Seasonal blooms of in a temperate semi-enclosed bay: linking community succession to thermal and nutrient regimes.

is a key picocyanobacterium in coastal ecosystems, yet its seasonal bloom dynamics and environmental responses remain unclear in temperate coastal seas. Here, we integrated flow cytometry and gene analysis to investigate its bloom development and community succession in Laizhou Bay, based on 3 years of 10 seasonal surveys and a year-long monthly observation at a fixed station. blooms reached their peak in summer (up to 10 cells mL), particularly in the southern part of the bay, with high abundances in autumn as well.

Comparison of the Predictive Roles of CT- and MRI-Based Pedicle Regional Osteoporosis Status Measurements for Pedicle Screw Loosening After Posterior Lumbar Interbody Fusion.

Study DesignRetrospective Study.ObjectivesTo compare the efficacy of pedicle Hounsfield unit (HU) values and pedicle bone quality (PBQ) scores in predicting pedicle screw loosening (PSL) after posterior lumbar interbody fusion (PLIF) in elderly patients and to identify the most discriminative bone mineral density (BMD) assessment indicator.MethodsThis retrospective analysis included 275 consecutive patients who underwent PLIF.

Genome-wide transcriptional analysis of tendon tissue-related genes and pathways in the torn rotator cuff of diabetes patient.

Background: Diabetes is a major factor affecting rotator cuff tear (RCT) progression and healing. However, the underlying molecular mechanisms linking diabetes to RCT remain unclear. We aimed to investigate these mechanisms for developing targeted therapeutic strategies to improve tendon healing in diabetes patients.

Association of paraspinal muscle morphology or composition with sagittal spinopelvic alignment: a systematic review and meta-analysis.

Purpose: The aim of this study was to evaluate the association of paraspinal muscle morphology and composition with sagittal spinopelvic alignment (SSA).

Methods: This review was registered at PROSPERO (CRD42022371879). Four databases including PubMed, Embase, Cochrane, and Web of Science were searched from their inception until December 15, 2024.

Evaluating the Performance of State-of-the-Art Artificial Intelligence Chatbots Based on the WHO Global Guidelines for the Prevention of Surgical Site Infection: Cross-Sectional Study.

Background: Surgical site infection (SSI) is the most prevalent type of health care-associated infection that leads to increased morbidity and mortality and a significant economic burden. Effective prevention of SSI relies on surgeons strictly following the latest clinical guidelines and implementing standardized and multilevel intervention strategies. However, the frequent updates to clinical guidelines render the processes of acquisition and interpretation quite time-consuming and intricate.

Deep Learning-Based Prediction for Bone Cement Leakage During Percutaneous Kyphoplasty Using Preoperative Computed Tomography: MODEL Development and Validation.

Study Design: Retrospective study.

Objective: To develop a deep learning (DL) model to predict bone cement leakage (BCL) subtypes during percutaneous kyphoplasty (PKP) using preoperative computed tomography (CT) as well as employing multicenter data to evaluate the effectiveness and generalizability of the model.

Summary Of Background Data: DL excels at automatically extracting features from medical images.

A novel deep learning system for automated diagnosis and grading of lumbar spinal stenosis based on spine MRI: model development and validation.

Objective: The study aimed to develop a single-stage deep learning (DL) screening system for automated binary and multiclass grading of lumbar central stenosis (LCS), lateral recess stenosis (LRS), and lumbar foraminal stenosis (LFS).

Methods: Consecutive inpatients who underwent lumbar MRI at our center were retrospectively reviewed for the internal dataset. Axial and sagittal lumbar MRI scans were collected.

CT- and MRI-based endplate osteoporosis status assessment for predicting adjacent vertebral fractures after thoracolumbar percutaneous kyphoplasty: a matched comparison study.

Purpose: This study aimed to investigate the predictive value of adjacent vertebral endplate osteoporotic status for adjacent vertebral fracture (AVF) after percutaneous kyphoplasty (PKP) for treating osteoporotic vertebral compression fracture (OVCF) and compared it with vertebral cancellous bone.

Methods: This study retrospectively analyzed consecutive patients with OVCF who underwent PKP. Participants were categorized into the study group (49 patients with AVF) and the control group (49 matched patients without AVF).

Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial.

Background: Sugammadex is well tolerated and effective for reversing neuromuscular blockade (NMB) in adults and children as young as 2 yr old. There is little information on its use in younger children. The aim of this study was to evaluate the efficacy and tolerability of sugammadex in children under 2 yr of age.

Vertebral CT Hounsfield units in postmenopausal women with osteoporotic vertebral compression fracture: identification and validation of reference intervals.

Purpose: Based on the population of postmenopausal women with osteoporotic vertebral compression fractures (OVCFs), this study aimed to identify the optimal and alternative levels of vertebral CT Hounsfield units (HU) for osteoporosis and osteoporosis-related complication assessment, establish age-specific reference intervals (RIs) of HU values, and validate its quantitative predictive value for new vertebral fractures (NVFs) after percutaneous kyphoplasty (PKP).

Methods: Consecutive postmenopausal women diagnosed with OVCFs at our department between January 2016 and August 2024 were retrospectively reviewed. The vertebral HU of T12-L2 was measured on CT images by two independent spine surgeons twice, with a 2-week interval.

Association Between Spinopelvic Alignment and Reoperation Following Percutaneous Transforaminal Endoscopic Decompression: A Matched Case-Control Study.

Purpose: Percutaneous transforaminal endoscopic decompression (PTED) is widely used for treating lumbar spinal stenosis (LSS), yet predictors of reoperation remain unclear. This study aimed to explore the association between spinopelvic alignment and the reoperation following PTED.

Patients And Methods: A 1:2 matched case-control study was conducted, involving patients who underwent single-level PTED for LSS at our institution from May 2014 to August 2022.

Percutaneous transforaminal endoscopic decompression versus posterior short-segment fusion for treating degenerative lumbar scoliosis with lumbar spinal stenosis: a cohort study with a minimum five year followup.

Purpose: This retrospective cohort study aimed to compare the clinical outcomes of percutaneous transforaminal endoscopic decompression (PTED) with those of posterior lumbar interbody fusion (PLIF) for the treatment of degenerative lumbar scoliosis (DLS) with lumbar spinal stenosis (LSS).

Methods: In this study, 143 DLS patients who met the inclusion criteria from January 2016 to March 2019 were retrospectively analyzed and divided into the PTED and PLIF groups. The propensity score matching (PSM) method was used to adjust for imbalanced confounding variables between the groups.

Alkaline phosphatase-mediated hydrolysis of dissolved organic phosphorus enhances phosphorus cycling in the Yellow Sea.

The utilization of dissolved organic phosphorus (DOP) driven by alkaline phosphatase hydrolysis contributes significantly to mitigating coastal nitrogen pollution through alleviating phosphorus (P) limitation. However, the lack of a parameterization for this process limits the quantitative assessment of its impact on marine nutrient pollution and cycling. Our study addresses this issue using data from a series of on-board microcosm experiments conducted in the Yellow Sea, where P limitation prevails.

Comparison of Learning Curves and Clinical Outcomes in Unilateral Biportal Endoscopic Spinal Surgery Versus Percutaneous Transforaminal Endoscopic Surgery: A Cumulative Sum Analysis.

Purpose: Endoscopic spine surgery has been widely performed to treat degenerative spinal diseases to mitigate the risks and complications associated with traditional open surgery. However, endoscopic procedures pose challenges, including a limited field of view and a restricted operating space, which can affect the surgeon's learning curve. This study aimed to evaluate the learning curves for unilateral biportal endoscopic spinal surgery (UBESS) and percutaneous transforaminal endoscopic surgery (PTES) by performing cumulative sum (CUSUM) analysis and to assess their efficacies in managing degenerative spinal diseases.

Automated diagnosis and grading of lumbar intervertebral disc degeneration based on a modified YOLO framework.

Background: The high prevalence of low back pain has led to an increasing demand for the analysis of lumbar magnetic resonance (MR) images. This study aimed to develop and evaluate a deep-learning-assisted automated system for diagnosing and grading lumbar intervertebral disc degeneration based on lumbar T2-weighted sagittal and axial MR images.

Methods: This study included a total of 472 patients who underwent lumbar MR scans between January 2021 and November 2023, with 420 in the internal dataset and 52 in the external dataset.

Clinical and radiological outcomes of lumbar endoscopic decompression for treating lumbar spinal stenosis and degenerative lumbar scoliosis: a retrospective study at mean 4.4 years follow-up.

Purpose: To assess the clinical and radiological outcomes of lumbar endoscopic decompression for the treatment of lumbar spinal stenosis (LSS) with concurrent degenerative lumbar scoliosis (DLS).

Methods: This study retrospectively reviewed 97 patients with LSS and DLS who underwent lumbar endoscopic decompression between 2016 and 2021. The average follow-up duration was 52.

Machine Learning and Deep Learning for Diagnosis of Lumbar Spinal Stenosis: Systematic Review and Meta-Analysis.

Background: Lumbar spinal stenosis (LSS) is a major cause of pain and disability in older individuals worldwide. Although increasing studies of traditional machine learning (TML) and deep learning (DL) were conducted in the field of diagnosing LSS and gained prominent results, the performance of these models has not been analyzed systematically.

Objective: This systematic review and meta-analysis aimed to pool the results and evaluate the heterogeneity of the current studies in using TML or DL models to diagnose LSS, thereby providing more comprehensive information for further clinical application.

Analysis of Risk Factors Causing Adjacent Disc Degeneration After Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fractures.

Purpose: Adjacent disc degeneration (ADD) is a common postoperative complication after percutaneous kyphoplasty (PKP). However, risk factors for ADD after PKP have not been reported. This study aimed to determine whether osteoporotic vertebral compression fracture (OVCF) following PKP is associated with a high risk for ADD and to identify the risk factors for ADD.

Equivalent Heat Source Model of Thermal Relay Contact Based on Surface Roughness of Silver-Magnesium-Nickel Contact.

In a sealed electromagnetic relay, the change in the surface roughness mainly depends on the collision wear between the contact and the moving reed and the ablation effect of the arc on the contact surface based on the strong correlation between the contact resistance and the surface roughness of the Ag-Mg-Ni contact. With a change in contact resistance, the contact temperature increase in a hermetically sealed electromagnetic relay (HSER) is greatly affected. Under extreme overload conditions, the contact surface is severely ablated by the arc, and the roughness increases rapidly with the number of cycles, which greatly affects the contact resistance of the contact surface and the reliability of the relay.

Effect of ocean dynamic processes on the temporal-spatial pattern of persistent organic pollutants (PCB-153 and BDE-47) in the shelf seas.

Field observations of persistent organic pollutants (POPs) in shelf seas presented abnormal phenomena such as high-concentration patches in offshore areas and different vertical profiles of POPs at the same location. We assumed that these phenomena were associated with the presence of bottom cold water mass (BCWM) in shelf seas and used a hydrodynamic-ecosystem-POP coupled model to confirm this hypothesis. Based on model results, with the formation of BCWM during summer, POPs accumulated inside BCWM due to their transport across the thermocline by the sorption to sinking particles.

Clinical outcomes of percutaneous transforaminal endoscopic decompression for the treatment of degenerative lumbar scoliosis associated with spinal stenosis in elderly individuals: a matched comparison study.

Purpose: This retrospective cohort study evaluated the efficacy and safety of percutaneous transforaminal endoscopic decompression (PTED) in elderly patients with degenerative lumbar scoliosis (DLS) associated with lumbar spinal stenosis (LSS).

Study Design: A matched comparison study.

Methods: In total, 97 patients with DLS associated with LSS who underwent PTED under local anesthesia between 2016 and 2021 were retrospectively analyzed.

Deep learning assisted segmentation of the lumbar intervertebral disc: a systematic review and meta-analysis.

Background: In recent years, deep learning (DL) technology has been increasingly used for the diagnosis and treatment of lumbar intervertebral disc (IVD) degeneration. This study aims to evaluate the performance of DL technology for IVD segmentation in magnetic resonance (MR) images and explore improvement strategies.

Methods: We developed a PRISMA systematic review protocol and systematically reviewed studies that used DL algorithm frameworks to perform IVD segmentation based on MR images published up to April 10, 2024.

Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma.

Background: Belzutifan, a hypoxia-inducible factor 2α inhibitor, showed clinical activity in clear-cell renal-cell carcinoma in early-phase studies.

Methods: In a phase 3, multicenter, open-label, active-controlled trial, we enrolled participants with advanced clear-cell renal-cell carcinoma who had previously received immune checkpoint and antiangiogenic therapies and randomly assigned them, in a 1:1 ratio, to receive 120 mg of belzutifan or 10 mg of everolimus orally once daily until disease progression or unacceptable toxic effects occurred. The dual primary end points were progression-free survival and overall survival.