How nutrients and antibiotics shape microbial network patterns: Comparative insights from Erhai Lake bays.

Freshwater lakes are increasingly subject to simultaneous nutrient enrichment and antibiotic pollution, yet the joint effects of these stressors on microbial network structure remain poorly characterized. This study examined the combined effects of nutrients and antibiotics on bacterial communities across eight bays in Erhai Lake, which were classified into high-, moderate-, and low-pollution zones. High-pollution bays (Haichao, Dongsha, and Shuanglang) recorded the region's highest nutrient concentrations, with chemical oxygen demand reaching 33.

Aquaculture Strategy and Genetic Diversity of in Beibu Gulf, China.

has become one of the pillar industries in the aquaculture of the Beibu Gulf since it was introduced into China in 1991. This study examined how stocking density and culture site affects growth in breeding populations, compared their growth performance and genetic diversity within control populations, and identified optimal culture locations for in the Beibu Gulf. The environmental investigation results revealed that among the three aquaculture sites of Beihai (BH), Qinzhou (QZ) and Fangchenggang (FCG), the fluctuation ranges of salinity, pH, and dissolved oxygen at the BH site were relatively narrower.

Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy.

Background: Primary Membranous Nephropathy (PMN) is characterized by dysregulated immune responses, with B cells playing critical roles in disease pathogenesis. However, the immunopathogenic mechanisms underlying B cell involvement in PMN remain elusive.

Methods: We employed single-cell RNA sequencing on peripheral blood mononuclear cell samples (PBMC) obtained from 6 patients with PMN and 3 healthy controls (NC) to explore the transformation of B cells and their interaction with immune cells.

Relationship between serum ferritin and the risk of all-cause death in patients with coronary artery disease.

Objective: Ferritin is independently associated with oxidized Low-Density Lipoprotein (LDL). While high LDL levels are known independent risk factors for cardiovascular diseases, few studies have investigated the relationship between serum ferritin levels and long-term outcomes in CAD patients.

Methods: A prospective cohort study of CAD participants was performed in Xinjiang Medical University Affiliated First Hospital from December 2016 to October 2021.

Composition of bacterial communities in mangrove sediments at different depths.

Mangroves are one of the most productive ecosystems in the intertidal zone and hold vital ecological functions. Using phospholipid fatty acid (PLFA) analysis, we investigated the composition of bacterial communities in mangrove sediments at different depths and their correlations with environmental factors in Mai Po Nature Reserve of Hong Kong. The results showed significant variations in PLFA content across sediment depths, with total PLFA decreasing from 37.

Therapeutic Effects of Sulforaphane on -Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver.

Sulforaphane, a natural isothiocyanate predominantly found in cruciferous vegetables, has shown potential in preventing and treating infection. However, the underlying metabolic mechanisms remain largely unclear. This study employed high-coverage metabolomics and lipidomics methods to comprehensively investigate the effects of sulforaphane on the serum and liver metabolic profiles of -infected mice.

Prospects, Advances, and Applications of BioMOF-Based Platforms.

Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host-guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure-property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail.

Oxidation-Enhanced Piezocatalytic Activity in Carbon Nitride-Based Catalysts for Hydrogen and Hydrogen Peroxide Production.

Driven by the urgent need for a green, safe, and cost-effective approach to producing H and HO-both highly valuable in green energy and environmental protection fields-piezocatalysis, which converts mechanical energy into valuable chemicals, has emerged as a promising solution. However, current catalyst systems face challenges due to the need for materials with both a strong piezoelectric effect and favorable catalytic activity. Herein, the construction of an oxidized carbon nitride (g-CN) matrix anchored with TiO nanoparticles via alkaline hydrothermal treatment is reported.

Galla Chinensis as an antiviral agent: Targeting Micropterus salmoides rhabdovirus infection.

Being a major pathogen affecting the health of largemouth bass (Micropterus salmoides) aquaculture, Micropterus salmoides rhabdovirus (MSRV) causes significant economic losses. Galla chinensis, a traditional Chinese medicinal herb, possesses diverse biological activities, including antiviral properties. This study evaluated the role of Galla chinensis in MSRV infection in vitro and investigated its mechanism of action.

Clinical significance of focal segmental glomerulosclerosis subclassification in IgA nephropathy.

Background And Hypothesis: Evidence from the VALIGA IgA nephropathy (IgAN) cohort supports the clinical value of subclassifying focal segmental glomerulosclerosis lesions (S). Our study aimed to validate and explore the clinical significance of S subclassification in an Asian population.

Methods: A total of 746 patients with IgAN were retrospectively included.

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma.

Background: The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC).

Methods: A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models.

Unraveling Solvent-Dependent Chirality Inversion in the Self-Assembly of Glutamide Amphiphiles.

This study investigates the solvent-modulated supramolecular chirality and assembly kinetics of two naphthalimide structural isomers, 18NG and 23NG, designed from glutamide derivatives linked to 1,8- and 2,3-naphthalic anhydrides, respectively. Time-dependent circular dichroism (CD) spectra reveal that 18NG exhibits chiroptical signal amplification with aging time and solvent-dependent chirality inversion: In methylcyclohexane (MCH), it forms chiral assemblies with a positive Cotton effect, whereas in dimethyl sulfoxide (DMSO), it exhibits a negative Cotton effect. FT-IR and XRD analyses demonstrate stronger amide-amide hydrogen bonds in MCH and dominant hydrophobic interaction in DMSO, where DMSO acts as both a hydrogen-bond acceptor (competing with intermolecular hydrogen bonds) and a high-polarity solvent promoting alkyl-chain aggregation.

Spleen Tyrosine Kinase Exacerbates Anti-Citrullinated Protein/Peptide Antibody-Mediated Osteoclast Bone Resorption via Promotion of Vav3 Phosphorylation.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by abnormal bone resorption. Anti-citrullinated protein/peptide antibodies (ACPAs), detected in most RA patients, can stimulate osteoclasts differentiation by targeting osteoclast precursors, thereby enhancing bone resorption. However, the underlying mechanism of ACPAs-induced osteoclast activation on bone resorption in RA remains unknown.

Advancements in the application of optical coherence tomography in hepatopancreatobiliary systems: a comprehensive review.

Optical coherence tomography (OCT) has emerged as a transformative diagnostic tool in the realm of uncertain biliary strictures within the digestive system. Its superiority over conventional methods lies in its ability to provide submucosal assessments and real-time, wide-ranging tissue evaluations. The latest advancement in OCT technology, exemplified by the NVision Volumetric Laser Endomicroscopy (VLE) system, has significantly enhanced imaging quality and microstructure delineation, particularly in characterizing the intricate anatomy of pancreaticobiliary ducts.

Characteristics and advances in signaling pathways, cellular communication, cell junctions, and oxidative stress in lymphedema.

Lymphedema is a chronic inflammatory disease without an effective treatment method, and it results in a high disease burden and psychological distress in patients. Although there have been significant advances in targeted therapies, there are still no effective options to treat this refractory disease. In recent years, new advances and breakthroughs have been made in signaling pathways, including RAS/MAPK, PI3K/AKT, VEGF-C/VEGFR-3, HGF/MET, and TGF-β1, which are important for understanding the pathogenesis and disease progression of lymphedema.

Phosphorylated sodium alginate-filled delignified wood-reinforced transparent wood: Crafting flame-retardant composites.

Transparent wood (TW), an emerging sustainable material with high optical transmittance and mechanical strength, is hindered by the inherent flammability of its cellulose-lignin matrix, posing fire risks. To address this, we developed an eco-friendly flame-retardant TW by integrating phosphorylated sodium alginate (PSA)-filled delignified wood with polyurethane acrylic resin (PUA). Delignified balsa wood was freeze-dried into a porous structure, functionalized with PSA, and reinforced with UV-cured PUA.

Effects of Cognitive Behavioral Therapy for Diet on Postprandial Glucose and Pregnancy Outcomes in Gestational Diabetes Mellitus: Multicenter Randomized Controlled Trial.

Background: Gestational diabetes mellitus (GDM) is associated with an elevated risk of adverse maternal and neonatal outcomes. Dietary management is a cornerstone of GDM treatment due to its beneficial effects on metabolic control. However, suboptimal adherence to dietary recommendations has diminished its potential benefits in achieving optimal glycemic outcomes.

Adapting to hypo-salinity: Molecular mechanisms in giant clams and symbionts with implications for coral reef resilience under climate change.

Typhoon climates and extreme rainy seasons drive changes in seawater salinity and quality, threatening coral reef ecosystems. As key contributors to coral reef ecosystems, giant clams face major survival pressures from salinity fluctuations. Understanding their salinity adaptation and recovery strategies is thus critical for the long-term conservation and sustainable management of coral reefs.

Rs61731397-C in OR2A25 increases the risk of chronic rhinosinusitis in the Chinese population.

Background: Chronic rhinosinusitis (CRS) is a multifactorial disorder driven by intricate interactions between genetic predispositions and environmental factors. Despite extensive research, the genetic underpinnings of CRS remain largely elusive.

Objective: Our aim was to identify genetic risk variants associated with CRS in the Chinese population and elucidate the underlying mechanisms.

Efficacy of different modes of exercise-based cardiac rehabilitation delivery for patients with heart failure: a systematic review and network meta-analysis.

Background: Cardiac rehabilitation (CR) has been shown to be an effective treatment for patients with heart failure (HF). However, the effect of different modes of CR delivery on HF remains unclear. The purpose of this study is to perform a large-scale pairwise and network meta-analysis (NMA) on the impact of various exercise types on patients with HF using multiple indicators.

Realizing High Wide-Temperature-Range Thermoelectric Performance in Ga, I, and S co-doped AgSbTe.

Herein, a peak ZT value of ≈2 at 625 K and an average ZT of 1.46 are achieved in the AgSbTe system through band engineering and multiscale phonon scattering. This demonstrates that Ga doping achieves band convergence and an additional impurity level between the valence and conduction bands.

Synthesis and biological evaluation of Sulforaphane derivatives with dual functions: Ischemia-reperfusion injury protection and antitumor effects.

Reperfusion therapy for the treatment of acute myocardial infarction (AMI) often leads to ischemia-reperfusion (I/R) injuries, characterized by excessive ROS. Sulforaphane (SFN) homologous, known for their anti-inflammatory and antioxidant properties, activate the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway and reduce mitochondrial ROS but are limited by poor stability and short half-life. SFN derivatives were synthesized through structural modifications of the dithiocarbamate and thiourea moieties at the isothiocyanate group, aiming to enhance stability and maintain therapeutic efficacy.

Enhanced Improvement of Menstrual Blood Derived Endometrial Stem Cells Encapsulated in Cross-Linked Hyaluronic Acid on Intrauterine Adhesions.

Intrauterine adhesions (IUA), characterized by fibrotic adhesions within the uterine cavity, frequently result in menstrual irregularities, recurrent miscarriages, secondary infertility, and increased pregnancy risks among women of childbearing age. Unfortunately, conventional clinical interventions mainly including surgical separation and physical isolation exhibit limited efficacy in promoting the regeneration of the injured endometrium and are associated with a high recurrence rate. Consequently, it is imperative to investigate novel therapies aimed at repairing the injured endometrium in IUA patients, particularly those desiring fertility.

Lightweight Spherical Cellulose Aerogels With High Zr-MOF Loadings for the Facile Extraction of Benzodiazepines From Human Urine and Hair Samples.

A facile dispersive micro-solid phase extraction (D-μ-SPE) method that uses spherical cellulose aerogels is proposed herein for the trace detection of seven benzodiazepines in biological samples. Zirconium metal-organic framework (MOF) particles were dispersed in the cellulose aerogels to improve the extraction efficiency. The prepared lightweight spherical aerogels (diameter of approximately 2 mm) were easily collected from the solution using a disposable dropper, overcoming the difficult recycling of powdered MOFs.

A Nearly 50% Risk of MACCE Cutdown by Personalized Antiplatelet Therapy: The Subgroup Analysis of Hypertension in PATH-PCI Trial.

Background: Individualized antiplatelet therapy has been gradually chosen by more and more (percutaneous coronary intervention) PCI patients. Hypertension, as an important risk factor for a variety of adverse outcomes after PCI, has been found in many studies. Therefore, we are interested in whether patients who undergo PCI have a different benefit from individualized antiplatelet therapy when they have hypertension.