Fabrication and Characterization of a Novel 3D-Printable Bio-Composite from Polylactic Acid (PLA) and Ruminant-Digested Corn Stover.

To address the growing demand for sustainable materials in advanced manufacturing, the objective of this study was to develop and characterize a novel 3D-printable biocomposite using ruminant-digested corn stover (DCS) as a reinforcement for polylactic acid (PLA). The methodology involved systematically optimizing DCS particle size (80-140 mesh) and loading concentration (5-20 wt.%), followed by fabricating composite filaments via melt extrusion and 3D printing test specimens.

Development and validation of a CT-measured body composition radiomics model for prognostic assessment in resected pancreatic adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis due to high post-resection recurrence, yet current prognostic tools inadequately capture systemic tumor-host interactions. This study developed and validated a novel CT-based body composition radiomics model for predicting recurrence-free survival (RFS) in 191 PDAC patients undergoing curative resection. Using a temporal validation design (training cohort: 2019-2022, n = 142; validation cohort: 2016-2018, n = 49), we extracted 1,688 radiomics features from adipose and muscle tissues at the L3 vertebral level.

Zinc mitigates copper toxicity in Crassostrea gigas by regulating metal homeostasis, oxidative stress, and immune responses.

To elucidate the interaction between zinc (Zn) and copper (Cu), this study investigates the mechanisms by which Zn mediates detoxification of Cu toxicity in the Pacific oyster Crassostrea gigas. Physiological indices and transcriptome analyses under control (CTR), Cu, and Zn_Cu treatments reveal that excess Cu induces systemic toxicity in oysters. Cu accumulation in tissues alters metal transporters, downregulating Cu importers and exporters (Zn and Cu transporters) while upregulating chaperones and metallothionein (MT1) for detoxification.

Agave striata transcriptome reveals candidate cellulose synthase A genes involved in sisal cellulose biosynthesis.

Agave striata is a typical ornamental agave species that can be used as a wild genotype to explore the domestication of agronomic traits in A. tequilana and A. H11648.

Transcriptome characterization of three main ganglia in Patinopecten yessoensis provides novel insights into a monophyletic origin of the bilaterian central nervous system.

The question of whether the central nervous system (CNS) of bilaterians arose independently or has a monophyletic origin has been hotly debated. Increasing evidence supports the monophyletic origin of CNS across the three major bilaterian groups. However, in Mollusca, the second largest animal phylum, evolutional information of CNS was mainly obtained from cephalopods, of which the ganglionated cephalic neural system is under controversy to be homolog to vertebrate brain.

Diagnosis models to predict peripheral arterial disease: a systematic review and meta analysis.

Peripheral arterial disease (PAD) affects approximately 236.62 million individuals globally, exposing them to significantly increased risks of major limb events such as death and amputation. Concurrently, the number of diagnostic prediction models for PAD patients is steadily rising; however, these studies exhibit varying results, and their quality and applicability in clinical practice and future research remain unclear.

The haplotype-resolved genome assembly of the hexaploid kiwifruit Actinidia deliciosa reveals its hybrid origin and polysomic inheritance.

The kiwifruit (genus Actinidia) exhibits extensive polyploidy, with natural populations ranging from diploid to tetraploid, hexaploid, and even higher ploidy levels. Actinidia deliciosa (green kiwifruit) is typically hexaploid (2n = 6x = 174), whereas its close relative A. chinensis (golden kiwifruit) is primarily diploid (2n = 2x = 58) or tetraploid.

CALR regulates the proliferation and drug sensitivity of multiple myeloma cells through the BCL2 signaling pathway.

Background: Calreticulin (CALR) has been implicated in the genesis and progression of numerous tumors. Nevertheless, its impact on multiple myeloma (MM) remains ambiguous. This study aimed to explore the effect of CALR on the proliferation and drug sensitivity of MM cells and to delve into its underlying mechanism.

Geriatric Nutritional Risk Index as a Predictor of Major Adverse Limb Events in Older Patients With Peripheral Artery Disease: A Prospective Cohort Study.

Background And Aim: The geriatric nutritional risk index (GNRI) predicts adverse outcomes in chronic diseases, but its prognostic value for major adverse limb events (MALE) in elderly patients with peripheral artery disease (PAD) remains unverified; thus, this study aimed to establish the association between GNRI and MALE.

Design: A multicenter, prospective study.

Methods: From January 2021 to August 2022, 1200 patients with PAD aged ≥ 60 years were enrolled.

Accumulation, biotransformation and time-dependent transcriptomic responses to PSTs in scallop kidneys.

As typical filter-feeding organisms, bivalve scallops exhibit strong capabilities in accumulating paralytic shellfish toxins (PSTs) from toxic algae, posing risks to public health. To investigate PST-induced molecular responses in the kidney, the major "center" for toxin transformation, a time-course transcriptome analysis of the Yesso Scallop (Patinopecten yessoensis) over six time points (0, 1, 3, 5, 10, and 15 days) after exposure to the PST-producing algae (Alexandrium catenella) were conducted. During the 15 days exposure, PST accumulation in scallop kidneys showed a continuous increase.

Gene network analysis reveals the responsive cascades of scallop (Patinopecten yessoensis) exposed to toxic Alexandrium catenella.

As filter-feeding bivalves, scallops exhibit remarkable tolerance to paralytic shellfish toxins (PSTs) produced by Alexandrium dinoflagellates, yet the molecular mechanisms enabling concurrent PST accumulation and physiological resilience remain poorly understood. Here, we integrated transcriptomics and weighted gene co-expression network analysis (WGCNA) to dissect dynamic gene networks in scallop digestive glands during a 15-day exposure to PST-producing algae. We identified eight responsive modules, with the hub module M4 coordinating all phases of xenobiotic metabolism: phase I oxidation (CYP enzymes), phase II conjugation (GST/GGT), and phase III efflux (MRP transporters).

Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA mA Modification for Waterlogging Tolerance.

Polyploidization is a major driving force for evolutionary innovation and environmental adaptation in plants and is notably prevalent in kiwifruits. However, the molecular mechanisms through which subgenome interactions influence vigor and stress resilience remain largely unclear. Here, the high-quality genome of the tetraploid kiwifruit Actinidia valvata, which exhibits strong waterlogging tolerance compared to cultivated varieties is reported.

Causal Association Between Genetically Predicted Circulating Metabolites and Pressure Ulcers: A Two-Sample Mendelian Randomization Study.

Introduction: Pressure ulcers (PU) are skin and soft tissue injuries caused by prolonged localized pressure, friction, or shear forces, particularly affecting individuals with limited mobility. Understanding the mechanisms behind PU formation, including the role of metabolites, is crucial for effective prevention.

Methods: We conducted a two-sample MR analysis to explore the causal relationship between circulating metabolites and PU.

Modest Experimental Warming Reduces Species Diversity and Biomass of Arthropods in a Tibetan Alpine Meadow.

Climate warming is expected to contribute to the decline of arthropod species diversity and biomass around the world. However, direct experimental evidence is lacking. Here, we report on a field experiment documenting arthropod species diversity and biomass responses to passive simulated warming for six consecutive years in an alpine meadow on the Tibetan Plateau.

Healthy and moribund Zhikong scallops () developed different viral communities during a mass mortality event.

Unlabelled: Viral assemblages of scallops are still relatively unknown. Here, metagenomic analysis was used to study virus communities in the gut of scallops to establish the first scallop virome data set (SVD); this contains 7,447 viral operational taxonomic units. Protein-sharing networks and phylogenetic analyses demonstrated the high diversity and novelty of the SVD, which is very different from viromes from other habitats.

Regulating triazine number in covalent organic frameworks modified separator to achieve high-energy-density performance in aqueous zinc-iodine batteries.

The development of separator by tunning the zincophilic and iodide ion-repulsive properties of covalent organic frameworks (COFs) that regulate cycle lifespan and capacity of aqueous zinc-iodine (Zn-I) batteries is one of challenges. In this work, we have shown a systematic strategic-driven investigation to elucidate the role of functional triazine properties in COF modified separator towards overall performance of aqueous Zn-I batteries. As such, three COFs with the same topology but different triazine number in their structures, have been synthesized, among which the triazine-richest framework, TAPA-TTB-COF-based separator demonstrated to be most effective to guide uniform Zn flux and simultaneously inhibit polyiodide shuttling due to the zincophilic nature and good iodide ion-repulsive capability of triazine.

Interpretable Prognostic Modeling for Postoperative Pancreatic Cancer Using Multi-machine Learning and Habitat Radiomics: A Multi-center Study.

Rationale And Objectives: Accurate risk stratification is critical for guiding personalized treatment in resectable pancreatic cancer (RPC). This retrospective study assessed the utility of habitat radiomics for predicting recurrence-free survival (RFS) in RPC patients.

Materials And Methods: A total of 455 RPC patients were divided into training and external test sets from January 2018 to July 2024.

Discriminating Central Lung Cancer Tumors from Atelectasis Using Radiomics Analysis on Contrast-Free CT.

Background: Accurate determination of tumor boundaries is crucial for staging and treating central lung cancer (CLC).

Objective: This retrospective study aimed to evaluate the feasibility of contrast-free CT radiomics in discriminating CLC tumors from atelectasis.

Methods: A total of 58 patients with CLC and associated lung atelectasis, corresponding to 58 tumors and 58 atelectasis regions, were included.

Ferroptosis: a new target for depression prevention and treatment.

Depression, a significant mental health issue, is one of the diseases with the highest disability rates worldwide. The exact etiology of depression remains undetermined, complicating the development of treatment strategies targeting specific mechanisms, and there is currently no effective cure. In this context, ferroptosis may represent a breakthrough in the understanding of depression.

Hollow flower-like WO@TiO heterojunction microspheres for the photocatalytic degradation of rhodamine B and tetracycline.

In the context of sustainable development, the utilization of semiconductor materials for the degradation of dyes, antibiotics, heavy metals, and pesticides in wastewater under visible light has emerged as a focal point of contemporary research. In this investigation, a WO@TiO composite was synthesized a solvothermal method, with the composite exhibiting a molar ratio of 5% WO to TiO precursors demonstrating optimal photocatalytic degradation performance. This material achieved complete degradation of 20 mg per L Rhodamine B (RhB) dye and tetracycline (TC) antibiotic within 30 min.

A Retrospective Analysis: CCTA TTE in Diagnosing Coronary Artery Fistula.

Objective This study aimed to compare and analyze the diagnostic performance of cardiac computed tomographic angiography (CCTA) and transthoracic echocardiography (TTE) for coronary artery fistula (CAF) and evaluate the effectiveness of these two imaging modalities. Methods We retrospectively collected and analyzed imaging data from 200 patients diagnosed with CAF through surgery or digital subtraction angiography (DSA). These patients underwent CCTA and TTE examinations in our hospital.

Retraction notice to "Congenital pulmonary lymphatic duct hypoplasia in a fetus with hydrops fetalis found at delivery: A case report" [Heliyon 9 (2023) e19587].

[This retracts the article DOI: 10.1016/j.heliyon.

CAR-T cell therapy for patients with extramedullary multiple myeloma：Opportunities and challenges.

Multiple myeloma (MM) is a hematological malignancy characterized by abnormal proliferation of clonal plasma cells, which is usually confined to the bone marrow (BM). But some malignant plasma cells grow independently of the BM, called extramedullary disease (EMD). With the clinical application of proteasome inhibitors, immunomodulators, monoclonal antibodies, and hematopoietic stem cell transplantation, the overall survival of MM patients has been significantly improved, but the survival of patients with EMD is still worse than that of non-EMD patients.

Type I Iodothyronine Deiodinase Functions in Thyroid Hormone Synthesis and Growth Regulation in Bivalve.

Bivalve breeding programs account for over 50% of global marine aquaculture, and growth is one of the most important traits of them. With the purpose of investigating the key genes related to growth performance of Yesso scallop (Patinopecten yessoensis), an economically important bivalve, we conducted transcriptome comparison between fast- and slow-growing individuals, and identified 1,531 differentially expressed genes (DEGs), with 656 up-regulated in fast-growing scallops, categorizing into six molecular function terms, of which the thyroxine 5'-deiodinase activity term exhibited the lowest p values. This term contained only two genes, and they were both type I iodothyronine deiodinase (D1), the enzyme catalyzing triiodothyronine (T) production in vertebrates.