Study on the deposition behavior of sodium/sulfide elements during the operation of radiant syngas cooler in an entrained-flow gasifier.

As a core process in the coal chemical industry, entrained-flow gasification technology promotes clean energy conversion by efficiently producing syngas. In industrial applications, radiant syngas cooler (RSC) is usually adopted to recover high-temperature syngas and slag waste heat from the gasifier outlet to improve system heat utilization. However, the ash deposition and slagging behavior in RSC can lead to a decrease in heat transfer efficiency and limited production capacity, becoming a key bottleneck, restricting technological development.

Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer.

Aims: This study investigates the mechanisms underlying acquired resistance to FGFR tyrosine kinase inhibitor (FGFR-TKI) in gastric cancer (GC), focusing on the interplay between ferroptosis and lipid metabolism of tumor cells.

Methods: We constructed FGFR-TKI-resistant cell lines from GC cells. RNA sequencing was performed to identify differentially expressed genes (DEGs) related to ferroptosis and assess lipid metabolism in resistant cells.

Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure.

Background: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). Recently, metabolomics has emerged as a crucial tool for diagnosing and understanding the pathogenesis of various diseases. This study aimed to differentiate diuretic-resistant patients from non-resistant HF to identify biomarkers linked to the emergence of DR.

A case report of implantable collamer lens removal with cataract extraction and TECNIS Symfony extended range of vision intraocular lens (ZXR00) implantation.

Background: Anterior subcapsular cataract (ASC) is a leading complication of implantable collamer lens (ICL) implantation and a common indication for secondary ICL removal. However, the visual outcomes of combined ICL explantation, cataract extraction, and implantation of a TECNIS Symfony ZXR00 IOL with a targeted myopic shift (-0.50D to -0.

Structural and Performance Optimization of Environmentally Friendly Phenolic Resin/Polyvinyl Alcohol/Pure Terephthalic Acid/Silicone Carbide (PF/PVA/PTA/SiC) Porous Composite Grinding Wheels Prepared via Freeze-Drying Methodology.

The traditional preparation of polyvinyl alcohol (PVA) grinding wheels typically involves hazardous chemicals such as formaldehyde and hydrochloric acid, posing significant health risks to operators and contributing to environmental pollution. In this study, we utilized the freeze-drying method to fabricate PVA grinding wheels, optimizing both the manufacturing process and the structure of the porous composite materials. The results demonstrate that phenolic resin (PF) participates in constructing a hydrogen-bonded network with PVA and pure terephthalic acid (PTA), which synergistically enhances the esterification efficiency between PTA and PVA.

Thermal decomposition behavior of retired wind turbine blades: kinetics, pyrolysis product distribution and characterization.

The rapid growth of the wind power industry has heightened the need for effective resource utilization of retired wind turbine blades (RWTB). Pyrolysis technology offers a promising approach for recovering high-value products from RWTB. In this study, the pyrolysis kinetic behavior of RWTB was investigated using three kinetic models (KAS, FWO, Miura) and the isoconversional method, based on thermogravimetric (TG) analysis at four heating rates.

X-type and MCM-41-type molecular sieves from full component utilization of coal gasification fine slag and amino modification for CO capture.

The development of coal gasification technology inevitably generates a substantial amount of coal gasification fine slag (CGFS), which contains abundant silica-aluminum elements. Utilizing these elements to synthesize molecular sieve materials for CO capture is of great significance. In this paper, to fully utilize the elements in CGFS, X-type and MCM-41-type molecular sieves were synthesized through activated hydrothermal and microwave treatment of the solid residue after alkali fusion and the silica source filtrate, respectively.

Causal Links between Gut Microbiota, Blood Metabolites, Immune Cells, Inflammatory Proteins, and Myopia: A Mendelian Randomization Study.

Purpose: This study aimed to investigate causal relationships between gut microbiota, blood metabolites, immune cell traits, circulating inflammatory proteins, and myopia through Mendelian randomization (MR) analysis.

Design: Mendelian randomization study.

Subjects: Genome-wide association study (GWAS) data of 412 gut microbiota, 1400 blood metabolites/metabolite ratios, 731 immune cell traits, and 91 circulating inflammatory proteins from the public GWAS database.

Luteolin ameliorates ischemic/reperfusion injury by inhibiting ferroptosis.

Ischaemic stroke is a large disease burden worldwide. Thrombolysis and thrombectomy are the main treatment methods for cerebral ischemia-reperfusion (I/R) injury. Luteolin, as a flavonoid compound, has an antagonistic effect on inflammation, oxidative stress, and tumorigenesis in disease.

MVB fault diagnosis based on time-frequency analysis and convolutional neural networks.

Traditional diagnostic methods for multifunction vehicle bus (MVB) faults often depend on feature extraction and classification, which typically require substantial expert experience and frequently yield low accuracy. To address this limitation, this paper introduces a MVB fault diagnosis method utilizing convolutional neural networks (CNNs). Initially, the method employs short-time Fourier transform (STFT) to convert the original vibration signals of MVB under various fault conditions into time-frequency images.

Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.

Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting myocardial mitochondrial function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered by the release of cytochrome c. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2) is considered a potential therapeutic target for treating myocardial I/R injury by enhancing the cellular antioxidant capacity through the induction of endogenous antioxidant enzymes.

Association of different emotional support status with cardio-cerebrovascular diseases.

Background: Evidence suggests that emotional status affect physical health. We aimed to investigate the association of different emotional support sources with morbidity or mortality of cardio-cerebrovascular diseases (CVDs).

Methods: We conducted a retrospective-cohort analysis using data in National Health and Nutrition Examination Survey from 1999 to 2004.

Efficacy of minimally invasive soft-channel drainage for chronic subdural hematoma utilizing 3D slicer: a retrospective comparative analysis.

Background: The main surgical interventions for chronic subdural hematoma (CSDH) include craniotomy for hematoma evacuation, neuroendoscopic hematoma evacuation, and burr hole drainage.However, elderly patients often present with significant comorbidities, which limit their ability to tolerate general anesthesia and invasive surgical procedures.Minimally invasive soft-channel drainage under local anesthesia has emerged as a viable alternative, particularly suitable for elderly patients or those with high surgical risk.

Coal gasification fine slag as a precursor to prepare mesoporous carbon materials by an activation-hydrothermal two-step method for CO adsorption.

Coal gasification fine slag (CGFS) is a solid waste produced from gasification process, which consists of residual carbon with porous structure and minerals. The capture of CO by porous materials is an effective method for reducing CO emissions from industrial sources. In this work, the effective separation of residual carbon and ash from CGFS was achieved by froth flotation.

Programmed death receptor-1/programmed death-ligand 1 inhibitors: Clinical progress and biomarker exploration in gastric cancer.

Gastric cancer is one of the most common malignant tumours, with limited treatment options and poor prognosis in its advanced stages. In recent years, breakthroughs in tumour immunotherapy have led to immune checkpoint inhibitors becoming a new class of clinical oncology drugs. Programmed death receptor-1 (PD-1) and programmed death-ligand 1 (PD-L1) play significant roles in inhibiting T cell responses and tumour immune escape.

Binding with HSP90β, cimifugin ameliorates fibrotic cataracts in vitro and in vivo by inhibiting TGFβ signaling pathways.

Fibrotic cataracts, the most frequent complications after phacoemulsification, cannot be cured by drugs in clinic. The primary mechanism underlying the disease is the epithelial-mesenchymal transition (EMT). Cimifugin is a natural monomer component of traditional Chinese medicines.

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway.

Background: Fibrosis cataract occurs in patients receiving cataract extraction. Still, no medication that can cure the disease exists in clinical. This study aims to investigate the effects and mechanisms of Entrectinib on fibrotic cataract in vitro and in vivo.

Causal relationship between Brugada syndrome and electrocardiogram traits: A bidirectional Mendelian randomization study.

Introduction: Observational studies have suggested associations between Brugada syndrome (BrS) and electrocardiograms traits. Nonetheless, the causal relationships remains uncertain in observational studies. This study aims to investigate the causal relationships between BrS phenotypic risk and electrocardiogram traits using Mendelian randomization (MR) analysis and colocalization analysis.

His bundle pacing combined with atrioventricular node ablation for atrial fibrillation: a systematic review and meta-analysis.

Introduction And Objective: His bundle pacing (HBP) could replace failed biventricular pacing (BVP) in guidelines (IIa Indication), but the high capture thresholds and backup lead pacing requirements limit its development. We assessed the efficacy and safety of HBP combined with atrioventricular node ablation (AVNA) for atrial fibrillation (AF) and compared with BVP and left bundle branch pacing (LBBP).

Methods: We reviewed PubMed, Embase, Web of Science, and Cochrane Library databases on left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) score, QRS duration (QRSd), and pacing threshold.

The relationship between risk perceptions and negative emotions in the COVID-19: a meta-analysis.

Background: COVID-19, as a significant public health issue, has had a major impact on the mental health of people worldwide. Research shows a significant positive correlation between individuals' risk perception levels and negative emotions during the outbreak of COVID-19. However, some studies also suggest that the relationship between the two is not significant.

Legumain-Guided Ferulate-Peptide Self-Assembly Enhances Macrophage-Endotheliocyte Partnership to Promote Therapeutic Angiogenesis After Myocardial Infarction.

Promoting angiogenesis and modulating the inflammatory microenvironment are promising strategies for treating acute myocardial infarction (MI). Macrophages are crucial in regulating inflammation and influencing angiogenesis through interactions with endothelial cells. However, current therapies lack a comprehensive assessment of pathological and physiological subtleties, resulting in limited myocardial recovery.

Causal association between blood metabolites and abdominal aortic calcification: A bidirectional Mendelian randomization study.

Previous studies have reported correlations between metabolic factors and abdominal aortic calcification (AAC). However, the causal relationship between blood metabolites and AAC remains to be fully explored. We employed bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal relationships between 486 blood metabolites and AAC.

Intrinsic promotion mechanism of calcium oxide on ketone production during catalytic fast pyrolysis of biomass via experiment and density functional theory simulation.

CaO modified with acetic acid solution or sodium hydroxide (H-CaO/OH-CaO) was used to explore the relationship between the physical and chemical properties of CaO and the components of bio-oil during the pyrolysis of rice straw (RS) and model compounds via experiment and density functional theory(DFT) simulation. The results showed that the modification changed the properties of CaO, and thus the catalytic performance on production of bio-oil components. H-CaO with the larger number of strong basic sites (1.