A modified QuEChERS method for extracting different classes of emerging contaminants in soil.

Emerging contaminants (ECs) in soil pose concerns due to their potential health risks and toxicities. However, the pretreatment method for simultaneously extracting different classes of ECs was limited in soil. In this study, a rapid and robust pretreatment method based on a "Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS)" technology was developed for simultaneous extraction of 50 ECs, including 28 per- and polyfluoroalkyl substances (PFAS), 17 organophosphate esters (OPEs) and 5 diesters (di-OPEs) in soil.

Enrichment process of phosphorite type REY based on the structure and geochemical features of the Zhijin Xinhua phosphorite in China.

In response to the insufficiently in-depth and systematic studies on the enrichment processes of phosphorite-type rare earths (REE), this study takes the recently discovered Early Cambrian Xinhua rare earth-phosphate composite deposit in Zhijin, Guizhou, as a case example. Building on detailed field investigations, this study conducts an in-depth analysis of the ore's structures. Employing a suite of analytical techniques, including X-Ray Fluorescence (XRF), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Total Organic Carbon (TOC) testing, and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS), we meticulously delineate the sourcing, transportation, and storage processes of REE.

Study on the Weathering Process and Re-enrichment Mechanism of the Ediacaran Phosphorus Deposits in Central Guizhou, China.

Phosphorus deposits in central Guizhou are typical of global phosphorogenic events after the Neoproterozoic Ice Age. These deposits exhibit a high correlation between weathering characteristics and the ore grade level. To investigate the mechanisms of the process in which phosphate is partially dissolved, phosphorus weathering migration, precipitation, and re-enrichment in the supergene environment, this study uses X-ray diffraction analysis, scanning electron microscopy, energy spectrum analysis, elemental geochemical tests, saturation method rock porosity experiments, and dissolution experiments to compare the primary ore and weathered ore of phosphorus deposits in central Guizhou.

A machine learning-based risk prediction model for diabetic oral ulceration.

Background: Diabetic oral ulceration (DOU) is a prevalent and debilitating complication among diabetic patients, significantly impairing their quality of life and imposing substantial economic burdens. Studies indicate that over 90% of diabetic patients experience oral complications, with 45% suffering from oral ulcers. Clear diagnosis is crucial for effective clinical management and prognosis improvement.

Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure.

Background: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). Recently, metabolomics has emerged as a crucial tool for diagnosing and understanding the pathogenesis of various diseases. This study aimed to differentiate diuretic-resistant patients from non-resistant HF to identify biomarkers linked to the emergence of DR.

Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a multi-institutional, randomized, controlled trial.

Background: The prevalence of burning mouth syndrome (BMS) is approximately 8% in clinical patients; thus, BMS remains a therapeutic challenge. Photobiomodulation (PBM) and oral cryotherapy (OCT) have been evaluated for the treatment of burning pain, but no confirmatory trials have been performed. To evaluate the comparative effectiveness of PBM combined with OCT at reducing pain and psychological distress compared with PBM alone, OCT alone, or drug therapy (DT) alone in a cohort of patients with BMS.

Electrocatalytic Conversion of Glucose into Renewable Formic Acid Using "Electron-Withdrawing" MoO Support under Mild Conditions.

Electrocatalysis is a sustainable and effective approach to produce value-added chemical commodities from biomass, where highly effective catalyst is required. Since transition metal hydroxide is a feasible catalyst for electrochemical biomass conversion, rational optimization of its electrocatalytic activity is highly desired. Herein, electrocatalytic activity of glucose oxidation is significantly optimized by reducing the electron density at Ni active sites, which is achieved by depositing Ni(OH) at "electron-withdrawing" MoO support (Ni(OH)MoO).

Promoting the glycosylation of drug-like natural products in a Saccharomyces cerevisiae chassis by deletion of endogenous glycosidases.

Glycosylation is an effective strategy to improve the absorption, distribution, metabolism, excretion, and toxicity of natural product (NP) pharmacophores. While heterologous production of broad-spectrum fungal glucosyltransferases such as BbGT86 of Beauveria bassiana yields varied phenolic glucoconjugates in S. cerevisiae, endogenous yeast glycosidases diminish the conversion yields and limit the structural diversity of the products.

Nitric Oxide Pre-Treatment Advances Bulblet Dormancy Release by Mediating Metabolic Changes in .

The lily is a globally popular cut flower, and managing dormancy in lily bulblets is essential for continuous, year-round production. While nitric oxide (NO) has been shown to influence seed dormancy and germination, its role in dormancy release in lilies was previously unconfirmed. In this study, we investigated the effects of NO on dormancy release in lily bulblets using SNP and c-PTIO.

Prolyl 4-hydroxylase α-subunit family regulation of type I collagen deposition and IL17RB/c-Jun activation synergistically mediate choline dehydrogenase promotion of colorectal cancer metastasis.

Metastasis continues to pose a significant challenge in tumor treatment. Evidence indicates that choline dehydrogenase (CHDH) is crucial in tumorigenesis. However, the functional role of CHDH in colorectal cancer (CRC) metastasis remains unreported.

The NAC transcription factor LpNAC48 promotes trichome formation in Lilium pumilum.

Trichomes play a crucial role in plant resistance to abiotic and biotic stresses, and their development and characteristics vary across different species. This study demonstrates that trichomes of Lilium pumilum exhibit synchronized growth during flower bud differentiation and enhance the plant's adaptability to UV-B radiation and aphid infection. We identified LpNAC48, a NAC family transcription factor (TF), that interacted with the B-box (BBX) family TF LpBBX28, during trichome formation in L.

Two fitness inference schemes compared using allele frequencies from 1068 391 sequences sampled in the UK during the COVID-19 pandemic.

Throughout the course of the SARS-CoV-2 pandemic, genetic variation has contributed to the spread and persistence of the virus. For example, various mutations have allowed SARS-CoV-2 to escape antibody neutralization or to bind more strongly to the receptors that it uses to enter human cells. Here, we compared two methods that estimate the fitness effects of viral mutations using the abundant sequence data gathered over the course of the pandemic.

Tinidazole mouth rinse for the treatment of oral lichen planus: an observational pilot study.

Background: Given the limited treatment options available for oral lichen planus (OLP), a study was undertaken to obtain preliminary information on the therapeutic efficacy of tinidazole mouth rinse in patients with OLP.

Methods: A prospective, open-label pilot study was conducted to assess the efficacy of thrice-daily tinidazole mouth rinse for one week in OLP patients (n = 27). Reticulation/erythema/ulceration (REU) scores and visual analog scale (VAS) scores were used to measure lesions at baseline and after one week of treatment.

Unloading and successful treatment with bioresorbable stents during percutaneous coronary intervention: A case report.

Background: With the development of percutaneous coronary intervention (PCI), the number of interventional procedures without implantation, such as bioresorbable stents (BRS) and drug-coated balloons, has increased annually. Metal drug-eluting stent unloading is one of the most common clinical complications. Comparatively, BRS detachment is more concealed and harmful, but has yet to be reported in clinical research.

Efflux of TolC protein to different antimicrobials can be replaced by other outer membrane proteins with similar β-barrel structures in extraintestinal pathogenic Escherichia coli.

Aim: As a major efflux pump system in Gram-negative bacteria, AcrAB-TolC plays a key role in the transport of multiple drug substrates and is considered a potential target for the development of novel antimicrobials. Our previous study found that TolC inactivation compromised the resistance to different antimicrobials in porcine extraintestinal pathogenic Escherichia coli (ExPEC) strain PPECC042 (WT). This study was designed to investigate the functional substitution of TolC by other outer membrane proteins (OMPs) with similar β-barrel structures in pumping out different antimicrobials.

Evaluation of compressive damage in concrete using ultrasonic nonlinear coda wave interferometry.

This study investigates the feasibility of nonlinear coda wave interferometry (NCWI) for evaluating compressive damage in concrete, with a particular focus on the interference caused by the compressive stress-induced slow dynamics. Slow dynamics refers to a phenomenon in which the stiffness of concrete immediately decreases after moderate mechanical conditioning and then logarithmically evolves back to its initial value over time. A series of experiments were conducted to validate this concept.

Machine Learning for Detecting Atrial Fibrillation from ECGs: Systematic Review and Meta-Analysis.

Background: Atrial fibrillation (AF) is a common arrhythmia that can result in adverse cardiovascular outcomes but is often difficult to detect. The use of machine learning (ML) algorithms for detecting AF has become increasingly prevalent in recent years. This study aims to systematically evaluate and summarize the overall diagnostic accuracy of the ML algorithms in detecting AF in electrocardiogram (ECG) signals.

High tensile regenerated cellulose fibers via cyclic freeze-thawing enabled dissolution in phosphoric acid for textile-to-textile recycling of waste cotton fabrics.

Recycling of waste cotton fabrics (WCFs) is a desirable solution to address the problems brought up by fast fashion, but it remains challenging due to inherent limitations in preparing stable and spinnable dopes by dissolving high molecular weight cellulose efficiently and cost effectively. Herein, we show that despite the prevailing concerns of cellulose degradation via glycosidic hydrolysis when dissolved in acids, fast and non-destructive direct dissolution of WCFs in aqueous phosphoric acid (a.q.

Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower ( L.): an important medicinal plant.

Safflower ( L.), a member of the Asteraceae family, is widely used in traditional herbal medicine. This review summarized agronomic conditions, genetic diversity, clinical application, and phytochemicals and pharmacological properties of safflower.

Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis.

Background: Tuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy. Identifying differentially expressed lipid metabolism related genes (DELMRGs) is crucial for guiding treatment decisions.

Methods: We acquired tuberous sclerosis related epilepsy (TSE) datasets, GSE16969 and GSE62019.

Function and regulation of RGS family members in solid tumours: a comprehensive review.

G protein-coupled receptors (GPCRs) play a key role in regulating the homeostasis of the internal environment and are closely associated with tumour progression as major mediators of cellular signalling. As a diverse and multifunctional group of proteins, the G protein signalling regulator (RGS) family was proven to be involved in the cellular transduction of GPCRs. Growing evidence has revealed dysregulation of RGS proteins as a common phenomenon and highlighted the key roles of these proteins in human cancers.

Effects of low-level laser therapy on burning pain and quality of life in patients with burning mouth syndrome: a systematic review and meta-analysis.

Background: Burning mouth syndrome (BMS) is a complex chronic pain disorder that significantly impairs patients' quality of life. Low-level laser therapy (LLLT) uses infrared or near-infrared light to produce analgesic, anti-inflammatory, and biological stimulation effects. The aim of this systematic review is to evaluate the effect of LLLT on burning pain, quality of life, and negative emotions in patients with BMS.

The Effect of the Cu Interlayer on the Interfacial Microstructure and Mechanical Properties of Al/Fe Bimetal by Compound Casting.

Al/Fe bimetals prepared by a compound casting method, combining the excellent properties of both the Al alloy and the ductile cast iron, exhibit great potential for application in achieving engine weight reduction. However, the problem of insufficient interfacial bonding ability because of the difference in thermophysical properties of Al and Fe is particularly prominent. Therefore, in this work, the electrodeposited Cu coating on the surface of the Fe matrix was used as the interlayer of Al/Fe bimetal fabricated by coupling hot-dipping with compound casting to solve the above problem.

[Effects of Fusobacterium nucleus derived outer membrane vesicles on claudin-4 expression in oral epithelial cells].

Purpose: To investigate the effect of outer membrane vesicles (OMVs) secreted by Fusobacterium nucleatum (F.n) on Claudin-4 of human oral keratinocytes (HOK) and oral epithelial barrier function.

Methods: Fusobacterium nucleatum was cultured under anaerobic conditions.