Correlations Between Variability of Preoperative Ocular Biometric Measurements and Accuracy of Intraocular Lens Power Calculation.

Objectives: To investigate the relationship between variability of preoperative ocular biometric measurements and the accuracy of intraocular lens (IOL) power calculation.

Methods: This retrospective study included cataract patients who underwent surgery at the People's Hospital of Baoan Shenzhen from January 2022 to December 2024. Preoperative ocular biometric parameters were measured using the Lenstar LS-900, and the coefficients of variation (CV) of corneal curvature (K1-CV, K2-CV), axial length (AL-CV), anterior chamber depth (ACD-CV) were calculated.

JMJ720 encodes an H3K9me2 demethylase that regulates grain size in rice.

Grain size is a crucial determinant of rice yield, yet the molecular mechanisms controlling this trait remain only partially understood. Here, we identified the JMJ720 locus as a key regulator of grain size through map-based cloning. The jmj720 mutant was found to exhibit significantly larger grains when compared to the wild type (WT).

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis have not been fully elucidated. Recently, m6A RNA modification has been found to regulate various biological processes.

A π-Conjugated Molecular Bridge Strategy for Constructing Efficient Hole Transport Pathways in Inverted Perovskite Solar Cells.

Metal halide perovskite solar cells (PSCs) hold promise for next-generation photovoltaics but are restricted by suboptimal efficiency and poor long-term stability. In inverted PSC architectures, self-assembled monolayers (SAMs) are widely employed as hole-selective layers (HSLs) due to their favorable energy-level alignment and negligible parasitic absorption. However, traditional SAMs often exhibit weak intermolecular interactions, leading to film aggregation, poor interfacial contact, and severe nonradiative recombination.

Polymerization of L-Arginine into Nanomicelles for Immunometabolic Engineering of Adoptive Macrophages in Solid Tumor Therapy.

The therapeutic efficacy of adoptive cell therapy is highly dependent on the status and function of the infused cells. However, insufficient nutrient availability within the immunosuppressive tumor microenvironment (TME) often impedes these cells from fully exerting their cytotoxic potential against solid tumors. Here, we present a strategy of integrating adoptively transferred macrophages with intracellular nutrient depots composed of L-arginine-based nanomicelles to provide a sustainable supply of essential metabolite and optimize the cellular activity in the nutrient-deprived TME.

Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial.

Reducing psychological craving is critical for preventing relapse in methamphetamine use disorder (MUD). This study aimed to evaluate the efficacy of virtual reality (VR)-based cue exposure therapy (CET) and cue exposure with aversion therapy (CETA) in reducing methamphetamine craving in men with MUD. In this randomized controlled trial, 89 men with MUD were assigned to three groups: VR-based cue exposure therapy (CET, n = 30), VR-based cue exposure combined with aversion therapy (CETA, n = 29), and neutral scenes (NS, n = 30).

Ultraefficiency Mg/Li Separation by Loose Nanofiltration Membrane: The Host-Guest Recognition of Crown Ether.

Nanofiltration (NF) stands as a pivotal method for lithium resource recovery. Nonetheless, traditional NF membranes predominantly rely on size exclusion and the Donnan effect, necessitating elevated operating pressures and encountering substantial hurdles in terms of ion selectivity for lithium ions. Inspired by the host-guest recognition of crown ethers toward alkali metal ions, we prepared a crown ether-functionalized loose NF membrane (CE-LNF) via interfacial polymerization of diamino-dibenzo-14-crown-4 (DAB14C4) and trimesoyl chloride on a chloromethylated polysulfone substrate.

Cation-π/π-π Synergy Induced Self-Assembly of Semiconductor Spacers for High Efficiency and Stable 2D/3D Perovskite Solar Cells.

2D/3D perovskite heterojunctions exhibit simultaneous improvement of efficiency and stability to meet commercial applications. However, dielectric confinement and an intrinsically uncontrollable crystallization process in 2D perovskites typically lead to large exciton binding energies and poor film quality, hindering charge dissociation, carrier transport, and ultimately device performance. Here, a strong aromatic conjugated ammonium salt spacer (PyPAI) that can spontaneously form self-assembled columnar stacks via synergistic cation-π and π-π interactions is introduced, thereby simultaneously regulating crystal growth and enhancing charge transfer for high performance perovskite solar cells (PSCs).

Molecular drivers of fusion plasmid: mechanistic insights and evolutionary implications.

Plasmid fusion, the recombination of distinct plasmids into a single plasmid, constitutes a critical mechanism shaping bacterial evolution. This process facilitates genetic resource consolidation, enabling bacterial populations to rapidly adapt to selective pressures such as antibiotic exposure. The growing recognition of plasmid fusion as a widespread genomic recombination event necessitates a comprehensive analysis of its prerequisites, molecular mechanisms, and functional consequences.

Behavior Change Resources Used in Mobile App-Based Interventions Addressing Weight, Behavioral, and Metabolic Outcomes in Adults With Overweight and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Overweight and obesity have become a public health issue. Lifestyle modifications delivered through mobile devices, especially mobile phones, present an opportunity to support weight loss efforts. However, evidence regarding the effects of mobile apps on other outcomes, such as blood pressure and physical activity (PA), remains limited.

Overcoming feature scarcity in complex system prediction: An alternative delay embedding.

Predicting the future dynamics of complex systems remains challenging in scientific research. Traditional methods generally approach this issue by approximating the correlations between predictors (features) and target variables, often employing predictors from a pool of target-related variables (system components). However, these approaches are inherently constrained when reliable target-related features are scarce.

Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.

Background: Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with no current cure. Developing diagnostic biomarkers is crucial for improving patient outcomes. Circular RNAs (circRNAs) are a class of noncoding RNAs that are more stable, abundant, and structurally distinct compared to linear RNAs.

Prevalence and the Mutual Relationship Between Chronic Obstructive Pulmonary Disease and Arbovirus: A Comprehensive Systematic Review and Meta-Analysis of Current Evidence.

Chronic obstructive pulmonary disease (COPD) is a progressive condition affecting the lungs, marked by persistent respiratory symptoms. The prevalence and the risk of COPD in arboviruses types is not fully addressed clinically. We aim to determine the prevalence and the risk of COPD in arboviruses by a systematic review and meta-analysis.

Functional Electrolyte Additives for Aqueous Zinc-Ion Batteries: Progress and Perspectives.

Aqueous zinc-ion batteries (AZIBs) have emerged as promising candidates for next-generation energy storage systems due to their inherent safety, cost-effectiveness, and environmental compatibility. However, practical applications are hindered by challenges, such as zinc (Zn) dendrite formation, hydrogen evolution reactions (HER), and other side reactions. This review systematically explores the role of electrolyte additives in addressing these limitations by modulating Zn deposition behavior, suppressing parasitic reactions, and enhancing interfacial stability.

Component characterization of Roxb., and its inhibitory activity against through targeted suppression of its secreted urease.

Background: Roxb. (SGR), known as "tufuling" in China, is a medical and edible plant, which has anti-inflammatory, antibacterial and antineoplastic activity. SGR is extensively utilized in the remedy of gastroenteric disorders associated with infection.

Comparative genomic analysis of Paraclostridium bifermentans in the intestinal microbiome of Hu sheep.

The emergence of Paraclostridium bifermentans as a human pathogen has garnered increasing attention. However, due to the challenges associated with isolation, there remains a scarcity of relevant clinical isolates and genomic information. Here, we isolated two P.

Cost-effectiveness of sacituzumab tirumotecan versus chemotherapy for patients with metastatic triple-negative breast cancer in China.

Purpose: Sacituzumab tirumotecan (sac-TMT), a trop-2-targeted antibody-drug conjugate, has demonstrated significant clinical benefit in the OptiTROP-Breast01 trial for patients with advanced or metastatic triple-negative breast cancer (TNBC). This study evaluated the cost-effectiveness of sac-TMT compared with chemotherapy from the perspective of the Chinese healthcare system.

Methods: A partitioned survival model incorporating multiple survival extrapolation approaches was developed to estimate long-term clinical and economic outcomes.

Thrombolytic therapy of human black hair and Au drug-loaded nanocapsules in vivo and in vitro based on near infrared II laser response.

Venous thromboembolism ranks as the third most prevalent cardiovascular disease. Nanotechnology-based drug carriers show significant potential for thrombolytic therapy. However, existing systems face challenges, including environmental impact and limited accessibility.

Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025.

Background: Adult trauma patients with refractory acute cardiopulmonary failure suffer from high morbidity and mortality. In the past decade, a growing body of researches has shown survival benefits of extracorporeal membrane oxygenation (ECMO) in trauma patients who fail to respond to optimal damage control resuscitation (DCR), and there is an opportunity to formulate clinical practice guidelines to guide clinicians in implementing trauma ECMO at the bedside.

Methods: The Chinese Society of Extracorporeal Life Support (CSECLS) convened a domestic panel of interdisciplinary experts to develop this guideline, adhering to the principles of the World Health Organization (WHO) Manual for Guideline Development and the policy of conflict of interest.

Mechanistic insights into electric field-driven specific ion effects on nanoplastics aggregation in heavy metal co-contaminated aquatic systems.

The concurrent pollution of nanoplastics and heavy metals poses emerging threats to relevant aquatic systems. To elucidate the interfacial mechanisms governing nanoplastics-heavy metal aggregation, specifically clarify the unreconized role of electric fields on these processes, systematic investigation of carboxyl-modified polystyrene nanoplastics (PNs) aggregation mediated by Pb²⁺, Cu²⁺, Cd²⁺ and Zn²⁺ were conducted. Quantitative analyses revealed distinct specific ion effects on PNs aggregation, as evidenced by critical coagulation concentrations (CCC: Pb (1.

Cortical microstructural changes in minimal hepatic encephalopathy: a gray matter-based spatial statistics study.

Background: Brain structural alterations have been implicated in the pathophysiology of minimal hepatic encephalopathy (MHE). This study aimed to investigate cortical microstructural abnormalities and their correlation with cognitive impairment in MHE using neurite orientation dispersion and density imaging (NODDI) and voxel-wise gray matter-based spatial statistics (GBSS).

Methods: The NODDI model was fit to multi-shell diffusion-weighted magnetic resonance imaging (dMRI) acquisitions obtained from 35 healthy controls (HC), 41 cirrhotic patients without MHE (NHE), and 21 cirrhotic patients with MHE.

Chitosan membrane tailored for topical acne treatment by incorporating Pickering encapsulated tea tree oil based on organosilane-modified palygorskite.

This study reports a facial approach to fabricate hydrogel membranes with tailored application in topical acne therapy by incorporating tea tree oil (TTO)-loaded Pickering emulsion stabilized by dodecyl triethoxysilane-modified palygorskite in chitosan (CS)/hydroxyethyl cellulose (HEC) polymer matrix. This adding Pickering encapsulated TTO strategy endowed the CS/HEC membrane with increased membrane thickness, mechanical strength, surface hydrophilicity and body fluid absorbability as well as a decreased transparency, all of which could be tailored by adjusting the content of TTO Pickering emulsion in the polymer matrix during preparation. Compared with the TTO directly added membrane, the composite membranes possessed well-distributed small droplets of TTO in the continuous phase of membrane matrix, which can be slowly released at skin physicochemical conditions within 10 h, providing favorable antioxidant scavenging of DPPH and potent bacterial inhibitory effects against Propionibacterium acnes and Staphylococcus aureus.

Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer.

Post-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA modifications and understanding mRNA modifications' occurrence, dynamics and function. Here, a highly sensitive, high-throughput and robust LC-MS/MS-based technique, mRQuant, was developed to simultaneously detect and quantify 84 modified ribonucleosides in cellular mRNA.

Click, assemble, destroy: Bioorthogonal surface programming of nanophotosensitizers for precision cancer therapy.

Phototherapy, a cutting-edge non-invasive cancer treatment, excels in precision and safety but suffers from poor tumor targeting. Bioorthogonal chemistry revolutionizes this field by enabling artificial molecular targets with unparalleled specificity to overcome these limitations and unlock its full therapeutic potential. Leveraging this unique capability, we designed a novel single-component phototherapeutic agent (C-SS-D) that integrates bioorthogonal reactivity to enhance tumor-specific delivery.

Salidroside ameliorates monocrotaline-induced pulmonary arterial hypertension in rats by modulating BKCa channels.

Salidroside (Sal) is a natural active ingredient extracted from Crassulaceae plants, which has pharmacological effects such as anti-tumor, anti-oxidation, and cardiovascular protection. Potassium channel function in pulmonary artery smooth muscle cells (PASMCs) is crucial in the development of pulmonary arterial hypertension (PAH). This study explored the effects of Sal on large-conductance calcium-activated potassium channels (BKCa) in these cells, focusing on the mechanisms underlying its protective effect in PAH.