Transformation of a covalent organic framework from dual pores to single pores and their different properties.

We have achieved a controllable transformation of covalent organic framework (COF) isomers from BATD-Dma-COF-K (dual pores) to BATD-Dma-COF-R (single pores). The fluorescence of BATD-Dma-COF-K was enhanced by clinafloxacin (CFN). After transformation from dual pores to single pores, BATD-Dma-COF-R can effectively adsorb CFN, but cannot fluoresce to detect CFN.

MIG-6 Plays a Critical Role as a PGR Mediator in Maintaining Epithelial and Stromal Cells for Uterine Receptivity.

Ovarian steroid hormones-estrogen and progesterone-play a central role in regulating epithelial-stromal interactions in the uterus. These interactions are critical for uterine function, including endometrial receptivity, implantation, and decidualization. These interactions involve complex signaling crosstalk between the uterine epithelium and the underlying stroma, with dynamic cell population-specific roles.

Cross-organ protection of MSC-derived extracellular vesicles in ischemia-reperfusion injury: angiogenic synergy in kidney, brain, and heart.

Ischemia-reperfusion injury, marked by transient blood flow disruption followed by tissue reperfusion, constitutes a unifying pathological mechanism across cerebral stroke, myocardial infarction, and acute kidney injury. Hypoxia, a central driver of ischemia-reperfusion injury progression, triggers molecular cascades that simultaneously exacerbate tissue damage and activate compensatory repair mechanisms. Notably, hypoxia-induced angiogenesis and vascular remodeling serve as critical adaptive processes for functional recovery, supporting neuronal plasticity in stroke, myocardial salvage in infarction, and tubular regeneration in renal ischemia-reperfusion injury.

Harnessing non-equilibrium hot electrons in a quantum-engineered ternary heterostructure for sub-ppb C9 biomarker detection.

Photoactivated sensors offer a safe, low-power alternative to thermal sensors, yet their performance against trace concentrations of weakly reactive biomarkers is fundamentally crippled by the rapid energy loss of photogenerated carriers electron relaxation into the band-edge. This process limits the number of electrons available for sensing. Here, we overcome this limitation by introducing a new principle: non-equilibrium hot-electron-mediated chemoresistance.

Quantitative Effects of Porous Obstruction Number on Explosion Dynamics of CH/H Mixtures.

This study investigates the effects of porous obstruction quantity on the explosion dynamics of CH/H hybrid fuel mixtures in semiconfined pipelines through integrated experimental and numerical approaches. High-frequency pressure transducers and ultrahigh-speed cameras were employed to record overpressure evolution and flame morphology, while numerical simulations incorporating the Charlette flame wrinkling model elucidated turbulence-flame interaction mechanisms. The study compared configurations with sequential porous obstructions to single-obstruction setups, revealing that obstruction number and blockage ratio critically govern flame speed, peak overpressure, and turbulent intensity.

Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease.

Parkinson's disease (PD) is the second most common neurodegenerative disease with progressive structural alterations throughout the brain, resulting in motor symptoms that seriously affect patients' daily life. The present study then aimed to explore the progressive co-changes in gray matter patterns in PD and identify the longitudinal neuroimaging biomarkers that could predict the progressive motor symptoms of PD. Non-negative Matrix Factorization (NMF) was first used to decompose gray matter images into 7 latent factors from healthy samples, and then the latent factors were validated on an independent dataset to verify the stability of the structural factors.

Deep Learning Enabled Optimization and Mass Transfer Mechanism in Ultrasound-Assisted Enzymatic Extraction of Polyphenols from Tartary Buckwheat Hulls.

Tartary buckwheat hulls, a phenolic-rich by-product of buckwheat processing, offer great potential for resource utilization. In this study, ultrasound-assisted enzymatic extraction with two temperatures (40 °C and 50 °C) was employed to obtain phenolics from Tartary buckwheat hulls. Compared with the traditional extraction method (207 mg/100 g), ultrasound-assisted enzymatic extraction increased the total phenolic yield by 91.

Enhanced Photo-Fenton Removal of Oxytetracycline Hydrochloride via BP/BiMoO Z-Scheme Heterojunction Photocatalyst.

Fenton oxidation technology utilizing hydrogen peroxide is recognized as an effective method for producing reactive oxygen species (ROS) to facilitate the degradation of antibiotics. However, the requirement for strongly acidic conditions during this process significantly restricts its broader applicability. In this study, we synthesized black phosphorus (BP) nanosheets by exposing the {010} crystal planes and then constructed a 0D/2D BP/BiMoO (PBMO) heterojunction to function as a Fenton catalyst.

Willingness to have a third child and its determinants among childbearing-age women in Chongqing under China's three-child policy.

Background: China's 2021 three-child policy aims to counter population aging and low fertility rates. Chongqing, being the largest economy and the most densely populated city in Southwest China, lacks a survey on the willingness among childbearing-age women to have a third child. This study is dedicated to understanding the willingness of childbearing-age women in Chongqing to have a third child under the new fertility policy and analyzing its determinants to provide a theoretical reference for the change in fertility situation and policy implementation in Chongqing.

Biomimetic lymph node-like scaffolds for optimized CAR-T cell expansion and potentiated antitumor efficacy.

Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable promise in treating hematological malignancies. However, the expansion of CAR-T cells is time-consuming, potentially impairing CAR-T cell function. Physiologically, T cell activation and proliferation occur within the lymph node (LN) paracortex, a dynamic environment structured by a three-dimensional (3D) reticular network (RN) that promotes cell migration and mediator delivery.

Varicella-zoster virus infection in pregnancy: a case of aseptic meningitis before 20 weeks gestation and review of the literature.

Background: Varicella zoster virus (VZV) infection during pregnancy can lead to severe complications. However, cases complicated by aseptic meningitis in early pregnancy (<20 weeks) are extremely rare, and clinical management and pregnancy outcomes remain unclear.

Case Report: We report a case of a 36-year-old pregnant woman who developed right upper abdominal pain, headache, and cough at 17 weeks of gestation, followed by clustered herpes zoster lesions in the right lumbar region and signs of meningeal irritation.

Targeting Glypican-3 for Liver Cancer Therapy: Clinical Applications and Detection Methods.

Recent advancements in cancer immunotherapy have highlighted glypican-3 (GPC3) as a prominent target for treating hepatocellular carcinoma (HCC). However, approximately 10% to 30% of HCC patients exhibit low or absent GPC3 expression on the surface of tumor cells, which limits the feasibility of GPC3-targeted therapies. Consequently, it is essential for patients to undergo pre-diagnostic assessments of GPC3 expression in tumor cells to evaluate their suitability for GPC3-directed therapy.

Experimental Investigation of Obstruction Effects on CH/H Hybrid Fuel Explosion Dynamics in Semiconfined Pipelines.

This study systematically investigates the effects of porous obstacle blockage ratios on the explosion characteristics of CH/H mixtures in semiconfined pipelines through experimental methods. High-speed imaging and high-frequency pressure sensors were employed to simultaneously capture flame propagation dynamics and pressure field evolution. The results demonstrate that porous obstacles significantly alter flame propagation mechanisms.

Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Infection in Patients With Pre-Existing Stage II-IV Lung Cancer.

Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have improved cancer outcomes but can induce immune-related adverse events, including mycobacterial infections. This study retrospectively analysed pulmonary nontuberculous mycobacteria (NTM) infection in 91 patients with pre-existing stage II-IV lung cancer at Shanghai Pulmonary Hospital between June 2015 and June 2024. Among these patients, 78.

Moisture fluctuations: An important but overlooked factor in the carbon cycle.

Global warming has intensified extreme weather events and current studies on soil carbon dynamics have predominantly focused on the stress of average moisture, while the significance of moisture fluctuation has been largely ignored. To fill this knowledge gap, we systematically explored the impact of multi-dimensional changes in soil moisture on different labile carbon pools through a meta-analysis using 1665 data points based on soils collected globally. By evaluating the interactive effects of different levels of average, fluctuation, and changing frequency of soil moisture during incubation experiments, our results showed that the dynamics of CO emissions and microbial biomass carbon (MBC) were mainly influenced by soil moisture level, while the change of dissolved organic matter (DOM) was more strongly associated with moisture fluctuation.

Non-surgical treatments for post-burn scars: A network meta-analysis.

Background And Aim: Post-burn scarring is a prevalent condition, and the existing non-surgical treatments exhibit varying degrees of efficacy. There is limited evidence available to determine the effective non-surgical treatment for post-burn scars. This study employs a multi-index network meta-analysis to conduct a comprehensive evaluation and comparative ranking of non-surgical treatments for post-burn scars.

Cryomicroneedle Arrays for Biotherapeutics Delivery.

Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost-effectiveness of biotherapeutics. The microneedle, as a minimally invasive drug delivery tool, has demonstrated considerable potential in biotherapeutic applications.

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication.

The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection. Here, we perform a genome-wide CRISPR knockout screen to identify host restriction factors for SARS-CoV-2, revealing DAZAP2 as a potent antiviral gene. DAZAP2, previously implicated in SARS-CoV-2 restriction, is found to inhibit viral entry by blocking virion fusion with both endolysosomal and plasma membranes.

Accommodating Spatial Heterogeneity in Geographically Weighted Regression with Group Penalty.

Data composed of multiple datasets, for example, survey study data collected from multiple geographic locations, has become routine and received increasing attention in recent years. Many existing strategies for analyzing such data either ignore the spatial heterogeneity across locations or are inefficient, leading to "suboptimal" estimation. Partly motivated by a Chinese social survey on pension and healthcare, we develop a geographically weighted group lasso regression (GWGPL), which can effectively accommodate spatial heterogeneity and conduct shared variable selection while promoting structural similarity across locations.

Spatial distribution, speciation, and release behavior of exogenous copper in soil aggregates: The role of aggregate structural reorganization.

Copper (Cu) contamination in soil poses serious environmental risks, impacting ecosystem health and groundwater quality. This study explored how soil aggregate structural reorganization influences the spatial distribution, chemical speciation, and release behavior of exogenous Cu. Aggregates with and without structural reorganization were prepared.

Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway.

Background: Platelet abnormalities are well-recognized complications of type 2 diabetes mellitus (T2DM). High glucose (HG) increases platelet mitochondrial dysfunction, apoptosis and hyperreactivity in T2DM, which underlie the occurrence of thrombotic events. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and possesses multiple biological activities.

Different anticoagulation methods for continuous renal replacement therapy in patients with hyperlactataemia and a high risk of bleeding.

Background: There is a lack of consensus regarding the optimal anticoagulation strategy for continuous renal replacement therapy (CRRT) in patients with hyperlactataemia and a high risk of bleeding. The purpose of this study was to evaluate the safety and efficacy of the commonly used anticoagulation methods for CRRT in these patients.

Methods: The present study included patients with hyperlactataemia (⩾2 mmol/L) and a high risk of bleeding who underwent CRRT at Xijing Hospital from 2020 to 2024.

A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants.

Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity.