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Article Abstract
The insufficient cellular infiltration and cell activity are the main challenges for bone regeneration in the central region. Here, actively infiltrative micro/nanochannels were engineered within the filaments of 3D printed scaffolds using supercritical CO foaming and particles leaching. This structure facilitated cell and protein migration, enabling deep infiltration within the filaments. These hierarchical micro/nanochannels induced cellular deformation, thereby enhancing mitochondrial activity. Transcriptomic analysis revealed that cytoskeletal stretching, triggered by actively infiltrative micro/nanochannels, activated the Wnt/β-catenin pathway via YAP-mediated mechanotransduction, significantly enhancing the tricarboxylic acid cycle to boost mitochondrial ATP production. By leveraging capillary forces for long-distance cell migration and activating a high-energy cellular state through mechanotransduction, this strategy enables rapid bone regeneration in the central region of large-scale rabbit cranial defects. Our findings overcome diffusion-limited osteogenesis and promote endogenous bone regeneration.
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| http://dx.doi.org/10.1021/acsnano.5c09462 | DOI Listing |
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