IFNα2b in combination with oncolytic adenovirus enhances antitumor activity against melanoma.

Melanoma is an aggressive malignancy originating from melanocytes, marked by its high metastatic potential, severe malignancy, and poor prognosis. The primary clinical approach involves surgical resection, complemented by adjuvant therapies such as radiotherapy, chemotherapy, targeted therapies, and immunotherapies. In recent years, high-dose IFNα2b has emerged as a pivotal adjuvant therapy following surgery.

Rapid Molten-Salt Synthesis of Phase-Controlled Mo-Doped Sulfides for Water Splitting.

Transition metal sulfides are promising electrocatalysts for water electrolysis. This work develops an innovative rapid low-temperature molten-salt template approach that enables one-step fabrication of free-standing Mo-doped sulfide nanowire arrays (Mo-NiS@NiS/NF) on nickel foam (NF) within merely 30 min, substantially reducing synthesis time compared to conventional methods. XRD and Raman analyses show that the doping of Mo makes the original NiS convert into NiS with higher catalytic activity.

Influences of structural helicity of aortic dissection on endovascular repair.

Stanford type B aortic dissections often exhibit helical morphology. However, the influences of structural helicity on periprocedural and mid-to long-term adverse events after thoracic endovascular aortic repair (TEVAR) remain unclear. In this article, a total of 197 patients who underwent TEVAR between October 2019 and December 2020 were studied.

Association between albumin-corrected anion gap and delirium in acute pancreatitis: insights from the MIMIC-IV database.

Background: Delirium frequently occurs as a severe complication among patients with acute pancreatitis (AP), contributing to extended hospital stays, higher mortality rates, and lasting cognitive deficits. The pathogenesis of delirium in this setting is strongly influenced by metabolic abnormalities, including disturbances in electrolyte balance and widespread inflammation. Although the albumin-corrected anion gap (ACAG) is a recognized indicator of metabolic dysfunction, its relevance to delirium in AP patients has not been adequately investigated.

Activating Ferroelectric-Magnetic Synergistic Effects at Cathode-Electrolyte Interfaces Toward Superfast and Stable Sodium Storage.

Layered oxides are promising cathode candidates for sodium-ion batteries due to their high energy density. However, the rate and cycling performances are hindered by severe interfacial side reactions and sluggish kinetics. Using NaNiMnO (NM) as a model material, ferroelectric-magnetic synergistic effects are activated at the NM-electrolyte interfaces via constructing a multiferroic layer on the NM surface, significantly realizing the superfast and stable sodium storage.

Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling.

Background: The proneural-to-mesenchymal transition (PMT) represents a crucial phenotypic transformation in glioblastoma. Glioma-associated mesenchymal stromal/stem cells (GaMSCs) play a significant role in diverse biological processes of gliomas. However, the impact of exosomes released from GaMSCs (GaMSCs-Exos) on the PMT of glioblastoma remains inadequately understood.

Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies.

Introduction: Human adenovirus serotype 4 (HAdV-4) is an epidemic pathogen associated with severe acute respiratory disease (ARD) in both pediatric and adult populations. Currently, no available vaccine or therapeutic interventions specifically targeting adenoviruses are available.

Methods: In this study, we isolated peripheral blood mononuclear cells (PBMCs) from HAdV-4 infected donors and generated fully human monoclonal antibodies using single-cell PCR technology.

Enhanced charge transport in A-site ordered perovskite derivatives AA'BiI (A = Cs; A' = Ag, Cu): a first-principles study.

Recent experiments have synthesized CsAgBiI by partially substituting Cs with Ag at the A-site of CsBiI, resulting in enhanced charge transport properties compared to CsBiI. However, the atomic-scale mechanisms behind this enhancement remain unclear. In this work, we investigate the carrier transport mechanisms in CsA'BiI (A' = Ag, Cu) using first-principles calculations and Boltzmann transport equation.

Experimental Observation of Screening and Amplification of Quantum Fluctuation in Aqueous Electrolyte Solution.

In a classical liquid, the static dielectric constant is always larger than 1, meaning that external static electric fields are always screened by the solvent. Under quantum mechanics, instantaneous electric fields exist due to the zero-point motion of electrons, and it is so far unexplored whether those instantaneous fields will always be screened by the solvent. Here, we show that a small-angle liquid electron scattering experiment is able to quantitatively measure the quantum fluctuation of the instantaneous dipole moment of hydrated ions.

Sorghum aphid/greenbug: current research and control strategies to accelerate the breeding of aphid-resistant sorghum.

Sorghum, one of the world's five major cereal crops, faces significant yield losses due to aphid infestations, particularly from the sorghum aphid () and the greenbug (). These pests not only cause a reduction in grain yield, but also transmit plant viruses, posing a serious threat to global food security. Current strategies to mitigate aphid damage include large-scale insecticide applications, biological control through natural enemies, and the development of aphid-resistant sorghum varieties.

PDCL3 promotes the vasculogenic mimicry of glioma-associated mesenchymal stem cells through VEGFR-2 in glioma environment.

Glioma-associated mesenchymal stem cells (GA-MSCs), as a critical component of the glioma microenvironment, play an essential role in the development and invasion of glioma. Recent studies have shown that GA-MSCs can differentiate into pericytes under certain conditions, thereby promoting angiogenesis. However, the biological properties and molecular mechanisms underlying this process remain poorly understood.

Additive value of perivascular fat density to CT angiography characteristics of carotid plaques in predicting symptomatic carotid plaques.

Objectives: This study aimed to investigate the relationship between perivascular fat density (PFD) and carotid plaque characteristics while exploring the additive diagnostic value of PFD in predicting symptomatic carotid plaques.

Materials And Methods: In a single-center retrospective case-control study, 315 patients with unilateral carotid atherosclerosis were classified into symptomatic and asymptomatic groups based on the presence of acute ischemic stroke or transient ischemic attack (TIA) within 2 weeks before carotid computed tomography angiography (CTA). Plaque CTA features and PFD were assessed, and their relationship was analyzed using Spearman's rank correlation.

Graphene oxide enhances aphid resistance in sorghum via the miR319-SbTCP7-SbLOX3 Pathway.

The aphid (Melanaphis sacchari) has emerged as a formidable pest, devastating sorghum plants and highlighting the need for sustainable management strategies. Graphene oxide (GO), as a novel material, has garnered attention for its use in crop cultivation and management, but its effects on biotic stresses remain elusive. Here, we used 10 mg/L GO to spray aphid-stressed sorghum seedlings four times in total.

Identification of Sinigrin as Active Compound of Rape Pollen for Treating Benign Prostatic Hyperplasia Through PI3K/AKT/mTOR Axis.

Benign prostatic hyperplasia (BPH) is a common proliferative disease in older males. PuleanPian, containing rape pollen (RP), is a certified BPH medicine, but its main active compound and mechanism are unknown. This study aims to identify the main active compound of RP for the treatment of BPH.

Genome-wide analysis of the KCS gene family in Medicago truncatula and their expression profile under various abiotic stress.

Very long-chain fatty acids (VLCFAs) are indispensable constituents of cuticular wax and exert pivotal functions in regulating plant growth, development and response to stress. β-Ketoacyl-CoA synthase (KCS) represents the rate-limiting enzyme for the biosynthesis of VLCFAs. In this study, 25 KCS genes were identified in the M.

Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via mA modification of CSF1.

Malignant glioma is the most common primary malignant tumor of the brain in adults, with glioblastoma (GBM) being the most aggressive subtype. Mesenchymal stem/stromal cells (MSCs) have been shown to fuse with tumor cells in various cancers including glioma, thereby regulating tumor progression. However, there has been no systematic research on the fusion of glioma-associated MSCs (GA-MSCs) with glioma cells.

Thermal decomposition behavior of retired wind turbine blades: kinetics, pyrolysis product distribution and characterization.

The rapid growth of the wind power industry has heightened the need for effective resource utilization of retired wind turbine blades (RWTB). Pyrolysis technology offers a promising approach for recovering high-value products from RWTB. In this study, the pyrolysis kinetic behavior of RWTB was investigated using three kinetic models (KAS, FWO, Miura) and the isoconversional method, based on thermogravimetric (TG) analysis at four heating rates.

X-type and MCM-41-type molecular sieves from full component utilization of coal gasification fine slag and amino modification for CO capture.

The development of coal gasification technology inevitably generates a substantial amount of coal gasification fine slag (CGFS), which contains abundant silica-aluminum elements. Utilizing these elements to synthesize molecular sieve materials for CO capture is of great significance. In this paper, to fully utilize the elements in CGFS, X-type and MCM-41-type molecular sieves were synthesized through activated hydrothermal and microwave treatment of the solid residue after alkali fusion and the silica source filtrate, respectively.

Green and chemical-free pretreatment of flavonoids in tea plant seed husk using ultrasound-cold isostatic pressure synergistic extraction.

A new method was established to extract flavonoids from tea plant seed husk: ultrasonic-cold isostatic pressure synergistic extraction. The effects of pressure, ethanol concentration, tea plant seed husk addition and treatment time on the extraction of flavonoids were investigated. The optimal extraction process was determined as follows: applied pressure 468.

Detection of Apple Leaf Diseases Based on LightYOLO-AppleLeafDx.

Early detection of apple leaf diseases is essential for enhancing orchard management efficiency and crop yield. This study introduces LightYOLO-AppleLeafDx, a lightweight detection framework based on an improved YOLOv8 model. Key enhancements include the incorporation of Slim-Neck, SPD-Conv, and SAHead modules, which optimize the model's structure to improve detection accuracy and recall while significantly reducing the number of parameters and computational complexity.

Ketamine Alters Specific Gene Expression Profiles by Transcriptome-Wide Responses in a Ketamine-Induced Schizophrenia-Like Mouse Model.

Psychotic disorder is a significant consequence of ketamine abuse. However, the molecular mechanisms and biomarkers for this psychotic disorder and associated long-term cognitive impairment remain unclear. To investigate the behavioral changes and comprehensive gene expression alterations in mice following ketamine administration, we employed behavioral testing and RNA sequencing (RNA-seq).