Exogenous arginine induced metabolic modulation and biomass enhancement in Nannochloropsis oceanica under high CO stress.

Given that excessive CO induces reactive oxygen species (ROS) which inhibit photosynthesis and microalgal survival, this study explores how exogenous arginine enhances stress resilience and biomass yield of Nannochloropsis oceanica under high CO stress. Arginine promoted NO synthesis, enhancing antioxidant enzyme activities to combat ROS damage. Transcriptomic analysis revealed that key enzymes in the Calvin cycle (PRK, GAPDH, FBPase and SBPase) and TCA cycle (CS, IDH, SCS and MDH) were significantly up-regulated, supporting carbon fixation and energy metabolism.

Recent advances in calcium peroxide nanomedicines for breast cancer treatment.

As a typical solid tumor, breast cancer is characterized by a tumor microenvironment featuring hypoxia, acidosis, and highly reductive conditions. These factors contribute to treatment resistance (e.g.

DNA methylation regulates the extinction of fear memory.

Background: Fear-related disorders, such as post-traumatic stress disorder (PTSD), significantly impact patients and families. Exposure therapy is a common treatment, but improving its effectiveness remains a key challenge. Fear conditioning and extinction in animal models offer insights into its mechanisms.

Damage and immunosuppression to Mytilus galloprovincialis hemocytes caused by chronic tris(chloropropyl)phosphate exposure.

Tris(chloropropyl)phosphate (TCPP), a pervasive aquatic contaminant, poses risks to ecologically important bivalves, including Mytilus galloprovincialis. However, its toxicity at environmentally related levels to M. galloprovincialis hemocytes remains poorly understood.

Case Report: Two children with factor XII deficiency caused by novel compound heterozygous variants.

Background: Factor XII (FXII) deficiency (OMIM 234000) is a rare hereditary coagulation disorder caused by pathogenic variants within the gene. It causes prolonged activated partial thromboplastin time without bleeding diathesis. Most patients have no obvious clinical symptoms, so the disease is difficult to be detected.

Advances in preparation techniques and antimicrobial properties of Aloe vera extract.

Aloe vera has a long history of use in traditional medicine for its diverse medicinal properties, especially its antibacterial effects. This review comprehensively analyzes various extraction techniques of A. vera, including traditional hand-filleted processing, whole leaves processing, and modern methods like hot water extraction, centrifugation-based gel extraction, freeze-drying, and solvent extraction.

The impact of respiratory syncytial virus on asthma development and exacerbation.

Asthma is a chronic inflammatory disorder of the lower airways clinically characterized by recurrent wheezing, breathlessness, cough, and dyspnea and the most prevalent chronic disease among children and adolescents. Respiratory viral infections are implicated in asthma inception and exacerbation, with respiratory syncytial virus (RSV) emerging as a key contributor. RSV is a leading cause of acute lower respiratory tract infections, particularly infant bronchiolitis, and is associated with a type 2-biased immune response, diminished interferon activity, epithelial barrier dysfunction, and altered airway microbiome.

Occurrence, spatial distributions, sources, and potential risks of organophosphate esters in Yarlung Tsangpo River and its main tributaries on the Tibetan Plateau.

Organophosphate esters (OPEs) are extensively utilized as flame retardants and plasticizers in a wide range of products. Because of their high solubility, mobility, and persistence, OPEs are frequently detected in aquatic environments with relatively high concentrations and may pose risks to the ecosystem and human health. In the present study, the occurrence, spatial distributions, influencing factors, sources, and potential risks of eight OPE congeners in the Yarlung Tsangpo River and its main tributaries (the Lhasa, Nianchu, and Niyang Rivers) in the summer were investigated.

[ Mixture improves α‑naphthylisothiocyanate-induced cholestasis in rats by inhibiting NLRP3 inflammasomes regulating farnesoid X receptor].

Objectives: To study the therapeutic mechanism of Mixture against cholestasis.

Methods: Forty-eight Wistar rats were randomized equally into blank group, model group, ursodeoxycholic acid group and Mixture group. Except for those in the blank group, all the rats were given α‑naphthylisothiocyanate (ANIT) to establish rat models of cholestasis, followed by treatments with indicated drugs or distilled water.

Volatile and non-volatile compound analysis of ginkgo chicken soup during cooking using a combi oven.

This study employed a range of analytical techniques to evaluate the changes in both volatile and non-volatile compounds during different cooking times (30, 60, 90, 120, and 150 min) of ginkgo chicken soup prepared using a multifunctional combi oven, and comparedthese results with those obtained from the traditional ceramic pot method.The techniques included electronic nose (e-nose), electronic tongue (e-tongue), gas chromatography-ion mobility spectrometry (GC-IMS), high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and automated amino acid analysis. A total of 64 volatile compounds, primarily aldehydes, ketones, esters, and alcohols, were detected, with 23 key aroma components identified.

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages.

Background: The liver undergoes significant hemodynamic changes during surgery, transplantation, or cirrhosis with portal hypertension(PH). The hepatic artery buffer response(HABR), which compensates for reduced portal venous flow by increasing hepatic artery(HA) flow, is hypothesized to induce pathological portal tract remodeling. This study investigates the molecular mechanisms underlying this process.

Activation of V-Domain Immunoglobulin Suppressor of T-Cell Activation by Baloxavir Marboxil Ameliorates Systemic Lupus Erythematosus through Inhibiting Lysophosphatidylcholine/CD40 Ligand.

Deficiency of the V-domain immunoglobulin suppressor of T-cell activation (VISTA) accelerates disease progression in lupus-prone mice, and activation of VISTA shows therapeutic effects in mouse models of a lupus-like disease. Metabolic reprogramming of T cells in systemic lupus erythematosus (SLE) patients is important in regulating T-cell function and disease progression. However, the mechanism by which VISTA affects the immunometabolism in SLE remains unclear.

Single-cell RNA sequencing unveils dynamic transcriptional profiles during the process of donkey spermatogenesis and maturation.

Introduction: With the increasing demand for donkey production, there has been a growing focus on the breeding of donkeys. However, our current understanding of the mechanisms underlying spermatogenesis and maturation in donkeys during reproduction remains limited.

Objectives: This study is to provide a comprehensive single-cell landscape analysis of spermatogenesis and maturation in donkeys.

Horizontal gene transfer from chloroplast to mitochondria of seagrasses in the yellow-Bohai seas.

Seagrasses are ideal for studying plant adaptation to marine environments. In this study, the mitochondrial (mt) and chloroplast (cp) genomes of Ruppia sinensis were sequenced. The results showed an extensive gene loss in seagrasses, including a complete loss of cp-rpl19 genes in Zosteraceae, most cp-ndh genes in Hydrocharitaceae, and mt-rpl and mt-rps genes in all seagrasses, except for the mt-rpl16 gene in Phyllospadix iwatensis.

L-methionine and the L-type Ca channel agonist BAY K 8644 collaboratively contribute to the reduction of depressive-like behavior in mice.

The L-type Ca channel (LTCC, also known as Cav1,2) is involved in the regulation of key neuronal functions, such as dendritic information integration, cell survival, and neuronal gene expression. Clinical studies have shown an association between L-type calcium channels and the onset of depression, although the precise mechanisms remain unclear. The development of depression results from a combination of environmental and genetic factors.

A New Approach Refined Probabilistic Health Risk Assessment of Shaoguan Smelter Based on Microenvironment - Guangdong Province, China, 2021.

Introduction: This study introduces a novel method for developing an advanced exposure conceptual model tailored for health risk assessment, focusing on microenvironments.

Methods: The research was conducted at a major smelter in China to assess the health risks associated with trace metals (TMs) pollutants in the facility and the surrounding soil.

Results: Deterministic risk assessment indicated that cobalt, cadmium, antimony, manganese, arsenic, plumbum, and mercury (Co, Cd, Sb, Mn, As, Pb, and Hg) necessitated further evaluation through probabilistic risk assessment to assess potential health risks to residents.

[Prognostic Significance of Progression of Disease within 24 Months in Mantle Cell Lymphoma].

Objective: To investigate the effect of progression of disease within 24 months (POD24) on overall survival (OS) in patients with mantle cell lymphoma (MCL), and compare the clinical characteristics between POD24 and non-POD24 patients.

Methods: A retrospective analysis was performed on 50 MCL patients with treatment indications and regular treatment who were admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to August 2020. According to the occurrence of POD24, the patients were grouped for prognostic evaluation and clinical characteristics comparison.