NIR-triggered temperature-sensitive polydopamine nanosystem with rapid phase transition for on-demand release to enhance antibacterial and antibiofilm performance.

The antibiotic abuse and bacterial biofilm barriers pose a formidable challenge to global public health. To address this issue, we developed a near-infrared (NIR)-triggered temperature-sensitive polydopamine nanosystem (PDA@Ag@Cur@PCM) by integrating silver nanoparticles (AgNPs) and curcumin (Cur) with the phase change material 1-tetradecanol. The system achieved NIR-triggered on-demand drug release and synergistic photothermal-chemo antibacterial, significantly enhancing antibacterial and antibiofilm efficacy.

Copper-catalyzed cross coupling reaction of sulfonyl hydrazides with 3-aminoindazoles.

A novel Cu-catalyzed radical-radical cross coupling reaction of 3-aminoindazoles with sulfonyl hydrazides has been disclosed, enabling the production of diverse 1,3-substituted aminoindazoles in good yields. This methodology is distinguished by readily available starting materials, wide substrate scope and operational simplicity. In addition, a gram-scale reaction has been well demonstrated.

Asymmetric Synthesis of Tetrahydroisoquinoline Derivatives through 1,3-Dipolar Cycloaddition of ,-Cyclic Azomethine Imines with Allyl Alkyl Ketones.

A [3 + 2] 1,3-Dipolar cycloaddition of ,-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to >25:1 dr, >95% ee).