Acetylation of Histones in the Nucleus Accumbens Increases the Expression of Dopamine Transporters to Regulate Executive Function in Sapap3 Knockout Mice.

Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric condition characterized by persistent, intrusive thoughts (obsessions) and repetitive ritualistic behaviors (compulsions). Accumulating evidence suggests that individuals with OCD demonstrate marked cognitive impairments, especially in executive function domains, including cognitive flexibility and working memory. Although existing therapeutic approaches (e.

Adverse childhood experiences and chronic pain in adolescent patients with depressive disorder: the mediating role of circadian rhythm disruption.

Background: There is growing evidence that adolescent patients with depressive disorder often experience somatic pain symptoms, but the evidence is inconclusive, and the underlying mechanisms are less known.

Methods: From October 2023 to October 2024,a cross-sectional study of the participants were recruited 256 participants from the Mental Health Clinic of the General Hospital of Ningxia Medical University. Using Chinese version of Revised Adverse Childhood Experience Questionnaire, Adolescent Biological Rhythm Disorder Evaluation Questionnaire and the Numeric Rating Scale for Pain.

Integrating eDNA and morphology reveals arsenic-associated assembly processes of benthic invertebrates in coral reef ecosystems.

Understanding how climate change and human activities affect the biodiversity and community assembly of benthic invertebrates is essential for monitoring and conserving coral reef ecosystems under accelerating environmental stress. Environmental DNA (eDNA) metabarcoding provides a rapid, standardized tool for biodiversity assessment, yet limitations such as primer bias and incomplete reference databases prevent it from fully replacing traditional morphological identification. Here, we proposed an integrated framework that combines morphological identification with eDNA metabarcoding to enhance the accuracy and scalability of benthic invertebrate diversity assessments in coral reef ecosystems.

Case Report: From coma to genetic insights: identification of a novel pathogenic variant in Chinese neonatal CTLN1.

Citrullinemia type I (CTLN1) is an autosomal recessive disorder caused by variants in the arginine succinate synthase gene (). These variants result in arginine succinate synthase deficiency, leading to a disruption of the urea cycle and hyperammonemia. To date, only a handful of CTLN1 cases have been reported in China.

Application of an electronic tongue and hyperspectral imaging with a CNN-transformer fusion model for rapid detection of botanical origins of honey.

The botanical origin of honey significantly impacts its nutritional composition, quality, and price. Traditional identification methods are often complex, require expensive equipment, and are time-consuming. This article proposes a rapid detection method for the botanical origin of honey based on an electronic tongue (ET) and hyperspectral imaging (HSI) combined with a CNN-transformer fusion model.

Evaluation of myocardial fibrosis and wall motion abnormality with Ga-FAPI PET/MR in coronary heart disease.

Background: To explore the characteristics of cardiac fibroblast activation protein inhibitor (FAPI) PET/MR in coronary heart disease (CHD) and its association with abnormal wall motion.

Results: In this prospective study, participants with CHD after PCI (Percutaneous Coronary Intervention) underwent gallium 68 ( Ga)-labeled FAPI PET/MR imaging. FAP signal was quantified using standardized uptake values.

Relevance of Household Chemical Usage to Respiratory Diseases in Older Adults in China.

Objective: This study investigated the association between household chemical use and respiratory disease (RD) in older Chinese adults.

Methods: The data were from the 2018 China Longitudinal Health and Longevity Survey (CLHLS) database, which included 12,866 participants aged ≥ 65 years. The prevalence of RD was based on self-reported medical history, and patients were divided into diseased and non-diseased groups.

Alternant P-Type/N-Type Conjugated Bipolar Copolymer Cathodes for Advanced Aqueous Zinc-Ion Batteries.

To synergistically combine the features of high specific capacity of n-type organic materials with the high voltage of p-type organic materials, bipolar phenolthiazine-based cathodes with p-type/n-type structures are gaining increased attention for aqueous zinc-ion batteries (AZIBs). Nevertheless, their small molecular structure often leads to dissolution during cycling. To address the challenge, a bipolar poly(phenothiazine iodide-3,3'-diaminobenzidine), abbreviated as P(PTD-DAB), was synthesized as a cathode material.

Room-temperature synthesis of a methacrylate-derived sulfurized polymer cathode for rechargeable lithium batteries.

We designed and synthesized three methacrylate-derived sulfurized polymer cathodes a one-step polymerization at room temperature. Among them, the cyclohexyl methacrylate-based sulfurized polymer (SP-2) cathode exhibited both high capacity and stability, enabling stable cycling over a 0-60 °C temperature range.

CMOS-Compatible Fabrication of 2D Semiconductor-Based CFETs via High- Dielectric van der Waals Encapsulation.

Two-dimensional (2D) semiconductors are potential candidates for advanced technology nodes, but their integration with silicon lines remains a significant challenge. Here, we present a high- dielectric van der Waals encapsulation strategy for the fabrication of 2D semiconductor-based complementary field-effect transistors (CFETs) compatible with established processes. This technique, involving the transfer of a high- dielectric onto 2D semiconductors, protects channels from polymer contamination, enables O plasma surface cleaning, and facilitates the following dielectric depositions without doping or damage.

Time trends in disability-adjusted life years for cataracts attributable to indoor air pollution across 17 low- and middle-income countries.

Indoor air pollution (IAP) is a risk factor leading to cataracts. The disease burden of cataracts due to IAP is currently greater in low- and middle-income countries, an in-depth analysis is necessary to track the current time trend of cataracts caused by IAP in low- and middle-income countries. Our data from the global burden of disease 2021 study.

8-bit states in 2D floating-gate memories using gate-injection mode for large-scale convolutional neural networks.

The fast development of artificial intelligence has called for high-efficiency neuromorphic computing hardware. While two-dimensional floating-gate memories show promise, their limited state numbers and stability hinder practical use. Here, we report gate-injection-mode two-dimensional floating-gate memories as a candidate for large-scale neural network accelerators.

Dielectric Integrations and Advanced Interface Engineering for 2D Field-Effect Transistors.

As silicon-based transistors approach their physical limits, the challenge of further increasing chip integration intensifies. 2D semiconductors, with their atomically thin thickness, ultraflat surfaces, and van der Waals (vdW) integration capability, are seen as a key candidate for sub-1 nm nodes in the post-Moore era. However, the low dielectric integration quality, including discontinuity and substantial leakage currents due to the lack of nucleation sites during deposition, interfacial states causing serious charge scattering, uncontrolled threshold shifts, and bad uniformity from dielectric doping and damage, have become critical barriers to their real applications.

Efficacy and safety of sintilimab plus bevacizumab and CAPOX as first-line treatment for patients with RAS-mutant, microsatellite stable, metastatic colorectal cancer.

Background: This research aimed to assess the efficacy and safety of combining sintilimab with bevacizumab, oxaliplatin, and capecitabine as a primary therapy for patients with RAS-mutated, microsatellite stable (MSS), and metastatic colorectal cancer (mCRC).

Methods: In this prospective, open-label, single-arm, phase II trial, eligible patients received up to 8 cycles of capecitabine and oxaliplatin/bevacizumab plus sintilimab, followed by maintenance therapy with capecitabine, bevacizumab, and sintilimab every three weeks until disease progression. Treatment response was evaluated every 2 cycles (6 weeks) according to the Response Evaluation Criteria in Solid Tumors version 1.

Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods.

Background: Pulmonary arterial hypertension is a severe pulmonary vascular disease, marked by high mortality and substantial treatment costs, underscoring the urgent need for the exploration of traditional Chinese medicine as a potential therapeutic strategy for pulmonary hypertension. This study aimed to investigate the underlying mechanisms of aloperine in treating PAH through network pharmacology and molecular docking approaches.

Methods: The Swiss Target Prediction database was employed to predict molecular targets of aloperine, while Cytoscape was used to construct the "active component-target" network.

Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with drug-naive obsessive-compulsive disorder.

The study aimed to investigate the correlation between Homocysteine (HCY), folate and vitamin B12 (VB12) levels and cognitive function in patients with drug-naive obsessive-compulsive disorder (OCD).Fifty patients with drug-naive OCD and 50 matched healthy controls recruited were enrolled. Subjects were cognitively assessed using The MATRICS Consensus Cognitive Battery (MCCB) scales.

Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress.

Background: Gastric cancer (GC) is marked by high incidence, malignancy, and poor prognosis. Understanding its development mechanisms and discovering effective drugs are urgent needs. Elevated oxidative stress levels in GC patients have been linked to disease progression.

Sn(II)-Pyrophosphate Complex with Low Plating/Stripping Potential for Sn-I Flow Battery Applications.

Exploring electrolyte formulations that can effectively reduce the plating/stripping potentials of metallic electrodes holds great significance in advancing the development of high-voltage redox flow batteries. In this study, we introduce a novel Sn-based chelated electrolyte, namely, Sn(PO), by directly reacting the Sn solution with an excess of PO solution. Electrochemical tests prove that the incorporation of high-concentration PO ligands could shift the plating/stripping potential to -0.

In-Sensor Polarization Convolution Based on Ferroelectric-Reconfigurable Polarization-Sensitive Photodiodes.

In-sensor computing can enhance the imaging system performance by putting part of the computations into the sensor. While substantial advancements have been made in latency, spectral range, and functionalities, the strategy for in-sensor light polarization computing has remained unexplored. Here, it is shown that ferroelectric-reconfigurable polarization-sensitive photodiodes (FPPDs) based on BiFeO nanowire arrays can perform in-sensor computations on polarization information.

Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats.

Purpose: High consumption of Ultra-processed foods (UPF) have been identified as a potential risk factor for Non-alcoholic fatty liver disease (NAFLD). Nevertheless, there is limited empirical evidence regarding the impact of UPF, which are typical combination of processed foods, on liver health through alterations in gut microbiota and metabolic processes. We aim to examine the potential impact of UPF on liver health and to explore the role of gut microbiota and metabolites.

Lead Phosphate Material for Exclusive Detection of Hydrogen Sulfide Gas.

Efficient gas sensors that can accurately detect and identify hydrogen sulfide are essential for various practical applications. Conventional resistive sensors often lack the necessary selectivity, which hampers timely and effective HS detection. This study presents lead phosphate-based gas sensors specifically designed for HS detection, which effectively eliminate interference effects.

Exposure to green space, nighttime light, air pollution, and noise and cardiovascular disease risk: A prospective cohort study.

Current literature lacks information regarding impacts of green spaces on susceptibility to cardiovascular disease (CVD) related to harmful environmental exposures. The UK Biobank cohort study was utilized to investigate whether green spaces can mitigate risks associated with air pollutants, nighttime light, noise, and traffic intensity. Latent Profile Analysis was performed on green spaces and adverse environmental exposures in order to assess individual level exposure.

Ferroelectric Polarization Coupling Effect in BiFeO/α-InSe Ferroelectric Field Effect Transistor for Stable Non-volatile Memory.

Ferroelectric field-effect transistors (FeFETs) commonly utilize traditional oxide ferroelectric materials for their strong remanent polarization. Yet, integrating them with the standard complementary metal oxide semiconductor (CMOS) process is challenging due to the need for lattice matching and the high-temperature rapid thermal annealing process, which are not always compatible with CMOS fabrication. However, the advent of the ferroelectric semiconductor α-InSe offers a compelling solution to these challenges.