Effects of Scalable, Wordless, Short, Animated Storytelling Videos on Flu Vaccine Hesitancy in China: Nationwide, Single-Blind, Parallel-Group, Randomized Controlled Trial.

Background: Low influenza vaccination rates in China pose a serious public health threat. The vaccination prevents infection, but widespread vaccine hesitancy remains a significant barrier. Short, animated storytelling videos may help by conveying health messages in an engaging, culturally neutral format that transcends literacy barriers.

Electrically-Driven Polarized Nano-Light Sources Based on Suspended Graphene Nanoscrolls.

Low-dimensional nanomaterials hold great promise for on-chip light-emitting applications and are expected to profoundly influence the evolution of next-generation photonic chips. Currently, microlasers and light-emitting diodes represent the predominant on-chip integrated light sources. Exploring how to employ low-dimensional materials to realize more miniaturized and controllable light sources remains a key research focus over the past decade.

Burden of chronic respiratory diseases and their attributable risk factors in 204 countries and territories, 1990-2021: Results from the global burden of disease study 2021.

Background: Chronic respiratory diseases (CRDs) remain a substantial global public health challenge, contributing significantly to morbidity and mortality worldwide. This study aimed to comprehensively characterize trends in CRD burden across various populations by examining differences by sex, age, and sociodemographic index (SDI).

Methods: We performed a systematic analysis using data from the Global Burden of Disease (GBD) 2021 study, covering the period from 1990 to 2021 across 204 countries and territories.

Effects of scalable, wordless, short, animated storytelling videos on hope in China: a nationwide, single-blind, parallel-group, randomised controlled trial.

Background: People with higher levels of hope are more likely to be vaccinated. Short, animated story (SAS) videos have shown promise for communicating health messages and boosting hope in certain populations. We explored the potential of scalable SAS vaccine promotion videos for boosting hope levels among Chinese adults.

Artificially Engineered Nonlinear Circular Dichroism with Chiral Nanoscrolling of 2D Materials.

Nonlinear chiroptical response, particularly nonlinear circular dichroism (CD), holds significant potential for advancing nanotechnology, biophotonics, and molecular imaging. While conventional approaches rely on intrinsic chiral materials, we demonstrate a novel strategy to engineer this effect by transforming achiral two-dimensional (2D) transition-metal dichalcogenides (TMDs) into chiral nanostructures. By scrolling monolayer TMDs into geometrically chiral nanoscrolls, we achieve pronounced nonlinear CD (up to 0.

[ Mixture improves α‑naphthylisothiocyanate-induced cholestasis in rats by inhibiting NLRP3 inflammasomes regulating farnesoid X receptor].

Objectives: To study the therapeutic mechanism of Mixture against cholestasis.

Methods: Forty-eight Wistar rats were randomized equally into blank group, model group, ursodeoxycholic acid group and Mixture group. Except for those in the blank group, all the rats were given α‑naphthylisothiocyanate (ANIT) to establish rat models of cholestasis, followed by treatments with indicated drugs or distilled water.

Engineered nanoparticles for the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is one of the most common diseases characterized by neurodegeneration and is becoming a major public health problem worldwide. AD is manifested mainly by progressive impairments in cognition, emotion, language and memory in the elderly population. Many treatment strategies have been explored for decades; however, there is still no effective way to address the root cause of AD pathogenesis, only to target symptoms to improve patient cognitive outcomes.

Enhancement Effect of Low-Frequency Raman Modes in Graphene Nanoscrolls.

Graphene nanoscrolls (GNSs) are unique structures with interlayer coupling modes distinct from those in graphene and carbon nanotubes, exhibiting potential physical properties yet to be explored. Here we investigated the low-frequency Raman modes in GNSs formed from 1 to 3 layer graphene (1-3LG). The results of the Raman spectroscopy show that both shear (C) and layer breathing (LB) modes have appeared in monolayer graphene nanoscrolls (1L-GNSs), although these modes never exist in the flat 1LG.

Nuclear magnetic resonance revealed the structural unit difference and polymerization process of pre-humic acid from different organic waste sources.

Pre-humic acid (HA) is brown humus that is only soluble in dilute alkali in natural soil. However, the mechanism underlying HA structural heterogeneity caused by material differences remains unknown. In this study, nuclear magnetic resonance (H NMR) and fourier transform infrared spectroscopy were used to analyze the structure of HA with varying molecular weights.

Exciton Emission Enhancement in Two-Dimensional Monolayer Tungsten Disulfide on a Silicon Substrate via a Fabry-Pérot Microcavity.

Exciton emitters in two-dimensional monolayer transition-metal dichalcogenides (TMDs) provide a boulevard for the emerging optoelectronic field, ranging from miniaturized light-emitting diodes to quantum emitters and optical communications. However, the low quantum efficiency from limited light-matter interactions and harmful substrate effects seriously hinders their applications. In this work, we achieve a ∼438-fold exciton photoluminescence enhancement by constructing a Fabry-Pérot cavity consisting of monolayer WS and a micron-scale hole on the SiO/Si substrate.

Manipulation of Moiré Superlattice in Twisted Monolayer-multilayer Graphene by Moving Nanobubbles.

In the heterostructure of two-dimensional (2D) materials, many novel physics phenomena are strongly dependent on the Moiré superlattice. How to achieve the continuous manipulation of the Moiré superlattice in the same sample is very important to study the evolution of various physical properties. Here, in minimally twisted monolayer-multilayer graphene, we found that bubble-induced strain has a huge impact on the Moiré superlattice.

Gaining insight into the effect of laccase expression on humic substance formation during lignocellulosic biomass composting.

The aim is to enhance lignin humification by promoting laccase activities which can promote lignin depolymerization and reaggregation during composting. 1-Hydroxybenzotriazole (HBT) is employed to conduct laccase mediator system (LMS), application of oxidized graphene (GO) in combination to strengthen LMS. Compared with control, the addition of GO, HBT, and GH (GO coupled with HBT) significantly improved laccase expression and activities (P < 0.

and Coordinately Regulated Tomato Ripening by Inhibiting Transcription.

As a typical climacteric fruit, tomato () is widely used for studying the ripening process. The negative regulation of tomato fruits by transcription factor has been reported, but its regulatory network was unclear. In the present study, we screened a transcription factor, , and found it had a stronger relationship with at the early stage of tomato fruit development through the use of transcriptome data, RT-qPCR, and correlation analysis.

Evaluation of the effectiveness of promoted psychological resilience intervention for oesophageal cancer patients in rural China: A randomized controlled study.

Purpose: The objective of this randomized controlled trial was to examine the effectiveness of promoted resilience intervention to facilitate resilience, self-efficacy, coping mode, and social support for oesophageal cancer patients in rural China.

Methods: A two-arm, parallel design, single-blinded, randomized controlled trial was conducted in a comprehensive tertiary hospital in Anhui from August 2021 to September 2022. A total of 82 oesophageal cancer patients were assigned to two groups via blocked randomization.

From VIB- to VB-Group Transition Metal Disulfides: Structure Engineering Modulation for Superior Electromagnetic Wave Absorption.

The laminated transition metal disulfides (TMDs), which are well known as typical two-dimensional (2D) semiconductive materials, possess a unique layered structure, leading to their wide-spread applications in various fields, such as catalysis, energy storage, sensing, etc. In recent years, a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption (EMA) has been carried out. Therefore, it is of great significance to elaborate the influence of TMDs on EMA in time to speed up the application.

Life-cycle impact assessment of hardwood forest resources in the eastern United States.

To explore the carbon sequestration potential of hardwood forests in the eastern United States, the forest vegetation simulator (FVS) and life cycle assessment (LCA) were integrated to analyze the forest carbon dynamics for the four subregions of the eastern United States: northeast (NE), mid-Atlantic (MA), southeast (SE), and north central (NC). This study quantitatively assessed current forest management practices for timber production and their associated life-cycle environmental impacts. The system boundary was selected to be consistent with the A1 module (extraction and upstream production) required by an Environmental Product Declaration (EPD) for wood products.

Natural products as potential lead compounds to develop new antiviral drugs over the past decade.

Virus infection has been one of the main causes of human death since the ancient times. Even though more and more antiviral drugs have been approved in clinic, long-term use can easily lead to the emergence of drug resistance and side effects. Fortunately, there are many kinds of metabolites which were produced by plants, marine organisms and microorganisms in nature with rich structural skeletons, and they are natural treasure house for people to find antiviral active substances.

The reverse function of lignin-degrading enzymes: The polymerization ability to promote the formation of humic substances in domesticated composting.

This study aimed to confirm the ability of lignin peroxidase (LiP) and manganese peroxidase (MnP) in promoting the formation of humic substances (HS) during domesticated composting. Three raw materials with different lignin types were used for composting, including rice straw, tree branches, and pine needles. Results suggested that LiP and MnP activity increased during domesticated composting.

Fabricating-scheme C-doped TiO/rGO nanocomposites for enhanced photocatalytic NO removal.

It is attractive to explore practical approaches to optimize the photodegraded NO property of TiO. Herein, a typical-shaped heterojunction C-TiO/rGO composed of carbon-doped TiOand reductive graphene oxide (rGO) was constructed to optimize the NO removal efficiency through anone-pot hydrothermal process with glucose as reductant and dopant. The C-TiO/rGO (0.

Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis.

The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize the functional valence (gain or loss-of-function) of missense variants identified in UBE3A, the gene whose loss-of-function causes the neurodevelopmental disorder Angelman syndrome. We identify numerous gain-of-function variants including a hyperactivating Q588E mutation that strikingly increases UBE3A activity above wild-type UBE3A levels.

Micro-structured copper and nickel metal foams for wastewater disinfection: proof-of-concept and scale-up.

It is necessary to disinfect treated wastewater prior to discharge to reduce exposure risks to humans and the environment. The currently practiced wastewater disinfection technologies are challenged by toxic by-products, chemicals and energy demand, a range of effectiveness limitations, among other concerns. An effective, eco-friendly, and energy-efficient alternative disinfection technique is desirable to modernize and enhance wastewater treatment operations.

Design of SnO₂ Aggregate/Nanosheet Composite Structures Based on Function-Matching Strategy for Enhanced Dye-Sensitized Solar Cell Performance.

Hierarchical SnO₂ nanocrystallites aggregates (NAs) were prepared with a simple room temperature⁻based aqueous solution method followed by simple freeze-drying treatment. The as-prepared SnO₂ NAs were subsequently combined with SnO₂ nanosheet⁻based structures from the viewpoint of a function-matching strategy, and under an optimized condition, a power conversion efficiency (PCE) of 5.59% was obtained for the resultant hybrid photoanode, a remarkable 60% enhancement compared to that of dye-sensitized solar cells (DSCs) fabricated with bare SnO₂ NAs architecture.