Ameliorating Effect of Bifidobacterium breve CM02-09T on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.

Evidences have demonstrated that the regulation of gut microbiota by probiotics can be utilized to prevent nonalcoholic fatty liver disease (NAFLD); Bifidobacterium was widely used as a potential therapeutic alternative for metabolic diseases. In this study, the probiotic functions of Bifidobacterium breve CM02-09T and its effects on NAFLD were investigated through genome annotation and high-fat diet (HFD)-induced mouse model. The genome of B.

Freely-Rotatable Multidentate Molecular Anchor Enables Self-Adaptive Aqueous Binders for Lithium-Ion Batteries.

The rational design and synthesis of reliable binders is a big challenge to efficiently mitigate the severe volume change of silicon-based anodes for lithium ion batteries. Herein, we report a multidentate molecular anchoring strategy to construct a novel self-adaptive aqueous binder. This binder composes of robust 3D dynamic networks derived from the crosslinking of the freely-rotatable multidentate molecular anchor (2,2-bis(hydroxymethyl)butyric acid, BHB) and polyacrylic acid (PAA) via dynamic hydrogen-mediated self-assembly, which effectively imparts the fabrication of high-strength Si/C anodes and achieves high areal capacities (6.

Hypotension prediction index in the prediction of better outcomes: a systemic review and meta-analysis.

Background: The hypotension prediction index (HPI) is an algorithm designed to predict hypotension. Some studies have reported that HPI-guided hemodynamic management strategies decrease intraoperative hypotension and complications; however, the effect of HPI on reducing perioperative complications are controversial. This meta-analysis aimed to assess the efficacy of the HPI in reducing major complications and intraoperative hypotension.

Silver-loaded hollow copper sulfide particles for antibacterial therapy.

The misuse of antibiotics has accelerated the spread of antibiotic resistance (AR), making it a major global health threat. Drug-resistant bacteria, such as (), (), (), and (), continue to cause severe infections worldwide. This underscores the need for alternative antibacterial strategies.

Subject-specific acceleration of simultaneous quantification of blood flow and T of the brain using a dual-flip-angle phase-contrast stack-of-stars sequence.

Purpose: To develop a highly accelerated MRI technique for simultaneous quantification of blood flow and T of the brain tissue.

Methods: A dual-flip-angle phase-contrast stack-of-stars (DFA PC-SOS) sequence was developed for simultaneous acquisition of highly-undersampled data for the quantification of velocity of arterial blood and T mapping of brain tissue. A deep learning-based algorithm, combining hybrid-feature hash encoding implicit neural representation with explicit sparse prior knowledge (INRESP), was used for image reconstruction.

Comparative analysis of clinical features, methylation and immune microenvironment in pediatric and adult papillary craniopharyngiomas: results from a multicenter study.

Papillary craniopharyngioma (PCP) was previously believed to occur only in adults. Sporadic pediatric PCP (PPCP), confirmed by detection of the BRAF V600E mutation, has been reported since 2018. The differences between PPCP and adult PCP (APCP) remain unclear.

Global vaccine confidence trends among adults above and below age 65.

This study is interested in global vaccine confidence because it directly impacts vaccination rates and public health outcomes, especially during the COVID-19 pandemic. Furthermore, due to the unique vulnerabilities to vaccine-preventable diseases, misinformation, and access to health information among adults aged 65 and older, understanding vaccine confidence in this population is crucial for developing targeted interventions and improving vaccination rates. The current research is limited by single-country surveys and cross-sectional designs, providing limited insights into these issues.

[Spatial Heterogeneity of Carbon Emissions from Construction Projects Based on XGBoost-SHAP].

To make the carbon emission reduction of highway construction more effective， this study focuses on the spatial heterogeneity of carbon emission in the process of highway construction. Based on the seven key indicators of carbon emission impacts of the type of structure， bridge-to-tunnel ratio， design gradient， route length， fill volume， excavation volume， and cement consumption screened out from the 40 segment samples of highway project A in Guangdong Province， we trained and validated the XGBoost carbon emission prediction model and constructed the SHAP algorithm to explain the impacts， total feature contributions， and feature interaction effects of the features of these 40 road segments. The SHAP algorithm was constructed to explain the spatial heterogeneity of carbon emissions of these 40 road sections， and the influence of road section features on carbon emissions， total feature contribution， and feature interaction effect were investigated.

Clinical Characteristics and Outcomes of Acute Myeloid Leukemia Patients Harboring Triple Mutations and the Potential Prognostic Value of .

IntroductionNucleophosmin 1 (), FMS-like tyrosine kinase 3-internal tandem duplication (), and de novo methyl transferase 3 A () triple-mutated acute myeloid leukemia (AML) represents a distinct entity with poor outcomes.MethodsWe explored the gene mutation spectrum and clinical characteristics of 165 AML patients retrospectively, particularly comparing patients with triple-mutations and those without.ResultsOur results demonstrated significantly elevated white blood cell counts ( < 0.

SnRNA-seq Interprets Mechanisms by which Three Glial Cell Types Influence Myelin Regeneration in Adult Drug-Resistant Epilepsy-Related Cognitive Impairment.

Myelin regeneration has been shown in previous studies to ameliorate varying degrees of cognitive impairment in patients with neurodegenerative disorders such as epilepsy. The problem of myelin regeneration in adults with drug-resistant status epilepticus is a major key to the difficulty of treating cognitive impairment in adults with drug-resistant epilepsy (DRE). The purpose of this study is to provide a molecular map of myelin-related molecules under the cognitive deficits seen in DRE.

Metal-organic framework containing Co(μ-OH)-based kagomé layers showing long-range weak ferromagnetic ordering.

The compounds Co(OH)(5-cnapp)(HO) (1) and Co(OH)(4-cnapp)(HO)·12HO (2) obtained using positionally isomeric phosphonic acids (5-/4-cnappH) have 3D framework structures. Compound 1 contains a distorted Co(μ-OH)-based kagomé layer and shows long-range weak ferromagnetic ordering below 30 K without significant spin frustration.

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects.

Micro-computed tomography (µCT) imaging analysis of bone volume is a necessary quantitative tool for investigating bone regeneration potential and outcomes within longitudinal in vivo studies. Established methods for bone segmentation utilize visualization software for whole bone µCT segmentation and alignment of complex anatomical structures. These segmentation protocols provide a robust, high-accuracy method for segmentation, alignment, and analysis but are limited in abilities of user-defined region of interest (ROI) analysis.

Endophthalmitis caused by Abiotrophia defectiva with initial presentation as retinal vasculitis: a case report.

Background: Abiotrophia defectiva is primarily known for its association with endocarditis rather than intraocular infections. We reported a case of endophthalmitis caused by Abiotrophia defectiva, presenting as retinal vasculitis in its early stages, a phenomenon rarely documented in literature.

Case Presentation: A 50-year-old Han Chinese man presented to the hospital with decreased vision in his left eye.

Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients.

Objective: ZW10 interacting kinetochore protein (ZWINT) has been demonstrated to play a pivotal role in the growth, invasion, and migration of cancers. Nevertheless, whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive. This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Coordinating transcription and replication via transcription factors (TFs) is a conserved mechanism in higher eukaryotes. The role of TFs in regulating these processes in cancers remains unclear. Here, it is shown that oncogenetic ETS transcription factor ETV4 controls DNA replication through both transcriptional and non-transcriptional mechanisms in non-small cell lung cancer (NSCLC).

Effect of a Shared Decision-Making-Based Exercise Management Program on Blood Glucose Control in Patients with Gestational Diabetes Mellitus.

Objective: To analyze the application of a shared decision-making (SDM)-based exercise management program in patients with gestational diabetes mellitus (GDM) and its impact on blood glucose control.

Methods: A retrospective analysis was conducted on the clinical data of 88 GDM patients who delivered at the Hangzhou Women's Hospitalbetween December 2022 and April 2024. Patients were divided into the control group (n=44, receiving conventional exercise management program) and the observation group (n=44, receiving SDM-based exercise management program).

Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration.

Regenerating critical-sized long bone defects poses substantial challenges due to limitations of autografts and processed allografts. Biomaterial scaffolds offer versatile alternatives, yet their effectiveness is often constrained by their limited innate osteoinductivity. While growth factors and cells can enhance osteoinduction, the inclusion of biologics in biomaterial scaffolds creates regulatory challenges for clinical translation.

Lactobacillus rhamnosus GR-1 alleviates Escherichia coli-triggered bovine endometrial epithelial cells damage via the ROS-mitochondrial pathway.

Objective: The objective of this study was to evaluate the function of the reactive oxygen species (ROS)-mitochondrial pathway in attenuating Escherichia coli (E. coli) induced apoptosis in bovine endometrial epithelial cells (BENDs) by Lactobacillus rhamnosus (L. rhamnosus) GR-1.

A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation.

In recent years, anti-tumor immunity has emerged as a central focus in cancer research, with the rapid advancement of immunotherapy heralding a new era in cancer treatment. Despite the significant potential of immunotherapy, the use of single-agent approaches or limited combination therapies has not consistently yielded optimal therapeutic outcomes. The strategic and controlled integration of diverse immune activation techniques within a single nanoparticle, utilizing a straightforward and universal methodology, continues to present a substantial challenge.

Enhancement of endometrial receptivity by Bushen Zhuyun Decoction via cryptotanshinone-mediated TRIM28 induction and HIF-1α suppression.

Ethnopharmacological Relevance: Bushen Zhuyun Decoction (BSZYD), a traditional Chinese remedy, has demonstrated clinical efficacy in the treatment of luteal phase deficiency (LPD), though its mechanistic pathways remain largely undefined.

Aim Of The Study: This study aims to elucidate the mechanism by which BSZYD enhances endometrial receptivity.

Materials And Methods: In an LPD rat model induced by RU-486 and treated with BSZYD, molecular markers of endometrial receptivity were evaluated using scanning electron microscopy (SEM).

Synergistic construction of highly symmetrical lanthanide single-ion magnets using neutral phosphoryl and anionic thiocyanate ligands.

A series of lanthanide single-ion compounds, [Dy(TMPO)(SCN)(HO)] (1), [Dy(TMPO)(SCN)(HO)][Dy(TMPO) (SCN)(HO)](SCN)·(HO) (2), [Ho(TMPO)(SCN)(HO)] (3) (TMPO = trimorpholinophosphine oxide) and [Dy(HMPA)(SCN)](PF) (4) (HMPA = hexamethylphosphoramide), were synthesized by assembling neutral phosphoryl and anionic thiocyanate ligands with lanthanide central ions. Compounds 1 and 3 were revealed to be isostructural with distorted axially compressed pentagonal bipyramidal (PBP, pseudo- symmetry) coordination environments, which consist of two TMPO ligands on the apical sites and three thiocyanate anions and two coordinated water molecules in the equatorial plane. Compound 2 contains two molecular fragments, among which the Dy1 molecular fragment has a composition and structure very similar to compound 1, except for a lower degree of local distortion; there are slight differences between Dy2 and Dy1 molecular fragments, with one SCN replaced by a coordinating water molecule to become a counter anion, resulting in lower local distortion and shorter axial bond lengths.

Integrated transcriptome profiling and in vitro analysis reveals MLN4924's role in inducing ferroptosis in acute myeloid leukemia.

Objectives: While ferroptosis induction emerges as a therapeutic strategy for solid tumors, its role in acute myeloid leukemia (AML) remains unexplored. This study aimed to investigate the role of MLN4924 in modulating ferroptosis and its molecular targets in AML.

Methods: Transcriptome sequencing and bioinformatics analyses were performed to identify MLN4924 potential targets in ferroptosis.

Biomechanical effects of different rotator cuff tear conditions and mediolateral offset in lateralized reverse total shoulder arthroplasty (Coralis Reverse Shoulder System).

Background: The indications for reverse total shoulder arthroplasty (rTSA) have expanded to include various shoulder pathologies regardless of rotator cuff condition. However, the biomechanical effects of the procedure based on the extent of the rotator cuff tear remain uncertain in medialized rTSA (m-rTSA) and lateralized rTSA (l-rTSA). Furthermore, the necessity of subscapularis repair for l-rTSA has been debated.

Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia.

The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including , , , and , as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients.

3-Fucosyllactose Prevents Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota-Derived Pantothenate in Mice.

Nonalcoholic fatty liver disease (NAFLD) is a growing global health threat. Human milk oligosaccharides (HMOs) exhibit prebiotic properties that may alleviate NAFLD progression. Herein, our study demonstrates that 3-fucosyllactose (3-FL), a distinctive and crucial HMO, significantly attenuates body weight gain, enhances hepatic lipid metabolism, and reduces inflammation in a high-fat diet (HFD)-induced NAFLD mouse model.