Enhanced Recovery After Surgery (ERAS) Program for InterTAN Nail Surgery in Intertrochanteric Femoral Fracture (ITF) Patients Over 75 years Old.

Background: Enhanced Recovery After Surgery (ERAS) has been extensively applied across numerous surgical specialties. However, there remains a paucity of research regarding the implementation of ERAS in advanced age patients (≥75 years) who undergo InterTAN nail surgery for intertrochanteric femoral fractures (ITF). This study aimed to assess if our ERAS protocol improves satisfaction and clinical outcomes in such patients.

An Integrated TDR Waveguide and Data Interpretation Framework for Multi-Phase Detection in Soil-Water Systems.

Time domain reflectometry (TDR) has been validated for monitoring water level evolution and riverbed scouring in the laboratory. Previous studies have also validated the feasibility of field-based single hydrological parameter monitoring using TDR. However, the current research focuses on developing separated TDR sensing systems, and integrated measurements of multiple hydrological parameters from a single reflected waveform have not been reported.

Environmentally relevant concentrations of 6-PPDQ disrupt vitamin D3 adsorption and receptor function in .

As a derivative of the antioxidant of -(1,3-dimethylbutyl)--phenyl--phenylenediamine (6-PPD), 6-PPD quinone (6-PPDQ) is frequently found in environments and the bodies of organisms. Vitamin D3 is an important vitamin that needs to be absorbed from the intestine. In , vitamin D3 content was reduced by 0.

Adsorption, immobilization mechanisms and potential risks of Cd in soil-biochar-microplastics system.

The problem of cadmium (Cd) and microplastic compound contamination in agricultural soils is becoming more and more prominent. However, research on biochar remediation for heavy metal-contaminated soils often overlooks the impact of microplastics. This investigation explored Cd adsorption and immobilization of biochar in soils containing varying percentages (0 %, 2 %, 4 %, 6 %, 8 %, and 10 %) of 500-mesh polyethylene microplastics (MP500).

The growing interests in Epstein-Barr virus: A bibliometric analysis of research trends, collaborations, and emerging hotspots.

Background: Epstein-Barr Virus (EBV) is a widespread human γ-herpesvirus linked to cancers and autoimmune diseases, but limited comprehensive bibliometric analysis appear to have been conducted in this field.

Methods: Using Web of Science data, 16,318 EBV-related documents (2014-2023) were analyzed via VOSviewer, Bibliometrix, and Citespace following the Strengthening the Reporting of Observational Studies in Epidemiology reporting guideline.

Results: This cross-sectional bibliometric analysis of 16,318 EBV-related documents (2014-2023) revealed a consistent upward trend in annual publications, reflecting growing global interest in EBV research.

Seasonal changes-facilitated release of phosphorus and tungsten from the Lake Taihu sediments through reductive dissolution of Fe/Mn (hydr)oxides and competitive adsorption with dissolved organic matter.

The release of phosphorus (P) and tungsten (W) from sediments can contribute to eutrophication and heavy metal contamination in water bodies, respectively. This study simultaneously investigated the seasonal variation characteristics of P and W in sediments in Meiliang Bay, China. The results indicated that seasonal variations in pH, dissolved oxygen (DO), and temperature (T) at the sediment-water interface influenced the P and W composition as well as their release from sediments.

Production and characterization of a novel exopolysaccharide produced by Pediococcus acidilactici BCB1H isolated from traditional Chinese sauerkraut.

Exopolysaccharides (EPSs) produced by lactic acid bacteria (LAB) have been widely studied, but there has been a smaller amount of research focused on EPSs produced by Pediococcus acidilactici, an important LAB species commonly used in the food and biotechnology industries. In this study, production of the EPS BCB1H by P. acidilactici under different fermentation conditions was investigated, and kinetic models of bacterial growth, substrate consumption, and EPS synthesis were established.

Photo-aged polylactic acid microplastics causes severe transgenerational decline in reproductive capacity in C. elegans: Insight into activation of DNA damage checkpoints affected by multiple germline histone methyltransferases.

At parental generation (P0-G), photo-aged polylactic acid microplastics (PLA-MPs) could cause severe toxicity on nematodes. However, their transgenerational toxicity and underlying mechanism remain largely unknown. Severe transgenerational decline in reproductive capacity was observed in nematodes after exposure to 1-100 μg/L photo-aged PLA-MPs.

The value of mental science: we publish what matters.

Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.

Deciphering Glutaminyl Cyclase Catalytic Pathways Enables Recognition of Anchor Pharmacophores for Inhibitor Discovery.

Glutaminyl cyclases are responsible for N-terminal pyroglutamate modifications of various protein/peptide substrates, influencing their metabolic stability or biological functions. However, the precise chemical pathways by which glutaminyl cyclases catalyze the conversion of N-terminal glutamine/glutamate to pyroglutamate are not yet fully understood. We initially identified the catalytically essential components by cross-species structural analysis, followed by ab initio quantum mechanics/molecular mechanics (QM/MM) calculations of human secretory glutaminyl cyclase (sQC) with two tripeptide substrates, and .

In Vitro Biomechanical Experiment on the Effect of Unilateral Partial Facetectomy Performed by Percutaneous Endoscopy on the Stability of Lumbar Spine.

Objectives: This study's purpose is to investigate the lumbar biomechanical effects of unilateral partial facetectomy (UPF) of different facet joint (FJ) portions under percutaneous endoscopy.

Methods: Forty fresh calf spine models were used to simulate UPF under a physiological load performed through three commonly used needle insertion points (IPs): (1) The apex of the superior FJ (as the first IP); (2) The midpoint of the ventral side of the superior FJ (as the second IP); (3) The lowest point of the ventral side of the superior FJ (as the third IP). The range of motion (ROM) and the L4/5 intradiscal maximum pressure (IMP) were measured and analyzed under a physiological load in all models during flexion, extension, left-right lateral flexion, and left-right axial rotation.

Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors.

CSN5 is responsible for the deneddylation of cullin-RING E3 ubiquitin ligases and is closely linked to the development of various cancers. We previously developed a noncatalytic activity assay platform using novel fluorescent probes derived from azaindole inhibitors, which also highlighted the potential for further structural optimization of azaindoles. Herein, we report a series of new 4-NH-substituted azaindole derivatives, some of which showed nanomolar activity against the CSN5 subunit.

Knowledge-guided diffusion model for 3D ligand-pharmacophore mapping.

Pharmacophores are abstractions of essential chemical interaction patterns, holding an irreplaceable position in drug discovery. Despite the availability of many pharmacophore tools, the adoption of deep learning for pharmacophore-guided drug discovery remains relatively rare. We herein propose a knowledge-guided diffusion framework for 'on-the-fly' 3D ligand-pharmacophore mapping, named DiffPhore.

Characterization of a postbiotic exopolysaccharide produced by Lacticaseibacillus paracasei ET-22 with antioxidant and anti-inflammatory efficacy.

Exopolysaccharides (EPSs) produced by lactic acid bacteria have been extensively studied, but the EPSs as postbiotics are much less investigated. In this study, the EPS, designated as ET22-EPS, was extracted and purified from the culture broth of Lacticaseibacillus paracasei ET-22 previously characterized with strong postbiotic activities. ET22-EPS was determined with a molecular weight of 5.

Comparative analysis of clinical efficacy of unilateral biportal endoscopic and open transforaminal lumbar interbody fusion in the treatment of lumbar degenerative.

Objective: To study the clinical efficacy of unilateral biportal endoscopic lumbar interbody fusion (ULIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of lumbar degenerative diseases, and to compare perioperative indicators, radiological outcomes, and paraspinal muscle -atrophy resulting from these two different surgical methods.

Background: Transforaminal lumbar interbody fusion (TLIF) is widely acknowledged as an efficacious surgical modality for alleviating low back pain. In recent years, unilateral biportal endoscopic lumbar interbody fusion (ULIF) has gained increasing application.

A Database on Antibiotics and Antibiotic Resistance in Wastewater and Solid Waste from Pharmaceutical Industry Based on a Systematic Review.

Residual antimicrobial agents in wastewater and solid waste from antimicrobial manufacturing facilities can potentially contaminate environments. The World Health Organization has established technical guidelines for managing antimicrobial resistance (AMR) in pharmaceutical wastewater and solid waste. However, the scarcity of publicly available data on antimicrobial manufacturing processes impedes the development of effective mitigation strategies.

Mechanism of dissolution of cellulose in quaternary ammonium phosphate/dimethyl sulfoxide.

Finding of new environmentally friendly cellulose solvent system is critical for efficient usage of cellulose. In this paper, cellulose solvent based on the mixture of di-tetrabutylammonium hydrogen phosphate and dimethyl sulfoxide (TBAHPO/DMSO) was developed. We found that TBAHPO/DMSO system has excellent solubility of cellulose.

6-PPD quinone causes lipid accumulation across multiple generations differentially affected by metabolic sensors and components of COMPASS complex in Caenorhabditis elegans.

The toxicity of 6-PPD quinone (6-PPDQ) has been frequently detected. However, the possible transgenerational effects of 6-PPDQ remain largely unclear. Due to short life cycle and high sensitivity to environmental exposure, Caenorhabditis elegans is useful for study of transgenerational toxicology.

Unilateral biportal endoscopic vs. open surgery in the treatment of young obese patients' lumbar degenerative diseases: a retrospective study.

Background: Obesity accelerates the development of lumbar disease and increase the risk during surgery. Unilateral biportal endoscopic discectomy (UBE) is a newly developed minimally invasive technique, which refers to the spinal surgery under unilateral double-channel endoscopic surgery. Therefore, the purpose of this study is whether UBE decompression alone can bring good clinical results to young obese patients with lumbar degenerative diseases.

6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process.

6-PPD quinone (6-PPDQ) could accelerate aging process. However, the underlying mechanism for the acceleration in aging process remains largely unclear. We aimed to examine the role of immunosuppression in 6-PPDQ in causing accelerated aging process in Caenorhabditis elegans.

pH-Responsive Modified HAMA Microspheres Regulate the Inflammatory Microenvironment of Intervertebral Discs.

Currently, intervertebral disc (IVD) degeneration is believed to lead to local accumulation of lactic acid in the IVD, a decrease in pH, activation of the inflammatory pathway, and continued destruction of homeostasis of the IVD. To address these issues, the intelligent and accurate release of drugs is particularly important. In this study, acid-sensitive release methacrylated hyaluronic acid (HAMA) microspheres were constructed by using microfluidic technology, which can be used as a targeted drug delivery system for intervertebral disc degeneration (IVDD) through Schiff base chemical bonding on the surface of the microspheres to achieve intelligent drug release.

Identification of potential key metabolites in synbiotic yoghurt made with probiotic Saccharomyces cerevisiae var. boulardii CNCM I-745 and prebiotic inulin by non-targeted metabolomics analysis.

Probiotic yeasts are attracting widespread attention due to their unique therapeutic properties and benefits to human health, but how they function in food system has been much less studied. Here, yoghurt was prepared using probiotic Saccharomyces cerevisiae var. boulardii CNCM I-745 with and without addition of prebiotic inulin, and the metabolic changes in yoghurt during 28 days of storage at 4 °C were analyzed by non-targeted metabolomics method.