Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic-Starvation Tumor Therapy.

Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation therapy is constrained by insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling piezoelectric potential-amplified enzyme activities and synergistic PEDT-starvation tumor therapy. Here hollow barium titanate (hBT) NPs are synthesized using SiO templates, followed by partial Au deposition via the Pickering emulsion-masking method to create Janus hBT@Au NPs, which are then conjugated with GOx and CAT on opposing sides to yield C-hBT@Au-G NPs.

Coenzyme Q10 modulates the immunity by enhancing mononuclear macrophage, NK cell activity, and regulating gut microbiota.

Introduction: Coenzyme Q10 (CoQ10), an important fat-soluble, bioactive molecule that predominantly found in the inner mitochondrial membrane, is widely used in functional food and health food raw materials, which has garnered considerable attention due to its potential role in immunoregulation. However, the intrinsic mechanism of CoQ10 on immunity, and the relationship to the gut microbiota have not been elucidated.

Methods: Here, we conducted a series of experiments with the aim of comprehensively exploring the effect of CoQ10 on both cellular and humoral immune functions, and on gut microbiota communities in mice.

pH-responsive photothermal effect and heterojunction formation for tumor-specific pyroelectrodynamic and nanozyme-catalyzed starvation therapy.

Pyroelectrodynamic therapy (PEDT) integrates photothermal ablation and catalytic generation of reactive oxygen species (ROS), yet tumor-specific PEDT remains unexplored. Herein, pyroelectric tetragonal BaTiO (tBT) nanoparticles (NPs) were capped with polyaniline (PANI) via a Pickering emulsion-masking method, followed by in situ deposition of MnO nanodots on PANI caps to synthesize Janus tBT@PANI-MnO NPs. PANI emeraldine salts (PANI-ES) at pH 6.

Development and Validation of a Predictive Model for Fall Risk in Pre-Frail Older Adults.

Purpose: To develop a predictive model for fall risk in pre-frail older adults, providing a basis for early identification and prevention of falls among this population.

Method: This was a multicenter prospective cohort study. A total of 473 pre-frail older adults were included, 335 as the training set and 142 as the test set.

Optoelectronic Synaptic Memtransistor Based on 2D SnSe/MoS van der Waals Heterostructure under UV-Ozone Treatment.

Memristive switching devices with electrically and optically invoked synaptic behaviors show great promise in constructing an artificial biological visual system. Through rational design and integration, 2D materials and their van der Waals (vdW) heterostructures can be applied to realize multifunctional optoelectronic devices. Here, a multifunctional optoelectronic synaptic memtransistor based on a SnSe/MoS vdW p-n heterojunction to simulate the human biological visual system is reported.

Synthesis of CoTe nanowires: a new electrode material for supercapacitor with high stability and high performance.

Highly dispersed CoTe electrode material were successfully prepared by using a facile one-step solvothermal process without any surfactants. Compared with the conventional hydrothermally prepared irregularly-shaped CoTe, a regular nanowire-formed CoTe can be obtained by a solvothermal process using ethylene glycol as a solvent. The prepared CoTe nanowire electrode can exhibit a relatively high specific capacity of 643.