Characterization of peptide-enriched walnut meal paste via microbial diversity and metabolite profiling.

Walnut meal (WM), a protein-rich byproduct of oil extraction, holds great potential for conversion into value-added food products but remains underutilized. In this study, a two-stage fermentation process involving Aspergillus oryzae inoculation for koji preparation followed by natural brine fermentation was developed to produce a peptide-enriched walnut meal paste (WMP). Physicochemical analysis showed significant increases in total acidity (0.

The FN1-targeted delivery of low-molecular-weight heparin to venous clots revolutionizes thrombosis treatment in CVT.

The systemic administration of low-molecular-weight heparin (LMWH) as the standard initial treatment for venous thromboembolism is intended to prevent thrombus growth during the acute phase and prevent thrombus recurrence during the chronic phase. However, precisely controlling the specificity and localization of LMWH presents significant challenges, which has necessitated research into targeted delivery methods. Furthermore, due to different thrombosis mechanisms, tailored pharmacologic interventions are needed, particularly for arterial and venous thrombosis.

Beyond the Microbiome: The Gut's Role in Hypertension.

This review emphasizes the importance of investigating the gut itself-beyond microbiota-centered studies in the context of hypertension. Since the initial discovery of the connection between gut microbiota and blood pressure regulation, research has increasingly focused on understanding the role of gut microbiota and exploring strategies to modify it for better blood pressure management. The intestine as an organ has received comparatively less attention.

A Shape-Recovery Polycationic Fibroin for Hemostasis-Regeneration Transition by Recapitulating Natural Coagulation Networks.

Large-scale and deep trauma restricts the effective hemostasis and tissue regeneration management, even causing death. The formation of the fibrin network is the initial stage of wound control. Inspired by Fn's characteristics during coagulation, an artificial polycationic fibroin (pCSF/β) is designed to achieve hemostasis-regeneration transition.

A New Design Strategy of Schiff-Base Cage Structure for Exceptional Strength-Toughness Waterborne Polyurethanes Toward Application in Infrared Stealth.

To address the escalating industrial demands for high-performance polymers with both superior strength and toughness, a unique boronic acid imine cage (BIC) compound containing a Schiff-base structure is innovatively synthesized and covalently incorporated into the molecular chains of waterborne polyurethanes to obtain the elastomers (DWPU-BIC-x) with outstanding strength, toughness, tear resistance, and fatigue resistance. In-depth mechanism analysis reveals that BIC functions as a "structural hub", leveraging its rigid cage-like geometry and high-density interaction sites (aromatic rings for π-π stacking and nitrogen atoms for hydrogen bonding) to modulate molecular chain movement and intermolecular forces, thereby facilitating efficient energy dissipation under mechanical stress. The optimized material achieves an outstanding strength (53.

Growth differentiation factor 11 attenuates sepsis-associated acute kidney injury by reducing inflammation and coagulation via PGC-1α/Nrf2 activation.

Background: Patients with sepsis commonly endure severe renal dysfunction and damage, hastening to end-stage renal failure with high mortality, and effective treatment options are currently lacking. Growth differentiation factor 11 (GDF11), belonging to the transforming growth factor beta (TGF-β) superfamily, has shown therapeutic potential for numerous acute and chronic inflammatory conditions. Nevertheless, its function in sepsis-associated acute kidney injury (SAKI) remains unclear.

Maintaining Balance: An Update on Nonpharmacological Cytoprotection Therapy for Acute Ischemic Stroke.

Reperfusion therapies have become the standard of care for patients with acute ischemic stroke (AIS). However, around half of treated patients do not regain functional independence despite successful recanalization. Potentially avoidable unbalanced states that prevail both before and after reperfusion therapy might account for such unfavorable functional outcomes.

NtPP2C42 negatively regulates NtCLE3-NtBAM3-3 mediated drought tolerance in tobacco.

Members of the BAM family, as plant leucine-rich repeat receptor-like kinases (LRR-RLKs), play essential roles in the recognition and signaling of CLE peptides. Previous studies have demonstrated that NtCLE3 enhances drought resistance in Solanaceae crops. In this study, we showed that NtCLE3 induces stomatal closure in Arabidopsis, with the Atbam3 mutant failing to respond, underscoring the critical role of AtBAM3 in perceiving this peptide.

Mitochondrial Regulation of Spermatozoa Function: Metabolism, Oxidative Stress and Therapeutic Insights.

Mitochondria are central to energy production and redox regulation in spermatozoa, supporting key functions such as progressive motility, capacitation, and the acrosome reaction. These processes are essential for successful fertilization and embryo development. However, species-specific differences exist in the reliance on oxidative phosphorylation versus glycolysis.

hypomethylation drives oncogenic signaling and stratifies poor prognosis in juvenile myelomonocytic leukemia.

Background: , an oncofetal RNA-binding protein regulating stem cell self-renewal and oncogenic signaling via let-7 miRNA suppression, is implicated in diverse malignancies but remains poorly characterized in juvenile myelomonocytic leukemia (JMML). Despite its reported overexpression in approximately 50% of JMML cases, the epigenetic mechanisms driving dysregulation and its clinical relevance for risk stratification are undefined. Therefore, this study aimed to elucidate the epigenetic regulation of in JMML, and determine its potential as a biomarker for risk stratification.

Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis.

Objective: While growing evidence supports the Geriatric Nutritional Risk Index (GNRI) as a prognostic indicator for various cancers, its predictive value in pancreatic cancer remains unclear. This meta-analysis systematically evaluates GNRI's ability to predict postoperative complications and long-term outcomes in pancreatic cancer patients.

Methods: We conducted a comprehensive literature search across nine databases (Web of Science, PubMed, Embase, Cochrane Library, Scopus, WanFang, CNKI, VIP, and SinoMed) through June 1, 2025.

Flexible porous carbon fiber composite electrodes for hydrogen and chlorine production with antibacterial applications.

Flexible porous carbon fiber composite electrodes (Pt@C-PES cathode/RuO@C-PES anode) for hydrogen and chlorine evolution reactions (HER/CER) in acidic NaCl electrolyte (1 M HCl + 5 M NaCl) were developed in this work. Functionalized with Pt and RuO electrodeposition and drop-coating, the electrodes demonstrated low overpotentials of 71 mV@25 mA cm (HER) and 77 mV@25 mA cm (CER). When applied in a two-electrode H-cell system, faradaic efficiencies of 99.

Sorption and Utilization of Per- and Polyfluoroalkyl Substances in Rechargeable Zinc-Ion Batteries.

Per- and polyfluoroalkyl substances (PFAS) are synthetic fluorinated organic compounds linked to severe health issues, highlighting the urgent need for environmentally sustainable remediation strategies. Here, an integrated PFAS sorption and utilization strategy for remediation is reported through incorporating into rechargeable aqueous zinc battery systems at room temperature. As a representative PFAS compound, perfluorooctanoic acid (PFOA) is successfully sorbed on zinc surface via hydrophobic and electrostatic interactions, with over 98% removal efficiency, and partially defluorinated into zinc fluoride after 24 h, enabling their application as an anode protective layer for improved battery performance.

Asparagine synthetase modulates glutaminase inhibitor sensitivity through metabolic reprogramming and serves as a prognostic biomarker in hepatocellular carcinoma.

Glutamine addiction represents a metabolic vulnerability in hepatocellular carcinoma (HCC), making glutaminase inhibitor CB-839 therapy a promising approach. However, effective therapeutic strategies are not yet available. In this study, we aim to investigate the potential role of asparagine synthetase (ASNS) as a target for HCC therapy during CB-839 treatment.

Construction of g-CN Metal-Free Heterostructure Film for Enhanced Photocatalytic Degradation of Organic Pollutants.

Traditional photocatalytic systems often face significant challenges in nanocatalyst recovery from aqueous solutions, hindering their practical implementation in industrial-scale wastewater remediation. In this study, graphitic carbon nitride (g-CN) metal-free heterostructure film was spontaneously coassembled at the gas-liquid interface, with a uniform film structure of g-CN, well-stacked graphene oxide, and hexagonal boron nitride over centimeters in size. The van der Waals heterostructure film exhibits excellent photocatalytic performance behavior and broadband photoperception from 450 to 550 nm.

Symmetric Group Semiempirical Valence Bond Method for Large Conjugated Molecules.

Based on the theory of symmetric group representations, we propose the symmetric group semiempirical valence bond (SGSVB) method for handling large molecular systems. In this approach, the bonded tableau functions are employed to directly construct the VB wave function rather than manipulating a large number of determinants. By truncating the overlap integrals between orbitals in the SGSVB method, efficient calculation of matrix elements is achieved.

Albumin for patients with acute large-vessel occlusive stroke undergoing endovascular therapy (ARISE): the protocol of a randomized double-blind trial.

Background: Albumin is a multifunctional plasma protein that is mainly synthesized in the liver and may play a neuroprotective role in treating acute ischemic stroke (AIS). The efficacy of albumin in patients with AIS receiving reperfusion therapy remains unknown.

Methods: ARISE is a multicenter, randomized, double-blind, placebo-controlled, phase 2 study.

Binocular vs. monocular 3D cues in multiple object tracking: expertise differences between soccer players and non-athletes.

Classical two-dimensional multiple object tracking (2D-MOT) measures the cognitive ability to track multiple moving elements in real-life-like scenarios. Stereo-three-dimensional MOT (S-3D-MOT), a more ecologically valid form of 2D-MOT, shows better tracking performance in soccer players. Its unique feature is the additional binocular and monocular 3D cues compared to 2D-MOT, but their individual contributions to MOT performance are unclear.

Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients.

The tumor ecosystem heterogeneity of papillary thyroid carcinoma (PTC) is poorly characterized in children and young adult patients (CAYA-PTC). In this study, single-cell RNA sequencing is used to profile transcriptomes from the paratumor and tumor tissues of 11 patients. Compared to adult, CD4T_Tfh and CD8T_Tex cells are significantly more prevalent in CAYA-PTC patients.

Self-Assembled Ion Transport Channels in Block Copolymer Electrolytes for Dendrite-Free All-Solid-State Sodium Batteries.

Sodium metal batteries are a promising low-cost alternative to lithium-based systems, offering abundant raw materials and high energy density. However, their development is hindered by challenges such as dendrite growth and interfacial instability, which compromise safety and cycling performance. To address these issues, we report a new class of fluorinated, ion conducting block copolymer electrolytes designed to self-assemble into well-defined ion transport channels.

Everolimus alleviates cognitive dysfunction in 5×FAD mice by regulating mitochondrial function and oxidative stress.

Everolimus, a well-characterized inhibitor of the mammalian target of rapamycin (mTOR), has been extensively profiled in both preclinical and clinical studies. Accumulating evidence from recent studies suggests that mTOR inhibitors potentially possess the capacity to protect against various age-related diseases. Nevertheless, the impacts of Everolimus on cognitive function and the underlying mechanisms remain underexplored.

Advanced mineralization of refractory contaminants by synergistic Cu(III)-O and O in doubly charged oxygen vacancy-mediated peroxymonosulfate activation.

The synergistic system integrating O-driven hydroxylation with Cu(III)-O-mediated single-electron transfer oxidation is expected to achieve efficient mineralization of contaminant. The targeted construction of the Cu(III)-O and O synergistic system is promising but limited by *SO formation and two-electron reaction barriers. Doubly charged oxygen vacancy (V) is expected to address these limitations by reducing the electron density at Cu sites.

Characterising and Evaluating the Immune Microenvironment Landscapes of Colorectal Cancer Shaped by Different Therapies.

Colorectal cancer (CRC) occurs as the third most common cancer with high mortality across the world. Understanding the intratumoral immune cell heterogeneity and their responses to various therapies is crucial for enhancing patient outcomes. This study aimed to characterise and evaluate the immune microenvironment landscapes of CRC shaped by different therapies including CD73 inhibitor, PD-1 blockade and photothermal therapy (PTT).