Quantitative Susceptibility Mapping for Evaluating Renal Functional Injury in Chronic Kidney Disease Patients: A Pilot Study.

Chronic kidney disease (CKD) is an increasing global health problem, resulting in gradual loss of renal function and irreversible renal injury. The noninvasive detection, monitoring, and timely intervention of CKD might benefit the patients' prognosis. This study aims to assess renal functional injury in CKD patients by using magnetic resonance imaging (MRI) of quantitative susceptibility mapping (QSM).

Injectable High-Adhesion Fibrinogen-Silk Fibroin Hydrogel Loaded with Curcumin Accelerates Pterygium Repair via Dual Anti-Inflammatory/Antiproliferative Mechanisms.

Pterygium is a common ocular surface lesion, and postoperative recurrence remains a major challenge due to insufficient therapeutic strategies targeting fibroblast proliferation and inflammation. Fibrinogen hydrogel (Fibrin glue, FG), a bioadhesive hydrogel, is widely used in pterygium surgery to secure conjunctival autografts. However, its low adhesion often leads to graft detachment, hindering effective repair.

Suppression of MERTK inhibits proliferation and migration of pterygium fibroblasts.

About 10.2 % of people worldwide suffer from pterygium, a proliferative disorder marked by a wing-shaped growth that stretches from corneoscleral limbus to central area. MER proto-oncogene tyrosine kinase (MERTK) has been linked in recent research to the promotion of organ fibrosis and tumor growth.

DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome.

Background: G-quadruplex structures (G4s) have been identified in the genomes of many organisms and have been proven to play significant epigenetic regulatory roles in gene transcription. Intriguingly, only a small portion of the predicted G4-forming sequences can fold into G4s under cellular conditions. Here, we employ publicly available data, methylation inhibitors, DNA methyltransferase 1 (DNMT1) knockout, and multiple 'Omics' technologies to study the interplay between DNA methylation and chromatin accessibility on G4 formation and the impact on gene expression.

Role of MS4A7 in Regulating Microglial Polarization and Neuroinflammation in Spinal Cord Injury via the cGAS-STING-NLRP3 Axis.

Background And Objectives: Spinal cord injury (SCI) leads to debilitating neurological deficits primarily due to the inflammatory response triggered by secondary injury mechanisms. Microglial activation and polarization significantly influence this response, with pro-inflammatory (M1) polarization exacerbating damage and anti-inflammatory (M2) polarization promoting repair. MS4A7, a membrane-bound protein involved in immune regulation, has been implicated in inflammation, but its role in SCI remains unexplored.

Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.

Background: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK cell-related genes (NRGs) in BC diagnosis and prognosis remains underexplored.

IL-33 alleviates corneal nerve damage in herpes simplex keratitis.

Herpes simplex keratitis (HSK) is a leading cause of corneal blindness globally, primarily resulting from herpes simplex virus type 1 (HSV-1) infection. HSK can cause pervasive and irreversible corneal nerve damage, leading to decreased corneal sensitivity and vision loss. Interleukin (IL)-33, a multifunctional cytokine, plays an important role in immune and inflammatory responses.

Reduction of artifacts from contrast media in spectral-detector CT by combined use of virtual monoenergetic images and orthopedic metal-artifact-reduction algorithm.

This study assesses the artifacts reduction caused by contrast media (CM) in the subclavian and axillary veins in dual-layer spectral-detector CT using virtual monoenergetic images (VMI) and orthopedic metal-artifact-reduction (O-MAR) algorithm. A total of 61 nonconsecutive patients who underwent enhanced chest CT examinations were enrolled in the present study. Conventional images (CI), VMI, CI with O-MAR algorithm (CI + O-MAR), and VMI with O-MAR algorithm (VMI + O-MAR) were reconstructed using the same arterial CT dataset.

Associations of life's crucial 9 with mortality among older adults with frailty: a prospective cohort study from the NHANES 2007 to 2018.

Background: Frailty among the elderly represents a considerable public health issue linked to increased vulnerability and adverse outcomes. The Life's Crucial 9 (LC9) score, which includes mental health assessments alongside traditional cardiovascular health metrics, may offer a more comprehensive prediction of mortality risk in frail elderly populations.

Methods: This prospective cohort study leveraged data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.

Inappropriate dosing of direct oral anticoagulants among very older inpatients with atrial fibrillation.

Among very older patients with atrial fibrillation (AF), the frequency of inappropriate direct oral anticoagulant (DOAC) dosing, associated factors, and temporal trends in practice are unknown.This retrospective study included consecutive inpatients aged 80 years or older with a discharge diagnosis of atrial fibrillation who were prescribed DOACs at discharge from Beijing Hospital between January 2018 and August 2023. Patients were stratified into underdosed, overdosed, or recommended dosing groups.

Gradient Structured Separator Enables Stable Aqueous Zinc Metal Batteries.

Developing a functional separator is an important strategy to improve the electrochemical performance of the Zn anode by suppressing the Zn dendrite growth and parasitic side reactions, thus advancing the aqueous zinc-ion batteries. Herein, we experimentally realize functional separator with gradient-structure based on CeF nanoparticles functionalized glass fibers. The experimental and theoretical results confirmed that the functional separator can tailor the Zn flux and restrain SO transport, promoting dense Zn deposition.

Development of an ultrasensitive magnetic bead-based non-competitive chemiluminescent immunoassay for 17β-estradiol in milk.

Chronic dietary intake of 17β-estradiol (E) poses significant health risks, necessitating rapid and accurate analytical techniques for effective surveillance. This study presents a magnetic particle (MP)-assisted non-competitive chemiluminescent immunoassay (NCLIA) designed for E quantification in milk. The NCLIA employs anti-E monoclonal antibody (mAb)-coated MPs to capture E target molecules, followed by the recognition of acridinium ester (AE)-conjugated anti-E@mAb immunocomplex antibody.

Harmine derivative H-2-168 induces the death of by regulating mitochondrial fusion and fission.

Context: H-2-168 has pharmacological effects similar to those of harmine, with less toxicity. The health of cells and organisms depends on a delicate balance between mitochondrial fusion and fission.

Objective: This study investigated the roles of H-2-168 and mitochondrial fusion and fission in .

Impact of myosteatosis on prognosis in multiple myeloma patients: A subgroup analysis of 182 cases and development of a nomogram.

Background: This study aims to explore the prognostic value of myosteatosis in multiple myeloma (MM) and to analyze the factors influencing myosteatosis.

Methods: A retrospective analysis was conducted on 182 patients treated for MM at our institution from 2009 to 2020 who underwent MRI examinations. The fatty infiltration rate (FIR) of the erector spinae and multifidus muscles at the L3 level was measured to assess the degree of myosteatosis.

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway.

Purpose: This study aims to explore the therapeutic efficacy of evodiamine (EVO) in the treatment of dry eye disease (DED).

Methods: Mouse models of DED was developed using benzalkonium chloride eye drops and subcutaneous atropine injections. Corneal epithelial defects were assessed by fluorescein sodium staining, and tear secretion was measured with the phenol red thread test.

Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011-2018).

Background: Out-of-hospital cardiac arrest (OHCA) is a significant global public health issue, few studies describe characteristics and trends in China. This study examines OHCA features and trends in Shenzhen, one of the fastest-growing cities.

Methods: This retrospective study analysed data from the Shenzhen Emergency Center database (2011-2018), including ambulance dispatch and pre-hospital medical records.

Temporal trends of presumed cardiac origin out-of-hospital cardiac arrest incidence in Guangzhou, southern China: A 10-year consecutive analysis.

Background: Despite the rising disease mortality rates, there is a dearth of studies on the incidence and trends of out-of-hospital cardiac arrests (OHCA) in China. This study aims to investigate the incidence and temporal trends of presumed cardiac origin OHCA in Guangzhou, Southern China, from 2011 to 2020.

Methods And Results: In this population-based retrospective cohort study, pre-hospital data from the Guangzhou Emergency Medical Service (GZ-EMS) from 2011 to 2020 were analyzed.

New emerging T-wave inversion in an elderly patient after atrial fibrillation ablation.

Takotsubo syndrome (TTS) is often misdiagnosed as acute coronary syndrome (ACS) due to the similarities in clinical presentation. The characteristic changes of ECG are helpful for the diagnosis of TTS. We present a case of TTS that occurred during the perioperative period of AF ablation.

Integrated Optical and Magnetic Navigation for Simplified Percutaneous Transforaminal Endoscopic Lumbar Discectomy: A Novel Approach.

Objective: This study aims to evaluate the clinical benefits of the integrated optical and magnetic surgical navigation system in assisting transforaminal endoscopic lumbar discectomy (TELD) for the treatment of lumbar disc herniation (LDH).

Methods: A retrospective analysis was conducted on patients who underwent TELD for LDH at Beijing Chaoyang Hospital, Capital Medical University from November 2022 to December 2023. Patients treated with the integrated optical and magnetic surgical navigation system were defined as the navigation-guided TELD (Ng-TELD) group (30 cases), while those treated with the conventional x-ray fluoroscopy method were defined as the control group (31 cases).

Short-term spinal cord stimulation versus debridement for the treatment of diabetic foot: A retrospective cohort study.

Background: This is the first study to evaluate the efficacy of short-term Spinal Cord Stimulation (st-SCS) versus debridement for treating Diabetic Foot Ulcers (DFU).

Methods: We retrospectively analyzed records from DFU patients treated at our hospital. Patients were divided into two groups: 62 received st-SCS with debridement (SCS group), and 43 received only debridement (debridement group).

The effect of clozapine on immune-related biomarkers in schizophrenia patients.

Globally, schizophrenia is one of the main causes of disability. Approximately 1 % of the general population suffers from schizophrenia, and 30 % of cases are unresponsive to therapy. Clozapine is the gold standard for therapy-resistant schizophrenia (TRS), yet it has limited effectiveness and serious adverse events in some patients.

Tailoring Li Local Coordination Environment of Solid Polymer Electrolytes to Boom Ionic Conductivity.

The low ionic conductivity is the key issue of solid polymer electrolytes (SPEs), hampering their practical application. Great efforts have been devoted to reducing their crystallinity to increase ionic conductivity but ignored their Li local coordination environment influence. Here, Li local coordination environment tunable poly(vinylidene fluoride-co-hexafluoropropylene)-based solid-state electrolytes are experimentally realized via d-cellobiose octaacetate.