Safe float nurses, safe patients: Problems and feasible solutions. A qualitative analysis and scoping review.

Background And Objective: Float nurses are frequently assigned to unfamiliar settings where they must perform a wide range of tasks, often without prior orientation, specific training, or knowledge of local protocols and equipment. Given the widespread use of floating as a staffing strategy, it is essential to allocate resources that support their integration while prioritising patient safety. This study aimed to develop a self-administered Integration Checklist for float nurses, highlighting key aspects to address before delivering direct patient care.

Highly stressful global event affecting health sciences students: A longitudinal qualitative study.

Background: Stressful events of great magnitude have produced significant changes in society and in health education. University students have faced considerable challenges both during and after such events, which have affected their lifestyles, mental health, the development of academic activities, and changes in education systems due to the adoption of new teaching models and the use of online technology.

Objectives: To explore the perspectives and experiences of university health sciences students regarding their lifestyles and academic stress both during and after the COVID-19 pandemic, a highly stressful event.

Patient and public involvement in a randomized study: a qualitative study of participants' experiences in a Mediterranean Diet trial.

Background: Randomized clinical trials (RCTs) based on Mediterranean Diet (MedDiet) have reported that higher adherence is associated with better health outcomes. Our aim was to describe the perspectives and experiences of older adults in a MedDiet RCT for cardiovascular disease prevention.

Methods: Three focus groups on 25 participants from a MedDiet RCT, aged from 63 to 76 years old, were conducted after a conference on patient and public involvement in research at the University of Granada (Spain).

Wafer-Scale Demonstration of BEOL-Compatible Ambipolar MoS Devices Enabled by Plasma-Enhanced Atomic Layer Deposition.

The relentless scaling of semiconductor technology demands materials beyond silicon to sustain performance improvements. Transition metal dichalcogenides (TMDs), particularly MoS, offer excellent electronic properties; however, achieving scalable and CMOS-compatible fabrication remains a critical challenge. Here, we demonstrate a scalable and BEOL-compatible approach for the direct wafer-scale growth of MoS devices using plasma-enhanced atomic layer deposition (PE-ALD) at temperatures below 450 °C, fully compliant with CMOS thermal budgets.

Extra-Virgin Olive Oil and Additional Cardiovascular Outcomes in the PREDIMED Trial: An Outcome-Wide Perspective.

Background And Aims: Olive oil, increasingly consumed in the U.S., has been inversely associated with cardiovascular disease (CVD) risk.

Modern Disposable E‑Cigarettes: Small in Size but Big in Toxic Metals.

Safety concerns continue to arise as lead and other potentially toxic metals are found in the aerosols of modern disposable e-cigarettes.

Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysis.

The "omnigenic" hypothesis postulates that the polygenic effects of common variants on a typical complex trait coalesce on relatively few core genes through trans-effects on their expression. Our aim was to identify core genes for systemic lupus erythematosus (SLE) by testing for association with genome-wide aggregated trans-effects (GATE) scores for gene expression in a large genetic dataset (5267/4909 SLE cases/controls). SLE was strongly associated with upregulation of expression of eight interferon-stimulated genes driven by shared trans-effects.

Identification of four autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia.

We investigated the influence of 55,583 autophagy-related single nucleotide polymorphisms (SNPs) on chronic lymphocytic leukemia (CLL) risk across four independent populations comprising 5,472 CLL cases and 726,465 controls. We also examined their impact on overall survival (OS), time to first treatment (TTFT), autophagy flux, and immune responses. A meta-analysis of the four populations identified, for the first time, significant associations between CDKN2A (rs3731204) and BCL2 (rs4940571, rs12457371, rs1026825) SNPs and CLL risk, with CDKN2A showing the strongest association (p=1.

Funerary practices of cremation at the megalithic societies of South-Eastern Iberia: The cemetery of Los Milanes.

The archaeological excavations undertaken at the Chalcolithic necropolis of Los Milanes have revealed a previously unknown variability in funerary practices in the south-eastern Iberia. For the first time, a megalithic tomb housed a large funerary deposit (28,740 bone fragments) of exclusively cremated human bone remains. For a comprehensive characterization of the funerary ritual, a cutting-edge multi-proxy approach has been undertaken including the osteological study of cremated bone remains, radiocarbon chronology, Fourier-Transform Infrared spectroscopy in Attenuated Total Reflectance mode (FTIR-ATR), and carbon, oxygen and strontium isotope analyses.

Redefining player roles in professional women's basketball: From traditional positions to functional profiles.

The analysis of box-score performance indicators has traditionally been used to classify player roles in women's basketball based on the five conventional positions: point guard, shooting guard, small forward, power forward, and center. However, this framework may not reflect the current tactical and functional demands of the game. The aim of this study was to identify and redefine functional player roles in professional women's basketball using performance data derived from actual competition.

The role of pharmacists in the management of patients with atrial fibrillation: A systematic review and meta-analysis.

Background: Pharmacist-led interventions have demonstrated benefits across various medical conditions; however, their impact on atrial fibrillation (AF) remains unexplored. This study aims to synthesize the available evidence regarding the pharmacist's role in AF management.

Methods: A systematic review with searches in PubMed, Scopus, and Web of Science was performed (PROSPERO: CRD42025647848).

Modulation of Gene Expression in Human Fibroblasts by Punicalagin and Ellagic Acid: An In Vitro Study.

The effects of the phenolic compounds punicalagin and ellagic acid, derived from pomegranate, were analyzed on the gene expression of cultured human fibroblasts. The focus was placed on genes associated with growth factors, differentiation markers, and extracellular matrix (ECM) components, all of which play a crucial role in effective wound healing. The human dermal fibroblast cell line CCD-1064Sk was used, and the bioactive compounds punicalagin and ellagic acid were administered to cultured fibroblasts at concentrations of 10 and 10 M, respectively.

Effects of manual therapy on oral opening, swallow function and upper quarter mobility in Chilean survivors of head and neck cancer: a study protocol for a controlled, randomised study (MAnual ThErapy for Oral Opening (MATEO) study).

Introduction: Head and neck cancer (HNC) accounts for over 4% of global cancer incidence, yet the oncological treatment induces several sequelae such as oral dysfunction, cervical and shoulder impairments or pain that are not well addressed. Thus, survivors of HNC (sHNC) perceive a decrease in their quality of life (QoL). This study protocol aims to investigate the effects of manual therapy (MT) to determine the effectiveness and safety on oral opening, swallow function and upper quarter mobility, cervical muscle strength, pain, functionality and QoL of sHNC.

Exploring the role of normalization and feature selection in microbiome disease classification pipelines.

Background: Disease classification using 16S rRNA microbiome data faces challenges of high dimensionality, compositionality, and sparsity, compounded by the inherent small sample sizes in many studies. Machine learning and feature selection techniques offer potential to identify robust biomarkers and improve classification performance; however, their comparative effectiveness across diverse methods and datasets has been insufficiently explored. This study evaluates multiple feature selection techniques alongside normalization strategies, focusing on their interplay with classifier performance.

Fluoranthene-Containing Distorted Nanographenes Exhibiting Two-Photon Absorption Response.

Two distorted nanographenes combining helicenes and a fluoranthene unit within their polycyclic scaffolds were synthesized. Their structural and electronic properties were elucidated by various spectroscopic methods, and the experimental data were corroborated computationally. The optical and electrochemical properties of the nanographenes were evaluated.

PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP.

Unlabelled: Lung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes in LUSC. This is particularly intriguing given that PKP1 is primarily known as a desmosomal component involved in cell adhesion, typically regarded as a tumor suppressor.

High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models.

Missense mutations in the 12 codon of KRAS are key drivers of lung cancer, with glycine-to-cysteine (G12C) and glycine-to-aspartic acid (G12D) substitutions being among the most prevalent. These mutations are strongly associated with poor survival outcomes. Given the critical role of KRAS in lung cancer and other cancers, it remains as a major target for the development of new and complementary treatments.

The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status.

Background: The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood. The objective of the current study is to ascertain the influence of a supervised concurrent exercise intervention from gestational week 17 until birth on key cytokines involved in placental development and function. Secondary aims were to explore: (a) the moderating effects of fetal sex and maternal weight status; and (b) whether gestational weight gain, lifestyle behaviors (diet, sleep patterns, and physical activity), and physical fitness (strength and cardiorespiratory fitness) mediated the effects of exercise on placental cytokines.

Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis.

The c-Src SH3 domain is one of the best-characterized modular domains from a biophysical and structural point of view. This SH3 domain displays noncanonical alternative folding, forming 3D domain-swapped oligomers and amyloid fibrils. These features make this small protein an ideal model for studying these phenomena.

Measuring breakfast dietary patterns in Spanish youth: Reliability of the Spanish Youth Breakfast Consumption Questionnaire (SYBC-Q).

Reliable tools to assess breakfast habits are essential, as breakfast quality is linked to health and development in youth. However, validated instruments for Spanish children and adolescents are scarce. To assess the reliability of the Spanish Youth Breakfast Consumption Questionnaire (SYBC-Q) in a sample of Spanish children and adolescents.

Risk and Benefit Assessment of Gene Therapy with Lentiviral Vectors and Hematopoietic Stem Cells: The Skysona Case.

Seven cases of hematological malignancy reported in recipients of Skysona™ (elivaldogene autotemcel) have reignited long-standing concerns about insertional mutagenesis in lentiviral vector (LV)-based gene therapy. Here, we dissect the molecular and clinical evidence underlying these events, place them in the broader context of over 300 patients treated with LV-modified hematopoietic stem and progenitor cells (HSPCs), and review the real-world safety record of LV-engineered chimeric antigen receptor T cells. We show that cancers associated with Skysona are mechanistically linked to the use of a potent viral MNDU3 promoter probably combined with intensive conditioning and growth-factor support, whereas LV products employing weak or physiological promoters continue to display an excellent safety profile.

Carbohydrate-Based Chiral Ligands for the Enantioselective Addition of Diethylzinc to Aldehydes.

: Carbohydrate-derived chiral ligands are promising tools in asymmetric catalysis due to their structural diversity, chirality, and availability. However, ligands based on galactose or sorbose have been scarcely explored in the enantioselective addition of dialkylzinc reagents to aldehydes. : A series of chiral diols and β-amino alcohols was synthesized from methyl D-glucopyranoside, methyl D-galactopyranoside, and D-fructose.

Eyes on the prize: Eye-tracking evidence of attentional biases toward gambling and natural rewards.

The present study investigates attentional biases (ABs) in gamblers and non-gamblers, focusing on both gambling-related and food-related stimuli to examine the relationship between these biases and the Incentive Sensitization (IS) and Reward Deficiency Syndrome (RDS) models of addiction. Using an eye-tracking methodology, we assess how ABs differ across three conditions involving two types of images: Food vs. Gambling, Food vs.