Minimally invasive surgical treatment for sigmoid colon cancer in a patient with situs inversus totalis: a case report.

Situs inversus totalis (SIT) is a rare congenital condition characterized by a complete reversal of the internal organ arrangement, presenting significant surgical challenges. While previous cases of colorectal cancer in SIT patients have been reported, cases involving sigmoid colon cancer are sporadic. Here, we present the case of a 68-year-old female with sigmoid colon cancer and SIT.

Impact of Clonorchis sinensis infection on long-term survival after curative resection for hepatocellular carcinoma: A multicenter cohort study.

Background: Hepatocellular carcinoma (HCC) prognosis is poor in East Asia. The impact of Clonorchis sinensis (C.sinensis) infection, a known carcinogen for cholangiocarcinoma, on HCC prognosis after curative resection in co-endemic regions is unclear.

Ice Nucleation Regulation by Nanoscale Surface Topography.

Heterogeneous ice nucleation, triggered by surfaces, profoundly impacts climate systems, biological processes, and technological applications. Classical nucleation theory (CNT) predicts that with curvature radii decreasing within 1 order of magnitude of the critical nucleus radius, convex surfaces should suppress nucleation and concave surfaces should promote nucleation; however, such regularity has not been observed explicitly in experiments, and there are even conflicting results. Here, we resolve this long-standing controversy by providing the first experimental evidence about the bidirectional regulation of ice nucleation from both liquid and vapor phases through precisely engineered convex (nanosphere) and concave (nanopore) surfaces.

Nanomagnesium promotes moso bamboo tolerance to cadmium toxicity: insights from photosynthesis phenomics, oxidative metabolism, and cellular adjustments.

Cadmium (Cd) stress severely hampers plant growth in forest ecosystems. Although magnesium oxide nanoparticles (MgONPs) are known to reduce Cd toxicity in numerous plant species, their detoxification mechanisms in Moso bamboo () remain unexplored. The present study investigates how MgONPs mitigate the Cd-induced phytotoxic effects in by examining morpho-physiological and cellular oxidative repair mechanisms.

Double-Edged Sword: Urbanization and Response of Amniote Gut Microbiome in the Anthropocene.

Projections indicate that the global urban population is anticipated to reach 67.2% by 2050, accompanied by a threefold increase in urban built-up areas worldwide. Urbanization has profoundly transformed Earth's natural environment, notably characterized by the drastic reduction and fragmentation of wildlife habitats.

Local structure, electronic and optical characteristics of Er-doped YScAlOgarnet: a multi-scale exploration based on first-principles.

In this study, the structural evolution, electronic properties, and optical characteristics of Er-doped YScAlO(YSAG) crystals were systematically investigated by the CALYPSO structure prediction methodology combined with density functional theory. The crucial findings are detailed as follows. (1) The ground state structure of Er:YSAG was determined.

Signature of oral microbial dysbiosis in different periodontitis risk levels.

Individuals categorized into distinct periodontitis risk levels often demonstrate substantial disparities not only in the likelihood of developing periodontitis but also in the rate at which the disease progresses. However, the oral microbial communities and their functional characteristics corresponding to different periodontitis risk levels remain to be further explored. Therefore, 52 subjects with periodontitis were selected and categorized into different periodontitis risk groups based on the periodontal risk calculator (PRC).

Prilocaine-loaded silicone dressing with dual-functionality: integrated pain management and wound protection for burn care.

Burn wounds encompass skin injuries resulting from exposure to thermal, cryogenic, electrical, chemical, radioactive, and frictional agents. Disruption of the skin barrier and an exaggerated inflammatory response contribute to the impaired healing of these wounds. With the development of burn wound treatment technology, the importance of comfortable treatment for burn wound is becoming increasingly prominent.

Emergence of cooperation promoted by higher-order strategy updates.

Cooperation is fundamental to human societies, and the interaction structure among individuals profoundly shapes its emergence and evolution. In real-world scenarios, cooperation prevails in multi-group (higher-order) populations, beyond just dyadic behaviors. Despite recent studies on group dilemmas in higher-order networks, the exploration of cooperation driven by higher-order strategy updates remains limited due to the intricacy and indivisibility of group-wise interactions.

Bridging Donor Ligands Enable an Ultrastable Graphite Anode for Sodium-Ion Batteries.

Graphite is widely utilized as an anode material in lithium-ion batteries due to its abundance, cost-effectiveness, and excellent structural stability during lithium intercalation and deintercalation, which contribute to a long cycle life. However, graphite is not inherently suitable for sodium-ion batteries (SIBs) due to the limited intercalation properties of sodium ions. To address this, we propose the concept of bridging-donor-ligands, which construct ligand channels and consistently expand the graphite interlayer spacing.

Compressed Adaptive-Sampling-Rate Image Sensing Based on Overcomplete Dictionary.

In this paper, a compressed adaptive image-sensing method based on an overcomplete ridgelet dictionary is proposed. Some low-complexity operations are designed to distinguish between smooth blocks and texture blocks in the compressed domain, and adaptive sampling is performed by assigning different sampling rates to different types of blocks. The efficient, sparse representation of images is achieved by using an overcomplete ridgelet dictionary; at the same time, a reasonable dictionary-partitioning method is designed, which effectively reduces the number of candidate dictionary atoms and greatly improves the speed of classification.

Local anesthetic ropivacaine inhibits non-small cell lung cancer progression by modulating the hsa_circ_0001320/miR-518a-5p axis.

Objective: This study investigated the possible mechanisms by which ropivacaine influences the progression of non-small cell lung cancer (NSCLC).

Methods: Plasmid vectors or oligonucleotides interfering with circ_0001320 or miR-518a-5p were transfected into ropivacaine-treated NSCLC cells, and circ_0001320 and miR-518a-5p levels were detected by RT-qPCR. Cell proliferation was assessed using CCK-8, apoptosis via flow cytometry, and cell migration and invasion through Transwell assays.

Ecological Risk and Human Health Assessment of Heavy Metals in Sediments of Datong Lake.

Heavy metal pollution of lake sediments is one of the prominent ecological and environmental problems worldwide, and it is of great significance to conduct research on heavy metal pollution in lake sediments to protect the ecological environment, safeguard human health, and promote sustainable development. As an integral part of Dongting Lake, Datong Lake holds a crucial ecological position. More than 10 years ago, due to a series of factors, including excessive fertilizer application and fishing, the water quality of Datong Lake declined, resulting in varying degrees of contamination by Cd, Mn, and other heavy metals in the sediments.

Policy support and the combination of artificial guidance with natural restoration can effectively restore the surface mine ecosystem in South China.

Assessing the effectiveness of ecological restoration policies in mining areas is vital for optimizing governmental investments and balancing financial expenditures with environmental recovery. Dongting Lake, China's second-largest freshwater lake, holds significant ecological importance in southern China, faces ecological challenges from legacy mines, yet the success of restoration efforts remains unclear. This study evaluated 170 abandoned surface mines (10 types) around Dongting Lake (2000-2023) using the Mine Landscape Restoration Index (MLRI) from remote sensing.

The role of ELK4 up-regulation in macrophage polarization and its mechanism in connective tissue disease-associated interstitial lung disease.

Objective: To examine the role of ETS domain containing protein ELK4 in macrophage polarization and pulmonary fibrosis in connective tissue disease-related interstitial lung disease(CTD-ILD).

Methods: This study analyzed gene expression datasets (SSc-ILD, ALI, COVID-19) to identify target genes in CTD-ILD. We performed RT-qPCR, Western blot, and immunohistochemistry to assess macrophage polarization and epithelial-mesenchymal transition (EMT) both in vitro and in a mouse model of pulmonary fibrosis.

Feasibility Study of Functional MRI-Based Biologically Guided Lattice Radiation Therapy.

Purpose: Lattice radiation therapy (LRT) is a promising approach for treating bulky tumors; however, current methods do not consider patient-specific tumor heterogeneity. Low apparent diffusion coefficient (ADC) regions, identified via diffusion-weighted magnetic resonance imaging, correspond to areas of high cellular density and radioresistance. Targeted dose escalation in these regions may enhance tumor control.

Doping Effects on Magnetic and Electronic Transport Properties in (BaRb)(ZnMn)As (0.1 ≤ x, y ≤ 0.25).

Diluted magnetic semiconductors (DMSs) represent a significant area of interest for research and applications in spintronics. Recently, DMSs derived from BaZnAs have garnered significant interest due to the record Curie temperature () of 260 K. However, the influence of doping on their magnetic evolution and transport characteristics has not been thoroughly investigated.

Post-pandemic one health: Unpacking the role of greenspaces and human-dog interactions in long-term health and well-being.

The social isolation measures implemented during the outbreak of COVID-19 in 2020 have had lasting effects on public health and well-being. In response, a growing body of discourse has emerged to examine the long-term impacts of the pandemic on human health and welfare. Addressing these complex challenges requires innovative, interdisciplinary approaches grounded in a conceptual framework that integrates perspectives from both the social and natural sciences.

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition.

Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD-1/PD-L1 inhibitors is only 20%-30%. Thus, more effective combination therapies are needed. This study finds that cystine and cysteine levels in tumor tissues of lung cancer patients are significantly higher than adjacent non-tumor tissues.

Synthesis and biological evaluation of Sulforaphane derivatives with dual functions: Ischemia-reperfusion injury protection and antitumor effects.

Reperfusion therapy for the treatment of acute myocardial infarction (AMI) often leads to ischemia-reperfusion (I/R) injuries, characterized by excessive ROS. Sulforaphane (SFN) homologous, known for their anti-inflammatory and antioxidant properties, activate the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway and reduce mitochondrial ROS but are limited by poor stability and short half-life. SFN derivatives were synthesized through structural modifications of the dithiocarbamate and thiourea moieties at the isothiocyanate group, aiming to enhance stability and maintain therapeutic efficacy.

Efficacy and Safety of Chemotherapy Combined with Anlotinib in Advanced Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer with Primary Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors: A Retrospective Cohort Study.

Introduction: In this study, we aimed to evaluate the efficacy and safety of the combination therapy with chemotherapy and anlotinib in patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations who exhibit primary resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).

Methods: Clinical data were collected from patients with advanced NSCLC harboring EGFR mutations and exhibiting primary resistance to EGFR-TKI, who were treated with a combination of chemotherapy and anlotinib. The primary endpoints were overall response rate (ORR), progression-free survival (PFS), disease control rate, overall survival (OS), and treatment-related adverse events (AEs).

Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in psoriasis via PI3K-AKT/mTOR pathway inhibition.

Psoriasis is a chronic inflammatory skin disease with significant impacts on quality of life. Current treatments face challenges like high costs and side effects. This study explores the therapeutic potential of Rosa rugosa polysaccharide (RRPS) and its nanofiber membrane in psoriasis treatment.

Real-World Analysis of Patient Characteristics, Adverse Events, and Economic Burden Among Patients with Giant Cell Arteritis Treated with Glucocorticoids.

Introduction: Giant cell arteritis (GCA) typically requires long-term treatment with glucocorticoids (GC). However, prolonged use of GCs has been associated with increased risk of GC-related side effects and adverse events. This study assessed the burden of GCs in GCA across the comprehensive framework of 39 adverse events, across 11 clinical categories, and side effects commonly associated with GC use (GRAEs).

Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants.

The emergence of SARS-CoV-2 variants has underscored the urgent need for innovative vaccine strategies that provide robust and enduring protection against diverse strains. Our study introduces the FP-HR5 nanoparticle vaccine, designed to target the highly conserved S2 subunit of the spike protein, including the fusion peptide (FP) and heptad repeats (HR1 and HR2), using a 24-mer Helicobacter pylori ferritin platform. Administered intranasally, the FP-HR5-NP vaccine elicits robust systemic and mucosal immune responses in vivo, generating high titers of FP- and HR5-specific IgG antibodies.