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http://dx.doi.org/10.1016/j.cell.2025.07.030 | DOI Listing |
Mod Pathol
September 2025
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
Uterine leiomyosarcoma (uLMS) is a rare and deadly gynecologic malignancy. uLMS is histologically heterogeneous and presents with a wide spectrum of tumor differentiation, with a broad range of genomic DNA instability, which can make the diagnosis and prognosis of uLMS challenging. Methylation has emerged as a useful molecular tool in tumor classification and diagnosis in certain neoplasms.
View Article and Find Full Text PDFAnal Biochem
September 2025
College of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
This study aimed to investigate potential biomarkers related to Endoplasmic reticulum (ER) stress in Amyotrophic lateral sclerosis (ALS) through a comprehensive bioinformatic approach. The gene expression profiles of ALS patients and healthy controls were downloaded from the Gene Expression Omnibus (GEO) database. ER stress-related genes were collected from the MSigDB databases and document literature.
View Article and Find Full Text PDFComplement Ther Med
September 2025
Fukuoka City Hospital, Fukuoka 812-0046, Japan.
Objectives: Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, have recently gained attention because of their potentially beneficial effects on lipid profiles and cardiovascular health.
Design And Setting: This systematic review aimed to synthesize current evidence on the efficacy of hot spring and sauna use, alone or combined with exercise therapy, in improving blood lipid profiles, with a focus on mechanisms, benefits, and limitations.
J Biol Chem
September 2025
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:
Posttranslational modifications (PTMs) of proteins are efficient biological mechanisms for expanding the genetic code and for regulating cellular physiology. However, there have been no systematic approaches to profile all the PTMs critical for autoreactive neoantigen production or the etiology and pathology of autoimmune diseases. In the present study, to gain insight into protein PTMs associated with systemic lupus erythematosus (SLE), we applied a mass spectrometry-based method for the comprehensive analysis of modified amino acids ("adductome").
View Article and Find Full Text PDFMult Scler Relat Disord
September 2025
Neurologist-Neuroimmunologist. Associate Professor of Neurology, Neuroscience Department, Division of Neurology, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia. Electronic address:
Background: Headache is a common but underrecognized symptom in optic neuritis (ON), with potential implications for diagnosis and management.
Objective: To assess the clinical and radiological factors associated with headache in patients with acute ON.
Methods: We conducted a retrospective case-control study in a tertiary hospital in Bogotá, Colombia (2022-2024).