Ischemic stroke in the context of high low-density lipoprotein cholesterol: A 30-year global burden perspective of 204 nations.

Background: High levels of low-density lipoprotein cholesterol (LDL-C) have a substantial impact on the onset and progression of ischemic stroke. However, the impact of high LDL-C level on ischemic stroke burden remains to be comprehensively investigated at the global, regional, and national levels. This study aimed to fill this gap by analyzing the trends of ischemic stroke associated with high LDL-C level from 1990 to 2021 using data obtained from the 2021 Global Burden of Disease (GBD) study to provide scientific evidence for policy-making and public health decision-making.

Global burden of low back pain attributable to smoking in 204 countries and territories in 1990-2021.

Background: Smoking has a major influence on the development and worsening of low back pain (LBP). However, the effect of smoking on the burden of LBP has not been thoroughly examined at the global, regional, and national levels. This study aims to analyze the trends in smoking-related LBP from 1990 to 2021.

Genome-Wide Identification and Expression Analysis of the HSP90 Gene Family in Relation to Developmental and Abiotic Stress in Ginger ( Roscoe).

Ginger ( Roscoe), valued both for its medicinal and culinary uses, can be adversely affected by abiotic stresses such as high temperature and drought, which can impact its growth and development. The HSP90 gene family has been recognized as a crucial element for enhancing heat and drought resistance in plants. Nevertheless, no studies have yet reported on the HSP90 gene family in ginger.

PhysCL: Knowledge-Aware Contrastive Learning of Physiological Signal Models for Cuff-Less Blood Pressure Estimation.

Training deep learning models for photoplethysmography(PPG)-based cuff-less blood pressure estimation often requires a substantial amount of labeled data collected through sophisticated medical instruments, posing significant challenges in practical applications. To address this issue, we propose Physiological Knowledge-Aware Contrastive Learning (PhysCL), a novel approach designed to reduce the dependence on labeled PPG data while improving blood pressure estimation accuracy. Specifically, PhysCL tackles the semantic consistency problem in contrastive learning by introducing a knowledge-aware augmentation bank, which generates positive physiological signal pairs using knowledge-based constraints during the contrastive pair generation.

Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis.

The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in the scientific community. However, it remains to be determined whether gut microbiota directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis to explore the potential causal link between gut microbiota and CS.

Low back pain trends attributable to high body mass index over the period 1990-2021 and projections up to 2036.

Background: High body mass index (BMI) is a crucial determinant in low back pain (LBP) incidence and progression. However, the effect of increased BMI on LBP has been largely overlooked at the global, regional, and national levels. This research aimed to use data from the 2021 global burden of disease (GBD) study to determine trends associated with LBP due to high BMI from 1990 to 2021, thereby providing evidence for developing targeted policies.

Prognostic role of long noncoding RNA CASC11 in cancer patients: A meta-analysis.

Background: Long noncoding RNA (lncRNA) is a significant component of the noncoding genome and refers to RNA molecules that exceed 200 nucleotides in length. It plays a crucial role in both promoting and suppressing cancer by regulating the proliferation, invasion, and metastasis of tumor cells. We have found a correlation between cancer susceptibility candidate 11 (CASC11) experssion and tumorigenesis development prognosis in a number of studies on tumors.

The effects of social defeat stress on hippocampal glial cells and interleukin-6 in adolescence and adulthood.

Adolescent social stress has been associated with the vulnerability to developing psychopathological disorders in adulthood that are accompanied by brain inflammatory processes. The purpose of this study is to investigate the dynamic changes of the hippocampal neuroinflammatory mediators, including microglia, astrocyte, and interleukin-6 (IL-6) levels in mice experiencing social defeat stress during adolescence. Adolescent mice were divided into the control group and stress group.

Covalent Amide-Bonded Nanoflares for High-Fidelity Intracellular Sensing and Targeted Therapy: A Superstable Nanosystem Free of Nonspecific Interferences.

A nanoflare, a conjugate of Au nanoparticles (NPs) and fluorescent nucleic acids, is believed to be a powerful nanoplatform for diagnosis and therapy. However, it highly suffers from the nonspecific detachment of nucleic acids from the AuNP surface because of the poor stability of Au-S linkages, thereby leading to the false-positive signal and serious side effects. To address these challenges, we report the use of covalent amide linkage and functional Au@graphene (AuG) NP to fabricate a covalent conjugate system of DNA and AuG NP, label-rcDNA-AuG.

NUF2 as an anticancer therapeutic target and prognostic factor in breast cancer.

Breast cancer (BC) is the most frequently diagnosed type of cancer, and the leading cause of cancer‑associated mortality in females worldwide. The aim of the present study was to investigate the prognostic and therapeutic potential of NUF2 in BC. The expression levels of NUF2 in BC tissues and cell lines were evaluated via bioinformatics, reverse transcription‑quantitative PCR, western blot analysis and immunohistochemistry (IHC).

Shell-Switchable SERS Blocking Strategy for Reliable Signal-On SERS Sensing in Living Cells: Detecting an External Target without Affecting the Internal Raman Molecule.

For SERS analysis in living cells, the inevitable desorption of Raman molecule on the substrate surface is a key challenge. To ensure high stability, SERS systems with Raman molecules protected inside the core-Raman molecule-shell (C-M-S) structures have been designed, but at the expense of sacrificed sensing performances. Here a shell-switchable SERS blocking strategy is developed for the reliable SERS analysis in living cells, relying on the shell blockers to regulate the SERS sensing signal without affecting the internal Raman molecules.

The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis.

Background: It is unknown whether gabapentin is effective in reducing acute pain following laparoscopic cholecystectomy. The purpose of the current meta-analysis was to evaluate the efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.

Methods: All randomized controlled trials (RCTs) evaluating the efficacy of gabapentin in reducing pain intensity and PONV after laparoscopic cholecystectomy were searched on the following databases: PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the Google database, the Chinese Wanfang database, and the China National Knowledge Infrastructure (CNKI).

miR141 expression is downregulated and negatively correlated with STAT5 expression in esophageal squamous cell carcinoma.

The aim of the present study was to investigate the association between microRNA-141 (miR141) and signal transducer and activator of transcription 5 (STAT5) expression levels in human esophageal squamous cell carcinoma (ESCC) and to investigate the effects of miR141 on ESCC cells. A total of 45 consecutive patients with ESCC were enrolled in the study. The expression of miR141 in ESCC tissue samples was detected using reverse transcription quantitative polymerase chain reaction (RT-qPCR).

Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice.

This study tested the hypothesis that in hypertensive arteries cyclooxygenase-1 (COX-1) remains as a major form, mediating prostacyclin (prostaglandin I2; PGI2) synthesis that may evoke a vasoconstrictor response in the presence of functional vasodilator PGI2 (IP) receptors. Two-kidney-one-clip (2K1C) hypertension was induced in wild-type (WT) mice and/or those with COX-1 deficiency (COX-1-/-). Carotid arteries were isolated for analyses 4 weeks after.

Concomitant activation of functionally opposing prostacyclin and thromboxane prostanoid receptors by cyclo-oxygenase-1-mediated prostacyclin synthesis in mouse arteries.

This study aimed to determine whether cyclo-oxygenase-1 (COX-1) mediates dilatation of mouse arteries via synthesis of prostacyclin (PGI(2)) and, if so, how PGI(2) (IP) receptors contribute and whether thromboxane prostanoid (TP) receptors are implicated in the process. Mesenteric arteries were isolated from wild-type mice or mice with COX-1 deficiency (COX-1(-/-)). The vasomotor reaction to the COX substrate arachidonic acid (AA) was determined with isometric force measurement, while the in vitro production or the plasma level of the PGI(2) metabolite 6-keto-PGF(1α) was analysed with high-performance liquid chromatography-mass spectroscopy or enzyme immunoassay, respectively.