Characterization and Functional Analysis of the Gene Family in Cotton: Insights into Fiber Development.

Fibrillins (FBNs) are indispensable for plant growth and development, orchestrating multiple physiological processes. However, the precise functional role of in cotton fiber development remains uncharacterized. This study reports a genome-wide characterization of the gene family in cotton.

Delicate preparation of in-situ biochar zirconium dioxide using the one-step method of repairing tailings with Pennisetum Hydridum: electrode study of symmetrical (snap-on) supercapacitor.

Utilizing plant-derived electrode materials with natural multi-channel structure for supercapacitors is an effective approach for developing sustainable energy and innovatively utilizing agricultural waste. In this study, based on the green synthesis strategy of recycling waste resources, Pennisetum Hydridum loaded zirconium dioxide composite electrode materials were prepared by low-temperature annealing under argon protection using the natively grown Pennisetum Hydridum in rare earth tailings as precursors. The process accomplished the recovery of carbon resources while realizing the ecological restoration of tailings.

A novel multi-parameter MRI-based model for identification of high-risk metabolic dysfunction-associated steatohepatitis.

Objectives: To develop and evaluate a novel multi-parameter MRI-based model (EFT1) for identifying high-risk metabolic dysfunction-associated steatohepatitis (MASH) to improve diagnostic accuracy and efficiency.

Materials And Methods: A prospective study included 118 patients (55 male; 48 ± 13 years) with hepatic steatosis and metabolic risk factors. Among these, 80 patients were classified as having high-risk MASH.

Effects of single and co-cultured lactic acid bacteria on antioxidant capacity and metabolite profiles during rambutan juice fermentation.

As a tropical fruit, rambutan has been predominantly studied for its peel. To explore the application of lactic acid bacteria (LAB) in rambutan juice fermentation, we investigated the metabolic characteristics of juice fermented with and . This study reveals the distinct metabolic characteristics and synergistic mechanisms of and during rambutan juice fermentation.

Cost-utility analysis of sotagliflozin for heart failure patients with diabetes in China.

Aims: Heart failure (HF) imposes a substantial economic burden, especially among populations with comorbidities in China. Sotagliflozin has shown clinical benefits in HF patients with type 2 diabetes mellitus (T2DM). This study evaluated the cost-utility of sotagliflozin in China and explored pricing strategies to support its potential market entry.

Mechanism and application of copper-based nanomedicines in activating tumor immunity through oxidative stress modulation.

Immunotherapy stands as a powerful weapon against tumors. However, tumor cells evade recognition and attack by the immune system through various mechanisms, achieving immune escape and exhibiting resistance to immunotherapy. Metalloimmunotherapy, as an emerging paradigm for immunotherapy, offers the potential to effectively overcome the limitations of current tumor immunotherapies.

Tandem Mass Tags Quantitative Proteomics Reveal the Mechanism by Which Paeoniflorin Regulates the PI3K/AKT and BDNF/CREB Signaling Pathways to Inhibit Parkinson's Disease.

Paeoniflorin (PF), a monomeric compound extracted from the dry roots of , has been widely used in the treatment of nervous system diseases, marking it as a critical formula in Parkinson's disease (PD). However, the action of PF against PD and its molecular mechanism are still unclear. In this study, tandem mass tags quantitative proteomics was performed to systematically clarify the underlying mechanism of action of PF against PD and to confirm it using in vivo and in vitro studies.

Associations between oxidative balance score and chronic kidney disease events in type 2 diabetes mellitus patients: a cross‑sectional study.

The Oxidative Balance Score (OBS) is a comprehensive metric that amalgamates 17 dietary and lifestyle elements to evaluate antioxidant status. This research aims to investigate the association between the OBS and the prevalence of chronic kidney disease (CKD) in individuals diagnosed with type 2 diabetes mellitus. This cross-sectional study included data from the National Health and Nutrition Examination Survey conducted between 2007 and 2018.

Preoperative embolization of head and neck tumors: a systematic review and meta-analysis.

Purpose: Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis.

Methods: A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane databases to identify relevant literature on preoperative embolization for head and neck tumors up to March 2025.

Multidimensional insights into efficiency-stability trade-off in anaerobic digestion from organic overloading stress: Kinetic behavior, energy harvesting, and genome-centric metagenomics microbial self-adaptation.

Despite its potential environmental and financial benefits, organic overloading poses a critical challenge to the stability of anaerobic digestion (AD). Currently, the trade-off between operational efficiency and process stability of AD has not been addressed, leaving opportunities for optimization to support sustainable and resilient energy self-sufficiency. This study systematically investigated how organic overloading affected the efficiency-stability trade-off of AD treating lignocellulosic biomass in batch-operated digesters, with a focus on kinetic behavior, energy harvesting, and microbial interactions.

Task-state hemodynamic responses correlate with consciousness levels and outcomes of patients with disorders of consciousness.

Background: Functional near-infrared spectroscopy (fNIRS) has emerged as a valuable tool for detecting brain functional activities. Motor imagery (MI) tasks have been employed to evoke brain responses in patients with disorders of consciousness (DOC), providing potential insights into their consciousness levels. However, the utility of brain functional characteristics for patient diagnosis and prognosis remains unclear.

Prognostic effect of CD74 and development of a radiomic model for predicting CD74 expression in non-small cell lung cancer.

Background: The classical prognostic indicators of lung cancer are no longer sufficient for prognostic stratification and individualized treatment of highly heterogeneous non-small cell lung cancer (NSCLC). This study aimed to establish a radiomics model to predict CD74 expression level in NSCLC patients and to explore its role in the tumor immune response and its prognostic value.

Methods: The prediction model was developed based on 122 NSCLC transcriptome samples, including 68 paired enhanced CT and transcriptome samples.

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing.

Background: Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival. To address this clinical need, we developed GutSeer, a blood-based assay combining DNA methylation and fragmentomics for multi-GI cancer detection.

Genome-wide association study reveals significant loci and candidate genes for fruit branch length in upland cotton.

The length of fruit branches significantly influences plant architecture in upland cotton (Gossypium hirsutum L.), which is crucial for optimizing fiber yield and quality. In this study, a comprehensive genome-wide association study was conducted based on whole-genome resequencing data that identified 249 significant SNPs associated with fruit branch length (FBL), forming 79 distinct quantitative trait loci (QTL) regions.

Prevalence, Progression, and Treatment of Asymptomatic Tuberculosis: A Prospective Cohort Study in Lanxi County, Zhejiang Province, China.

Background: Individuals with asymptomatic tuberculosis (TB) are considered a significant risk to the disease burden and transmission. However, the progression and treatment for asymptomatic TB remain incompletely described.

Methods: This prospective cohort study was embedded within a prevalence survey conducted in 2021 and 2022 in Lanxi County, China.

Mechanism by which low-intensity focused ultrasound promotes angiogenesis and neurogenesis after traumatic brain injury in a rat model via the OXA/MAPK signaling pathway.

Low-intensity focused ultrasound is a type of ultrasound that primarily relies on cavitation and mechanical effects. It is non-invasive, transient, and well tolerated. Previous studies have confirmed that low-intensity focused ultrasound can reduce neuroinflammation after traumatic brain injury and exert neuroprotective effects.

Nutrient consumption patterns of Streptococcus thermophilus F7 under acid stress and their application in enhancing biomass production.

The nutrient consumption patterns of Streptococcus thermophilus F7 under acid stress were investigated in this study. The strain was incubated at 42°C for 16 h in a chemically defined medium with different pH values (6.5, 5.

Soy Isoflavones Protects Against Stroke by Inhibiting Keap1/NQO1/Nrf2/HO-1 Signaling Pathway: Network Pharmacology Analysis Combined with the Experimental Validation.

: Ischemic stroke is a severe neurological disorder with high morbidity, mortality, and disability rates, posing a substantial burden on patients, families, and healthcare systems. Soy isoflavone (SI), a naturally occurring phytoestrogen, has demonstrated promising neuroprotective effects. This study aimed to evaluate the anti-stroke efficacy of SI and elucidate its underlying mechanisms through integrated phytochemical profiling, network pharmacology, and both in vitro and in vivo experimental validation.

Detecting cognitive motor dissociation by functional near-infrared spectroscopy.

Background: Behavioral assessment based on external manifestations of consciousness fails for patients with cognitive motor dissociation (CMD). Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging technique that can detect internal brain functional activities. However, the extent to which fNIRS can help identify CMD patients among those with disorders of consciousness (DOC) remains unclear.

Mitophagy in perioperative neurocognitive disorder: mechanisms and therapeutic strategies.

Perioperative neurocognitive disorder (PND) is a common neurological complication after surgery/anesthesia in elderly patients that affect postoperative outcome and long-term quality of life, which increases the cost of family and social resources. The pathological mechanism of PND is complex and not fully understood, and the methods of prevention and treatment of PND are very limited, so it is particularly important to analyze the mechanism of PND. Research indicates that mitochondrial dysfunction is pivotal in the initiation and progression of PND, although the precise mechanisms remain elusive and could involve disrupted mitophagy.

A critical review on bioaugmentation assisted anaerobic digestion for methane production: Performances, microbiome-functionalities and challenges.

Bioaugmentation technology is considered as a straightforward approach to improve anaerobic digestion performances, with advantages of high efficiency and sustainability. However, the mechanisms and challenges of bioaugmentation in anaerobic digestion have yet to been well reviewed. In this review, the advantages of bioaugmentation in anaerobic digestion are systematically identified and discussed, covering enhancing anaerobic digestion process, relieving toxic inhibition of ammonia, and overcoming limitation of psychrophilic anaerobic digestion.

Investigation of aromatic compounds and olfactory profiles in cocoa pulp fermentation using yeast-based starters: A Volatilomics and machine learning approach.

The interaction and complex metabolism of microorganisms in cocoa pulp drive the fermentation process. To investigate this, four strains from spontaneous cocoa fermentation, including and were combined to ferment cocoa pulp. Nineteen machine learning algorithms were run with the dataset of volatile compounds quantified by headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) against integrated olfactory evaluation to reveal metabolite-sensory attribute relationships.

Digestate-based organic amendment substitution improves the red soil quality and pakchoi yield.

This study investigated the effect of the partially substituting chemical fertilizers (CF) with digestate-based organic amendment (OA) on the amelioration of red soil and the growth of plant. OA with nitrogen substitution rates ranging from 10 % to 40 % were mixed with CF and applied to red soil in a pot experiment. The results indicated that plant growth was significantly enhanced in the treatment where 20 % of the CF was substituted with the OA (OA20) compared to other treatments (p < 0.

Green and chemical-free pretreatment of flavonoids in tea plant seed husk using ultrasound-cold isostatic pressure synergistic extraction.

A new method was established to extract flavonoids from tea plant seed husk: ultrasonic-cold isostatic pressure synergistic extraction. The effects of pressure, ethanol concentration, tea plant seed husk addition and treatment time on the extraction of flavonoids were investigated. The optimal extraction process was determined as follows: applied pressure 468.

The effect of perioperative cognitive training on postoperative delirium in older patients undergoing total hip and knee arthroplasty: a prospective randomised trial.

Objective: This study investigated whether cognitive training (CT) ameliorates postoperative delirium (POD) in older patients undergoing total hip and knee arthroplasty.

Methods: This clinical trial was conducted from 18 February to 10 July 2023 and included individuals aged 60-79 who underwent elective total hip and knee arthroplasties with surgery durations ≤3 hours under general anaesthesia. Patients with preoperative cognitive dysfunction and dementia were excluded.