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Article Abstract
A [3 + 2] 1,3-Dipolar cycloaddition of ,-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to >25:1 dr, >95% ee). Moreover, the absolute configuration of the product was previously determined by using the quantum electronic circular dichroism calculation and ECD spectrum method.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156229 | PMC |
| http://dx.doi.org/10.3390/molecules26102969 | DOI Listing |
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