Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing.

Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously.

Asian Subgroup Analysis of Patients in the Phase 2 DeLLphi-301 Study of Tarlatamab for Previously Treated Small Cell Lung Cancer.

Introduction: Tarlatamab is a bispecific T-cell engager (BiTE) immunotherapy that binds delta-like ligand 3 on the surface of small cell lung cancer (SCLC) cells and CD3 on T cells, facilitating T cell-mediated cancer cell lysis. In the primary analysis of the phase 2 DeLLphi-301 study (NCT05060016), tarlatamab showed a favourable benefit-to-risk profile with durable objective responses and promising survival outcomes in patients with previously treated SCLC. Here, phase 2 data for the Asia region subgroup are presented.

Self-luminous probes: Illuminating the path to biomedical breakthroughs.

Self-luminous probes, encompassing chemiluminescent and bioluminescent types, generate light through chemical or enzyme-catalyzed reactions, respectively. Unlike photoluminescent probes, their independence from external excitation eliminates autofluorescence and enhances signal-to-noise ratios in imaging. Recent research highlights their versatility in detecting and imaging biomarkers, reactive oxygen species (ROS), heavy metals, and other analytes.

Impact mechanisms of polyethylene microplastic on Cd adsorption and passivation by KMnO-modified biochar in different soils.

In the current situation of increasing cadmium (Cd) and microplastic composite pollution, Cd adsorption and passivation in various soils by biochar under microplastic co-contamination conditions require further investigation. In this study, the behaviors and mechanisms of KMnO-modified biochar on Cd adsorption and passivation were examined in 50 different soils (5 soil types, 5 Cd concentrations, and 2 microplastic treatments) with the three-layer mesh method. Moreover, acidified biochar was employed to quantify the contributions of mineral and non-mineral mechanisms to Cd adsorption by biochar in soils.

GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder characterized by excessive scarring of lung tissue, predominantly affecting middle-aged and elderly populations. Oxidative stress plays a pivotal role in the pathogenesis of pulmonary fibrosis, disrupting redox homeostasis and driving fibrotic progression. Glutathione reductase (GSR), a key antioxidant enzyme, is essential for maintaining cellular glutathione (GSH) levels and mitigating oxidative damage.

Adsorption, immobilization mechanisms and potential risks of Cd in soil-biochar-microplastics system.

The problem of cadmium (Cd) and microplastic compound contamination in agricultural soils is becoming more and more prominent. However, research on biochar remediation for heavy metal-contaminated soils often overlooks the impact of microplastics. This investigation explored Cd adsorption and immobilization of biochar in soils containing varying percentages (0 %, 2 %, 4 %, 6 %, 8 %, and 10 %) of 500-mesh polyethylene microplastics (MP500).

Neuroinflammatory mechanism of Volatile oil from Acori graminei Rhizoma in tourette syndrome: GC-MS, network pharmacology and experimental validation.

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics that significantly impair childhood development. Volatile oil from Acori graminei Rhizoma (VOA), known for its anti-inflammatory and neuroprotective properties, holds therapeutic potential for TS, though its molecular mechanisms remain undefined. In this study, VOA was extracted via hydrodistillation (yield: 1.

Adult-onset Still's disease during pregnancy: two case reports and a comprehensive literature review.

Background: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.

Objectives: To present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD.

Clinical Features and Therapeutic Evaluation of Central Nervous System Involvement in Pediatric Anaplastic Large Cell Lymphoma.

Background: This study analyzed the clinical features of central nervous system involvement (CNS3) in pediatric anaplastic large cell lymphoma (ALCL) and evaluated the CNCL-ALCL-2017 treatment protocol efficacy.

Methods: The clinical data of 215 pediatric ALCL patients aged ≤18 years, including 16 with CNS3, treated following the CNCL-ALCL-2017 protocol, were enrolled. Independent risk factors of CNS3 were determined using multi-factor logistic regression analysis, and survival curves were constructed.

HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.

Homeobox C8 (HOXC8) is a transcription factor preferentially overexpressed in a large percentage of non-small cell lung carcinoma (NSCLC). To investigate the function of HOXC8 in NSCLC, we showed that knockdown of HOXC8 led to massive NSCLC cell death in a mechanism of pyroptosis because both YVAD, a caspase-1 (CASP1) inhibitor, and disulfiram, which prevents gasdermin D (GSDMD) pore formation, blocked cell death caused by HOXC8 depletion. Intriguingly, ASC, a key component of canonic inflammasome, was dispensable for pyroptosis occurring in HOXC8-depleted cells.

Traditional Chinese medicine treatment for epilepsy: Focusing on voltage-gated ion channels.

Ethnopharmacological Relevance: Epilepsy (EP) is a chronic neurological disease, and the clinical treatment of EP is dominated by modern drugs, but one-third of the patients have drug-resistant reactions, which seriously affects the quality of patients' survival. Traditional Chinese medicine (TCM), however, as a promising resource, plays a unique advantage in improving the clinical symptoms of EP and alleviating the adverse effects of modern drug therapy. A large number of studies in recent years have reported that TCM plays an important role in EP treatment by regulating voltage-gated ion channels (VGICs).

LncRNA BACE1-AS delays the propagation of through regulating cell apoptosis by targeting the miR-6805-5p/IRF3 axis.

spp. are important zoonotic pathogens causing diarrhea in humans and various animals. To date, there are still no effective drugs and vaccines for the prevention and treatment of cryptosporidiosis, mainly due to the absence of knowledge on the interaction mechanisms between hosts and .

Comprehensive integration strategy combining chemical modification and physical processing for the efficient formulation of cottonseed protein-derived fish feeds with superior animal husbandry potential.

Growing concerns over antibiotic resistance in animal production highlight bayberry tannin (BT), a bioactive polyphenol, as a promising alternative. Cottonseed protein concentrate (CPC), a premium plant-based protein with exceptional functional versatility, holds significant potential for animal feed applications. Herein, innovative C@B complexes, comprising CPC, BT, hydrogen peroxide, and ascorbic acid, were developed through a safe protein-polyphenol grafting modification technique, and followed by an efficient co-extrusion process.

Concurrent chemotherapy for older patients with locoregionally advanced nasopharyngeal carcinoma: A randomized clinical trial.

Introduction: We aimed to evaluate the efficacy of two different radiotherapy strategies in elderly patients with locally advanced nasopharyngeal carcinoma (NPC) using geriatric assessment.

Materials And Methods: We conducted a randomized phase 2 trial for older patients (≥ 65 years) with stage III-IVA NPC. Patients were randomized into either intensity-modulated radiotherapy (IMRT) alone (RT Arm) or concurrent chemoradiotherapy (CCRT Arm).

Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential.

Microelectrode arrays (MEAs) are essential tools for studying the extracellular electrophysiology of cardiomyocytes in a multi-channel format. However, they typically lack the capability to record intracellular action potentials (APs). Recent studies have relied on costly fabrication of high-resolution microelectrodes combined with electroporation for intracellular recordings, but the impact of microelectrode size on micro-electroporation and the quality of intracellular signal acquisition has yet to be explored.

Deep learning-enhanced anti-noise triboelectric acoustic sensor for human-machine collaboration in noisy environments.

Human-machine voice interaction based on speech recognition offers an intuitive, efficient, and user-friendly interface, attracting wide attention in applications such as health monitoring, post-disaster rescue, and intelligent control. However, conventional microphone-based systems remain challenging for complex human-machine collaboration in noisy environments. Herein, an anti-noise triboelectric acoustic sensor (Anti-noise TEAS) based on flexible nanopillar structures is developed and integrated with a convolutional neural network-based deep learning model (Anti-noise TEAS-DLM).

Intrathecal rituximab in pediatric CD20-positive central nervous system limited lymphoproliferative disease: report of two cases and literature review.

Isolated central nervous system (CNS) involvement due to posttransplantation proliferative disorder (PTLD) is even rarer, with only a few cases reported in the literature. CNS involvement in patients with mature B-cell non-Hodgkin's (NHL) and PTLD confers a significantly worse prognosis as compared to patients without CNS lymphoma disease. Treatment of CNS lymphoma (CNSL) is challenging due to resistance to conventional cytotoxic and intrathecal chemotherapy.

Spectrum and Frequencies of Genes for Inherited Hearing Loss in Southwestern Chinese Families.

Inherited hearing loss is an extremely heterogeneous and often ethnicity-specific disorder, with more than 150 genes identified to date. Thus, clinical diagnosis is challenging, particularly because of the thousands of different severe causal mutations between populations. In this study, we aimed to identify the mutational spectra associated with hearing loss in 89 Southwestern Chinese families.

Effects of Antibiotics on First-line Immunotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma.

Immunotherapy combined with chemotherapy has become the first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). However, the impact of antibiotic (ATB) use on the efficacy of immunotherapy in RM-NPC remains unclear. A total of 200 patients with RM-NPC who started first-line immunotherapy between October 2021 and September 2023 were included.

A case series of B-Lymphoblastic lymphoma with C-MYC rearrangement in children: diagnostic and therapeutic challenges.

C-MYC rearrangement has been listed as a new subcategory of B-cell acute lymphoblastic leukemia (B-ALL) in the latest International Consensus Classification (ICC), but B-cell lymphoblastic lymphoma (B-LBL) with C-MYC rearrangement is extremely rare and therefore is a novel finding worth reporting. In this study, we described a small number of pediatric cases of B-LBL with C-MYC rearrangement, which overlapped features of B-LBL and Burkitt lymphoma (BL), including highly aggressive clinical presentation, lymphoblasts with precursor B-cell phenotype and C-MYC rearrangement; the combination treatment of the mature B-NHL protocol and ALL-type protocol may be appropriate for this rare entity, and more studies are required to identify an adequate therapeutic strategy.

Current Status and Future Perspectives of Robot-Assisted Dental Implant Surgery.

Dental implant surgery is now a well versed approach for tooth replacement, addressing various limitations of fixed bridges and removable dentures, thereby reinstating both the form and function of missing teeth. However, it is technically sensitive and highly dependent on the clinical experience and the expertise of the dentist. With breakthrough progress in robot-assisted surgery for a variety of systemic diseases, robot-assisted dental implant surgery has emerged as a new way to potentially enhance the efficacy of dental implant procedures.

Granulocyte-macrophage colony-stimulating factor for newly diagnosed glioblastoma.

Background: There is a clear need to improve the efficiency of therapeutic strategy for patients with newly diagnosed glioblastoma (GBM). The purpose of this study was to evaluate the feasibility of hypofractionated intensity-modulated radiation therapy (IMRT), temozolomide and granulocyte-macrophage colony-stimulating factor (GM-CSF) for patients with newly diagnosed GBM.

Methods: Patients were treated with hypofractionated IMRT (15 × 3.

Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center.

Background And Objective: Bench surgery (BenS) with kidney autotransplantation serves as an alternative to nephron-sparing surgery (NSS) for patients harboring high-complexity renal tumors that are ineligible for in situ partial nephrectomy (PN). However, the experience of BenS with robot-assisted kidney autotransplantation (RAKAT) has been scarce in such cases. Here, we describe the operative techniques, and functional and oncological outcomes of BenS with RAKAT.

Patient-Reported Outcomes for Patients with Previously Treated Small Cell Lung Cancer Receiving Tarlatamab: Results from the DeLLphi-301 Phase 2 Trial.

Introduction: Tarlatamab demonstrated a durable response and promising survival outcomes in patients with previously treated small cell lung cancer (SCLC) in the phase 2, open-label DeLLphi-301 trial. Patient-reported outcomes (PROs) were evaluated to assess the benefit-risk profile of tarlatamab.

Methods: Patients received tarlatamab intravenously every 2 weeks at a dose of 10 mg (regulatory approved dose) or 100-mg until progression or loss of benefit.

KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer.

Constitutively active mutations of KRAS are prevalent in non-small cell lung cancer (NSCLC). However, the relationship between these mutations and resistance to platinum-based chemotherapy and the underlying mechanisms remain elusive. In this study, we demonstrate that KRAS mutants confer resistance to platinum in NSCLC.