Modulating ion migration realizes both enhanced and long-term-stable nanozyme activity for efficient microplastic degradation.

Degradation of microplastics represents a significant global environmental challenge, necessitating the development of bio-inspired catalysts with superior activity and stability, capable of mimicking natural plastic-degrading enzymes. Although nanozymes possess advantages such as low cost, ready availability, and multienzymatic activities, issues of self-consumption often hinder their practical application. Here, motivated by the acceleration of Li migration for improving the electrochemical reactivity and cycling stability of lithium iron phosphate (LFP), we engineered LFP by introducing Mn to expand the lattice structure, resulting in Mn-doped LFP (LFMP) that modulates ion migration in nanozymes.

T17 cells regulate chemokine expression in epithelial cells through C/EBPβ and dictate host sensitivity to colitis and cancer immunity.

T17 cells play a critical role in inflammation, cancer development, and antitumor immunity in a context-dependent manner, but detailed mechanisms and their downstream signaling events remain poorly understood. Here, we describe that T17 cytokines strongly inhibit expression of critical chemokines in epithelial tissues, which leads to blocking infiltration of proinflammatory immune cells into the colon, rendering resistance to DSS-induced colitis and colon cancer. We show that key chemokine expression dictates the sensitivity of WT mice to DSS treatment.

Explainable machine learning prediction of internet addiction among Chinese primary and middle school children and adolescents: a longitudinal study based on positive youth development data (2019-2022).

Background: Internet Addiction (IA) has emerged as a critical concern, especially among school age children and adolescents, potentially stalling their physical and mental development. Our study aimed to examine the risk factors associated with IA among Chinese children and adolescents and leverage explainable machine learning (ML) algorithms to predict IA status at the time of assessment, based on Young's Internet Addiction Test.

Methods: The longitudinal data consisting of 8,824 schoolchildren from the Chengdu Positive Child Development (CPCD) survey were analyzed, where 33.

Prognosticating salvage stereotactic radiosurgery outcomes in relapsed primary central nervous system lymphoma: A machine learning-driven decision tree analysis.

Purpose: To identify key clinical risk factors affecting therapeutic outcomes in relapsed primary central nervous system lymphoma (r-PCNSL) patients undergoing stereotactic radiosurgery salvage therapy (SRS-ST) and develop a decision tree-based predictive model.

Patients And Methods: A retrospective analysis was performed on r-PCNSL patients undergoing SRS-ST at The Second Affiliated Hospital of Xuzhou Medical University between January 2012 and November 2021. The cohort was randomly divided into training and validation sets (7:3 ratio).

Double-edged sword of microbial self-adaptive mechanisms in biofilm systems under non-antibiotic bisphenol stress: Promoting contaminant degradation and antibiotic resistance genes propagation.

Biofilm systems demonstrate significant potential for the efficient degradation of persistent organic pollutants and serve as a crucial reservoir for antibiotic resistance genes (ARGs) due to the widespread misuse of antibiotics. However, the role of biofilm systems under non-antibiotic bisphenol stress in contaminant removal and ARGs dissemination remains uncertain. This research investigates the removal performance of bisphenol S (BPS) as a representative bisphenol and its impact on ARG dynamics in biofilm systems.

Droplet confined binary colloidal co-assembly into hierarchical Supraparticles with controllable morphology.

Physically confined assembly of binary colloidal mixtures in emulsion droplets provides a versatile platform for engineering supraparticles with tunable morphologies and functionalities. While single-component and hard-sphere colloidal assemblies have been extensively studied, the co-assembly of binary soft colloids presents unresolved challenges in architecture control and functional integration. In this work, we investigate the co-assembly performance of emulsion droplet confined binary soft colloids of spherical polystyrene nanoparticles (PS) and wire-like carbon nanotubes (CNTs).

Ligand Field Electronic State Regulation of Monoclinic Prussian White Toward Highly Stable Sodium-Ion Batteries.

Manganese hexacyanoferrate (MnHCF) has a high output voltage and is expected to be a promising cathode material for high energy density sodium-ion batteries (SIBs). However, the capacity decay problem caused by the Jahn-Teller effect of high-spin Mn restricts its use in sodium-ion batteries. In this study, an elemental modulation strategy is proposed to regulate the electronic state of the ligand field by introducing the nickel element, which can keep the Mn in a low-spin configuration during cycling to inhibit the Jahn-Teller aberration of MnHCF.

Mitochondrial genome analysis of the endangered Oreocharis esquirolii: insights into evolutionary adaptation and conservation.

Background: H. Lév., a member of the Gesneriaceae family with an actinomorphic corolla, is evaluated as vulnerable and classified as a National Grade I Protected Plant.

Descriptor-Based Screening of Dual-Atom Photocatalysts for Efficient Urea Synthesis from CO and N.

The development of efficient photocatalysts with high activity and selectivity for coreduction of N and CO under ambient conditions represents a highly promising but still challenging strategy for sustainable urea synthesis. In this study, using density functional theory (DFT) calculations, we present a comprehensive descriptor strategy integrating geometric, electronic, and energetic factors to screen Cu-metal dual-atom photocatalysts (CuM/CeO, where M = 27 transition metals) for urea synthesis. According to the screening of the catalyst stability, coadsorption capability of N and CO, energy barriers of the rate-determining step (RDS), and urea desorption energies, CuMn/CeO emerged as the most promising candidate photocatalyst.

Kinetic modelling and reactivity of liquid nitromethane under detonation conditions.

Liquid nitromethane (NM) may undergo detonation under accidental stimuli, making kinetic modeling crucial for assessing the safety risks associated with its detonation. This study employs first-principles molecular dynamics to investigate chemical behavior of nitromethane under high temperature (>2000 K) and pressure (>1 GPa) conditions, revealing five previously unidentified intermediates (CHNOH, CHNOH, CHNOH, CHONO, NOCHNO) and establishing a nitromethane chemical kinetic model which include 543 elementary reactions and 79 species, which is successfully applied in the prediction of nitromethane detonation characteristics. The calculated detonation pressure (13.

Unleashing Electrocatalytic Oxygen Evolution Activity: Engineering Spin States in Strained Correlated Oxides for Enhanced Performance.

Perovskite oxides have emerged as compelling contenders for catalyzing the oxygen evolution reaction (OER) due to their low cost, high efficiency, and structural flexibility. Nevertheless, unraveling the intricate structure-activity relationships within correlated oxides remains challenging, impeding the rational design of efficient catalysts. Here, using LaCoO epitaxial thin films as a model system, we illustrate a direct correlation between the spin state and OER activity.

Development and validation of a fusion model based on multi-phase contrast CT radiomics combined with clinical features for predicting Ki-67 expression in gastric cancer.

The present study aimed to develop and validate a fusion model based on multi-phase contrast-enhanced computed tomography (CECT) radiomics features combined with clinical features to preoperatively predict the expression levels of Ki-67 in patients with gastric cancer (GC). A total of 164 patients with GC who underwent surgical treatment at our hospital between September 2015 and September 2023 were retrospectively included and were randomly divided into a training set (n=114) and a testing set (n=50). Using Pyradiomics, radiomics features were extracted from multi-phase CECT images and were combined with significant clinical features through various machine learning algorithms [support vector machine (SVM), random forest (RandomForest), K-nearest neighbors (KNN), LightGBM and XGBoost] to build a fusion model.

Genetic polymorphisms of antioxidant enzymes (GSTP1/CAT/HMOX1/EPHX1) and childhood asthma risk in Fuzhou.

Objective: Discuss the correlation between single nucleotide polymorphisms (SNPs) of the Glutathione s-transferase Pi-1 (GSTP1), Catalase (CAT), Heme oxygenase-1 (HMOX1), and Homo sapiens epoxide hydrolase 1 (EPHX1) genes and the risk of childhood asthma in Fuzhou.

Methods: Next generation sequencing (GS) was employed to conduct whole-exome sequencing (WES) on 50 asthmatic children and 50 healthy children. Genetic models for the GSTP1 gene rs1695, rs4891, HMOX1 gene rs2071747, rs17878790, CAT gene rs7943316, rs1049982, rs769217, and EPHX1 gene rs2234922, rs41266231, rs1051740 sites were constructed.

Novel Computational Approaches in the Discovery and Identification of Bioactive Peptides: A Bioinformatics Perspective.

Bioactive peptides are protein molecules known for their specific biological functions, offering promising applications across various fields including medicine, food, and cosmetics. Traditional approaches to the investigation of bioactive peptides typically encompass extraction, separation, purification, identification, and experimental evaluation. However, these methodologies are frequently subject to human-related variables, which consequently lead to reduced efficiency and compromised accuracy.

The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer.

Unlabelled: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic, stiff tumor microenvironment in which tumor-associated macrophages (TAM) drive extracellular matrix remodeling, progression, and immune evasion. The contribution of mechanical cues to monocyte differentiation into TAMs remains largely unexplored. In this study, we show that mechanical force is required for monocyte-to-macrophage differentiation.

Ventriculoscopy combined with Ommaya reservoir implantation for treatment of hydrocephalus with atypical neuroimaging features of neurocysticercosis: A case report.

Rationale: Cysticercosis-induced hydrocephalus presents diagnostic and therapeutic challenges owing to its heterogeneous clinical manifestations. Acute hydrocephalus secondary to parasitic infections of the central nervous system (CNS) requires tailored surgical interventions to address impaired cerebrospinal fluid (CSF) dynamics and intracranial hypertension.

Patient Concerns: A 27-year-old male reported intermittent dizziness and headaches persisting for 3 years and a recent onset of vomiting over the past month.

Temporobasal Hemorrhage Following Retrosigmoid Resection of Cerebellopontine Angle Meningioma: A Rare Surgical Complication.

The authors aim to report a rare case of supratentorial temporobasal hemorrhage occurring after resection of a cerebellopontine angle (CPA) meningioma through a retrosigmoid approach and to elucidate the underlying mechanisms of this postoperative complication while offering surgical insights to prevent its occurrence. In the present study, the authors report a case of a 52-year-old female patient admitted for "dizziness for 1 year, exacerbated over the past 3 months". Preoperative magnetic resonance imaging (MRI) revealed a 2.

Reversible fluorination of brownmillerite SrCoO by MgF annealing.

Two distinct oxyfluorides were synthesized by annealing a brownmillerite SrCoO (BM-SCO) thin film in MgF powder through soft-chemistry reduction. Throughout the annealing, BM-SCO undergoes two successive phase transitions, which are referred to as perovskite F-doped SrCoO (P-SCOF) and brownmillerite F-doped SrCoO (BM-SCOF). P-SCOF retains randomly distributed F-ions, while BM-SCOF forms an F-ordered structure characterized by alternative stacking of square-planar CoOF and octahedral CoOF.

Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.

NETosis plays a pivotal role in the innate immune response after diabetic myocardial infarction (MI), exerting a profound influence on the overall pathological process and potential recovery outcomes. The metabolism of diabetic cardiomyocyte actively creates a specialized micro environment for the innate immune response after MI. However, the mechanism by which cardiac metabolism drives NETosis remains unclear.

The impact of depression and cardiovascular disease on fall risk in type 2 diabetes mellitus: a gender and sleep status analysis.

Background: This study aims to examine the combined effects of depressive symptoms (DS) and cardiovascular disease (CVD) on fall risk in patients with type 2 diabetes mellitus (T2DM), as well as evaluating the potential moderating effects of sleep status and gender.

Methods: This study analyzed 941 participants from the China Health and Retirement Longitudinal Study (CHARLS). Participants were divided into four groups: those with both depressive symptoms and CVD (DS+/CVD+), those with only depressive symptoms (DS+/CVD-), those with only CVD (DS-/CVD+), and those with neither depressive symptoms nor CVD (DS-/CVD-).

Defect and Strain Engineering Coenhanced Nanoscale Ferroelectricity in SrTiO Thin Films.

Tensile biaxial strain has been demonstrated to induce in-plane ferroelectricity in SrTiO thin films at room temperature. However, out-of-plane ferroelectricity is more favorable for electronic device applications. Here, we report the achievement of room-temperature out-of-plane ferroelectric SrTiO thin films with giant tetragonality (/ ∼ 1.

The impact of social determinants of health on chronic kidney disease risk: evidence from the CHARLS study.

Background: Empirical evidence regarding the relationship between social determinants of health (SDH) and renal outcomes remains limited. Consequently, the objective of this study was to investigate the potential association between SDH and the development of chronic kidney disease (CKD) across various levels.

Methods: Data were sourced from the 2011 China Health and Retirement Longitudinal Study (CHARLS), which included 6,290 Chinese participants aged 40 years and older.

In Situ/Operando Insights into the Selectivity of CH/CH in CO Electroreduction by Fine-Tuning the Composition of Cu/SiO Catalysts.

Copper-silica-based catalysts have drawn much attention for the remarkable product selectivity in the electrochemical CO reduction reaction, particularly toward CH and CH. However, systematic studies exploring the underlying reasons for the selectivity differences are lacking. Herein, Cu/SiO catalysts with different Cu/Si ratio are controllably synthesized by fine-tuning the precursor ratio, enabling selective CO electroreduction to CH/CH.

Distribution of Vanadium in the Upper Permian Coal of the Northwest Guizhou Area: What Affects This Distribution?

Research on the enrichment mechanism of vanadium in coal can increase its economic value. Vanadium is abundant in Guizhou, and the exploitation extent is low due to a lack of clarity on the occurrence state and enrichment mechanism of vanadium. Herein, the coal seam of the Upper Permian Longtan Formation in the northwest Guizhou area was selected as the research object.

Photocatalytic and straightforward olefination of alkyl aldehydes with alkynylphosphonates enabled by Cu(I)-photosensitizers.

A visible light-driven photocatalytic olefination of alkyl aldehydes into vinylphosphonates directly with alkynylphosphonates has been successfully developed with high -selectivity through a P/N-heteroleptic Cu(I)-photosensitizer-enabled, secondary amine-aided tandem radical process comprising generation of an alkyl-substituted α-amino radical, addition of the α-amino radical across alkynylphosphonates, 1,5-HAT, C-N bond cleavage and 1,3-allylic isomerization.