Varied influence of aged microplastics and related leachates on phosphorus transformation and release from the sediments.

Microplastics (MPs) accumulate and age in freshwater sediments, releasing leachates that may alter sediment nutrient cycling. While phosphorus (P) is crucial for freshwater eutrophication, previous studies have rarely focused on MPs leachates. Herein, this work investigated the effects of polyethylene (PE), polystyrene (PS), polyvinyl chloride (PVC), and related leachates on the sediment P cycling.

Biological and genomic characterization of a novel gammabaculovirus for biocontrol of Diprion infuscalae (Hymenoptera: Diprionidae).

Diprion infuscalae Wang & Wei, an emerging sawfly pest of the Chinese red pine, Pinus massoniana, is currently endemic to Jiangxi and Fujian provinces within the mainland China. To mitigate its infestation and to reduce our reliance on chemical pesticides, a naturally occurring nucleopolyhedrovirus (DiinNPV), was isolated from the deceased D. infuscalae larvae.

A case report of implantable collamer lens removal with cataract extraction and TECNIS Symfony extended range of vision intraocular lens (ZXR00) implantation.

Background: Anterior subcapsular cataract (ASC) is a leading complication of implantable collamer lens (ICL) implantation and a common indication for secondary ICL removal. However, the visual outcomes of combined ICL explantation, cataract extraction, and implantation of a TECNIS Symfony ZXR00 IOL with a targeted myopic shift (-0.50D to -0.

Insights into effects of drying-wetting cycles on dissolved organic matter and Cd bioavailability in riparian sediments amended with microplastics.

Microplastics (MPs) affect the fractionation of cadmium (Cd) by altering physicochemical properties of sediment. However, differences in the effect of drying-wetting cycles on the bioavailability of heavy metals and dissolved organic matter (DOM) in sediment amended with MPs remain unclear. In this study, we investigated the influence of polystyrene (PS), polylactic acid (PLA), and tire wear particles (TWPs) at concentrations of 0.

Co-occurrence of microplastics and heavy metals to urban river sediments: The vertical distribution characterization and comprehensive ecological risk assessment.

Microplastics (MPs) and heavy metals (HMs) are deemed to pose ecological risks in river ecosystems. The vertical distribution of these pollutants is more conducive to reflecting pollution status and monitoring trends in the sediment. This work analyzed the horizontal and vertical distribution, carried out a risk assessment of HMs and MPs in urban river sediment, and further optimized the two-dimensional comprehensive index (TPI) model for MPs-HMs combined pollution.

NezhNPV, a new biocontrol agent for Nesodiprion zhejiangensis Zhou & Xiao (Hymenoptera: Diprionidae), an emerging forest pest.

Background: Nesodiprion zhejiangensis, a multivoltine sawfly, is widely distributed in south China and has caused serious damage to forests. Historically, N. zhejiangensis management has relied heavily on synthetic chemicals.

Binding with HSP90β, cimifugin ameliorates fibrotic cataracts in vitro and in vivo by inhibiting TGFβ signaling pathways.

Fibrotic cataracts, the most frequent complications after phacoemulsification, cannot be cured by drugs in clinic. The primary mechanism underlying the disease is the epithelial-mesenchymal transition (EMT). Cimifugin is a natural monomer component of traditional Chinese medicines.

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway.

Background: Fibrosis cataract occurs in patients receiving cataract extraction. Still, no medication that can cure the disease exists in clinical. This study aims to investigate the effects and mechanisms of Entrectinib on fibrotic cataract in vitro and in vivo.

Photoaged tire wear particles hinder the transport of Pb(II) in urban soils under acid rain: Experimental and numerical investigations.

Rapid urbanization brought lots of serious environmental contamination, including the accumulation of heavy metals, acid rain, and the emission of tire wear particles (TWPs), with detrimental effects for terrestrial ecosystems. Nevertheless, how naturally aged TWPs affect the mobilization of heavy metals in soils under acid rain is still unclear. Here, we investigate the adsorption and transport mechanisms of Pb(II) co-existing with acid rainwater in soil-TWP mixtures via batch experiments, column experiments and modeling.

Interaction of Pb(II) with microplastic-sediment complexes: Critical effect of surfactant.

In this study, the impact of surfactants on the adsorption behavior of Pb(II) onto microplastics-sediment (MPs-S) complexes was investigated. Firstly, virgin polyamide (VPA) and polyethylene (VPE) were placed in Xiangjiang River sediment for six months to conduct in-situ aging. The results indicated that the biofilm-developed polyamide (BPA) and polyethylene (BPE) formed new oxygen-containing functional groups and different biofilm species.

Evaluation of nintedanib efficacy: Attenuating the lens fibrosis in vitro and vivo.

Purpose: Organ fibrosis is a huge challenge in clinic. There are no drugs for fibrotic cataracts treatments in clinic. Nintedanib is approved by the FDA for pulmonary fibrosis treatments.

Effects of microplastics on microbial community structure and wheatgrass traits in Pb-contaminated riparian sediments under flood-drainage-planting conditions.

The coexistence of microplastics (MPs) and heavy metals in sediments has caused a potential threat to sediment biota. However, differences in the effects of MPs and heavy metals on microbes and plants in sediments under different sediment conditions remain unclear. Hence, we investigated the influence of polyethylene (PE) and polylactic acid (PLA) MPs on microbial community structure, Pb bioavailability, and wheatgrass traits under sequential incubation of sediments (i.

Effects of microplastics on sedimentary geochemical properties and microbial ecosystems combined with hydraulic disturbance.

Microplastics (MPs) pollution is widely investigated owing to its potential threats to river ecosystems. However, it remains unclear whether hydraulic disturbance deepens or mitigates the effects of MPs-contaminated sediments on the river environment. Herein, we studied the impact of sediment aggregates, organic matter, and enzyme activity, with emphasis on microbial community structure and function in sediments exposed to MPs (1 %, 5 %, and 10 % w/w) in conjunction with hydraulic disturbance.

Effect of TEMPO-oxidized bacterial cellulose nanofibers stabilized Pickering emulsion of cinnamon essential oil on structure and properties of gelatin composite films.

Pure gelatin film often exhibits high hydrophilicity and a lack of antibacterial activity, hindering its practical application in the field of food preservation. To address these issues, we incorporated 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized bacterial cellulose (TOBC) nanofibers stabilized cinnamon essential oil (CEO) Pickering emulsions into the gelatin matrix to develop active food packaging films. The study revealed that the good distribution of emulsion droplets in the film matrix.

The mitochondrial genome and life history of Tomostethus sinofraxini (Hymenoptera: Tenthredinidae), an emerging pest of Fraxinus chinensis.

Tomostethus sinofraxini Wang & Wei (a new name is proposed for Tomostethus fraxini Niu & Wei, 2022: Tomostethus sinofraxini Wang & Wei, nom. nov.), an emerging sawfly pest of the Chinese ash, Fraxinus chinensis, is now endemic to Beijing, Tianjin, Hebei, and Shandong provinces.

Impact of polyamide microplastics on riparian sediment structures and Cd(II) adsorption: A comparison of natural exposure, dry-wet cycles, and freeze-thaw cycles.

Microplastics (MPs) accumulation in sediments has posed a huge threat to freshwater ecosystems. However, it is still unclear the effect of MPs on riparian sediment structures and contaminant adsorption under different hydrological processes. In this study, three concentrations of polyamide (PA) MPs-treated sediments (0.

Corrigendum: Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel.

[This corrects the article DOI: 10.3389/fonc.2022.

[Corrigendum] METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.

Subsequently to the publication of the above article, the authors alerted us to the fact that the data shown in Fig. 8I (for the 'Sh‑CN / 0' panel) on p. 11 were mistakenly selected from those data belonging to the experiments shown in Fig.

Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel.

The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). Inhibition of OGT serves as a potential strategy for PC treatment alone or combinational therapy. PC is the second common cancer type in male worldwide, for which chemotherapy is still the first-line treatment.

Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019.

Background: To evaluate the global burden of cataracts by year, age, region, gender, and socioeconomic status using disability-adjusted life years (DALYs) and prevalence from the Global Burden of Disease (GBD) study 2019.

Methods: Global, regional, or national DALY numbers, crude DALY rates, and age-standardized DALY rates caused by cataracts, by year, age, and gender, were obtained from the Global Burden of Disease Study 2019. Socio-demographic Index (SDI) as a comprehensive indicator of the national or regional development status of GBD countries in 2019 was obtained from the GBD official website.

METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.

Colorectal cancer (CRC) is one of top five leading causes of cancer‑associated mortalities worldwide. 5‑Fluorouracil (5‑FU) is the first‑line chemotherapeutic drug in the treatment of CRC; however, its antineoplastic efficiency is limited due to acquired drug resistance. The regulatory mechanism underlying 5‑FU chemotherapeutic response and drug resistance in CRC remains largely unknown.

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis.

Methyltransferase-like 3 (METTL3) and N-methyladenosine (mA) are involved in many types of biological and pathological processes, including DNA repair. However, the function and mechanism of METTL3 in DNA repair and chemotherapeutic response remain largely unknown. In present study, we identified that METTL3 participates in the regulation of homologous recombination repair (HR), which further influences chemotherapeutic response in both MCF-7 and MDA-MB-231 breast cancer (BC) cells.

Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway.

Chimeric antigen receptor T-cell (CAR-T) therapy has shown tremendous success in eradicating hematologic malignancies. However, this success has not yet been extrapolated to solid tumors due to the limited infiltration and persistence of CAR-T cells in the tumor microenvironment (TME). In this study, we screened a novel anti-CD70 scFv and generated CD70 CAR-T cells that showed effective antitumor functions against CD70 renal carcinoma cells (RCCs) both in vitro and in vivo.

Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.

Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 is highly expressed and associated with poor patient prognosis. The suppression of APE1 could lead to the accumulation of unrepaired DNA damage in cells.