FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation.

High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice.

Identification and expression of a novel antimicrobial peptide Gloverin and its antibacterial effect against Staphylococcus aureus.

Background: Antimicrobial peptides (AMPs) have attracted extensive attention in various fields. Gloverin is a group of AMPs derived from Lepidoptera insects. In this study, a novel gloverin CpGlv was identified through sequence alignment.

encapsulation of coumarin/fluorescent bleacher/carbazole derivatives@Eu MOF materials for white light-emitting diodes.

Metal-organic frameworks (MOFs), characterized by their high porosity, large specific surface area, and tunable pore structures, have emerged as promising host materials for advanced functional applications. In this study, two organic dyes, fluorescent bleacher (CBS) and coumarin (C6), exhibiting blue and green fluorescence, respectively, were co-encapsulated into europium (Eu)-based MOFs, where Eu served as the central metal to introduce red emission. The ligand employed was 9-butylcarbazole-2-carboxylhydrazide thiophene (Cz).

High-Strength, Thermally Stable Phthalazinone-Containing Bismaleimide Composites Engineered for Electronic Packaging Substrates.

To address the escalating demands imposed by artificial intelligence computations, advanced electronic packaging technologies have increasingly emphasized miniaturization, high integration, and superior stability. Nonetheless, such advancements frequently encounter challenges such as severe heat accumulation, inadequate rigidity, and electrical signal interference. Consequently, there is an urgent need for packaging materials that possess exceptional thermal resistance, elevated flexural modulus, and superior dielectric attributes to satisfy these stringent application criteria.

Superconducting properties of LiKH with a cage configuration under high pressure.

The search for room-temperature superconductors in high-pressure hydrides is of significant scientific importance. Here, we systematically studied the Li-K-H system using a genetic algorithm combined with density functional theory calculations. At 150 GPa, the stable phases identified are -LiKH, 6̄2-LiKH, 6̄-LiKH, 1-LiKH and 3-LiKH, while at 300 GPa, the stable phases are 2/-LiKH, 3̄-LiKH, 3-LiKH and -LiKH.

High-Density W Single Atoms in Two-Dimensional Spinel Oxide Break the Structural Integrity for Enhanced Oxygen Evolution Catalysis.

The performance of oxygen evolution reaction (OER) catalysts heavily depends on intrinsically active and robust sites as well as high active site number, which poses challenges in catalyst design concerning composition and structure. This study presents a general oxygen-vacancy anchoring strategy for preparing oxide-based 4d/5d transition metal single-atom 2D materials as efficient and robust OER catalysts. In a typical synthesis, Keggin-structure polyoxometalate [PWO] clusters decompose into tetrahedral WO anions, which in situ adhere to the newly nucleated metal (Co, Fe, Ni) hydroxide (M(OH)) due to the latter's abundant oxygen vacancies, ensuring a uniform distribution of W single atoms.

A multidimensional comparison of the benefit degrees for patients between ileostomy and colostomy.

Introduction: Enterostomy is widely used in the treatment of various diseases, especially in the treatment of colorectal malignant tumors. It remains to be determined which type of enterostomy can bring more benefits to patients. This study compares the differences in the degrees of benefits for patients between ileostomy and colostomy from multiple dimensions.

Artificial intelligence-based multimodal model for the identification of ulcerative colitis with concomitant cytomegalovirus colitis.

Background: Ulcerative colitis (UC), a chronic immune-mediated colon inflammation, impacts patients' quality of life. Immunosuppressive-treated UC patients are prone to opportunistic infections like cytomegalovirus (CMV) infection, which exacerbates UC, causes steroid resistance, and elevates surgery and mortality risks. Identifying CMV colitis from UC exacerbation is difficult due to overlapping symptoms and low biopsy detection rates.

Precision positioning measurement sensor based on the integration of confocal techniques and three-degree-of-freedom geometric measurement.

For the fields of optical imaging and focal plane measurement and adjustment in optical processing, this paper proposes a compact three-degree-of-freedom measurement sensor suitable for high-precision positioning of small measurement surfaces. The advantage of the measurement sensor is that it effectively combines multi-degree-of-freedom geometric measurement with confocal measurement, achieving multi-degree-of-freedom measurement by the correspondence between the position of the measured surface and the position of the laser spot on the camera and achieving high-precision, large-range Z-axis axial measurement by confocal technology and triangular light measurement. In addition, compared with traditional multi-degree-of-freedom methods, the measurement points of the sensor are small, and no special target is required.

The role of traditional culture and career calling in medical staff job performance: an examination using structural equation modeling.

Purpose: This study aims to investigate the current state of career calling among medical personnel and its connection to traditional culture and work performance.

Methods: By analyzing data from 414 medical staff members in Hangzhou through a questionnaire survey and structural equation modeling, the research explores the direct and indirect impacts of traditional culture and career calling on job performance.

Results: The results show significant variations in traditional culture, career calling, and job performance across different demographics and hospital levels.

Ultra-small spectral confocal displacement sensors based on GRIN lenses.

Spectral confocal displacement sensors have been widely used in various precision measurement fields such as aerospace, biology, and medicine due to their advantages of high accuracy, non-contact, fast response, and high resolution. In this paper, a new method of spectral confocal measurement of a ultra-compact probe based on a GRIN lens, to our knowledge, is proposed. Through ray tracing analysis, it is found that the axial dispersion is close to linear in a specific wavelength range, and a theoretical model of spectral confocal measurement with the GRIN lens is deduced.

A novel thermo-activated one-pot RPA-CRISPR-Cas12b assay for Mycoplasma pneumoniae POCT.

Mycoplasma pneumoniae (M. pneumoniae), a major human respiratory pathogen, necessitates the development of rapid point-of-care testing (POCT) platforms for clinical management. However, current two-step workflows suffer from operational complexity and aerosol contamination risks.

Substrate-Controlled Divergent Synthesis of Multisubstituted Cyclopentenones and 1,4-Diketones.

Multisubstituted cyclopentenones and 1,4-diketones are valuable chemicals for synthesizing biologically relevant compounds. We established the Rh(III)-catalyzed divergent synthesis of multisubstituted cyclopentenones and 1,4-diketones from quinoline-8-carbaldehydes and cyclopropanols. Switchable product selectivity was achieved using different cyclopropyl alcohols under the optimized reaction conditions.

High-Strength and Fast-Response Liquid Crystal Elastomer Fiber and Fabric Actuators.

LCE (liquid crystal elastomer) fibers can achieve large and reversible deformation under stimulation, which has attracted widespread attention in the field of materials. Current LCE fiber production methods include 3D/4D printing that uses layer-by-layer deposition principles. While wet spinning overcomes these limitations by achieving in situ active alignment of mesogens during curing, enabling reliable kilometer-scale continuous fiber fabrication.

GTP hydrolysis triggers membrane remodeling by AMPH-1.

Membrane-enclosed transport carriers return biological molecules from the recycling endosome to the plasma membrane using a mechanism that is not well understood. In , the formation of carriers from the recycling endosome requires the amphiphysin protein AMPH-1. Recently, we found that purified AMPH-1 is sufficient for tubulation and vesiculation of liposomes in a mechanism that is regulated by guanine nucleotides.

Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor.

Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (BiS)-titania (TiO) heterostructure is designed based on the excellent photothermal property of BiS, which could improve intratumor oxygen content through increasing blood flow with the help of near infrared light. BiS-TiO heterostructure nanoparticles (NPs) present similar photothermal performance to BiS NPs, while BiS-TiO NPs show higher reactive oxygen species (ROS) generating ability than BiS NPs under ultrasonic irradiation.

C Fullerene as the Active Site for CO Electroreduction.

Fullerene (C) was considered as a catalyst promoter in various electrochemical reactions, yet its catalytic role in enhancing catalytic performance beyond electron transfer remains a puzzle to chemists. Traditional simulations imply C's inertness in CO reduction reaction (CORR) due to weak interaction with COOH* intermediates. Here, according to a pH-field coupled microkinetic model at reversible hydrogen electrode (RHE) scale, we demonstrate that C acts as molecular active sites to facilitate the CORR toward CO through a strong binding to COOH* in the electrochemical conditions.

Ultra-low noise nanoporous Ag/AgCl electric field sensor for telluric electric field detection.

This paper presents an ultra-low noise nanoporous Ag/AgCl electric field sensor fabricated using a sol in situ composite method, aiming to address the issues of high noise and significant drift encountered in traditional electric field sensors during low-frequency signal measurements. By utilizing polyvinylpyrrolidone (PVP) sol to regulate the nucleation process of AgCl and combining it with nano-silver powder, nanoscale Ag/AgCl particles were prepared. Through the use of NaCl as a pore-forming agent, an electrode with a porous structure was developed.

Mitochondria-resident SBK3 confers protection against pressure overload-induced heart failure in mice.

Pathological myocardial hypertrophy, often caused by hypertension, is a well-established independent risk factor for heart failure. , a gene selectively expressed at relatively high levels in cardiac tissues, has an unclear functional role in the heart. This study is designed to examine the role of SBK3 in transverse aortic constriction (TAC)-induced heart failure, aiming to identify a novel mitochondrion-targeted therapeutic strategy for heart failure.

A stick-slip piezoelectric actuator utilizing a special parallelogram flexible mechanism.

A stick-slip actuator based on a parallelogram flexible mechanism is proposed to achieve high-performance output. This actuator utilizes the coupled motion generated when the parallelogram is driven by the piezo-stack to propel the slider. To minimize the shear force on the piezo-stack during operation, straight circular flexible hinge structure is added to the output end of the piezo-stack.