Sleep duration and mental health in middle-aged and older adults: a study on gender differences.

Background: As the global population ages, mental health issues among middle-aged and older adults have become an important public health concern. Although the impact of sleep disorders on mental health is widely recognised, the specific mechanisms underlying the gender differences in mental health among middle-aged and older adults due to differences in sleep duration remain unclear. This study aims to explore the impact of sleep duration on mental health differences between middle-aged and older adults of different genders, providing key mechanistic evidence for understanding gender inequality in mental health among middle-aged and older adults.

An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities.

Phytochemical investigation of the ethanol extract from Artemisia anomala twigs and leaves led to the isolation and structural elucidation of four previously unreported compounds, including a phytyl melilotic acid ester designated as artemanoin A (1), and three chromomoric acid derivatives named anomalones E - G (2-4). Their structures, including the absolute configurations, were unambiguously established through extensive spectroscopic characterization (HRESIMS, 1D/2D NMR) coupled with chemical derivatization study and quantum chemical calculations (including ECD, optical rotation and NMR computations). Notably, artemanoin A (1) represents an acyclic diterpenoid featuring an unusual ester linkage with melilotic acid, a structural motif rarely encountered in natural products.

High PD-L2 Expression Is Associated with Better Disease-Free Survival in Patients with Intrahepatic Cholangiocarcinoma.

Objective: PD-L2 is expressed in various cancer tissues. Currently, the value of PD-L2 expression in intrahepatic cholangiocarcinoma (ICC) tissues remains unclear. This study investigated the prognostic and clinical significance of PD-L2 expression in ICC.

Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography.

Aim: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques.

Methods: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp.

Understanding EFL learners' flow: The development and validation of English Learning Flow Scale.

With the positive turn in second language acquisition, learners' flow in English learning has gradually attracted attention. However, there are limited tools that are specifically developed to measure learners' flow in English learning. The item analysis and exploratory factor analysis were conducted with a sample of 403 students to assess the proposed structure.

Unveiling Stage-Specific Flavonoid Dynamics Underlying Drought Tolerance in Sweet Potato ( L.) via Integrative Transcriptomic and Metabolomic Analyses.

Drought stress severely limits the productivity of sweet potato ( L.), yet the stage-specific molecular mechanisms of its adaptation remain poorly understood. Therefore, we integrated transcriptomics and extensive targeted metabolomics analysis to investigate the drought responses of the sweet potato cultivar 'Luoyu 11' during the branching and tuber formation stage (DS1) and the storage root expansion stage (DS2) under controlled drought conditions (45 ± 5% field capacity).

Development of a CXCR4 antagonistic peptide, P12, to suppress pancreatic cancer progress enhancing T cell responses and sensitizing cells to gemcitabine.

The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed by pancreatic cancer cells. This work developed a CXCR4 antagonistic peptide P12, which was identified by pancreatic-cell-based selection from among the designed peptides and was able to specifically bind to the pancreatic cancer cells as well as fibroblasts and macrophages and . CXCL12-mediated migration of tumor cells and adhesion to stromal cells were effectively inhibited by P12, and the phosphorylation of Erk and P38 was down-regulated.

Revealing the pathogenesis of vasculitis induced by aggregation of cryoglobulins associated with the immune response through an study.

Cryoglobulinemic vasculitis (CryoVas) is the most common symptom of cryoglobulinemia. However, the mechanism by which cryoglobulins (CGs) induce vascular injury remains unclear. Herein, serum samples from patients with type I, II, and III cryoglobulinemia were analyzed, with healthy individuals as controls.

Zinc mitigates copper toxicity in Crassostrea gigas by regulating metal homeostasis, oxidative stress, and immune responses.

To elucidate the interaction between zinc (Zn) and copper (Cu), this study investigates the mechanisms by which Zn mediates detoxification of Cu toxicity in the Pacific oyster Crassostrea gigas. Physiological indices and transcriptome analyses under control (CTR), Cu, and Zn_Cu treatments reveal that excess Cu induces systemic toxicity in oysters. Cu accumulation in tissues alters metal transporters, downregulating Cu importers and exporters (Zn and Cu transporters) while upregulating chaperones and metallothionein (MT1) for detoxification.

Evaluating and predicting disease damage accumulation of IgG4-RD over ten years: utility of the IgG4-related Disease Damage Index.

Objectives: To describe the cumulative degree of disease-induced damage in patients with immunoglobulin G4-related disease (IgG4-RD) during long-term follow-up.

Methods: A total of 334 patients who were diagnosed with IgG4-RD and followed for over 5 years were included from a prospective cohort, with 99 followed for 10 years. The Chinese IgG4-RD Consortium IgG4-RD Damage Index (DI) was scored at baseline (6 months), 5 years, and 10 years.

Characteristics of adverse drug reactions and risk management strategies for methylprednisolone sodium succinate in the treatment of idiopathic sudden sensorineural hearing loss: a clinical study of 1026 patients.

Objective: To systematically analyze the patterns, risk factors, and clinical management strategies of adverse drug reactions (ADRs) associated with methylprednisolone sodium succinate in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL).

Methods: A retrospective study was conducted on 1026 ISSNHL patients treated with methylprednisolone sodium succinate at Nanjing Tongren Hospital from January 2020 to December 2024. The incidence, types, severity, and outcomes of ADRs were recorded.

iPro-CSAF: identification of promoters based on convolutional spiking neural networks and spiking attention mechanism.

A promoter is a DNA segment which plays a key role in regulating gene expression. Accurate identification of promoters is significant for understanding the regulatory mechanisms involved in gene expression and genetic disease treatment. Therefore, it is an urgent challenge to develop computational methods for identifying promoters.

Characterization of methylation profile in biofluid cell-free DNA and identification of differentially methylated genes for phenotypic representations in Parkinson's disease.

Background: The potential biomarkers for Parkinson's Disease (PD) in blood circulating cell-free DNA (cfDNA) have been infrequently explored. This study aims to identify specific methylation markers in blood cfDNA that could aid in the diagnosis of PD.

Methods: A total of twenty patients with PD and nine healthy participants were recruited for this study.

Pore-Space-Partition-Oriented Sandwich Platinum Array Confined in a Metal-Organic Framework for Boosting Overall Water Splitting.

The atomic-level dispersion of noble metals in porous materials is prospective for highly efficient catalyst systems but is still inscrutable. Inspired by sandwich compounds, platinum (Pt) atoms were rationally confined within a metal-organic framework (MOF) through pore space partition by conjugate interactions between Pt and parallel-distributed aromatic pore partitioners, forming 1D infinite Pt arrays. By regulating the distance between adjacent aromatic rings from 7 to 4.

Efficacy and Safety of Catheter-Based Renal Denervation for Patients With Hypertension: A Systematic Review and Meta-Analysis.

This meta-analysis evaluates the efficacy and safety of renal denervation (RDN) for patients with hypertension. PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systematically searched to identify relevant studies published before December 31, 2024.

Evaluating the feasibility and safety of a self-crosslinked hyaluronic acid hydrogel for experimental retinal detachment repair.

Hyaluronic acid (HA), a glycosaminoglycan, maintains the gel consistency of the vitreous humors by retaining water. It hydrates the vitreous and prevents it from collapsing and is a major component of native vitreous. HA hydrogel, renowned for its high biocompatibility and biodegradability, has great potential for the development of an artificial vitreous.

Association between family factors and 24-h movement behaviors of adolescents-a cross-sectional study of Chinese high school students.

Background: Families have a significant effect on the patterns of physical activity exhibited by adolescents, and they influence the movement behaviors of adolescents through both direct and indirect roles. The aim of this study was to examine the association between meeting the 24-h movement guidelines and family factors.

Methods: A total of 1,250 students (mean age16.

Mefunidone treats pulmonary fibrosis by targeting SDH to regulate fibro-promoting macrophages.

Background And Objective: Pulmonary fibrosis, a pathological process where the extracellular matrix overly deposits in lung tissue because of various pathogenic factors, leads to lung structure damage and function decline. Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and high mortality, lacking effective drug treatments. Mefunidone (MFD), a new small-molecule compound, showed therapeutic effects on it in previous studies, but its specific molecular target is unknown.

Exploring the clinical characteristics and long-term outcome of serologically active clinically quiescent IgG4-related disease: knowledge from a prospective cohort.

Objective: In the long-term management of IgG4-related disease (IgG4-RD), it is common to observe clinical remission accompanied by elevated IgG4 levels, namely, serologically active clinically quiescent (SACQ). We aimed to determine and characterize the SACQ status in IgG4-RD and evaluate its prognosis.

Methods: We performed this single-center study based on a prospective IgG4-RD cohort.

Risk of heart disease in neonates born to mothers with primary Sjögren's syndrome: a multicenter retrospective study.

Objective: The impact of primary Sjögren's syndrome (pSS) on adverse pregnancy outcomes remains a debated issue. Research suggests that newborns of mothers with pSS may be at a higher risk of developing heart conditions. This study aimed to examine the relationship between maternal pSS and the risk of cardiac disorders in neonates.

Peroxiredoxin-1 aggravates hypoxia-induced renal injury by promoting inflammation through the TLR4/MAPK/NF-κB signaling pathway.

Hypoxia can induce pathological alterations to the kidneys, such as activation of inflammatory signaling pathways. This form of inflammation is pathogen-free and is referred to as aseptic inflammation. Currently, the mechanisms leading to aseptic inflammation under hypoxia are not well understood.

Effect of simultaneous intravitreal ranibizumab and extended-release dexamethasone injection on patients with naïve versus refractory retinal vein occlusion macular edema: a prospective, multicenter, and interventional open-label study.

Aim: To evaluate the efficacy and safety of concurrent intravitreal ranibizumab (IVR) and extended-release dexamethasone injections (Dex-I) in naïve and refractory patients with retinal vein occlusion macular edema (RVO-ME).

Methods: This was a prospective, interventional, and open-label clinical trial. There were two groups: naïve and refractory patients (received ≥5 times of previous IVR within one year prior to enrollment) enrolled.

Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic-Starvation Tumor Therapy.

Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation therapy is constrained by insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling piezoelectric potential-amplified enzyme activities and synergistic PEDT-starvation tumor therapy. Here hollow barium titanate (hBT) NPs are synthesized using SiO templates, followed by partial Au deposition via the Pickering emulsion-masking method to create Janus hBT@Au NPs, which are then conjugated with GOx and CAT on opposing sides to yield C-hBT@Au-G NPs.

Safety and efficacy of inhalable ambroxol hydrochloride aerosol for adult patients with respiratory diseases: an open-label, single-arm, multicentre study.

Background: Airway mucus hypersecretion is a key pathophysiological feature in many respiratory diseases and could lead to airway obstruction and repeated infections, consequently accelerating disease progression, which impacts on pulmonary function and quality of life (QoL), highlighting the importance of mucolytic therapy targeting airway mucus hypersecretion.

Objectives: To investigate the safety and efficacy of inhalable ambroxol hydrochloride aerosol for adult patients with respiratory diseases.

Design: An open-label, single-arm, multicentre postmarketing surveillance study.

Psychological Distress Among Chinese Manufacturing Employees: Prevalence and a Symptom Network Analysis.

The psychological distress among manufacturing workers is an increasingly important issue and has attracted extensive attention. However, the mental health of this subgroup of the Chinese population is underexplored. This study aimed to evaluate the prevalence of psychological distress in Chinese manufacturing employees and identify central symptoms, important bridge symptoms, and associations between symptoms using network analysis.