A strategy to re-sensitise drug-resistant Gram-positive bacteria to oxazolidinone-class antibiotics.

Background: Multidrug-resistant bacterial infections have high mortality rates and few treatment options. Synergistic combinations may improve clinical outcome but traditional strategies often damage healthy microbiome. Oxazolidinone-class antibiotics are typical last-resort drugs for treating drug-resistant bacterial infections but are becoming less effective due to resistance development.

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis have not been fully elucidated. Recently, m6A RNA modification has been found to regulate various biological processes.

YOLOv11-GSF: an optimized deep learning model for strawberry ripeness detection in agriculture.

The challenge of efficiently detecting ripe and unripe strawberries in complex environments like greenhouses, marked by dense clusters of strawberries, frequent occlusions, overlaps, and fluctuating lighting conditions, presents significant hurdles for existing detection methodologies. These methods often suffer from low efficiency, high computational expenses, and subpar accuracy in scenarios involving small and densely packed targets. To overcome these limitations, this paper introduces YOLOv11-GSF, a real-time strawberry ripeness detection algorithm based on YOLOv11, which incorporates several innovative features: a Ghost Convolution (GhostConv) convolution method for generating rich feature maps through lightweight linear transformations, thereby reducing computational overhead and enhancing resource utilization; a C3K2-SG module that combines self-moving point convolution (SMPConv) and convolutional gated linear units (CGLU) to better capture the local features of strawberry ripeness; and a F-PIoUv2 loss function inspired by Focaler IoU and PIoUv2, utilizing adaptive penalty factors and interval mapping to expedite model convergence and optimize ripeness classification.

Clinical and genetic features of UNC13D deficiency with hypogammaglobulinemia.

Background: UNC13D deficiency is the most common form of familial hemophagocytic lymphohistiocytosis (FHL) in Asia. Hypogammaglobulinemia is a rare phenotype observed in both patients with FHL3 and sporadic hemophagocytic lymphohistiocytosis (HLH). Our observations suggest that UNC13D deficiency with hypogammaglobulinemia presents a distinct clinical phenotype compared to other HLH patients.

Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism.

Background: Pancreatic cancer, characterized by aggressive proliferation and metastasis, is a lethal malignancy. The nightly hormone melatonin serves as a rhythm-regulating hormone, and is used to treat different cancers including pancreatic cancer.

Aim: To investigate how melatonin acts against human pancreatic cancer cell lines and analyze the biological processes that cause the observed effects.

Preferential Texture of Surface Coating on Zn Anodes for Advanced Aqueous Batteries: Small Change but Big Gain.

Zinc metal, as the mainstream anode material of aqueous batteries, faces severe side reactions and notorious dendrite growth. Surface passivation of Zn anodes with a protective layer is one of the effective strategies to address these issues. The previous reports have focused on applying different components as surface layers while neglecting the impact of their crystallographic orientation on electrochemical performance.

Regulation of fatty acid synthesis in oilseed crops: multidimensional insights and strategies for enhancing oil quality.

The adage "Food is the God of the people" underscores the profound interconnectedness between agriculture and the food industry. Agriculture forms the backbone of the food industry, while evolving consumer preferences continuously shape its progress. The balance between saturated and unsaturated fatty acids (SFAs and UFAs) in vegetable oils is critical to human health.

Evaluating Causal Effects of Gut Microbiome on Bipolar Disorder.

Background: Previous studies have shown that gut microbiome dysbiosis has pathogenic significance in the development of bipolar disorder (BD), but the direct causal relationship remains unclear. We aimed to investigate this potential correlation.

Methods: Using a two-sample Mendelian randomization (TSMR) analysis, we examined the potential causal effects of gut microbiota on BD.

Correction: Tropical postbiotics alleviate the disorders in the gut microbiota and kidney damage induced by ochratoxin A exposure.

Correction for 'Tropical postbiotics alleviate the disorders in the gut microbiota and kidney damage induced by ochratoxin A exposure' by Shuaiming Jiang , , 2024, , 3980-3992, https://doi.org/10.1039/D3FO05213C.

Multi-layer network analysis of ACG color semantic hierarchies in digital cultural communication.

Digital color design lacks scientific guidance beyond designer intuition, limiting cultural product effectiveness. This study develops a cognitive hierarchy framework integrating feature integration, ecological perception, and cultural semiotics theories to quantify ACG color cognition through network analysis. Analyzing 38,566 social media posts, three-layer semantic networks (perceptual, associative, symbolic) reveal systematic structural differences with"scale reduction-power concentration"patterns.

Vehicle Load Information Acquisition Using Roadside Micro-Electromechanical Systems Accelerometers.

Vehicle load is crucial for road design, maintenance, and expansion, while vehicle speed and lateral position are essential for traffic management and driving safety. This paper introduces a method for collecting vehicle speed, lateral position, and load information using roadside Micro-Electromechanical Systems (MEMS) accelerometers located on the pavement. Firstly, this research analyzes the distribution of pavement vibration responses in both lateral and vertical directions based on the Finite Element Method (FEM) data provided in the literature.

Joint association of sleep quality and physical activity with hypertension: a cross-sectional population study in agricultural workers.

Objective: The study explores the prevalence of hypertension and evaluates the joint association of sleep quality and physical activity (PA) levels in influencing hypertension among the Kazakh agricultural workers in Xinjiang.

Methods: In this chronic disease study conducted in Xinjiang, participants were selected from Habahe County, a predominantly Kazakh region, between October and November 2023. Restricted cubic spline (RCS) analysis and multivariate logistic regression models were used to evaluate the associations between sleep quality, PA levels, and the prevalence of hypertension.

miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.

Objective: To investigate the diagnostic value and mechanism of action of miR-326 in gestational diabetes mellitus (GDM).

Methods: The study population consisted of 98 GDM patients and 71 healthy pregnant women. Subjects' serum were collected early in pregnancy (10-12 weeks) for cryopreservation.

Unleashing the Therapeutic Power of Natural Alkaloids in Triple-Negative Breast Cancer: State-of-the-Art Advances and Future Directions.

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of ER, PR, and HER2, presenting significant challenges due to its heterogeneity and limited treatment options. Recent studies have identified naturally derived alkaloids as promising therapeutic agents, capable of targeting critical signaling pathways involved in TNBC progression, including PI3K/AKT/mTOR, STAT3, TGF-β, NF-κB, and p38 MAPK. This review provides a comprehensive overview of the past decade's advancements in alkaloid-based therapies for TNBC, emphasizing their impact on key pathways.

The Relationship Between Gut Microbiota-Related Hippocampal Tryptophan Metabolite and Alzheimer's Disease-Like Neurobehavioral Changes Induced by Chronic Inorganic Arsenic Exposure in Rats.

Arsenic is recognized for its harmful effects on neurodevelopment and cognitive function, and neurodegenerative alterations induced by arsenic exposure may eventually lead to Alzheimer's disease (AD). However, the precise changes in the gut microbiome and tryptophan (Trp) metabolism resulting from arsenic exposure, as well as their role in the "microbiome-tryptophan metabolite-brain axis" in AD, remain poorly understood. In this study, the rats were exposed to arsenic in utero, with continued exposure lasting until 185 days after birth, through free drinking water contaminated with varying concentrations of NaAsO (0, 30 mg/L, and100mg/L).

Melatonin reverses lenvatinib resistance in HCC by regulating the ATF4-NRF1 pathway mediated by ceramide synthase 6.

The tyrosine kinase inhibitor lenvatinib is a first-line drug for the treatment of advanced hepatocellular carcinoma (HCC). However, its efficacy is significantly compromised by the development of drug resistance. Gaining insights into the molecular mechanisms underlying lenvatinib resistance could offer novel strategies to enhance and prolong therapeutic responses.

A systematic review and meta-analysis of randomized controlled trials on the efficacy and safety of tanshinone IIA sodium sulfonate injection as adjunctive therapy for stroke.

Ethnopharmacological Relevance: Tanshinone IIA is the core ingredient of Salvia miltiorrhiza Bge, with the effect of blood circulation promotion and blood stasis removement, widely used in cardiovascular and cerebrovascular diseases treatment as adjunctive therapy.

Aim Of The Study: Stroke, remains a leading cause of disability and death, posing a serious public health threat. Tanshinone IIA sodium sulfonate injection (STS), derived from Salvia miltiorrhiza Bge (Danshen), is widely used in China as adjunctive therapy for ischemic stroke.

Geometrically insensitive deform-and-go liquid crystal elastomer actuators through controlled radical diffusion.

The geometric shape and programming of mesogen alignment are two critical prerequisites for the effective actuation of liquid crystal elastomer (LCE) actuators. However, existing alignment programming approaches inevitably impose limitations on the geometric design of LCEs. In this study, we introduce a controlled radical diffusion mechanism that enables geometrically insensitive programming of actuation.

Suppressing thermal degradation of CsPbBr quantum dot/EVA films APTES-mediated interface engineering: toward efficient and stable luminescence down-shifting for silicon solar cells.

Luminescence down-shifting technology is increasingly recognized as a crucial option for enhancing the efficiency of silicon solar cells. However, high-quality down-shifting materials, such as perovskite quantum dots, face challenges related to poor thermal stability. These materials tend to agglomerate into larger sizes, leading to the deterioration of the luminescence films at high temperature.

Multidisciplinary insights for salt reduction and flavor enhancement in foods: integrating strategies via molecular design, taste signal transduction, and cognitive perception.

Salt, as a vital food additive, is indispensable in human life. However, excessive sodium intake poses a significant risk factor for hypertension and cardiovascular diseases, underscoring the imperative for effective salt reduction and flavor enhancement strategies in the food industry. Conventional salt reduction flavor enhancement (SRFE) strategies include salt substitutes, optimized salt physical forms, salty peptides (SPs), non-thermal processing (NTP) technologies, odor-induced saltiness enhancement (OISE), and gradual salt reduction.

Mechanistic insights into nutrient profiles, cellulose, and hemicellulose dynamics in red and green buds during cold storage.

() is a popular woody vegetable with distinct red and green varieties in China. Despite its significance, research on the comparative nutrient composition profiles and cellulose and hemicellulose dynamics between these two varieties remains limited. This study comprehensively investigated the refrigerated storage characteristics of buds from multiple aspects, related to cellulose and hemicellulose synthesis.

Study of high-order nonlinear propagation characteristics of partially coherent beams.

This study develops a numerical simulation method and investigates the propagation characteristics of partially coherent beams in nonlinear media, specifically addressing the research gaps related to the accuracy of numerical methods and higher-order nonlinear effects. Key findings include the validated of a new simulation method against the split-step Fourier method with analytical formulas, demonstrating enhanced accuracy. Our findings reveal that, under the higher-order nonlinear effect conditions, the focusing ability of Gaussian-Schell model (GSM) beams under nonlinear conditions is opposite to that when only considering the third-order nonlinear refractive index coefficient ().

Tumor-infiltrating lymphocytes in NSCLC: from immune surveillance to immunotherapy.

Lung cancer, predominantly non-small cell lung cancer (NSCLC), remains a principal driver of cancer-related morbidity and mortality worldwide. Despite advancements in surgery, radiotherapy, chemotherapy, and targeted treatments, outcomes remain poor in advanced NSCLC. The tumor microenvironment (TME) exerts a critical influence on therapy responses.

Qian Zhao.

"The most rewarding part of my job is turning an immature idea into a project and eventually into something useful…I am most proud of my research group when members from multiple disciplines work together seamlessly to build new things…" Find out more about Qian Zhao in her Introducing…Profile.