Metallothionein 2A-Silencing Antimonene-Based Nanoagonist for Amplifying the Photothermal Immunotherapy of Gynecologic Malignancy.

Gynecologic malignancies are prone to metastasis and recurrence due to the low efficacy and sensitivity of current clinical treatments. Here, we construct ultrasmall Sb@Au nanodots (Sb@Au NDs) as a metallothionein 2A (MT 2A)-silencing nanoagonist for effective photothermal immunotherapy of gynecologic malignancies. Sb@Au NDs show high photothermal conversion efficiency of 56.

Extracoronary Arterial Pathologies in Patients With Spontaneous Coronary Artery Dissection (SCAD).

Background/objective: Spontaneous coronary artery dissection (SCAD) is increasingly recognized as a cause of acute coronary syndrome and has been associated with extracoronary arteriopathies, such as fibromuscular dysplasia (FMD), aneurysms, and dissections across other vascular beds. However, these associations remain understudied in the literature. This study aims to characterize the prevalence and distribution of extracoronary arteriopathies in a large cohort of SCAD patients.

Ultrastrong circularly polarized electroluminescence achieved by chiral co-assembly of a liquid crystal-functionalized carbazole derivative.

Circularly polarized organic light-emitting diodes (CP-OLEDs) exhibiting circularly polarized electroluminescence (CP-EL) properties hold significant promise for future display technologies. However, enhancing the electroluminescence dissymmetry factor ( ) remains a substantial challenge. Herein, ultrastrong CP-EL emissions are achieved using a liquid crystal (LC)-functionalization strategy under the regulation of chiral co-assembly.

Recent Advances in Metasurfaces: From THz Biosensing to Microwave Wireless Communications.

In recent years, important progress has been made in the field of biosensing and wireless communications by using metamaterials and metasurfaces. These technologies enable efficient manipulation of electromagnetic waves through judiciously designed subwavelength structural units. This review begins by focusing on the design and optimization of terahertz metasurface sensors, emphasizing their unique advantages in biomedical diagnostics.

A Shape-Recovery Polycationic Fibroin for Hemostasis-Regeneration Transition by Recapitulating Natural Coagulation Networks.

Large-scale and deep trauma restricts the effective hemostasis and tissue regeneration management, even causing death. The formation of the fibrin network is the initial stage of wound control. Inspired by Fn's characteristics during coagulation, an artificial polycationic fibroin (pCSF/β) is designed to achieve hemostasis-regeneration transition.

Transcriptomic Plasticity in the Small Hive Beetle () Under Heat Stress.

Global warming is increasing in severity, affecting insects across various biological species. This study investigated the heat resistance ability of the small hive beetle () by studying gene expression under heat stress and showed that exhibits strong heat resistance and transcriptomic plasticity under heat stress. RNA-seq analysis identified 547, 1127, and 866 differentially expressed genes (DEGs) at 38 °C, 42 °C, and 46 °C, respectively, compared to 25 °C.

Deep learning-based prediction of axillary pathological complete response in patients with breast cancer using longitudinal multiregional ultrasound.

Background: Noninvasive biomarkers that capture the longitudinal multiregional tumour burden in patients with breast cancer may improve the assessment of residual nodal disease and guide axillary surgery. Additionally, a significant barrier to the clinical translation of the current data-driven deep learning model is the lack of interpretability. This study aims to develop and validate an information shared-private (iShape) model to predict axillary pathological complete response in patients with axillary lymph node (ALN)-positive breast cancer receiving neoadjuvant therapy (NAT) by learning common and specific image representations from longitudinal primary tumour and ALN ultrasound images.

Effects of changes in rumen microbial adaptability on rumen fermentation and nutrient digestion in Horqin beef cattle during different seasons of grazing and supplementary feeding.

Background: The purpose of this study was to investigate the effects of changes in rumen microbial adaptability on rumen fermentation and nutrient digestion in Horqin beef cattle during different seasons of grazing and supplementary feeding. Four healthy female Horqin beef cattle were selected as experimental animals for grazing and supplementary feeding. The feed, feces, and rumen fluid were collected in spring (March), summer (June), autumn (September), and winter (December) to determine nutrient digestibility, rumen fermentation parameters and microflora.

An Integrated Grid Interface of Electrode for Sodium-Ion Battery.

Sodium-ion batteries (SIBs) attract the research interest of many scientists due to their cost-effectiveness, the abundance of natural sodium resources, and the great potential to replace metal lithium batteries. However, they also encounter substantial issues including sluggish ion kinetics, substantial volume changes, and interfacial instability during cycling. In this study, a GDY/SnO/GDY heterostructured anode is fabricated using a grid encapsulation strategy, where SnO nanoparticles are dispersed within a framework of graphdiyne (GDY) nanowalls.

Postoperative Outcomes and Valvular Involvement in Loeys-Dietz Syndrome: A Multicenter Cohort Study of Surgical Risk and Complications.

Loeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by significant vascular and valvular abnormalities; however, perioperative outcomes involving aortic and valvular interventions remain underreported. This study aimed to evaluate surgical interventions and postoperative complications in LDS patients. We retrospectively reviewed 94 patients diagnosed with LDS from 2018 to 2024 across Mayo Clinic sites.

Actively Infiltrative Micro/Nanochannels Propel Cell Migration-to-Mechanoactivation Transition for Centralized Osteogenesis.

The insufficient cellular infiltration and cell activity are the main challenges for bone regeneration in the central region. Here, actively infiltrative micro/nanochannels were engineered within the filaments of 3D printed scaffolds using supercritical CO foaming and particles leaching. This structure facilitated cell and protein migration, enabling deep infiltration within the filaments.

Clinical value of dual detector spectral CT in predicting risk of femoral head necrosis.

Osteonecrosis of the femoral head (ONFH) is an ischemic bone necrosis affecting young adults; early-stage ONFH often presents with nonspecific symptoms, and delayed diagnosis may necessitate total hip arthroplasty, severely impairing quality of life and increasing healthcare costs. Although magnetic resonance imaging (MRI) is the gold standard for early detection, its use in multi-center screening is constrained by cost, scan duration, and contraindications. Dual-layer spectral CT (DLSCT) has emerged as a promising alternative, providing quantitative assessment of bone microarchitecture and perfusion.

CRISPR/Cas system targeting RNA and its derivative technology.

RNA editing is one of the important research directions in the field of epigenetics. With further research, scientists have discovered that the CRISPR/Cas system can target not only DNA but also RNA, thereby achieving precise gene editing at the transcriptional level. Moreover, using the CRISPR/Cas system for RNA editing can also avoid damage to genome.

A Comparative Analysis of the Efficacy of Three Plant Growth Regulators and Dose Optimization for Improving Agronomic Traits and Seed Yield of Purple-Flowered Alfalfa ( L.).

This study evaluated the effects of different plant growth regulators and their concentration gradients on the agronomic traits, seed yield, and yield components of L. cv. "Xinmu No.

Phase-specific and laser-modulated polydopamine-chlorella-curdlan hydrogels: pioneering a melanoma integrative therapy.

Patients with melanoma are confronted with postoperative challenges such as tumor relapse, impaired wound healing, infection, and hypertrophic scarring, with chronic wound inflammation potentially increasing the risk of tumor recurrence. Photoresponsive hydrogels have great potential for integrated postsurgical treatment of melanoma by embedding photosensitizers or photothermal agents in porous polymer networks, combining the advantages of hydrogels and phototherapy technologies. The photoresponsive PCCUR hydrogel was synthesized via a thermal induction method, incorporating polydopamine nanoparticles (PDA-NPs), extract (CE), and curdlan (CUR).

regulates the resistance of to Verticillium wilt through jasmonic acid and flavonoid-related pathways.

F-box-LRR (FBL) genes play crucial roles in the response of plants to pathogen stress. This study involved a systematic analysis of the evolution of the FBL gene family in from a whole-genome perspective, and through expression pattern analysis combined with virus-induced gene silencing (VIGS), was identified as a gene associated with resistance to Verticillium wilt in . Further RNA-seq analysis revealed key pathways and genes regulated by .

Body composition analysis in adolescents idiopathic scoliosis and its correlation with the severity of scoliosis.

To analyze the body composition of adolescents idiopathic scoliosis(AIS) patients at different stages of skeletal maturity and to explore the correlation between body composition and the severity of scoliosis. Data were collected from 243 patients diagnosed with AIS who fulfilled the specified inclusion and exclusion criteria at the Spine Surgery Outpatient Clinic of Xiangya Hospital, Central South University, during the period from 2023 to 2024. The data encompassed basic demographic information, radiological assessments, and body composition metrics.

The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination.

Background: Despite significant advancements in therapeutic approaches for lung cancer, the prognosis of lung squamous cell carcinoma (LUSC) remains suboptimal, underscoring the critical need to identify novel molecular targets and develop targeted therapeutic strategies. Through bioinformatic analysis, SH3RF2 was identified as a gene significantly upregulated in LUSC patients, and its high expression was strongly associated with lower survival rates. However, no significant differences in expression or survival correlation were observed in lung adenocarcinoma.

Integrated therapy reduces serum IgG4 in patients with IgG4-related sclerosing mesenteritis: A Case Report.

Objectives: To evaluate the potential effectiveness of Chinese herbal medicine (CHM) as an adjunct to conventional corticosteroid therapy in the management of IgG4-related sclerosing mesenteritis.

Clinical Features And Outcome: A 61-year-old male presented with a two-month history of persistent diarrhea, anorexia, postprandial bloating, and significant weight loss. Diagnostic evaluation, including serum IgG4 measurement and tissue biopsy, confirmed a diagnosis of IgG4-related sclerosing mesenteritis.

Performance Degradation of Amine-Infused Fiber Sorbents for Direct Air Capture: Mechanisms and Solutions.

Sorbent stability poses significant impacts on long-term performance of direct air capture (DAC) of CO and levelized cost of capture (LCOC). We report the DAC performance degradation of amine-infused fiber sorbents based on poly-(ethylenimine) (PEI), mesoporous SiO, and cellulose acetate (CA) over CO cyclic sorption cycles in a nonoxidative environment. Infrared and nuclear magnetic resonance spectra indicate that the aminolysis reactions between CA ester moieties and PEI amine sites lead to the formation of acetamides and hence lower CO affinities of the sorbents.

Polydopamine-modified collagen membrane loading with platelet-rich plasma for enhancing diabetic wound healing.

Platelet-rich plasma (PRP), a reservoir of growth factors, is instrumental in the repair and regeneration of damaged tissues, orchestrating wound healing at all stages. However, PRP's rapid degradation and instability at the wound site, prone to displacement and degradation, limit its efficacy. Collagen, the most abundant protein in the human body, boasts exceptional biocompatibility, biological activity, and minimal immunogenicity.

C/EBP-α Promotes Mitochondrial Fission and Inhibits the Activation of Hepatic Stellate Cells via YAP-Drp1 Pathway.

The activation of hepatic stellate cells (HSCs) plays a key role in the pathogenesis of liver fibrosis. However, the activation of HSCs requires energy from mitochondria-highly dynamic organelles. In our previous studies, we have confirmed that CCAAT/enhancer binding protein α (C/EBP-α) can inhibit the activation of HSCs, but whether it can affect the activation of HSCs by regulating mitochondrial dynamics is still unclear.

DCGCN: Dual-Channel Graph Convolutional Network-Based Drug-Target Interaction Prediction Method with 3D Molecular Structure.

Exploring drug-target interactions (DTIs) is crucial for drug discovery. Most existing methods for predicting DTIs rely solely on the linear structures of molecules, such as SMILES or the amino acid sequence. However, these linear features fail to reflect the substructures of molecules or the relative positions of atoms.

Host Immune Response to Infection: Implications for Vaccine Development.

Tuberculosis (TB) is an infectious disease caused by () infection, including pulmonary tuberculosis and extrapulmonary tuberculosis. About a quarter of the people in the world are infected with TB, but only 5-10% of them will progress to active TB, posing a major challenge to the eradication of TB. The study of the host immune response to infection is a key aspect of the development of effective vaccines and immunotherapies to eradicate tuberculosis.