"We feel like a family here": person-centered outcomes of adult day services use from the voices of people living with dementia and their caregivers.

Background: As the number of persons living with dementia (PLWD) grows, there is a pressing need for person-centered long-term care solutions that prioritize their experiences. Adult day centers (ADCs) play a critical role in supporting PLWD, yet most research focuses on outcomes relevant to caregivers and payors rather than the voices of those receiving care. This study explores PLWD’s firsthand perspectives on their ADC experiences, using Kitwood’s (1997) person-centered dementia care framework which identifies five key psychological needs: inclusion, attachment, comfort, occupation, and identity.

Beyond the Microbiome: The Gut's Role in Hypertension.

This review emphasizes the importance of investigating the gut itself-beyond microbiota-centered studies in the context of hypertension. Since the initial discovery of the connection between gut microbiota and blood pressure regulation, research has increasingly focused on understanding the role of gut microbiota and exploring strategies to modify it for better blood pressure management. The intestine as an organ has received comparatively less attention.

Feature-guided multilayer encoding-decoding network for segmentation for 3D intraoral scan data.

Accurate segmentation of malocclusion is crucial in orthodontic diagnosis and treatment planning, but existing deep learning methods seriously affect the reliability of clinical applications due to poor robustness and feature confusion between neighboring tooth classes when dealing with malocclusion. To address this problem, a U-shaped 3D dental model segmentation method based on hierarchical feature guidance is proposed. First, a feature-guided deep encoder architecture is constructed, which introduces a normalization method that combines the local mean with the global standard deviation.

Trophodynamic mechanisms of per- and polyfluoroalkyl substances in oligotrophic ecosystem from the Tibetan Plateau river.

Tibetan Plateau (TP) is known as the Third Pole, yet little is known about environmental behavior and trophodynamic of PFAS in pristine ecosystem linked to accelerated glaciers melting. We characterized sediment-water partition behaviors in high-altitude region, compared trophic magnification potential between different climatic zones, and used structural equation model (SEM) to link geographic, biologic variability to PFAS bioaccumulation. Short-chained (including PFBA and PFBS) were predominant in water, whereas long-chained (6:2 FTS, PFOS) contributed more in organisms from Yarlung Tsangpo River, suggesting long-chain dependence bioaccumulation potential.

Kinetics of Proton Transfer and String of Conformational Transformation for 4-Pyridone-3-carboxylic Acid Under External Electric Field.

In order to explore the essence of the anticoccidiosis of anticoccidial drugs under bioelectric currents, the intermolecular double-proton transfer and conformational transformation of 4-pyridone-3-carboxylic acid were investigated by quantum chemistry calculations (at the M06-2X/6-311++G**, M06-2X/aug-cc-pVTZ and CCSD(T)/aug-cc-pVTZ levels) and finite temperature string (FTS) under external electric fields. The solvent effect of HO on the double-proton transfer was evaluated by the integral equation formalism polarized continuum model. The results indicate that the influences of the external electric fields along the direction of the dipole moment on double-proton transfer are significant.

Angle-controlled synthesis and redox properties of a tetraphenylethene-based hexacationic triangular macrocycle.

A tetraphenylethene-based hexacationic triangular macrocycle (T·6PF) was synthesized the Zincke reaction using an angle-controlled synthesis strategy. Under chemical or electrochemical reduction conditions, T·6PF can undergo two-step reversible and stable redox transformations, accompanied by a distinct visual color change.

Ferroelectric small molecule enabled high-performance zinc-ion batteries.

To address the challenges of zinc-anode corrosion, hydrogen evolution reactions and dendrite growth in aqueous zinc-ion batteries, we introduce tetraethylammonium perchlorate (TEACC) as ferroelectric small molecules additives in an aqueous electrolyte. The TEACC molecules partially replace water molecules in the Zn solvation sheath and enrich the electrode/electrolyte interface with TEACC-OTf, creating a water-deficient inner Helmholtz plane. As a result, the activity of free water is suppressed and the hydrogen-evolution potential shifts from -0.

High-Efficiency Screening of Compounds Targeting Postmenopausal Osteoporosis in Cuscutae Semen Based on Affinity Ultrafiltration-UPLC-QE-Orbitrap-MS Platform.

Introduction: Postmenopausal osteoporosis, a skeletal disorder induced by estrogen deficiency, is commonly addressed in clinical practice through the use of Cuscutae semen and its compound formulations, owing to their significant therapeutic efficacy.

Objective: This study sought to systematically identify bioactive compounds present in Cuscutae semen that interact with estrogen receptor β (ESR2) using Affinity Ultrafiltration combined with Ultra-Performance Liquid Chromatography-Quadrupole-Orbitrap Mass Spectrometry (UPLC-QE-Orbitrap-MS) to find possible therapy options for PMOP.

Methods: The Cuscutae semen extract was fractionated using a C18 column to obtain fractions based on distinct polarity.

Tetrahydroindazolone-substituted Benzamide Compound W-H4 Induces Apoptosis and Autophagy of Acute Myeloid Leukemia Cells.

Background/aim: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy. Hsp90 inhibitors, like SNX-2112, are promising anti-cancer agents. However, SNX-2112's clinical use is limited by poor solubility and side effects.

NIR-triggered temperature-sensitive polydopamine nanosystem with rapid phase transition for on-demand release to enhance antibacterial and antibiofilm performance.

The antibiotic abuse and bacterial biofilm barriers pose a formidable challenge to global public health. To address this issue, we developed a near-infrared (NIR)-triggered temperature-sensitive polydopamine nanosystem (PDA@Ag@Cur@PCM) by integrating silver nanoparticles (AgNPs) and curcumin (Cur) with the phase change material 1-tetradecanol. The system achieved NIR-triggered on-demand drug release and synergistic photothermal-chemo antibacterial, significantly enhancing antibacterial and antibiofilm efficacy.

Exploring the Influence of Left Dorsolateral Prefrontal Cortex Intermittent Theta-Burst Stimulation on Working Memory Load: An EEG Study in Healthy Participants.

Aims: Working memory (WM), a short-term cognitive process involving the prefrontal cortex, is critical for daily functioning. This study investigated the effects of iTBS on WM performance and its neural mechanisms in healthy adults.

Methods: Thirty-one healthy adults completed 1-back and 2-back tasks while undergoing EEG recording.

Myeloid-Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that expand aberrantly in cancer and exhibit potent immunosuppressive properties. They contribute to tumor progression through both immunological and nonimmunological mechanisms. Immunologically, MDSCs suppress antitumor responses by inhibiting effector cells such as T cells and NK cells, facilitating immune evasion.

Intervention of Bazi Bushen Capsule on Benign Prostatic Hyperplasia Concomitant with Erectile Dysfunction Induced by Testosterone Supplementation in Spontaneously Hypertensive Rats.

Objective: To explore the intrinsic relationship between benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) and evaluate the therapeutic effects of Bazi Bushen Capsule (BZBS).

Methods: A model of BPH concomitant with ED was established by using testosterone-supplemented spontaneously hypertensive rats (SHRs). Forty SHRs were divided into 4 groups based on the random number table (n=10 per group), including the model group (SHR+T), the BZBS low-dose group (SHR+T+BZ-low), the BZBS high-dose group (SHR+T+BZ-high), and the finasteride group (SHR+T+Fi).

Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers.

Mitochondrial dysfunction is one of the important signs of cellular and even individual aging. Ganoderma lucidum is a common edible and medicinal mushroom, widely used as a functional food in Asia. This study investigated the potential anti-aging effects of Ganoderma lucidum extract (GLE).

Negative experiences of undergraduate nursing students in simulation training: A meta-synthesis of qualitative studies.

Background: Currently, simulation training programs are widely used in the teaching of undergraduate nursing students. Studies has focused more on the positive experiences of learners and less on the negative experiences, which hinders the improvement and upgrading of nursing simulation training programs.

Purpose: To systematically synthesize qualitative data on the negative experiences of undergraduate nursing students in simulation training.

Regulating Amine Substitution in Fluorosulfonyl-Based Flame-Retardant Electrolytes for Energy-Dense Lithium Metal Batteries.

Sulfone-based electrolytes offer unusually high anodic and thermal stability that in principle makes them promising candidates for fabricating energy-dense lithium metal batteries (LMBs). Their uses in practical batteries are currently limited by their inability to sustain long-term Li metal plating/stripping processes due to their high reactivity toward the Li metal. Here, we report on the design and synthesis of a unique family of fluorosulfonyl group-based (FSO) molecules, modified with ethyl (FSE)/,-dimethyl (FSNDM)/,-diethyl (FSNDE)/-pyrrolidine (FSNP) end groups to create exceptionally stable single-salt single-solvent electrolytes.

Synergistic ionic modification strategy enhances the stability of naphthalene diimide zwitterions for cost-effective aqueous organic redox flow batteries.

Aqueous organic redox flow batteries (AORFBs) hold significant promise for energy storage due to their unique advantages and characteristics. However, their development is hindered by the lack of decomposition resistance and cycle stability over long periods. In this study, we synthesized naphthalene diimide (NDI) derivatives with zwitterions in their side chains via the atmospheric pressure method, namely and .

An RNA helicase coordinates with iron signal regulators to alleviate chilling stress in Arabidopsis.

Chilling stress is one of the major environmental stresses that restrains plant development and growth. Our previous study showed that a potential iron sensor BTS (BRUTUS) was involved in temperature response in Arabidopsis plants. However, whether plant iron homeostasis is involved in plant response to temperature fluctuation is not known.

Assessing Dynamic Capabilities in Adult Day Services: A Pilot Study for Measurement Development.

Research on Community-based Adult Day Services (ADS) primarily focuses on individual-level outcomes, often neglecting broader organizational factors that impact service quality and accessibility. In this study, we aim to develop a structured tool to assess the dynamic capabilities of ADS to meet the needs of a diversifying aging population. Utilizing a mixed-method approach, including literature review, expert consultations, online surveys, and interviews, we formulated a theory-driven set of measures.

Effect of Brain Computer Interface Training on Frontoparietal Network Function for Young People: A Functional Near-Infrared Spectroscopy Study.

Aims: Inattention in young people is one of the main reasons for their declining learning ability. Frontoparietal networks (FPNs) are associated with attention and executive function. Brain computer interface (BCI) training has been applied in neurorehabilitation, but there is a lack of research on its application to cognition.

iTBS over the left hV6A enhances PPC-PPC functional connectivity during reaching tasks: an EEG study.

Introduction: The functional connectivity of the posterior parietal cortex-primary motor cortex (PPC-M1) is involved in goal-directed reaching actions and integrating visuomotor transformation. Human area V6A (hV6A), located in the medial PPC, is a critical node of the dorsomedial system that is involved in targeting during reaching movements. Here, we used Electroencephalography (EEG) to investigate functional connectivity and network efficiency during right-hand reaching tasks after inducing left hV6A activity with intermittent theta burst stimulation (iTBS).

Gas concentration prediction in photoacoustic spectroscopy using PSO-EAP-CNN to address correlation degradation.

Photoacoustic spectroscopy (PAS) gas detection is frequently compromised by noise-induced correlation degradation, which significantly impacts measurement accuracy. To mitigate this issue, an advanced convolutional neural network (CNN) architecture, termed PSO-EAP-CNN, is proposed, which combines particle swarm optimization (PSO) with an ensemble augmented prediction (EAP) strategy. The proposed framework employs a multi-scale feature extraction mechanism through its convolutional architecture, while simultaneously optimizing network parameters via PSO, thereby achieving accelerated convergence and improved prediction stability.

['s experience in treatment of post-stroke depression with holistic therapy of acupuncture and moxibusiton for ].

This paper introduces 's clinical experience in treatment of post-stroke depression with holistic therapy of acupuncture and moxibusiton for (soothing the liver and regulating the mind). In pathogenesis, post-stroke depression is associated with the loss of the mind control and the failure of the liver in maintaining the free flow of . In treating principle, soothing the liver and regulating the mind are equally important, and the holistic regulation is applicable with the combination of multiple therapies.

Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy.

Nonhistone acetylation plays a crucial role in key cellular processes associated with ageing, such as autophagy. Heat shock cognate protein 70 (Hsc70), a vital chaperone protein for chaperone-mediated autophagy (CMA), exerts a molecular chaperone function that is regulated by its acetylation status. However, the effects of this acetylation on CMA and granulosa cell senescence remain unclear.