FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation.

High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice.

An Olive Oil-Based High-Fat Diet Promotes Obesity-Driven Metastasis of Triple-Negative Breast Cancer.

Obesity is strongly associated with triple-negative breast cancer (TNBC). A better understanding of the molecular mechanisms driving obesity-induced TNBC progression could facilitate development of precision dietary intervention strategies. Here, we used murine models of obesity induced by different high-fat diets (HFDs) to examine their impact on TNBC progression.

Efficient Hydrogen Production from Ethylene Glycol Steam Reforming Catalyzed by Na-Promoted Pt/γ-MoN.

Ethylene glycol (EG) derived from biomass and plastic wastes can serve as a sustainable H resource through steam reforming (HOCHCHOH + 2HO ⇄ 5H + 2CO). However, achieving high activity in H production with good selectivity toward CO under mild conditions poses a challenge. A thoughtful understanding of the active sites that accelerate the cleavage of the C-C bond rather than the C-O bond and the activation of the water molecule is still lacking.

Comparison of direct oxidative transfer process (DOTP) with Fenton and ozonation processes for water treatment.

The removal of emerging contaminants is a pressing challenge in modern water treatment. Among oxidation water purification processes, Fenton and ozonation are the most widely applied, with well-established mechanisms and broad engineering applicability. More recently, the direct oxidative transfer process (DOTP) has emerged as a promising alternative, offering high water purification efficiency.

Cascaded quadratic nonlinear compensation of small-scale self-focusing in a kHz, 100-mJ picosecond laser.

In pursuing kHz high-power picosecond lasers, small-scale self-focusing becomes an inevitable nonlinear effect as the peak intensity increases. By utilizing cascaded quadratic nonlinear effects to introduce a nonlinear phase with controllable sign and magnitude on the initial fundamental wave, an equivalent nonlinear refractive index is generated. This property can be used to compensate for the nonlinear phase accumulated during beam propagation, thus mitigating self-focusing.

Femtosecond laser-induced three-level micro/nanostructures for zirconia surface modification.

The femtosecond laser is a promising surface modification tool for zirconia. The influence of femtosecond laser parameters on the micro/nanostructures and mechanical properties of zirconia, however, is not yet clear. In this work, three-level micro/nanostructures, microgrooves, nanoparticle or striped periodic structures, and moss-like structures, were prepared on the surface of zirconia with a femtosecond laser.

Lithium-ion battery recycling relieves the threat to material scarcity amid China's electric vehicle ambitions.

The electric automotive transition is crucial for achieving carbon neutrality, especially in emerging economies like China. However, the scarcity of critical materials in lithium-ion batteries (LIBs) challenges electric vehicle (EV) deployment targets. Our work delivers a comprehensive framework of EV battery recycling, considering resource compensation, environmental performance, geospatial optimization, and cost feasibility of closed-loop LIB recycling under China's carbon neutrality.

The construction of spatio-temporal functional brain network based on Ising model for EEG classification.

Functional brain networks (FBN) are important tools for understanding, classifying and analyzing the brain. However, the multi-term features and temporal correlation of individuals are not adequately represented in single-layer and single-scale FBNs, resulting in room for improvement in the classification accuracy and generalizability of FBNs.Based on the temporal variability and spatial distribution of electroencephalography (EEG), a multi-scale spatio-temporal FBN is constructed on both temporal and spatial scales.

Anions-Impacted Water Purification from a Dual-Substrate Perspective.

Heterogeneous chemical oxidation for water treatment based on direct electron transfer has attracted great interest due to its low oxidant consumption and selective oxidation capabilities. Under low oxidant dosages (e.g.

Extrapulmonary Comparisons Between and Non-Tuberculous Mycobacteria: From Manifestations and Diagnosis to Treatment.

The incidence of tuberculosis (TB) and non-tuberculous mycobacteria (NTM) diseases and the number of deaths from these diseases are steadily increasing worldwide. However, the pathologic diagnosis of NTM disease is similar to that of tuberculosis, and it is often difficult to distinguish between the two, which can lead to misdiagnosis and treatment aversion. Therefore, differentiation between the two can help in accurate diagnosis and treatment planning.

In vitro efficacy of bovine lactoferrin against bovine viral diarrhea virus.

Bovine viral diarrhea virus (BVDV) infection represents a significant economic challenge to the global cattle industry, leading to considerable losses in productivity and increased management costs. This underscores the urgent need for effective antiviral strategies to combat BVDV infection. In this study, we demonstrated that bovine lactoferrin (bLF), a multifunctional glycoprotein with known antimicrobial properties, exhibited potent inhibitory activity against BVDV infection.

Giant myxofibrosarcoma of neck: A case report and review of the literature.

Rationale: Myxofibrosarcoma (MFS) is a subtype of soft tissue sarcoma that commonly occurs in the extremities but is rare in the neck. It is characterized by a high risk of local recurrence due to its specific infiltrative growth pattern.

Patient Concerns: A 56-year-old male presented with a large mass in the right neck with disability of the right upper limb.

Ecological outcomes of seagrass restoration in the Bohai Sea: Five-year shifts in sediment carbon, microbial diversity, and macrobenthic communities underscore the need for long-term monitoring.

Seagrass meadow restoration is essential for bolstering ecosystem functions, including biodiversity and carbon sequestration. This study evaluates the ecological impacts of a five-year seagrass restoration effort in the Bohai Sea, with a focus on sediment organic carbon (SOC) storage, microbial diversity, and macrobenthic communities. Using sediment analysis, microbial DNA sequencing, and macrobenthic assessments, we explored how restoration influenced these key parameters.

Blocking the Operando Formation of Single-Atom Spectators by Interfacial Engineering.

Aside from activity and selectivity, catalyst stability is a key focus in heterogeneous catalysis research. Although sintering of metal species has been considered the primary cause for deactivation of metal catalysts, our study reveals that the loss of activity at low reaction temperatures in the CeO-supported Pt (Pt/CeO) catalyst in complete propane oxidation is due to the dispersion of Pt ensemble sites (nanoclusters) and their subsequent operando conversion into Pt single atoms under reaction conditions. These Pt single-atom species exhibit low reactivity and act as spectators in the low-temperature reaction region.

Need for Mechanisms to Monitor Ocean Circulation-Driven Seagrass Population Expansions.

Seagrass beds are increasingly degraded; however, their protection and restoration are still confined to localized marine areas, making it difficult to establish connectivity between differently protected and restored areas. One limiting factor is the lack of understanding of the processes and mechanisms contributing to seagrass population expansion at the ocean area scale, which is the main driver of seagrass dispersal via oceanic circulation. Coastal China.

Molecular Descriptor for Catalytic Direct Oxidative Transfer Process Based on Thermodynamic State Changes during Reactions.

The direct oxidative transfer process (DOTP) in heterogeneous catalytic persulfate oxidation (HCPO) systems has gained increasing attention. In this process, the reaction rate is linked to pollutant properties, and identifying this correlation through descriptors offers insights into reaction mechanisms and water treatment strategies. However, most of the existing descriptors are based on static molecular properties and show limited correlation with reactivity and mechanisms.

Expression profiles of FABP4 and FABP5 in breast cancer: clinical implications and perspectives.

The incidence of breast cancer continues to rise each year despite significant advances in diagnosis and treatment. Obesity-associated dysregulated lipid metabolism is believed to contribute to the increasing risk of breast cancer. However, the mechanisms linking lipid dysregulation to breast cancer risk and progression remain to be determined.

Towards sustainable future: Assessing the impact of coal phase-down on the sustainable development goals in China.

Coal phase-down (CPD) is critical for climate mitigation and impacts resource use and environmental emissions, key to achieving the Sustainable Development Goals (SDGs). As the world's largest coal consumer and producer, China's decarbonization significantly influences global energy transitions and SDG fulfillment. This study employs an integrated assessment model to evaluate the impacts of CPD on energy systems, resource use, environmental quality, and SDG progress.

Long non-coding RNA CRNDE promotes the progress of hypertrophic scar via regulating the proliferation and migration of hypertrophic scar fibroblasts through targeting microRNA-29a-3p.

Hypertrophic scar (HS) represents an excessive fibrotic response during the healing of skin injuries, constituting a common and intricate pathological process that is tightly regulated. This study aimed to explore the clinical significance and potential mechanisms of long non-coding RNA CRNDE in the development of HS. This study encompassed 71 HS patients, and the expression levels of lncRNA CRNDE were assessed via RT-qPCR.

Shielding Pt/γ-MoN by inert nano-overlays enables stable H production.

The use of reactive supports to disperse metal species is crucial for constructing highly efficient interfacial catalysts, by tuning the competitive reactant adsorption-activation pattern in supported metal catalysts into a non-competitive mechanism. However, these reactive supports are prone to deterioration during catalysis, limiting the lifespan of the catalyst and their potential practical applications. New strategies are needed to simultaneously protect reactive supports and surface metal species without compromising the inherent catalytic performance.

Interfacial Catalysis at Atomic Level.

Heterogeneous catalysts are pivotal to the chemical and energy industries, which are central to a multitude of industrial processes. Large-scale industrial catalytic processes rely on special structures at the nano- or atomic level, where reactions proceed on the so-called active sites of heterogeneous catalysts. The complexity of these catalysts and active sites often lies in the interfacial regions where different components in the catalysts come into contact.

The Environmental and Public Health Benefits of Offshore Wind Power Deployment in China.

With the rapid decline in the levelized cost, offshore wind power offers a new option for the clean energy transition of the power sector in China's coastal areas. Here, we develop a power system capacity expansion and operation optimization model to simulate the penetration of offshore wind power in China and quantify the associated health effects. We find that offshore wind power has great potential in mitigating the negative impacts of existing coal-fired power emissions.

Modification mechanism of Te and morphology evolution of primary MgSi in an Al-20MgSi alloy.

In the present work, the modification effect of Te and the corresponding growth process of MgSi were clarified. With 0.5 wt% Te addition, the dendritic primary MgSi transformed to polygons, accompanied by a reduction in size from over ∼165 μm-∼18 μm.

Retrofitting Coal Power Units with Biomass and Coal Cofiring Intensifies Air Pollution and Health Risks.

Retrofitting coal power units with biomass and coal cofiring technology provides a promising pathway toward low-carbon transition. However, such a retrofitting approach may also pose potential environmental and health risks, even aggravating regional disparities. Here, we propose a comprehensive framework to evaluate the associated risks of Biomass and Coal Cofiring Retrofit (BCCR) in China.

Insight into characteristics in rice starch under heat- moisture treatment: Focus on the structure of amylose/amylopectin.

Heat-moisture treatment (HMT) could improve the structure and physicochemical characteristics of rice starch, the structural changes of amylose and amylopectin needed to be further investigated. Hence, the starch, amylose and amylopectin were modified by HMT with different moisture contents (MC). As MC increased, starch granules became irregular, amylose appeared molten while amylopectin was less damaged.