Psychometric Evaluation of the Core Competencies in Disaster Nursing Scale for Disaster Rescue Nurses in Mainland China.

Disaster rescue nurses (DRNs) play an essential role in disaster medical rescue. To ensure an effective response, it is imperative to assess the core competencies of DRNs. In 2019, the International Council of Nurses (ICNs) published the Core Competencies in Disaster Nursing Version 2.

Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.

Background: Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with no current cure. Developing diagnostic biomarkers is crucial for improving patient outcomes. Circular RNAs (circRNAs) are a class of noncoding RNAs that are more stable, abundant, and structurally distinct compared to linear RNAs.

Shorter versus longer-duration antibiotic treatments for immunocompetent patients with bloodstream infections: a systematic review and meta-analysis.

Background: The optimal duration of antibiotic treatment for bloodstream infections remains uncertain. This study aimed to compare the efficacy and safety of shorter versus longer duration antibiotic treatment for immunocompetent patients with bloodstream infections.

Methods: We searched Medline, Embase, and Cochrane Central Register of Controlled Trials without language restrictions for randomized controlled trials (RCTs) published between database inception and 25 November 2024, comparing shorter-duration antibiotic treatments with longer-duration antibiotic treatments in patients with bloodstream infections with a minimum difference of 3 days in duration of therapy.

The Cyclic Peptide Cyclo-zp80r Controls and Replication in Non-Concentrated (NFC) Orange Juice: Antibacterial Effects and Mechanisms of Action.

The market for non-concentrated (NFC) orange juice is increasing rapidly due to consumer demand for nutrients and flavor. However, it encounters challenges in microbial safety, particularly from and This study aimed to exploit a bio-preservative for NFC orange juice. Results showed that the cyclic peptide cyclo-zp80r had good antibacterial activity, with minimum inhibitory concentration values of 2-8 μM against and .

Isolation, genomic characterization and biocontrol potential of the lytic Pectobacterium phage Pcc_P10 against soft rot of pepper fruits.

Pectobacterium carotovorum (PBC) is a major plant pathogen responsible for soft rot disease in peppers, and its prevention and control remain highly challenging. In this study, a novel lytic phage targeting Pectobacterium carotovorum subsp. carotovorum (PCC), designated as Pcc_P10, belonging to the Pektosvirus genus within the Autographiviridae order, was isolated and characterized.

Case Report: Rare aplastic anemia in pediatric systemic lupus erythematosus: a case series and systematic literature review.

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the immune system mistakenly attacks healthy cells and tissues. This condition can impact various organs and systems, including the hematological system, where aplastic anemia (AA) emerges as a particularly severe and rare complication. Relevant clinical manifestations and treatment experiences must be shared and updated urgently.

The effect of continuous positive airway pressure on nocturnal blood pressure among obstructive sleep apnea-hypopnea syndrome patients.

Purpose: Few articles focus on the effect of CPAP on the nocturnal blood pressure in OSA patients. This study aims to evaluate the effects of continuous positive airway pressure (CPAP) therapy on nocturnal blood pressure in individuals with obstructive sleep apnea-hypopnea syndrome (OSAHS), which fills the research gap. Additionally, differences in nocturnal blood pressure measurements before and after CPAP therapy were analyzed across varying disease severities.

Mediterranean-DASH Intervention for Neurodegenerative Delay Diet to Improve Cognitive Function in Mild Stroke Patients: Rationale and Design of Two Replicate, Pilot Randomized Control Trials.

Introduction: Approximately one-third of stroke survivors develop post-stroke cognitive impairment (PSCI), yet effective preventive strategies remain limited. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was originally developed to promote cognitive health, but its effect on changes in cognitive function among mild stroke patients remains unclear. In this study, we aimed to explore the effect of MIND intervention on cognitive function among mild stroke patients.

Two novel lytic bacteriophages with antibiofilm activity against carbapenem-resistant Klebsiella pneumoniae infections.

Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major challenge in clinical settings due to high morbidity, mortality, and limited treatment options. In response, phage therapy has reemerged as a promising alternative to conventional antibiotics. In this study, two lytic bacteriophages, Kpn_PImp2 and Kpn_PImp3, were isolated from urban sewage, a rich source of phages owing to its diverse microbial community.

[Effect of Obstructive Sleep Apnea Syndrome on Nocturnal Ambulatory Blood Pressure Monitoring Results in Older Adults Without Cardiovascular or Cerebrovascular Diseases].

Objective: To investigate the effect of obstructive sleep apnea syndrome (OSAS) on nocturnal ambulatory blood pressure monitoring results in older adults without cardiovascular or cerebrovascular diseases, and to identify factors causing fluctuations in nocturnal blood pressure in older adults with OSAS.

Methods: A total of 169 older adult OSAS patients with no history of cardiovascular or cerebrovascular diseases were enrolled. According to their severity of OSAS, the participants were divided into 4 groups, including a normal OSAS group, a mild OSAS group, a moderate OSAS group, and a severe OSAS group.

Association of biological aging acceleration transitions and burdens with incident cardiovascular disease: longitudinal insights from a national cohort study.

Background: Previous studies have examined the association between biological aging acceleration (BioAgeAccel) and cardiovascular disease (CVD). However, the effects of BioAgeAccel transitions and burdens on CVD risk remained unclear, and little was known about the association of BioAgeAccel with age at CVD onset.

Methods: We included 316,417 participants from the UK Biobank in the baseline analyses and reserved 7249 in the visit-to-visit analyses.

Ischemia-free liver transplantation improves long-term outcomes in a 5-year follow-up study.

Background & Aims: Ischemia-free liver transplantation (IFLT) is a novel technique designed to avoid ischemia-reperfusion injury (IRI). Here, we report the first detailed 5-year follow-up outcomes.

Methods: We conducted a cohort study comparing long-term outcomes between IFLT and conventional liver transplantation (CLT) recipients of livers donated after brain death (DBD).

Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress.

Objectives: Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.

Methods: This cross-sectional study included 658 community-dwelling older adults (70.

Upcycling distillery waste: N, P, Fe Co-doped porous biochar from excess sludge of sauce-flavor liquor for high-performance supercapacitors.

Enhancing supercapacitor performance by incorporating heteroatoms into biochar represents a fascinating strategy. Our study presented an uncomplicated process for creating porous biochar simultaneously doped with nitrogen (N), phosphorus (P), and iron (Fe). The source material was excess sludge from sauce-flavor liquor production, which conveniently provided high initial N and Fe content for the resulting biochar.

Sarcopenia prediction model based on machine learning and SHAP values for community-based older adults with cardiovascular disease in China.

Background: Sarcopenia (SP), is recognized as a complication of cardiovascular disease (CVD), but few relevant diagnostic models have been developed. This study aims to establish an interpretable diagnostic model for the occurrence of SP in older adult CVD patients living in Chinese community-dwelling (CD).

Methods: We randomly selected participants with CVD recruited from CHARLS from 2011 to 2015 and divided them into a training set and a test set.

Self-Assembly of Bottlebrush-Linear, Rod-Coil Copolymers into Discoidal Nanoparticles.

Block copolymers can self-assemble into nanoscale objects with various morphologies, offering custom nanomaterials for diverse fields of application. However, achieving an amorphous 2D morphology through self-assembly in solution remains challenging. Here, we systematically investigate the structural requirements of rod (bottlebrush)-coil (linear) block copolymers for self-assembly into nanoscale discs by independently varying side chain and backbone lengths.

A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases.

Objectives: Polygenic risk score (PRS) has increasingly shown promise in predicting disease risk; however, studies examining the influence of PRS on age at onset remain limited. This study aimed to systematically assess the impact of PRS on age at onset across multiple diseases.

Study Design: Prospective cohort study METHODS: We calculated PRS with two methods (C+T and PRS-CS) and compared their predictive capability in age at onset of 30 diseases in the UK Biobank.

Fabrication of a Lipopolysaccharide-Targeting Peptide-Based Colloid for Alleviating Carbapenem-Resistant Enterobacteriaceae-Induced Cutaneous Infection.

Carbapenem-resistant Enterobacteriaceae (CRE) becomes a growing threat to human health. Many clinical isolates have shown strong resistance to commonly used antibacterial agents. Inspired by cationic amphiphiles with tandem-repeat sequence, two novel peptides termed IW (IWRRIWRRIWRRIWRR-NH) and WI (WIRRWIRRWIRRWIRR-NH) are designed, synthesized, and investigated in this study.

Associations of life's crucial 9 with mortality among older adults with frailty: a prospective cohort study from the NHANES 2007 to 2018.

Background: Frailty among the elderly represents a considerable public health issue linked to increased vulnerability and adverse outcomes. The Life's Crucial 9 (LC9) score, which includes mental health assessments alongside traditional cardiovascular health metrics, may offer a more comprehensive prediction of mortality risk in frail elderly populations.

Methods: This prospective cohort study leveraged data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.

Clinical value of NT-proBNP, MPO, and NLR combined with echocardiography in prediction of malignant arrhythmia in elderly patients with valvular heart disease.

Objective: We aimed to probe the clinical value of N-terminus pro-brain natriuretic peptide (NT-proBNP), myeloperoxidase (MPO), and neutrophil lymphocyte ratio (NLR) combined with echocardiography in the prediction of malignant arrhythmias (MA) in elderly patients with valvular heart disease (VHD).

Methods: MPO, NT-proBNP, and NLR were detected in blood samples. After 1 year of follow-up, receiver operating characteristic curves were analyzed to determine the clinical value of NT-proBNP, MPO, NLR, and echocardiography for predicting MA in patients with VHD.

Relatively independent and complementary roles of family history and polygenic risk score in age at onset and incident cases of 12 common diseases.

Few studies have systematically compared the overlap and complementarity of family history (FH) and polygenic risk score (PRS) in terms of disease risk. We here investigated the impacts of FH and PRS on the risk of incident diseases or age at disease onset, as well as their clinical value in risk prediction. We analyzed 12 diseases in the prospective cohort study of UK Biobank (N = 461,220).

Influence and role of polygenic risk score in the development of 32 complex diseases.

Background: The polygenic risk score (PRS) has been perceived as advantageous in predicting the risk of complex diseases compared to other measures. We aimed to systematically evaluate the influence of PRS on disease outcome and to explore its predictive value.

Methods: We comprehensively assessed the relationship between PRS and 32 complex diseases in the UK Biobank.