Mapping Long COVID: Spatial and Social Inequities Across the United States.

Background Long COVID affects a substantial portion of the U.S. population, yet its spatiotemporal distribution remains poorly characterized.

Transcriptome Screening and Identification of Chemosensory Genes in the Goji Berry Psyllid, (Hemiptera: Psyllidae).

Goji berry is widely consumed worldwide and holds substantial market value, yet its cultivation faces significant threats from the goji berry psyllid (). Chemosensory-related genes play critical roles in regulating insect behaviors, which makes them key molecular targets for the development of environmentally friendly pest control strategies. However, chemosensory genes in have not been previously identified or characterized.

Unveiling Defect Dynamics in Gallium Oxide: In-Situ TEM Insights under Ion Irradiation and Annealing.

Gallium oxide (GaO) is distinguished in the electronics field for its ultrawide bandgap, high breakdown field, and transparency to visible and infrared light, making it highly attractive for sensor applications in harsh environments. This study investigates the evolution of defects in GaO under ion irradiation, annealing, and their combined effects, with a unique focus on in situ transmission electron microscopy (TEM) observations. We examined three electron-transparent GaO lamellas (samples A, B, and C) under distinct conditions: Sample A was subjected to Kr ion irradiation up to 15.

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan-Coronavirus Inhibitor.

The emergence of novel and highly transmissible coronavirus (CoVs) highlights the urgent need for broad-spectrum antiviral agents. In our pursuit of effective treatments for coronavirus, we identified tetrandrine, the traditional Chinese medicine, as a pan-coronavirus inhibitor, exhibiting efficacy against HCoV-229E, HCoV-OC43, SARS-CoV-2, and its major variants of concern (VOCs), including alpha, beta, and omicron. Mechanistic investigations revealed that tetrandrine primarily targets the viral entry stage by binding to the Spike protein, disrupting its interaction with the host protease transmembrane serine protease 2 (TMPRSS2), and promoting Spike protein degradation, ultimately blocking the membrane fusion.

A survival prediction model for biliary tract cancer based on least absolute shrinkage and selection operator-cox regression.

Background: Biliary tract cancer (BTC) is a digestive tract tumor with low incidence, high malignancy, and short survival times. Abnormal lipid metabolism may be related to the occurrence and development of tumors; therefore, we constructed a survival prediction model for patients with BTC using clinical data that included lipid indicators rarely considered in previous studies.

Patients And Methods: Clinical and pathological data were collected from 124 patients with BTC.

Single-nucleus RNA sequencing reveals developmental dynamics and cellular heterogeneity in the mammary gland of young fillies and adult Mongolian mares.

Mongolian horses are famous for their lactation traits. Their milk contains a high protein content and low levels of fatty acids. Given their superior milk composition and historical use in dairy production across Inner Mongolia and Central Asia, Mongolian horses serve as a valuable model for understanding lactational biology.

Screening of an FDA-Approved Drug Library: Menadione Induces Multiple Forms of Programmed Cell Death in Colorectal Cancer Cells via MAPK8 Cascades.

: Colorectal cancer (CRC) is a prevalent gastrointestinal malignancy, ranking third in incidence and second in cancer-related mortality. Despite therapeutic advances, challenges such as chemotherapy toxicity and drug resistance persist. Thus, there is an urgent need for novel CRC treatments.

Recurrence and influencing factors of moderate-to-severe atopic dermatitis after dupilumab withdrawal: a retrospective cohort analysis.

Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease. Although dupilumab has demonstrated favorable efficacy in the treatment of patients with moderate-to-severe atopic dermatitis, data on its recurrence after discontinuation remain limited.

Objective: To explore the recurrence rate, time to recurrence, and factors influencing recurrence in patients with moderate-to-severe AD after discontinuing dupilumab, to bridge the existing knowledge gap and provide a reference for promoting long-term standardized management of the disease in AD patients to reduce AD recurrence.

The multi-target intervention reveals the mechanism by which Finerenone alleviates Polymyxin B-induced kidney injury: an integrated study of network pharmacology, transcriptomics, and molecular docking.

Background: Polymyxin B (PMB), a last-resort antibiotic against multidrug-resistant Gram-negative pathogens, faces clinical limitations due to dose-dependent nephrotoxicity. Current protective strategies have proven inadequate, underscoring an urgent need for novel interventions. We hypothesize that Finerenone may mitigate PMB-induced kidney injury through multi-mechanism renoprotective effects.

Membrane sensitization biosensor based on magnetic inducing for Tau protein detection.

Surface stress-based biosensors exhibit excellent performance in detecting high concentrations of biomolecules; however, their sensitivity at low concentrations is often limited by insufficient deformation caused by weak binding-induced signals. To overcome this limitation, we propose an actively driven biosensor based on a multilayered heterogeneous magnetic film (PDMS/NiFe/FeMn), which achieves synergistic amplification of surface stress and geometric deformation under magnetic field modulation, thereby breaking through the sensitivity bottleneck of conventional designs. The sensor architecture leverages the high magnetic permeability of NiFe and the magnetostrictive effect of FeMn to construct a magneto-mechanical coupling interface: the NiFe layer efficiently transduces magnetic field energy, while the FeMn layer actively deforms to amplify the surface stress generated by target binding (Tau protein).

Pediatric maxillofacial soft-tissue injuries: a retrospective analysis of 19,979 cases in a stomatology emergency department in southern China.

Object: The primary aim of this study was to review the demographic characteristics and treatments of maxillofacial trauma patients treated in the Oral Emergency Department of a hospital between 2016 and 2022. This study may serve as a reference for improving emergency healthcare systems and injury prevention in pediatric populations.

Methods: We searched the records of patients who were diagnosed with maxillofacial soft tissue trauma in the hospital information systems of Shenzhen Children's Hospital.

-level bias stability of a tri-axial grating Talbot-effect-based MOEMS accelerometer.

With the advantage of high-precision and anti-electromagnetic interference, micro-opto-electro-mechanical system (MOEMS) accelerometers have significant applications in inertial navigation, the automotive industry, and attitude reference. The cross-axis interference of the accelerometer has seriously affected the accuracy of acceleration measurements. This paper presents a three-axis integrated grating MOEMS accelerometer, featuring lower cross-axis interference and higher bias stability.

hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis.

Objective: Diabetic retinopathy (DR) is a leading cause of vision loss, driven by hyperglycemia-induced human retinal microvascular endothelial cell (HRMEC) dysfunction, mitochondrial impairment, oxidative stress, inflammation, and aberrant angiogenesis. Circular RNAs (circRNAs) have emerged as critical regulators in various ocular pathologies, yet their contributions to DR remain unclear. This study identified and characterized hsa_circ_0099682, derived from the alpha motif domain-containing protein 1B (ANKS1B) gene, and investigated its role and molecular mechanism in high glucose (HG)-induced HRMEC injury.

The impact of ultrasound-guided thoracic paravertebral nerve block on the quality of recovery after video-assisted thoracoscopic surgery: a meta-analysis of randomized controlled trials.

Background: The ultrasound-guided thoracic paravertebral nerve block (TPVB) is widely used in video-assisted thoracoscopic surgery (VATS). However, the impact of ultrasound-guided TPVB on the postoperative quality of recovery (QoR) remains unclear in patients undergoing VATS. The objective of this systematic review and meta-analysis was to explore the impact of ultrasound-guided TPVB on postoperative QoR score after VATS in comparison to the control group without receiving either TPVB or other blocks.

NOX1 inhibition sensitizes HCC cells to sorafenib and radiotherapy by modulating ROS-mediated programmed cell death.

The progression of hepatocellular carcinoma (HCC) is partly driven by reactive oxygen species (ROS)-induced tissue damage and inflammation. Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are key regulators of ROS production, yet the specific role of NOX1 in HCC progression and therapeutic response remain incompletely understood. In this study we investigated the critical role of NOX1 in progression, metastasis and therapeutic sensitivity of HCC, and explored its potential as a therapeutic target.

Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma.

Alterations in the diversity and abundance of oncogenic gene transcripts are key factors driving tumor initiation and progression. DCLK1, an emerging cancer stem cell marker, is activated during tumorigenesis, triggering cancer stemness and metastasis. It produces long or short isoforms through selective usage of alternative promoters (α- or β-promoter).

Atopic dermatitis in amyotrophic lateral sclerosis successfully treated by dupilumab: A case report.

Rationale: Atopic dermatitis (AD) is a common skin disorder characterized by symmetric erythematous papules in flexural areas, with pruritus of varying intensity persisting throughout its course. Amyotrophic lateral sclerosis (ALS) is a neurological disease with progressive loss of muscle function, and its treatment remains a challenge worldwide. When patients suffer from both conditions, the skin issues are often overlooked by both physicians and family members.

End-tidal CO corrected for ambient CO risk adjusted phototherapy threshold for the management of neonatal hyperbilirubinemia: a randomized clinical trial.

Background: Neonatal hyperbilirubinemia risk factors determination is challenging due to the lack of quantifiable indicators for bilirubin production, resulting in phototherapy decisions made without real-time information. End-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc) may be helpful for identifying hemolysis, but evidence on the application of ETCOc as a risk factor for the development of neonatal hyperbilirubinemia is scarce. This study aimed to evaluate whether the use of ETCOc to adjust neonatal hyperbilirubinemia risk categories and thus phototherapy thresholds can reduce the rate of phototherapy within the first seven days of life.

Risk score model with two immune infiltration-related long non-coding RNAs to predict prognosis in patients with osteosarcoma.

Osteosarcoma (OS) is the most frequent type of cancer, as well as a common malignant tumor in orthopedics. Multiple long non-coding RNAs (lncRNAs) are implicated in immune infiltration in numerous types of cancer. Using single-sample gene set enrichment analysis to assign patients with OS, two immunotypes of OS were identified.

Fragment-Based Immune Cell Engager Antibodies in Treatment of Cancer, Infectious and Autoimmune Diseases: Lessons and Insights from Clinical and Translational Studies.

Since the advent of recombinant DNA technologies and leading up to the clinical approval of T cell engager blinatumomab, the modular design of therapeutic antibodies has enabled the fusion of antibody fragments with proteins of various functionalities. This has resulted in an expansive array of possible mechanisms of action and has given birth to fragment-based antibodies (fbAbs) with immune cell engager modalities. In searchable databases, the preclinical development of these antibodies has shown promise; however, clinical outcomes and restructuring efforts involving these agents have produced mixed results and uncertainties.

[Effects of transcutaneous electrical acupoint stimulation at Neiguan (PC6) and Jianshi (PC5) on autonomic nervous function and inflammatory factors in frail elderly patients after surgery].

Objectives: To explore the effects of transcutaneous electrical acupoint stimulation (TEAS) at the bilateral acupoints Neiguan (PC6) and Jianshi (PC5) on heart rate variability (HRV) and inflammatory factors in frail elderly patients undergoing laparoscopic colorectal cancer surgery under general anesthesia.

Methods: A total of 78 frail elderly patients undergoing elective laparoscopic colorectal cancer surgery were randomized into the TEAS group (39 patients, with 2 patients dropping out) and the control group (39 patients, with 1 patient dropping out). In the TEAS group, TEAS was applied to the bilateral PC6 and PC5 from 30 min before anesthesia induction until the end of the surgery.

Case Report: Omalizumab-associated hair loss: a case of eyebrow alopecia areata, literature review and FAERS database analysis.

Hair loss is a rare adverse reaction associated with omalizumab, with limited literature reports. The incidence, underlying mechanisms, and clinical characteristics of omalizumab-associated hair loss have not been clarified. We report a 52-year-old female with chronic spontaneous urticaria (CSU) who developed significant loss of eyebrows after 12 weeks of omalizumab treatment at 300 mg per 4 weeks.

Diammonium Glycyrrhizinate Exerts Broad-Spectrum Antiviral Activity Against Human Coronaviruses by Interrupting Spike-Mediated Cellular Entry.

Glycyrrhizic acid (GA) and its derivatives have been reported to have potent pharmacological effects against viral infections, including SARS-CoV and SARS-CoV-2. However, their antiviral mechanisms against coronaviruses are not fully understood. In this study, we found that diammonium glycyrrhizinate (DG) can effectively reduce infections of several human coronaviruses, including HCoV-OC43, HCoV-229E, and SARS-CoV-2, as well as newly emerged variants, with EC values ranging from 115 to 391 μg/mL being recorded.

Application of transcutaneous electrical nerve stimulation in monitored anesthesia care during foraminoscopy: a randomized double-blind controlled trial.

Background: As minimally invasive surgical techniques have evolved, foraminoscopy has emerged as a predominant surgical procedure. This technique utilizes the intervertebral foramen as the primary surgical pathway and addresses lumbar intervertebral disk issues through endoscopic intervention. However, since the surgery is performed under local anesthesia, achieving satisfactory anesthesia poses significant challenges.

Exploration of the role and mechanism of Rhizoma Paridis total saponins in osteosarcoma based on SPI1/LCN2-mediated ferroptosis.

Background: Osteosarcoma (OS) is a highly aggressive bone malignancy with limited therapeutic options and poor prognosis, particularly in cases of recurrence or metastasis. Recent studies have identified ferroptosis as a promising therapeutic target in OS, with the SPI1/LCN2 regulatory axis emerging as a critical modulator of this process. We hypothesized that Rhizoma Paridis total saponins (RPTS) exert anti-osteosarcoma effects by inducing ferroptosis through inhibition of the SPI1/LCN2 axis.