Membrane sensitization biosensor based on magnetic inducing for Tau protein detection.

Surface stress-based biosensors exhibit excellent performance in detecting high concentrations of biomolecules; however, their sensitivity at low concentrations is often limited by insufficient deformation caused by weak binding-induced signals. To overcome this limitation, we propose an actively driven biosensor based on a multilayered heterogeneous magnetic film (PDMS/NiFe/FeMn), which achieves synergistic amplification of surface stress and geometric deformation under magnetic field modulation, thereby breaking through the sensitivity bottleneck of conventional designs. The sensor architecture leverages the high magnetic permeability of NiFe and the magnetostrictive effect of FeMn to construct a magneto-mechanical coupling interface: the NiFe layer efficiently transduces magnetic field energy, while the FeMn layer actively deforms to amplify the surface stress generated by target binding (Tau protein).

Thermosensitive polygalacturonic acid glycoprotein hydrogel encapsulating bionic shikonin nanoparticles for the treatment of psoriasis.

Psoriasis is histopathologically characterized by hyperproliferation of keratinocytes, loss of the granular layer, and elongation and thickening of the rete ridges in the epidermis. The thickening of the stratum corneum in psoriatic skin poses a significant barrier to effective drug delivery, as many therapeutic agents with poor solubility, limited release, and side effects struggle to penetrate the skin and achieve prolonged retention, thereby limiting their therapeutic efficacy. To address these challenges, we developed a non-invasive transdermal delivery system.

Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice.

With increasing age, skeletal muscle gradually loses mass and strength, and the risk of falls and fractures escalates among elderly individuals. Inflammation is closely related to age-related muscle atrophy and is the potential target for treating muscular atrophy. Here, biomimetic curcumin nanoparticles (M12MNCs) are prepared via encapsulating curcumin in the skeletal muscle cell membranes modified via muscle-homing peptides (M12) for the treatment of aging related skeletal muscle atrophy.

Trends in research on preterm birth in twin pregnancy based on bibliometrics.

Background: Twin pregnancies are associated with a higher risk of perinatal mortality compared to singleton pregnancies. This study evaluated the developmental trends and summarized the key features of research on preterm births in twin pregnancies.

Methods: A bibliometric analysis was conducted using publications on preterm births in twin pregnancies from 2014 to 2023, retrieved from the Web of Science Core Collection database.

Paclitaxel-Ang-2-functionalized bionic mesoporous selenium nanoparticles for targeted therapy of glioma.

Glioma, the most prevalent primary intracranial tumor, presents significant clinical treatment challenges due to its high invasiveness and therapeutic resistance. Therefore, the development of a targeted therapeutic agent that is both highly effective and low in toxicity is crucial. In this research, we aimed to design a bionic mesoporous selenium nanoparticle (ACMLMSeP) functionalized with paclitaxel and Ang-2 for nasal administration as a targeted treatment approach for glioma.

Cryptotanshinone alleviates cerebral ischemia reperfusion injury by regulating ferroptosis through the PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway.

Ethnopharmacological Relevance: The Cryptotanshinone (CT) is a kind of Chinese medicine extracted from salvia miltiorrhiza, which has various pharmacological activities and is widely used in the treatment of diseases.

Aim Of The Study: The objective is to delve into the mechanism by which cryptotanshinone (CT) exerts its effects on rats with the middle cerebral artery occlusion/reperfusion (MCAO/R) model. Additionally, it aims to further assess the interplay between inflammation and oxidative stress, along with the underlying mechanism of CT's anti-ferroptosis function.

Dextran sulfate-coated curcumin nanocrystals for the treatment of DSS-induced ulcerative colitis in mice.

Ulcerative colitis is an inflammatory disease that primarily involves intestinal inflammation and epithelial damage. The nano-targeted drug delivery system delivers drugs to the disease site, exerting effects such as inhibiting inflammatory response and reducing reactive oxygen species expression, thereby promoting recovery from ulcerative colitis. In this experiment, dextran sulfate-coated curcumin nanocrystals (NBD) were prepared for the oral treatment of ulcerative colitis (UC).

Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis.

In this study, we developed calcium alginate-coated nanovesicles derived from macrophage membranes loaded with berberine (Ber@MVs-CA) for the oral treatment of ulcerative colitis (UC). Ber@MVs-CA demonstrates resistance to gastric acid and controlled drug release in the colonic pH environment, while actively targeting sites of ulcerative colitis injury. pH-responsive release of Ber in Ber@MVs-CA was confirmed through in vitro release experiments.

Preparation of Biomimetic Selenium-Baicalein Nanoparticles and Their Targeted Therapeutic Application in Nonsmall Cell Lung Cancer.

In this study, we prepared bionic selenium-baicalein nanoparticles (ACM-SSe-BE) for the targeted treatment of nonsmall cell lung cancer. Due to the coating of the A549 membrane, the system has homologous targeting capabilities, allowing for the preparation of target tumor cells. The borate ester bond between selenium nanoparticles (SSe) and baicalein (BE) is pH-sensitive and can break under acidic conditions in the tumor microenvironment to achieve the targeted release of BE at the tumor site.

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.

Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization. Exosomes show potential as ideal delivery vehicles. However, an affordable generalizable system for efficient loading of oligonucleotides on exosomes remain lacking.

Functional imaging and targeted drug delivery in mice and patient tumors with a cell nucleolus-localizing and tumor-targeting peptide.

Tumor-targeting peptides have profound clinical implications in early detection and delineation of microscopic lesions for surgical resection, and also delivery of therapeutics with reduced systemic toxicity. Here, we demonstrate that a peptide (RS), evolved from a previously reported hepatocellular carcinoma (HCC)-targeting peptide P47, enables improved HCC micrometastasis discrimination and delineation from noncancerous tissues in murine orthotopic mice and patient biopsies, with up to 21-fold contrast. Importantly, RS targets non-small cell lung (NSCLC) and colon cancers in mice and patient biopsies, with higher selectivity for highly proliferative tumor nodules.