Pollen-inspired magnetic nanoparticles with dual-recognition sensing interfaces for intelligent-response modulation of circulating tumor cells capture and release.

A critical prerequisite for translating circulating tumor cells (CTCs) detection technologies into clinical practice is achieving high-efficiency capture and non-destructive release of low-abundance CTCs in blood. In recent years, innovative designs and surface modification of bioinspired topological micro/nanostructured materials have provided efficient solutions to capture and release CTCs. Motivated by pollen morphology and multimodal regulation, this study designed pollen-inspired spiky topological magnetic nanoparticles (IP-GSMNs) based on dual-recognition interface and intelligent-response modulation for high-efficiency capture and non-destructive release of CTCs from peripheral whole blood.

SmbZIP5 Integrates Abscisic and Jasmonic Acid Signalling to Positively Regulate Tanshinone Biosynthesis in Salvia miltiorrhiza.

Salvia miltiorrhiza produces pharmacologically bioactive diterpenoid tanshinones which are regulated by jasmonate (JA) and abscisic acid (ABA) signalling, while their crosstalk in this process remains unclear. Here, we demonstrated that MeJA and ABA acted synergistically to enhance tanshinone biosynthesis. We reported that a novel bZIP transcription factor, SmbZIP5, was involved in ABA- and JA-induced tanshinone biosynthesis.

Integrated pan-cancer and melanoma-specific analysis of angiopoietin-2: prognostic value, immune microenvironment modulation, and ceRNA network regulation.

Objective: This research seeks to comprehensively explore the expression patterns of Angiopoietin-2 (ANGPT2) in pan-cancer and examine its relationship with clinical outcomes, tumor immune microenvironment dynamics, and biological functions, with particular emphasis on skin cutaneous melanoma (SKCM).

Methods: Data from six databases, including UCSC Xena, TCGA, GTEx, TIMER2.0, GEPIA, and cBioPortal, were analyzed to assess ANGPT2 expression in pan-cancer.

Pediatric trigger thumb treated with A1 pulley release with or without postoperative thumb immobilization: a retrospective study.

Background: This study aimed to compare clinical outcomes in patients with trigger thumb who underwent A1 pulley release, with or without postoperative thumb immobilization.

Methods: We retrospectively analyzed 207 patients with trigger thumb, comprising 97 in the splinted group and 110 in the non-splinted group, who underwent surgical treatment at our center. Recurrence rates, differences in extension angles between affected and unaffected interphalangeal (IP) joints, and postoperative complications were compared between the two groups.

Transcriptome Analysis Reveals the Molecular Mechanisms by Which Influences the Proliferation of Ovarian Granulosa Cells in Sheep.

Normal proliferation of ovarian granulosa cells is essential for follicular development. The results of this study showed that ADAMTS1 was primarily localized in the cytoplasm of granulosa cells in sheep ovarian follicles, as revealed by immunohistochemistry and immunofluorescence staining. Knockdown and overexpression experiments of in granulosa cells demonstrated that the number of EdU-positive cells significantly decreased in the knockdown group ( < 0.

HIV Removal by MOF-Based Microspheres: A Potential Adsorbent for Hemoadsorption.

At present, AIDS remains a significant global health issue that requires ongoing attention. Although there is no practical cure for AIDS, hemoadsorption can effectively remove the virus from the blood and may serve as a promising treatment strategy. In this research, cellulose acetate/metal-organic framework composite beads (CA/MIL-125) with interconnected macropores were first fabricated using a one-step phase inversion method and then applied as a viral hemoadsorbent for the treatment of AIDS.

The cultivation of enhances the metabolites and microbial network complexity in the soil of rather than .

Introduction: The species of tree most appropriate for the cultivation of Sanqi in an understory environment is pine. Nevertheless, the precise type of pine that confers the greatest benefit to soil health during Sanqi cultivation has not been definitively established.

Methods: Herein, four distinct land use configurations were established, including the , , Sanqi- (SPA), and Sanqi- (SPK) systems.

The predictive value of preoperative inflammatory status for anastomotic leakage after esophagectomy for esophageal cancer.

Background: Anastomotic leakage is one of the most severe complications after esophageal cancer surgery. The purpose of this study was to evaluate the impact of preoperative inflammatory status on anastomotic leakage after esophageal cancer surgery and to construct a model for predicting anastomotic leakage after esophageal cancer surgery.

Methods: A retrospective analysis was conducted on 1106 patients with esophageal cancer who underwent surgical treatment between September 2018 and December 2022.

Intratumorally specific microbial-derived lipopolysaccharide contributes to non-small cell lung cancer progression.

As an emerging component of the tumor microenvironment (TME), the intratumoural microbiota imperceptibly influences the progression of various human malignancies. However, the critical intratumoural microbiota and its role in non-small cell lung cancer (NSCLC) progression have not been fully elucidated. Here, we used high-throughput sequencing and clinical samples analysis to identify the relationship between intratumoural bacteria and NSCLC progression.

Automatic and accurate phase aberration compensation for a digital holographic microscopy system based on one-dimensional weighted curve fitting.

We propose an automatic and accurate phase aberration compensation method for a digital holographic microscopy system. The phase aberrations are extracted by the one-dimensional weighted curve fitting method where the pre-compensated phase is obtained by the phase segmentation method based on the median absolute deviation (MAD) criterion, and the weights of the object phase and the background phase are acquired such that the object phase can be eliminated. Our approach does not require manual selection of area with no sampling and prior optical system parameters.

[Clinical efficacy of endocrinotherapy combined with Shenqi Pills on patients with hormone-sensitive prostate cancer].

Objective: The aim of this study is to explore the clinical efficacy and safety of endocrinotherapy combined with Shenqi Pills on hormone-sensitive prostate cancer (HSPC).

Methods: Eighty patients who were diagnosed with HSPC and renal-yang deficiency at the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine and the Hospital of Traditional Chinese Medicine of Mayang Miao Autonomous County from 1st April 2021 to 30th April 2024 were randomly divided into 2 groups. The patients in the control group were treated with androgen deprivation therapy (ADT).

Sorption and Utilization of Per- and Polyfluoroalkyl Substances in Rechargeable Zinc-Ion Batteries.

Per- and polyfluoroalkyl substances (PFAS) are synthetic fluorinated organic compounds linked to severe health issues, highlighting the urgent need for environmentally sustainable remediation strategies. Here, an integrated PFAS sorption and utilization strategy for remediation is reported through incorporating into rechargeable aqueous zinc battery systems at room temperature. As a representative PFAS compound, perfluorooctanoic acid (PFOA) is successfully sorbed on zinc surface via hydrophobic and electrostatic interactions, with over 98% removal efficiency, and partially defluorinated into zinc fluoride after 24 h, enabling their application as an anode protective layer for improved battery performance.

[Effect of Guilu Taohong Formula on semen quality and spermatogenic cell apoptosis in a varicocele model of rats].

Objective: To observe the effect of Guilu Taohong Formula on semen quality in varicocele (VC) models of rats, and to explore its possible mechanism.

Methods: Forty-eight male SD rats were randomly divided into four groups (sham group, model group, Guilu Taohong Formula group and L-carnitine group). After the establishment of models, the rats were treated with intragastric administration for eight consecutive weeks.

Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China.

Background: Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge. Understanding the drug susceptibility profiles, molecular epidemiology, and mechanisms underlying adaptive echinocandin resistance in C. glabrata is crucial.

Intelligent excitation adaptability for full-spectrum real-time vibration isolation.

Vibration isolation systems frequently face challenges in varying environments due to their inherent resonance effects and responsive delays. Here, we report an intelligent excitation-adaptative vibration isolation (IEA-VI) architecture that mimics the biological adaptive mechanism of human muscle, enabling real-time stiffness adjustment to mitigate variable environmental impacts through sensing, processing, and controlling modules. The IEA-VI system operates in high-static-low-dynamic-stiffness and high-dynamic-stiffness modes, capable of intelligent on-demand mode switching.

Interleukin Family-Based Signature Relates to Cancer-Associated Fibroblasts Spatial Distribution and Immune Therapy Response in Pancreatic Carcinoma.

Background: Cancer-associated fibroblasts (CAFs) and interleukins (ILs) family play crucial roles in pancreatic carcinoma (PC) immune response. However, the correlation between the IL family, CAFs infiltration, and PC prognosis remains uninvestigated.

Methods: An IL family expression pattern for prognosis was constructed using a stepwise Cox proportional hazards regression model using TCGA data.

Identification and Validation of Calcium-Related Diagnostic Markers for Acute Myocardial Infarction via Bioinformatics Analysis and Machine Learning.

The incidence of acute myocardial infarction (AMI) is increasing, and existing diagnostic techniques exhibit limited capacity for early AMI diagnosis. Given the robust association between Ca levels and the AMI initiation, calcium-related genes represent promising biomarkers for the early diagnosis of AMI.The expression data of patients with AMI and normal samples were obtained from the gene expression omnibus database.

Bending-Induced Progressive Damage of 3D-Printed Sandwich-Structured Composites by Non-Destructive Testing.

With the extensive application of 3D-printed composites across multiple industries, the investigation into their structural reliability under complex loading conditions has become a critical research focus. This study comprehensively employs acoustic emission (AE) monitoring, digital image correlation (DIC) measurement, and micro-computed tomography (Micro-CT) visualization techniques to explore the progressive damage behavior of 3D-printed sandwich-structured composites reinforced with continuous carbon fiber sheets under three-point bending. Mechanical tests show that increasing the fiber content of face sheets from 10% to 20% enhances average bending strength by 56%, while low fiber content compromises stiffness and load-bearing capacity.

Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report.

The present case report describes a rare granular cell tumor (GCT) found in the right lower lobe bronchus of a 36-year-old male patient. The tumor was incidentally discovered during preparation for thyroid cancer surgery. The patient had noticed a neck mass 3 months prior to admission, which led to an ultrasound-guided bilateral thyroid mass perforated biopsy and pathological examination.

"Plasmonic Blackbody" with Broadband Absorption Facilitates Efficient Colorimetric/Fluorescence Dual-Response for Sensitive Bimodal-Type Immunochromatography.

While exploring the physicochemical properties of plasmonic metal nanoparticles provides fascinating optical properties, current research typically ignores the ever-increasing point-of-care (POC) demands with target-dependent dual-response variation and built-in self-calibration function. Herein, we propose utilizing the distinct difference in reduction potential between Au/Au (1.00 eV) and Pt/Pt (1.

H-O Bond Dynamics: Length, Energy, and Flexibility under Perturbation.

This study reveals the dynamic flexibility of the intramolecular H-O bond under perturbations (pressure, temperature, coordination, and electric field), challenging its conventional rigidity and proton dynamic mobiity. By integrating bond nature index () analysis, tight-binding theory, and perturbation-resolved phonon spectroscopy (PRS), we quantify perturbation-driven changes in H-O bond length, energy, vibrational stiffness, O 1s core-level energy, and O:H nonbonding distance. A spectroscopic database correlates H-O bond relaxation and energy transfer in water, ice, hydroxides, and extraterrestrial systems (e.

Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery.

This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery. The system alleviates dynamic wrinkles by inhibiting neurotransmitter release and repairs static wrinkles by promoting collagen production. transdermal studies showed that the 24-h cumulative permeation of AHP-8 in BMa/AHP-8 was 3.

Ultrastable Bifunctional Electrocatalyst Based on High-Entropy Layered Hydroxide/Sulfide Heterostructure Enabled by Cerium Modulation for Water/Seawater Splitting.

Developing efficient, durable electrocatalysts for sustainable hydrogen production via water/seawater electrolysis remains a critical challenge due to the sluggish kinetics of oxygen evolution reactions (OER) and material degradation in corrosive environments. Herein, a cerium ion-modulated high-entropy layered hydroxide/sulfide heterostructure composite (HELH/HEMS-6h) is synthesized through a two-step hydrothermal strategy integrating lattice distortion, defect engineering, and hierarchical architecture. The optimized catalyst exhibits exceptional bifunctional activity, achieving low overpotential of 239 mV (OER) and 71 mV (HER) at 10 mA cm in alkaline seawater media, alongside requiring only 1.

Dynamics of respiratory virus transmission in children during and after COVID-19 outbreak control in Baiyin, China.

Purpose: We aimed to study the changes in respiratory virus detection rates during the control of the COVID-19 outbreak and to elucidate possible epidemiologic disturbances after the lifting of control measures.

Methods: Severe acute respiratory infection (SARI) specimens were collected from hospitalized children in Baiyin, China, from 2021 to 2023. We conducted real-time fluorescence quantitative PCR (RT-qPCR) to detect various respiratory viruses, including influenza virus (IFV), human respiratory syncytial virus (HRSV), human rhinovirus (HRV), human parainfluenza virus (HPIV), human metapneumovirus (HMPV), human adenovirus (HADV), enterovirus (EV), and human coronavirus (HCoV).