The role and clinical value of natriuretic peptide receptor family in malignant tumor.

The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions.

Association of microtubule-based processes gene expression with immune microenvironment and its predictive value for drug response in oestrogen receptor-positive breast cancer.

Objective: The development of acquired endocrine resistance and reduced chemosensitivity in oestrogen receptor-positive (ER+) breast cancer presents significant challenges. Microtubule-based process-related genes (MBPRGs) play essential biological roles in the cell cycle and the development of migration. This study aimed to establish a novel prognostic signature based on MBPRGs to improve patient outcomes and offer additional treatment options for those with ER+ breast cancer.

Motion-induced phase-shifting profilometry for dynamic objects via Fourier fringe analysis and speckle correlation-assisted phase unwrapping.

Fringe projection profilometry, particularly phase-shifting profilometry, has been extensively studied and widely adopted due to its non-contact operation, high accuracy, and efficiency. However, in dynamic applications, it faces two major challenges: the increased number of encoded patterns required for absolute phase retrieval, and motion-induced phase errors. To address these limitations while preserving measurement accuracy, this study proposes a motion-induced phase-shifting method that integrates Fourier fringe analysis with speckle correlation-assisted phase matching.

Prediction of 3D spatial distribution, driving factors, and risk for heavy metal(loid)s in sediment of Dongdagou River based on ensemble learning.

Sediments contaminated with heavy metal(loid)s can cause harm to the environment. This study proposed the use of machine learning methods to predict, classify, and identify the three-dimensional distribution of heavy metal(loid)s in sediment. Based on the 1423 sampling data from Dongdagou, a total of 8 metal(loid)s and 18 covariates were used to train and test the model.

Machine learning and SHAP value interpretation for predicting the response to neoadjuvant chemotherapy and long-term clinical outcomes in Chinese female breast cancer.

Background: Most models of neoadjuvant chemotherapy (NACT) for breast cancer (BC) suffer from insufficient data and lack interpretability. Additionally, there is a notable absence of reports from China in this field. This study is also the first to integrate the Advanced Lung Cancer Inflammation Index (ALI) into such a model to evaluate its effectiveness.

Multi-omics analysis of the effects of pla2g4a on the prognosis of various cancers and its experimental validation in breast cancer cell lines.

Background: Platelet-related exosomes (PREs) are microparticles secreted by platelets into the bloodstream and are implicated in various cancer processes. This study aims to identify critical genes involved in Breast Cancer (BC)-associated PREs and to evaluate their role in cancer prognosis. PLA2G4A was identified as a key gene through the use of machine learning techniques and various genomic analyses, providing a foundation for precision medicine in BC treatment.

Revealing the main toxic factor and mechanisms of shale gas flowback water on the growth of algae Chlorella pyrenoidosa.

Flowback Water (FBW) have been proved to show toxicity towards some aquatic organisms, but the toxic effect across different flowback periods and underlying mechanism remained unclear due to their complex and changeable constitutes. In this study, the toxicity of FBW, the respective activated carbon treated FBW (AC-FBW) with most organic compounds removed, and equivalent salt control (SC) towards Chlorella pyrenoidosa were tested in three different flowback periods. Their toxicity increased with the duration of flowback time due to the change of composition.

Metabolic trade-offs in : dose-dependent FeS nanoparticles modulate extracellular electron transfer and gene expression for mineral transformation.

Biogenic ferrous sulfide nanoparticles (FeS NPs) regulate sulfate (SO)-reducing bacteria (SRB)-driven iron/sulfur cycling in SO-rich anaerobic environments, yet their dose-dependent impacts on SRB metabolism remain unclear. This study revealed how FeS NPs dose modulates (a model SRB) in reducing schwertmannite (Sch). SRB preferentially reduced Fe(III) over SO in Sch FeS NPs-mediated extracellular electron transfer (EET).

Discovery of degrader for FLT3, GSPT1 and IKZF1/3 proteins merging PROTAC and molecular glue targeting FLT3-ITD mutant acute myeloid leukemia.

Fms-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase expressed in hematopoietic progenitor cells and in most AML cell lines. Pharmacological inhibition of FLT3 enzymatic function is now a well-established strategy for the treatment of patients with these malignancies. Herein, we report the discovery and characterization of a FLT3 degrader A2.

Airway involvement in pulmonary sarcoidosis: Clinical and CT features.

Background: Sarcoidosis is a systemic granulomatous disorder with frequent respiratory system involvement, yet comprehensive data on airway abnormalities remain limited. This study aims to assess the prevalence and characteristics of airway involvement in pulmonary sarcoidosis and its correlation with clinical and radiological features.

Methods: A retrospective, single-center study was conducted at Shanghai Pulmonary Hospital, including 842 patients diagnosed with pulmonary sarcoidosis between March 2013 and September 2023.

Dietary exposure to per- and polyfluoroalkyl substances and health risk assessment in 7-year-old children in Shandong, China.

Background: Dietary intake, especially foods of animal-origin, is an important source of per- and polyfluoroalkyl substances (PFAS) exposure to the general population. However, the distribution of legacy and emerging PFAS in different food categories is unclear, as well as their potential health risk for children.

Objectives: To investigate dietary sources of PFAS and evaluate the risk for 7-year-old children in Laizhou Wan, a region with high PFAS exposure in Shandong, China.

LncRNA BACE1-AS delays the propagation of through regulating cell apoptosis by targeting the miR-6805-5p/IRF3 axis.

spp. are important zoonotic pathogens causing diarrhea in humans and various animals. To date, there are still no effective drugs and vaccines for the prevention and treatment of cryptosporidiosis, mainly due to the absence of knowledge on the interaction mechanisms between hosts and .

FCGR2A contributes to M2 macrophages polarization in HCC through IL-4/JAK/STAT6 axis.

The most common subtype of primary liver cancer is hepatocellular carcinoma (HCC), which accounts for about 90 % of primary liver cancers. Tumor microenvironment (TME) plays important roles in HCC development. TME coexists and interacts with various immune cells.

Wound treatment with curcumin prevents hypertrophic scarring and promotes remodeling by inhibiting fibroblast activation and regulating collagen deposition.

More and more attention is paid to the prevention of hypertrophic scars (HS). This study aimed to investigate the mechanisms of topical curcumin application in alleviating HS secondary to wounds. Human dermal fibroblasts (HDFs) were cultured with transforming growth factor-β1 and varying concentrations of curcumin for 48 h.

Alternative splicing analysis of stress tolerance to Al and flg22 in Vitis quinquangularis.

Alternative splicing of transcriptomes after Al and flg22 treatment for 12 h in response to plant defense of Chinese wild Vitis quinquangularis: genes related to stress resistance and splicing factors were identified in response to Al and flg22 treatment. Alternative splicing (AS) is one of the major post-transcriptional regulation processes that potentially regulates the response to biotic and abiotic stresses in plants. So far, the insight into potential roles of AS in grapevine response to aluminium (Al) and flagellin 22 (flg22) stresses remains poorly understood.

Identifying the critical windows and joint effects of greenness and particulate matter exposures for preterm birth: a retrospective study across Guangdong Province in China from 2014 to 2018.

Background: Green space may have a wide range of beneficial health effects, but its association with preterm birth (PTB) remains inconclusive. Therefore, our study aims to investigate the effect of green space and its joint effect with particulate matter (PM) on PTB. Additionally, we seek to identify its critical susceptibility window.

Nurses' knowledge-attitude-practice of the importance of quality control of nursing documents and the influence of intensive training: a study from a tertiary hospital in China.

Objective: This study aims to investigate nursing staff's current knowledge-attitude-practice(KAP) regarding nursing document quality control and to explore effective methods to enhance their awareness of nursing documents' importance through intensive training.

Methods: We developed the questionnaire based on a systematic literature review and two rounds of Delphi expert consultation. Then, we sent the questionnaire to the nurses before and after the intensive training.

Anion-Dipole Repulsions Improve Low-Temperature Performance of μ-Sn for Advanced Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are attractive for large-scale energy storage and have to work at a wide temperature range. Compared to the performance at room temperature, the low-temperature performance of SIBs is always poor. Herein, tetrahydrofuran (THF) and 2-methyltetrahydrofuran (MTHF) are mixed as a model of weak solvating effect to improve the low-temperature performance.

Advances in Tandem Mass Spectrometry Imaging for Next-Generation Spatial Metabolomics.

Spatial metabolomics based on mass spectrometry imaging (MSI) is a promising approach for fundamental biological research and disease biomarker discovery. It simultaneously reveals the spatial distributions of hundreds of metabolites across tissue sections. While previous MSI experiments predominantly rely on high-resolution mass analysis for metabolite annotation, the high specificity in resolving molecular structures is essential to distinguish isomers or isobars to obtain ultimate identities of the metabolites.

Clinical study of the relationship between hepatitis B core antibody and mechanical ventilation in patients with Guillain-Barré syndrome.

Introduction: The aim of this study was to investigate the association between hepatitis B core antibody (HBcAb) positivity and the need of mechanical ventilation (MV) in patients with Guillain-Barré syndrome (GBS).

Methods: We retrospectively analyzed the clinical data of 159 patients who were diagnosed with GBS between December 2014 and April 2023 in the Affiliated Hospital of Xuzhou Medical University. Patients were categorized into two groups according to the need for MV.

The influence of meaning in life on smartphone addiction among nursing undergraduates: the mediating roles of professional identity and achievement motivation.

Background: Smartphone addiction is a behavioral addiction characterized by excessive smartphone use, leading to physical and mental health issues. This condition significantly affects individuals' well-being. Undergraduate nursing students, as the future backbone of the nursing profession, face challenges in maintaining their physical and mental health.

Rational Screening of Siloxane Molecules as Electrolyte Additives for High-Temperature Sodium-Ion Batteries.

Sodium-ion batteries hold great promise for large-scale energy storage but face significant challenges at extreme temperatures. Especially at high temperatures, side reactions and electrode dissolution are exacerbated by repeated cycling. It is, therefore, essential to optimize the electrolyte formulation.

Long-term yogurt intake and colorectal cancer incidence subclassified by abundance in tumor.

Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains . We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue . We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies.

Permeability-Enhancing and Protective Effect on Small Intestine of Punicic Acid in Different Forms and Their Nanoemulsions With Low Toxicity.

Purpose: Most absorption enhancers boost the oral absorption of drugs via increasing intestinal permeability. However, they often damage intestinal mucosa and induce inflammatory reactions. The aim of this study is to synthesize a new absorption enhancer, punicic acid ethyl ester (PAEE), with excellent absorption-prompting effect and low toxicity.