Trophodynamic mechanisms of per- and polyfluoroalkyl substances in oligotrophic ecosystem from the Tibetan Plateau river.

Tibetan Plateau (TP) is known as the Third Pole, yet little is known about environmental behavior and trophodynamic of PFAS in pristine ecosystem linked to accelerated glaciers melting. We characterized sediment-water partition behaviors in high-altitude region, compared trophic magnification potential between different climatic zones, and used structural equation model (SEM) to link geographic, biologic variability to PFAS bioaccumulation. Short-chained (including PFBA and PFBS) were predominant in water, whereas long-chained (6:2 FTS, PFOS) contributed more in organisms from Yarlung Tsangpo River, suggesting long-chain dependence bioaccumulation potential.

Occurrence, spatial distributions, sources, and potential risks of organophosphate esters in Yarlung Tsangpo River and its main tributaries on the Tibetan Plateau.

Organophosphate esters (OPEs) are extensively utilized as flame retardants and plasticizers in a wide range of products. Because of their high solubility, mobility, and persistence, OPEs are frequently detected in aquatic environments with relatively high concentrations and may pose risks to the ecosystem and human health. In the present study, the occurrence, spatial distributions, influencing factors, sources, and potential risks of eight OPE congeners in the Yarlung Tsangpo River and its main tributaries (the Lhasa, Nianchu, and Niyang Rivers) in the summer were investigated.

Homologues of PFOA substitutes in a semi-closed bay near source region: contamination status and risk assessments.

Laizhou Bay (LZB) is heavily polluted by perfluoroalkyl substances (PFAS), especially perfluorooctanoic acid (PFOA), from the nearby industrial emission. PFOA has been subjected to strict control, leading to the increasing use of PFOA substitutes. However, the present pollution status of PFOA substitutes in the LZB area is unclear.

Long non-coding RNA in IgA nephropathy: a comprehensive review.

Immunoglobulin A nephropathy (IgAN) stands as the most prevalent primary glomerulonephritis globally, almost half of patients progress to end-stage kidney disease (ESKD). However, the precise pathogenesis of IgAN remains elusive. Long non-coding RNAs (lncRNAs), non-protein-coding transcripts that regulate gene expression, have been found to exhibit distinct expression patterns in various disease states.

The impact of water-sediment regulation scheme (WSRS) on the chemistry of dissolved organic matter in the Yellow River estuary and adjacent waters.

Dissolved organic matter (DOM) plays important roles in the global carbon cycle and aquatic ecosystem health. Estuaries are critical zones connecting land and ocean in which DOM experiences dispersion, transformation, degradation, deposition, etc. The Water-sediment regulation scheme (WSRS) was implemented in Yellow River (YR) and approximately half of annually sediment and a quarter of annually water were poured into estuary in around 20 days.

The role of JPX in regulating FUS/SLC7A11 signaling pathway mediated ferroptosis in keloid fibroblasts and its potential in scar repair.

Background: Keloid scar, a fibrotic disease initiated by aberrant fibroblast proliferation, is influenced by ferroptosis. This investigation aims to elucidate the mechanism of lncRNA JPX regulating ferroptosis in keloid fibroblasts.

Methods And Results: We procured 30 samples of keloid tissue and adjacent normal skin tissues from patients undergoing treatment for keloid scars, subsequently isolating fibroblasts from both the keloid lesions and unaffected portions.

Predictive Framework for Species Sensitivity Distribution Curves of Emerging Contaminants: A Comparative Study in Marine and Freshwater Environments.

Emerging pollutants increasingly threaten aquatic ecosystems and human health. However, the risk assessment of these pollutants is constrained by insufficient toxicity data for aquatic species. In this study, a predictive framework has been established to predict the toxicity of potential pollutants across 16 aquatic species, including marine and freshwater species of varying trophic levels and to simulate their species sensitivity distributions (SSDs).

Partitioning behavior of short-chain legacy and novel perfluorinated substances (PFAS) between dissolved and particulate phases in a river-estuary-coast continuum.

In this study, legacy and novel perfluoroalkyl substances (PFAS) in dissolved and particulate phase samples of Xiaoqing River from the headwater to estuary region were investigated. The downstream area of Xiaoqing River was found to be heavily influenced by discharged wastewater from a fluorochemical industry park and possessed an extremely high total PFAS concentration (as high as 123,000 ng/L for July and 2,170,000 ng/L for December in dissolved phase, and 33,600 ng/g dw for July and 741,000 ng/g dw for December in suspended particulate matter [SPM]). Various PFAS substance were observed in the samples: apart from a high concentration of perfluorooctanoic acid (PFOA), several perfluoropolyether carboxylic acids (PFECAs) were also found in remarkable concentration, constituting ∼17 %-35 % of the dissolved phase.

Effect of ocean dynamic processes on the temporal-spatial pattern of persistent organic pollutants (PCB-153 and BDE-47) in the shelf seas.

Field observations of persistent organic pollutants (POPs) in shelf seas presented abnormal phenomena such as high-concentration patches in offshore areas and different vertical profiles of POPs at the same location. We assumed that these phenomena were associated with the presence of bottom cold water mass (BCWM) in shelf seas and used a hydrodynamic-ecosystem-POP coupled model to confirm this hypothesis. Based on model results, with the formation of BCWM during summer, POPs accumulated inside BCWM due to their transport across the thermocline by the sorption to sinking particles.

Dissolved N pollution and its biogeochemical constraints along a river-sea continuum of a typical dense oyster mariculture coastal water, northwest South China Sea.

Dissolved nutrients, including nitrate (NO-N) and its dual isotopes (δN-NO and δO-NO) were systematically studied along a river-sea continuum, wherein dense oyster mariculture is implemented, to constrain the pollution sources and biogeochemical cycling mechanisms of nitrogen (N). Total dissolved N, mainly composed of inorganic N, showed strong anthropogenic influence. Based on MixSIAR model results, N pollution was predominantly sourced from sewage/wastewater (55.

On-site evaluation of DGT passive sampling for quantitatively measuring per- and polyfluoroalkyl substances in a river-estuary-sea water system.

The passive sampling technique of diffusive gradients in thin-films (DGT) is promising for monitoring emerging contaminants such as per- and polyfluoroalkyl substances (PFAS). It is urgent to evaluate the impacts of salinity and exposure time on DGT sampling before it can be set as a standard method. Herein, DGT sampler based on the binding gel of weak anion exchanger (WAX) resin was deployed in a representative water system of the Xiaoqing river-estuary-sea for representative sampling windows (<1 day to 28 days) with high pH (8.

Observation-Based Diagnostics of Reactive Nitrogen Recycling through HONO Heterogenous Production: Divergent Implications for Ozone Production and Emission Control.

Understanding of nitrous acid (HONO) production is crucial to photochemical studies, especially in polluted environments like eastern China. In-situ measurements of gaseous and particulate compositions were conducted at a rural coastal site during the 2018 spring Ozone Photochemistry and Export from China Experiment (OPECE). This data set was applied to investigate the recycling of reactive nitrogen through daytime heterogeneous HONO production.

Species-specific and habitat-dependent bioaccumulation of halogenated flame retardants in marine organisms from estuary to coastal seas.

Halogenated flame retardants (HFRs) have attracted global attention owing to their adverse effects on ecosystems and humans. The Shandong Peninsula is the largest manufacturing base for HFRs in East Asia, yet its impacts on marine ecosystems are unclear. Seventeen HFRs were analyzed in organisms captured from the Xiaoqing River estuary, Bohai Sea (BS), Yellow Sea and Northern East China Sea to investigate the distribution and bioaccumulation of HFRs on a broad scale.

Effect of hydrodynamic and ecosystem conditions on persistent organic pollutant temporal-spatial variations in the Yellow Sea.

Coastal seas are important pools of persistent organic pollutants (POPs) discharged from land. Considering the complex conditions in coastal seas and various biochemical features of POPs, special temporal-spatial variations in POPs have been reported. To understand these variations, we developed a three-dimensional hydrodynamic-ecosystem-POP coupled model and applied it to the Yellow Sea.

Distribution, sources, and eco-risk of Current-Use Pesticides (CUPs) in the coastal waters of the northern Shandong Peninsula, China.

This study investigated the spatial distributions and seasonal variations of 19 CUPs in the coastal areas of the Shandong Peninsula and its surrounding rivers and assessed their ecological risk. In freshwater and seawater, insecticides (chlorpyrifos, methoxychlor, and pyridaben), as well as fungicides (fenarimol) and herbicides (dichlobenil) were the main pollutants (Detection Frequency: 100 %). Spatially, during winter, the regional pollution levels of ΣCUPs in seawater showed a trend of Laizhou Bay (LZB, mean:4.

Molecular signatures and formation mechanisms of water-soluble chromophores in particulate matter from Karachi in Pakistan.

Excitation-emission matrix (EEM) fluorescence spectroscopy is a widely-used method for characterizing the chemical components of brown carbon (BrC). However, the molecular basics and formation mechanisms of chromophores, which are decomposed by parallel factor (PARAFAC) analysis, are not yet fully understood. In this study, we characterized the water-soluble organic carbon (WSOC) in aerosols collected from Karachi, Pakistan, using EEM spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).

Nitrate transformation and source tracking of rivers draining into the Bohai Sea using a multi-tracer approach combined with an optimized Bayesian stable isotope mixing model.

Excessive levels of NO can result in multiple eco-environmental issues due to potential toxicity, especially in coastal areas. Accurate source tracing is crucial for effective pollutant control and policy development. Bayesian models have been widely employed to trace NO sources, while limited studies have utilized optimized Bayesian models for NO tracing in the coastal rivers.

Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption.

With the replacement of perfluorooctanoic acid (PFOA) with perfluorinated ether carboxylic acids (PFECAs), residents living near fluorochemical industrial parks (FIPs) are exposed to various novel PFECAs. Despite expectations of low accumulation, short-chain PFECAs, such as perfluoro-2-methoxyacetic acid (PFMOAA), previously displayed a considerably high body burden, although the main exposure routes and health risks remain uncertain. Here, we explored the distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in diverse environmental media surrounding a FIP in Shandong Province, China.

Development of a trace quantitative method to investigate caffeine distribution in the Yellow and Bohai Seas, China, and assessment of its potential neurotoxic effect on fish larvae.

Caffeine is an emerging contaminant in aquatic environments. The study utilized a validated method to investigate the presence and distribution of caffeine in the surface water of the Yellow and Bohai Seas, urban rivers, and the Yantai estuary area. The analytical method conforms to EPA guidelines and exhibits a limit of quantification that is 200 times lower than that of prior investigations.

Spatiotemporal distribution and particle-water partitioning of polycyclic aromatic hydrocarbons in Bohai Sea, China.

The Bohai Sea is one of the most polluted marine areas in China with polycyclic aromatic hydrocarbons (PAHs) due to its unique hydrological and geographical environment. To investigate differences in PAH concentrations, composition, and particle-water partitioning before and after the rainy reason, water samples were collected during two surveying voyages covering most of the area of the Bohai Sea. Total and dissolved PAH concentrations were higher during the June voyage (total PAHs: 32.

Riverine microbial communities impacted by per- and polyfluoroalkyl substances (PFAS) emissions from a fluoropolymer-manufacturing plant.

Per- and polyfluoroalkyl substances (PFAS) are widespread pollutants that can influence microorganisms. To unveil the effects of PFAS in natural microecosystems, a study that focused on the bacterial, fungal, and microeukaryotic communities around the PFAS point source was conducted in China. A total of 255 specific taxa were significantly different between the upstream and downstream samples, 54 of which were directly correlated with PFAS concentration.

Trophic behaviors of PFOA and its alternatives perfluoroalkyl ether carboxylic acids (PFECAs) in a coastal food web.

With the increasing restrictions and concerns about legacy poly- and perfluoroalkyl substances (PFAS), the production and usage of alternatives, i.e., perfluoroalkyl ether carboxylic acids (PFECAs), have risen recently.

Microcosm experiment to test bacterial responses to perfluorooctanoate exposure.

The impact of perfluoroalkyl and polyfluoroalkyl substances on microbial communities is challenging to investigate in situ because of the complexity and dynamics of natural ecosystems. In the present study, four microcosms were established to explore the impact of perfluorooctanoate (PFOA) on bacterial communities in riverine and marine settings. PFOA distribution between the aqueous and sedimentary phases fluctuated in both PFOA-amended and unamended control systems.