers. Besides, an IPPM method is presented to diminish the multipath effect, improving communication robustness.

Association of Serum Thromboinflammatory Biomarkers With Atherosclerotic Plaques and Burden in a Community-Based Population.

Background: The pathogenesis of atherosclerosis involves complex mechanisms, with inflammation playing a central role. Thromboinflammation may contribute to its development and progression. We investigated the association between circulating thromboinflammatory biomarkers and atherosclerotic plaques.

Insulin resistance as a mediator between obesity and periodontitis risk.

Background: Obesity is a well-established risk factor for periodontitis, a chronic inflammatory disease with systemic implications. While diabetes has been proposed as a potential mediator in this relationship, its clinical heterogeneity limits its utility in causal modeling. Insulin resistance, quantified by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), offers a more mechanistically grounded alternative.