Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain.

: Chemotherapy-induced neuropathic pain (CINP) represents a critical challenge in oncology, emerging as a common and debilitating side effect of widely used chemotherapeutic agents, such as paclitaxel (PTX). Current therapeutic interventions and preventive strategies for CINP are largely insufficient, as they fail to address the underlying peripheral nerve damage, highlighting an urgent need for the development of new drugs. This study aimed to investigate the dual-function effects on normal cell protection and tumor suppression of BMX-001, a redox-active manganese metalloporphyrin that has demonstrated antioxidant and anti-inflammatory properties, which offers potential in protecting central nervous system tissues and treating CINP.

The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables.

Background: The process of fruit ripening after harvest renders them susceptible to water loss and disease development by fungal pathogens. Postharvest fungal diseases compromise produce quality and reduce marketable yield, resulting in economic losses and increased food wastage. Fungal disease development is mitigated by plant defense response, fungal pathogenicity factors and control interventions.

FGF4 alleviates renal injury caused by ischemia-reperfusion(I/R) by inhibiting ferroptosis and pyroptosis.

Renal ischemia-reperfusion injury can lead to severe renal function impairment, manifested by a significant increase in serum creatinine, renal tubular obstruction, and even necrosis, which can lead to acute renal failure. This injury can also trigger systemic inflammatory response syndrome and even lead to multiple organ dysfunction. It poses a serious threat to the life and health of patients, so it is urgent to find potential drugs for treatment.

Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.

Peripheral nerve injury (PNI) is a common problem worldwide. PNI can lead to loss of sensory and motor functions, chronic neuropathic pain, and mental health issues, significantly impacting the patients' quality of life. Recent studies revealed that, beyond the topical injury site at peripheral nerves, PNIs can also induce dysfunctions in the central nervous system by causing maladaptive plasticity, which will result in exaggeration and exacerbation of the pathological condition caused by the primary injuries.

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long-Gap Peripheral Nerve Injury.

Severe peripheral nerve injury (PNI) requiring nerve graft remains a clinical challenge due to limitations associated with currently available grafts. While decellularized nerve grafts (DNGs) are commonly used, their efficacy is largely restricted to short-gap repairs due to their acellular and dense structure, which poses a persistent challenge in the treatment of critical long-gap nerve defects. It is hypothesized that making porous DNGs (PDNGs) can create a suitable microenvironment that would facilitate the cell infiltration, recellularization, and further axonal growth to enhance nerve regeneration.

A weak acid-responsive porous polyelectrolyte membrane enables the high efficiency of a zinc anode interface.

Polymer coatings are promising candidates as artificial interfacial materials due to their significant barrier properties and zincophilicity, whereas modified zinc anodes for high depth of discharge (DOD) remain a major challenge. Herein, we present a novel approach that combines electrostatic complexation with phase separation in a weak-acid solution, which induces the formation of acid-responsive porous polyelectrolyte membranes, leading to an extended lifespan of the zinc anode of up to 900 h at a high current density of 40 mA cm. Additionally, the Zn@PEI-PSSNa anode demonstrates excellent zinc utilization, operating for up to 200 h at an ultra-high DOD of 97.

A parallelly distributed microscope and software system for scalable high-throughput multispectral 3D imaging.

Recent advances in high throughput optical microscopy have achieved whole-organism scale imaging at diffraction-limited resolutions. Current microscopes, however, require making compromises between achieving the optimal resolution, imaging depth, multispectral capability, and data throughput due to limitations in optical design and data stream handling. We have created a parallel-line scanning confocal microscope (plSCM) which provides 1.

Quantum machine learning-based electrokinetic mining for the identification of nanoparticles and exosomes with minimal training data.

Synthetic and naturally occurring particles, such as nanoparticles (NPs) and exosomes; a type of extracellular vesicles (EVs), have garnered widespread attention across various fields, including biomaterials, oncology, and delivery systems for drugs and vaccines. Traditional methods for identifying NPs and EVs, such as transmission electron microscopy, are often prohibitively expensive and labor-intensive. As an alternative, the assessment of electrokinetic attributes such as zeta potential or electrophoretic mobility, conductance, and mean count rate, offers a more cost-effective, rapid, and reliable means of characterizing these particles.

SpaLinker identifies phenotype-associated spatial tumor microenvironment features by integrating bulk and spatial sequencing data.

The emergence of spatial transcriptomics (ST) technology offers unprecedented opportunities to elucidate the complexity and heterogeneity of the tumor microenvironment (TME). However, quantitatively linking spatially resolved features with clinical phenotypes remains challenging due to the scarcity of clinical annotations of spatial sequencing samples. Herein, we introduce SpaLinker, an innovative integrated framework that utilizes ST data to decipher spatially resolved TMEs at molecular, cellular, and tissue structure levels.

Smart Self-Healing Anode/Electrolyte Interphases for Stabilizing Zn Anode.

The rational design of Zn anode/electrolyte interphases (AEIs) is an effective strategy for regulating the Zn stripping/plating process, as well as suppressing the interfacial side reactions. However, the formation of defects during the cycling process is still inevitable, and the exacerbation of defects would lead to the failure of the electrode, limiting the long-term stability of the Zn anode. In recent years, self-healing AEIs (SAEIs) have received great attention in Zn anode modification, as they can self-heal and suppress the defects.

Room-temperature synthesis of a methacrylate-derived sulfurized polymer cathode for rechargeable lithium batteries.

We designed and synthesized three methacrylate-derived sulfurized polymer cathodes a one-step polymerization at room temperature. Among them, the cyclohexyl methacrylate-based sulfurized polymer (SP-2) cathode exhibited both high capacity and stability, enabling stable cycling over a 0-60 °C temperature range.

A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.

Postoperative abdominal adhesions are a common and painful complication after surgery, leading to high healthcare costs and diminished quality of life. This report presents a novel bilayer hydrogel barrier featuring an inner adhesive layer and an outer antiadhesive layer. The inner adhesive layer hydrogel (PT) is prepared by mixing polyethyleneimine (PEI) and thioctic acid (TA).

High-Performance Broadband Mixed-Dimensional Phototransistors Based on the Boron Nitride Quantum Dots/MoSe Heterostructure with Enhanced UV Sensitivity.

Two-dimensional (2D) semiconductors have been of great interest in phototransistors in recent years due to their unique optoelectronic and electronic properties. However, their discernible spectral range and the efficiency of light absorption are usually restricted. Here, we present phototransistors based on mixed-dimensional heterostructures formed by zero-dimensional (0D) boron nitride quantum dots (BNQDs) and molybdenum diselenide (MoSe), which have high responsivity (), specific detectivity (*), and external quantum efficiency (EQE), especially in the ultraviolet (UV) spectral range.

Polyacrylamide-incorporated copper electrodes for electrochemical-colorimetric dual-mode detection of HO released from tomato leaves.

Hydrogen peroxide (HO) plays a key role in a diverse array of cellular signaling pathways, which is closely related to plant health and physiological status. The accurate and efficient monitoring of HO in living plant cells has attracted enormous interest. Herein, we developed an electrochemical-colorimetric dual-mode sensor based on the peroxidase-like activity of a polyacrylamide (PAM) -modified copper electrode (Cu-PAM), allowing for the in situ detection of HO released from tomato leaves.

Double-Layer Microneedle Patch Loaded with HA-PBA-QCT for Management of Paclitaxel-Induced Peripheral Neuropathic Pain.

Chemotherapy-induced neuropathic pain (CINP) is a common adverse effect of antineoplastic drugs, often leading to dose reduction, treatment delays, or cessation of chemotherapy. Chemotherapy agents, like paclitaxel (PTX), damage the somatosensory nervous system by inducing neuroinflammation and oxidative stress, resulting in the sensitization of sensory neurons. Quercetin (QCT), known for its anti-inflammatory, antioxidant, and neuroprotective properties, is investigated for various neurological disorders.

Mott-Schottky Heterojunction Modulating Iron-Vanadium Oxide for High-Performance Aqueous Zinc Battery Cathodes.

Vanadium-based oxides have garnered significant attention for aqueous zinc batteries (AZBs), whereas sluggish Zn diffusion and structural collapse remain major challenges in achieving high-performance cathodes. Herein, different structures of iron-vanadium oxides were fabricated by modulating the amount of vanadium content. It is found that the porous Mott-Schottky heterojunction composed of FeVO and FeVO mixed phase was used to construct a self-generated FeVO-5 structure, which could lower the diffusion barrier and improve the electron transport derived from the formed built-in electric field at the interface, showing faster reaction kinetics and improved capacity compared with the singe-phase FeVO-1.

Symmetry Donor-Acceptor Molecule Regulating Hydrogen-Bonding Network for Improved Metal Zinc Anode.

The issues of zinc dendrites and side reactions caused by active water molecules have seriously affected the development of aqueous zinc batteries (AZBs). Herein, a symmetry hydrogen-bond donor-acceptor molecule additive named 1,3-bis(hydroxymethyl)urea (BHMU) can preferentially adsorb on the anode surface and lock up water molecules through hydrogen bonding, thus isolating water molecules and reducing side reactions caused by active water molecules. With these advantages, the mixed electrolyte containing BHMU additive impels a reversible Zn anode with a high Coulombic efficiency (99.

Strong near-infrared upconversion luminescence of the Er/Y co-doped YbVO phosphor for multimode optical temperature measurement.

This study explored the enhancement of near-infrared emissions in YbVO: Er through Y ion doping under a 980 nm laser excitation. The phosphor exhibits weak green emissions at 527 nm (H → I) and 553 nm (S → I), red emissions at 654 nm (F → I), and a strong near-infrared emission at 803 nm (I → I). Optimal doping concentration of Y ion in YbVO: 0.

Combination of Cinnamaldehyde/β-cyclodextrin inclusion complex and L-phenylalanine effectively reduces the postharvest green mold in citrus fruit.

The essential oil and β-cyclodextrin inclusion complex was able to inhibit the growth of Penicillium digitatum, a damaging pathogen that causes green mold in citrus fruit. In this study, cinnamaldehyde-β-cyclodextrin inclusion complex (β-CDCA) for controlling citrus green mold was synthesized by the co-precipitation method. Characterization of β-CDCA revealed that the aromatic ring skeleton of cinnamaldehyde (CA) was successfully embedded into the cavity of β-CD to form the inclusion complex.

A Multifunctional Additive Based on the Cation-Anion Synergistic Effect for Highly Stable Zinc Metal Anodes.

The Zn dendrite and hydrogen evolution reaction have been a "stubborn illness" for the life span of zinc anodes, which significantly hinders the development of aqueous zinc batteries (AZBs). Herein, considering the ingenious molecular structure, a multifunctional additive based on the synergistic regulation of cations and anions at the interface is designed to promote a dendrite-free and stable Zn anode. Theoretical calculations and characterization results verified that the electrostatic shield effect of the cation, the solvation sheath structure, and the bilayer structural solid electrolyte film (SEI) jointly account for the uniform Zn deposition and side reaction suppression.