Curcumin derivatives as ferroptosis inducers: design, synthesis and anti breast cancer activity evaluation.

Curcumin (CUR) is a natural product isolated from Curcuma longa L., which has become a research hotspot due to its significant anti-tumor activity by inducing tumor cell apoptosis and inhibiting proliferation. This study designed and synthesized 20 CUR derivatives containing 1,2,3-triazoles and heterocycles by modifying the methylene group between two carboxyl groups of CUR and hybridizing with aldehyde containing fragments.

Comparison of the Predictive Roles of CT- and MRI-Based Pedicle Regional Osteoporosis Status Measurements for Pedicle Screw Loosening After Posterior Lumbar Interbody Fusion.

Study DesignRetrospective Study.ObjectivesTo compare the efficacy of pedicle Hounsfield unit (HU) values and pedicle bone quality (PBQ) scores in predicting pedicle screw loosening (PSL) after posterior lumbar interbody fusion (PLIF) in elderly patients and to identify the most discriminative bone mineral density (BMD) assessment indicator.MethodsThis retrospective analysis included 275 consecutive patients who underwent PLIF.

Genome-wide transcriptional analysis of tendon tissue-related genes and pathways in the torn rotator cuff of diabetes patient.

Background: Diabetes is a major factor affecting rotator cuff tear (RCT) progression and healing. However, the underlying molecular mechanisms linking diabetes to RCT remain unclear. We aimed to investigate these mechanisms for developing targeted therapeutic strategies to improve tendon healing in diabetes patients.

Electro-Mechanical Mapping of the Small Intestine and the Influence of High-Energy Pacing.

Purpose: Compromised electrical and mechanical activity in the gastrointestinal tract is associated with several motility disorders. Conventional treatment fails in a significant proportion of the patient population, and pacing is a promising alternative therapy. However, the correlation between slow waves and contractions during pacing remains unexplored.

Genetic correlation and causal relationships between autoimmune thyroid disease and major depressive disorders.

Background: Autoimmune thyroid disease (AITD) and major depressive disorder (MDD) are common genetic diseases. The comorbidity of AITD and MDD has been widely demonstrated by large amounts of epidemiological studies. However, the genetic architectures of the comorbidity remain unknown.

Spectral Regulation in CsPtCl Double Perovskite via Low-Temperature and High-Pressure Engineering for Advanced Optical Thermometry and Manometry.

To build a bifunctional luminescent platform for optical thermometry and manometry, the CsPtCl double perovskite was synthesized. Upon 468 nm excitation, the designed compound emitted bright red light centered at ≈675 nm, originating from the T,T → A transition of Pt, whose fluorescence intensity and bandwidth are highly temperature dependent. Moreover, the temperature-dependent decay curves of the developed CsPtCl double perovskite were measured to explore its application in optical thermometry, of which its maximum relative sensor sensitivity is 1.

Targeting MondoA-TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment.

In the tumour microenvironment, accumulated lactic acid (LA) promotes tumour immune evasion by facilitating regulatory T cell (T) immunosuppressive function and restraining CD8 T cell cytotoxicity, but the underlying mechanism remains elusive. Here we report that transcriptional factor MondoA-induced thioredoxin interacting protein (TXNIP) transcription is a common feature of both T and CD8 T cells in response to lactic acid. In contrast to reduction in immunosuppressive capacity in MondoA-deficient T cells, loss of MondoA enhanced CD8 T cell cytotoxic function in the lactic-acid-induced immunosuppressive microenvironment, by restoring glucose uptake and glycolysis.

ADM ameliorates disc degeneration by inhibiting the MAPK signaling pathway and nucleus pulposus cell senescence.

Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Current therapies fail to address the underlying molecular mechanisms of IVDD, necessitating novel targets.

Methods: Bioinformatics analysis identified differentially expressed genes (DEGs) from GSE186542 and GSE167199 datasets.

FGF4 alleviates renal injury caused by ischemia-reperfusion(I/R) by inhibiting ferroptosis and pyroptosis.

Renal ischemia-reperfusion injury can lead to severe renal function impairment, manifested by a significant increase in serum creatinine, renal tubular obstruction, and even necrosis, which can lead to acute renal failure. This injury can also trigger systemic inflammatory response syndrome and even lead to multiple organ dysfunction. It poses a serious threat to the life and health of patients, so it is urgent to find potential drugs for treatment.

Application of KLDS 1.1105 Postbiotics for Resisting Pathogenic Bacteria Infection in the Intestine.

Postbiotics, defined as metabolites produced by probiotics, encompass both bacterial cells and their metabolic byproducts, and offer significant health benefits to the host. However, there are relatively few reports on their effects on intestinal microbiota. In this study, we investigated the components, total antioxidant capacity of postbiotics () and their impact on intestinal flora using the Simulator for Human Intestinal Microecology Simulation (SHIME).

Influence of isoflurane and propofol on gastric slow wave patterns and pacing efficacy in pigs.

Gut motility is partly driven by underlying rhythmic electrical activity called slow waves. The origin and propagation of these electrical events are studied extensively in anesthetized animal models. However, the effects of anesthesia on slow waves remain unclear.

Negative Correlation Between Fractional Anisotropy on Diffusion Tensor Imaging and Neck Disability Index in Cervical Spondylotic Radiculopathy After Percutaneous Cervical Nucleoplasty: A Cross-Sectional Study.

Purpose: This study aimed to examine the correlation between diffusion tensor imaging (DTI) parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC) and clinical outcomes (neck disability index, NDI; visual analog scale, VAS) in cervical spondylotic radiculopathy (CSR) patients following percutaneous cervical nucleoplasty (PCN), respectively.

Methods: This is a cross-sectional study. We collected clinical data from 30 patients with CSR who underwent DTI before and 3 months after PCN.

Markerless recurrence analysis of gastric electrophysiology during vagus nerve stimulation.

Objective: Gastric bioelectrical slow waves exhibit complex, temporally dynamic patterns affected by various regulatory inputs and stimulation protocols. This paper uses recurrence analysis to determine the re-occurrence of activity patterns in gastric slow waves measured using high-resolution electrode mapping arrays.

Methods: Experimental data were obtained from the ventral gastric serosa of five rats, and three different electrical vagus nerve stimulation protocols were administered repeatedly to induce changes in slow wave activity.

Clinical and radiological comparison of percutaneous cervical nucleoplasty combined with ultrasound-guided pulsed radiofrequency of cervical nerve root for cervical radicular pain: a retrospective, matched-cohort study.

Background: The best treatment yielding clinical benefits was still equivocal and controversial for the treatment of cervical radicular pain (CRP). This study aimed to propose a novel combination strategy of percutaneous cervical nucleoplasty (PCN) and ultrasound-guided pulsed radiofrequency (PRF) of cervical nerve root for CRP, and to compare its therapeutic effects with PRF alone.

Methods: 120 CRP patients who satisfied the inclusion requirements between January 2016 and March 2019 were retrospectively analyzed and split into PCN + PRF and PRF groups.

Novel cyclometalated iridium(III) complex-based two-photon probe for visualizing mitochondrial nitroreductase and assessing treatment responses in sepsis-induced lung injury.

Background: Sepsis-induced lung injury (SILI) is an acute condition characterized by respiratory failure, with lung hypoxia as a prominent feature. Nitroreductase (NTR) is significantly upregulated during SILI, highlighting its potential as a promising biomarker for assessing the severity of SILI and monitoring therapeutic response. Molecular biology studies indicate that mitochondria serve as potential therapeutic targets for SILI.

Prognosticating salvage stereotactic radiosurgery outcomes in relapsed primary central nervous system lymphoma: A machine learning-driven decision tree analysis.

Purpose: To identify key clinical risk factors affecting therapeutic outcomes in relapsed primary central nervous system lymphoma (r-PCNSL) patients undergoing stereotactic radiosurgery salvage therapy (SRS-ST) and develop a decision tree-based predictive model.

Patients And Methods: A retrospective analysis was performed on r-PCNSL patients undergoing SRS-ST at The Second Affiliated Hospital of Xuzhou Medical University between January 2012 and November 2021. The cohort was randomly divided into training and validation sets (7:3 ratio).

C Fullerene as the Active Site for CO Electroreduction.

Fullerene (C) was considered as a catalyst promoter in various electrochemical reactions, yet its catalytic role in enhancing catalytic performance beyond electron transfer remains a puzzle to chemists. Traditional simulations imply C's inertness in CO reduction reaction (CORR) due to weak interaction with COOH* intermediates. Here, according to a pH-field coupled microkinetic model at reversible hydrogen electrode (RHE) scale, we demonstrate that C acts as molecular active sites to facilitate the CORR toward CO through a strong binding to COOH* in the electrochemical conditions.

Global burden of low back pain attributable to smoking in 204 countries and territories in 1990-2021.

Background: Smoking has a major influence on the development and worsening of low back pain (LBP). However, the effect of smoking on the burden of LBP has not been thoroughly examined at the global, regional, and national levels. This study aims to analyze the trends in smoking-related LBP from 1990 to 2021.

Fine-scale analysis of the cumulative and time-lagged effects of drought on vegetation in the Ili River Basin, Central Asia.

Under intensifying climate change, drought impacts on vegetation have become increasingly complex. Although the Ili River Basin is highly sensitive to drought, the underlying mechanisms of drought-vegetation interactions remain insufficiently understood. This study quantifies the cumulative, time-lagged, and dominant effects of drought on vegetation gross primary productivity (GPP) at the daily scale, and investigates their variations across land use types, wetness gradients, and seasons.

TNF Signaling Pathway Is the Key Pathway Regulated by Disitamab Vedotin in Bladder Cancer Cells.

Disitamab Vedotin has shown good therapeutic efficacy against bladder cancer. Although its mechanism is clear, the regulation of gene expression in bladder cancer cells by Disitamab Vedotin is not fully understood. We searched the GEO database and identified the GSE237789 dataset, in which researchers treated the bladder cancer cell line SW780 with Disitamab Vedotin and performed high-throughput transcriptome sequencing.

CREM-activated LTBP1 transcription promotes radioresistance and immune escape in triple-negative breast cancer.

Although radiotherapy is one of the first-line treatments for triple-negative breast cancer (TNBC), acquired radioresistance blunts its clinical efficacy. The current study sought to evaluate the effect of latent-transforming growth factor beta-binding protein 1 (LTBP1) on radioresistance in TNBC cells and to explore the molecular mechanism. Two TNBC-related GEO datasets (GSE120798 and GSE210306) were included to analyze the novel molecule involved in radioresistance.

Deep Learning-Based Prediction for Bone Cement Leakage During Percutaneous Kyphoplasty Using Preoperative Computed Tomography: MODEL Development and Validation.

Study Design: Retrospective study.

Objective: To develop a deep learning (DL) model to predict bone cement leakage (BCL) subtypes during percutaneous kyphoplasty (PKP) using preoperative computed tomography (CT) as well as employing multicenter data to evaluate the effectiveness and generalizability of the model.

Summary Of Background Data: DL excels at automatically extracting features from medical images.

Exploring the origin of the development: totipotent stem cells.

As the origin of the development, a fertilized egg owns the ability to generate a whole new organism, including both embryonic and extraembryonic tissues, representing the highest developmental potency, totipotency. For more than 40 years, pluripotent stem cells, with differentiation potential weaker than that of totipotent cells, have been easily derived from inner cell mass and maintained in vitro. Until now, capturing totipotent stem cells is still challenging.